The role of recombinant PTH in human fracture healing: A systematic review

Journal of Orthopaedic Trauma

Volumn 28, Issue 1, 2014, Pages 57-62

  Zhang, Dafang ^a,b   Potty, Anish ^c,d   Vyas, Parth ^c,d   Lane, Joseph ^c,d  

^a HARVARD MEDICAL SCHOOL   (United States)

^b HARVARD MIT DIVISION OF HEALTH SCIENCES AND TECHNOLOGY   (United States)

^c HOSPITAL FOR SPECIAL SURGERY   (United States)

^d WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

Fracture; Healing; Human; PTH; Teriparatide

Indexed keywords

PARATHYROID HORMONE; PARATHYROID HORMONE[1-34]; PLACEBO; RECOMBINANT PARATHYROID HORMONE; PTH PROTEIN, HUMAN; RECOMBINANT PROTEIN;

BONE DENSITY; BONE REMODELING; CALLUS; FRACTURE; FRACTURE HEALING; HUMAN; OSSIFICATION; OSTEOBLAST; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; SYSTEMATIC REVIEW; TREATMENT DURATION; DRUG EFFECTS; FRACTURES, BONE;

FRACTURE HEALING; FRACTURES, BONE; HUMANS; PARATHYROID HORMONE; RECOMBINANT PROTEINS;

EID: 84891835842     PISSN: 08905339     EISSN: 15312291     Source Type: Journal    
DOI: 10.1097/BOT.0b013e31828e13fe     Document Type: Review

References (34)

