AAV8 induces tolerance in murine muscle as a result of poor APC transduction, T cell exhaustion, and minimal MHCI upregulation on target cells

Molecular Therapy

Volumn 22, Issue 1, 2014, Pages 28-41

  Mays, Lauren E ^a   Wang, Lili ^a   Lin, Jianping ^a   Bell, Peter ^a   Crawford, Alison ^b   Wherry, E John ^a   Wilson, James M ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b REGENERON PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; B7 ANTIGEN; BETA GALACTOSIDASE; CD244 ANTIGEN; CD4 ANTIGEN; CD40 ANTIGEN; CD86 ANTIGEN; IMMUNOGLOBULIN; LYMPHOCYTE ACTIVATION GENE 3; LYMPHOCYTE ANTIGEN; PROGRAMMED DEATH 1 RECEPTOR; TOLL LIKE RECEPTOR; TRANSCRIPTION FACTOR FOXP3; UNCLASSIFIED DRUG;

ADENO ASSOCIATED VIRUS; ADENO ASSOCIATED VIRUS 2; ADENO ASSOCIATED VIRUS 8; ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN PRESENTING CELL; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL FUNCTION; CONTROLLED STUDY; GENE CONTROL; GENE EXPRESSION; GENE TRANSFER; IMMUNOGENICITY; IMMUNOHISTOCHEMISTRY; IMMUNOLOGICAL TOLERANCE; LACZ GENE; LIVER; LYMPHOCYTIC INFILTRATION; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN INTERACTION; RECEPTOR UPREGULATION; REGULATORY T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; TARGET CELL; TARGET CELL DESTRUCTION; TRANSGENE; VIRUS ACTIVATION; VIRUS CAPSID; VIRUS TRANSCRIPTION;

ADENO-ASSOCIATED VIRUS; MURINAE; MUS;

ANIMALS; ANTIGEN-PRESENTING CELLS; DEPENDOVIRUS; GENE EXPRESSION; GENETIC VECTORS; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; IMMUNE TOLERANCE; INFLAMMATION; LYMPHOCYTE ACTIVATION; MALE; MICE; MICE, INBRED C57BL; MUSCLE, SKELETAL; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, CYTOTOXIC; T-LYMPHOCYTES, REGULATORY; TOLL-LIKE RECEPTORS; TRANSDUCTION, GENETIC; TRANSGENES;

EID: 84891827301     PISSN: 15250016     EISSN: 15250024     Source Type: Journal    
DOI: 10.1038/mt.2013.134     Document Type: Article

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