Microaneurysm formation rate as a predictive marker for progression to clinically significant macular edema in nonproliferative diabetic retinopathy

Retina

Volumn 34, Issue 1, 2014, Pages 157-164

  Haritoglou, Christos ^a   Kernt, Marcus ^a   Neubauer, Aljoscha ^a   Gerss, Joachim ^b   Oliveira, Carlos Manta ^c   Kampik, Anselm ^a   Ulbig, Michael ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY OF MÜNSTER   (Germany)

^c Critical Health SA   (Portugal)

Author keywords

Diabetic macular edema; Microaneurysm turnover; Progression

Indexed keywords

HEMOGLOBIN A1C;

ADULT; ARTICLE; AUTOMATION; BLOOD PRESSURE; COMPUTER AIDED DESIGN; COMPUTER PROGRAM; DIABETES MELLITUS; DIABETIC RETINOPATHY; DIAGNOSTIC TEST ACCURACY STUDY; DISEASE COURSE; DISEASE DURATION; EYE FUNDUS; EYE PHOTOGRAPHY; FEMALE; FOLLOW UP; HUMAN; MAJOR CLINICAL STUDY; MALE; MICROANEURYSM; MIDDLE AGED; NEOVASCULARIZATION (PATHOLOGY); PREDICTIVE VALUE; RANDOMIZED CONTROLLED TRIAL (TOPIC); RETINA MACULA EDEMA; SENSITIVITY AND SPECIFICITY; YOUNG ADULT;

ADULT; AGED; ANEURYSM; BIOLOGICAL MARKERS; BLOOD PRESSURE; DIABETIC RETINOPATHY; DISEASE PROGRESSION; FEMALE; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; MACULAR EDEMA; MALE; MIDDLE AGED; RETINAL VESSELS; RISK FACTORS; TIME FACTORS;

EID: 84891850605     PISSN: 0275004X     EISSN: 15392864     Source Type: Journal    
DOI: 10.1097/IAE.0b013e318295f6de     Document Type: Article

References (20)

1. Harris MI. Diabetes in America: epidemiology and scope of the problem. Diabetes Care 1998;21:C11-C14.
2. The Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group. Retinopathy and nephropathy in patients with type 1 diabetes four years after a trial of intensive insulin therapy. N Engl J Med 2000;342:381-389.
3. Klein R, Klein BE, Moss SE. Prevalence of diabetes mellitus in southern Wisconsin. Am J Epidemiol 1984;119:54-61.
4. Richter B, Kohner E. Medical interventions for diabetic retinopathy. In: Wormald R, Smeeth L, Henshaw K, eds. Evidence-Based Ophthalmology. London, United Kingdom: BMJ Books; 2004:331-340.
5. Early Treatment Diabetic Retinopathy Study Research Group. Photocoagulation for diabetic macular edema. Early Treatment Diabetic Retinopathy Study report number 1. Arch Ophthalmol 1985;103:1796-1806.
6. Haritoglou C, Kook D, Neubauer A, et al. Intravitreal bevacizumab (Avastin) therapy for persistent diffuse diabetic macular edema. Retina 2006;26:999-1005.
7. Mitchell P, Bandello F, Schmidt-Erfurth U, et al; RESTORE study group. The RESTORE study: ranibizumab monotherapy or combined with laser versus laser monotherapy for diabetic macular edema. Ophthalmology 2011;118:615-625.
8. Haritoglou C, Gerss J, Sauerland C, et al; The CALDIRET Study Group. The calcium dobesilate (Dexium®) in diabetic retinopathy (CALDIRET)-study: final results. Lancet 2009; 373:1364-1371.
9. Early Treatment Diabetic Retinopathy Study Research Group. Grading diabetic retinopathy from stereoscopic colour fundus photographs-an extension of the modified Arlie House classification EDTRS report number 10. Ophthalmology 1991;98: 786-806.
10. Bernardes R, Nunes S, Pereira I, et al. Computer-assisted microaneurysm turnover in the early stages of diabetic retinopathy. Ophthalmologica 2009;223:284-291.
11. Goatman K, Cree M, Olson J, et al. Automated measurement of microaneurysm turnover. Invest Ophthalmol Vis Sci 2003; 44:5335-5341.
12. Fleming AD. Automated microaneurysm detection using local contrast normalization and local vessel detection. IEEE Trans Med Imaging 2006;25:1223-1232.
13. Tuzel O, Porikli F, Meer P. Region covariance: a fast descriptor for detection and classification. In: Leonardis A, Bischof H, Pinz A, eds. Computer Vision-ECCV 2006. Berlin/Heidelberg: Springer; 2006:589-600.
14. Nunes S, Pires I, Rosa A, et al. Microaneurysm turnover is a biomarker for diabetic retinopathy progression to clinically significant macular edema: findings for type 2 diabetics with nonproliferative retinopathy. Ophthalmologica 2009; 223:292-297.
15. Bernardes R, Baptista P, Cunha-Vaz J, Dias J. Multimodal functional and morphological nonrigid image registration. In Image Processing, 2005. ICIP 2005. IEEE International Conference on 2005:I-1133-1136.
16. Ferreira J, Bernardes R, Baptista P, et al. Earmarking retinal changes in a sequence of digital color fundus photographs. The 3rd European Medical and Biological Engineering Conference, EMBEC'05, November 20-25, 2005, Prague, Czech Republic, IFMBE Proc 2005, 11. 2005 IFMBE.
17. Altman DG, Bland JM. Diagnostic tests 2: predictive values. BMJ 1994;309:102.
18. Lipsitz SR, Laird NM, Harrington DP. Generalized estimating equations for correlated binary data: using the odds ratio as a measure of association. Biometrika 1991;78:153-160.
19. Csaky KG, Richman EA, Ferris FL. Report from the NEI/FDA Ophthalmic Clinical Trial Design and Endpoints Symposium. Invest Ophthalmol Vis Sci 2008;49:479-489.
20. Sjølie AK, Klein R, Porta M, et al. Retinal microaneurysm count predicts progression and regression of diabetic retinopathy. Post-hoc results from the DIRECT Programme. Diabet Med 2011;28:345-351.