1. Body JJ, Gaich GA, Scheele WH, et al. A randomized double-blind trial to compare the efficacy of teriparatide [recombinant human parathyroid hormone (1-34)] with alendronate in postmenopausal women with osteoporosis. J Clin Endocrinol Metab. 2002;87:4528-4535.
2. Krege JH, Wan X. Teriparatide and the risk of nonvertebral fractures in women with postmenopausal osteoporosis. Bone. 2012;50:161-164.
3. Neer RM, Arnaud CD, Zanchetta JR, et al. Effect of parathyroid hormone (1-34) on fractures and bone mineral density in postmenopausal women with osteoporosis. N Engl J Med. 2001;344:1434-1441.
4. Moricke R, Rettig K, Bethke TD. Use of recombinant human parathyroid hormone(1-84) in patients with postmenopausal osteoporosis: a prospective, open-label, single-arm, multicentre, observational cohort study of the effects of treatment on quality of life and pain-the PROPOSE study. Clin Drug Investig. 2011;31:87-99.
5. Zanchetta JR, Bogado CE, Cisari C, et al. Treatment of postmenopausal women with osteoporosis with PTH(1-84) for 36 months: treatment extension study. Curr Med Res Opin. 2010;26:2627-2633.
6. Alkhiary YM, Gerstenfeld LC, Krall E, et al. Enhancement of experimental fracture-healing by systemic administration of recombinant human parathyroid hormone (PTH 1-34). J Bone Joint Surg Am. 2005;87:731-741.
7. Bostrom MP, Gamradt SC, Asnis P, et al. Parathyroid hormone-related protein analog RS-66271 is an effective therapy for impaired bone healing in rabbits on corticosteroid therapy. Bone. 2000;26:437-442.
8. Komrakova M, Stuermer EK, Werner C, et al. Effect of human parathyroid hormone hPTH (1-34) applied at different regimes on fracture healing and muscle in ovariectomized and healthy rats. Bone. 2010;47:480-492.
9. Mognetti B, Marino S, Barberis A, et al. Experimental stimulation of bone healing with teriparatide: histomorphometric and microhardness analysis in a mouse model of closed fracture. Calcif Tissue Int. 2011;89:163-171.
10. Rowshan HH, Parham MA, Baur DA, et al. Effect of intermittent systemic administration of recombinant parathyroid hormone (1-34) on mandibular fracture healing in rats. J Oral Maxillofac Surg. 2010;68:260-267.
11. Goldhahn J, Feron JM, Kanis J, et al. Implications for fracture healing of current and new osteoporosis treatments: an ESCEO consensus paper. Calcif Tissue Int. 2012;90:343-353.
12. Bukata SV. Systemic administration of pharmacological agents and bone repair: what can we expect. Injury. 2011;42:605-608.
13. Bukata SV, Puzas JE. Orthopedic uses of teriparatide. Curr Osteoporos Rep. 2010;8:28-33.
14. Cheng ML, Gupta V. Teriparatide-indications beyond osteoporosis. Indian J Endocrinol Metab. 2012;16:343-348.
15. Larsson S, Fazzalari NL. Anti-osteoporosis therapy and fracture healing. Arch Orthop Trauma Surg. 2012.
16. Silverman SL, Nasser K. Teriparitide update. Rheum Dis Clin North Am. 2011;37:471-477, vii.
17. Aspenberg P, Genant HK, Johansson T, et al. Teriparatide for acceleration of fracture repair in humans: a prospective, randomized, doubleblind study of 102 postmenopausal women with distal radial fractures. J Bone Miner Res. 2010;25:404-414.
18. Aspenberg P, Johansson T. Teriparatide improves early callus formation in distal radial fractures. Acta Orthopaedica. 2010;81:234-236.
19. Carvalho NN, Voss LA, Almeida MO, et al. Atypical femoral fractures during prolonged use of bisphosphonates: short-term responses to strontium ranelate and teriparatide. J Clin Endocrinol Metab. 2011;96:2675-2680.
20. Chintamaneni S, Finzel K, Gruber BL. Successful treatment of sternal fracture nonunion with teriparatide. Osteoporos Int. 2010;21:1059-1063.
21. Fabbriciani G, Pirro M, Floridi P, et al. Osteoanabolic therapy: a nonsurgical option of treatment for Kummell's disease? Rheumatol Int. 2012; 32:1371-1374.
22. Gagnon C, Sims NA, Mumm S, et al. Lack of sustained response to teriparatide in a patient with adult hypophosphatasia. J Clin Endocrinol Metab. 2010;95:1007-1012.
23. Gomberg SJ, Wustrack RL, Napoli N, et al. Teriparatide, vitamin D, and calcium healed bilateral subtrochanteric stress fractures in a postmenopausal woman with a 13-year history of continuous alendronate therapy. J Clin Endocrinol Metab. 2011;96:1627-1632.
24. Oteo-Alvaro A, Moreno E. Atrophic humeral shaft nonunion treated with teriparatide (rh PTH 1-34): a case report. J Shoulder Elbow Surg. 2010; 19:e22-28.
25. Paridis D, Karachalios T. Atrophic femoral bone nonunion treated with 1-84 PTH. J Musculoskelet Neuronal Interact. 2011;11:320-322; quiz 323.
26. Peichl P, Holzer LA, Maier R, et al. Parathyroid hormone 1-84 accelerates fracture-healing in pubic bones of elderly osteoporotic women. J Bone Jt Surg. 2011;93:1583-1587.
27. Resmini G, Iolascon G. 79-year-old post-menopausal woman with humerus fracture during teriparatide treatment. Aging Clin Exp Res. 2007;19(4 Suppl): 30-31.
28. Rubery PT, Bukata SV. Teriparatide may accelerate healing in delayed unions of type III odontoid fractures: a report of 3 cases. J Spinal Disord Tech. 2010; 23(2):151-155.
29. Schalin-Jäntti C, Mornet E, Lamminen A, et al. Parathyroid hormone treatment improves pain and fracture healing in adult hypophosphatasia. J Clin Endocrinol Metab. 2010;95:5174-5179.
30. Whyte MP, Mumm S, Deal C. Adult hypophosphatasia treated with teriparatide. J Clin Endocrinol Metab. 2007;92:1203-1208.
31. Wu CC, Wei JC, Hsieh CP, et al. Enhanced healing of sacral and pubic insufficiency fractures by teriparatide. J Rheumatol. 2012;39: 1306-1307.
32. Yu CT, Wu JK, Chang CC, et al. Early callus formation in human hip fracture treated with internal fixation and teriparatide. J Rheumatol. 2008; 35:2082-2083.
33. Misiorowski W. Parathyroid hormone and its analogues-molecular mechanisms of action and efficacy in osteoporosis therapy. Endokrynologia Polska. 2011;62:73-78.
34. Drake MT, Srinivasan B, Modder UI, et al. Effects of intermittent parathyroid hormone treatment on osteoprogenitor cells in postmenopausal women. Bone. 2011;49:349-355.