Vitamin D supplementation reduces the risk of acute otitis media in otitis-prone children

Pediatric Infectious Disease Journal

Volumn 32, Issue 10, 2013, Pages 1055-1060

  Marchisio, Paola ^a   Consonni, Dario ^b   Baggi, Elena ^a   Zampiero, Alberto ^a   Bianchini, Sonia ^a   Terranova, Leonardo ^a   Tirelli, Silvia ^c   Esposito, Susanna ^a   Principi, Nicola ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b MINISTRY OF HEALTH   (Sri Lanka)

^c FONDAZIONE IRCCS CA GRANDA OSPEDALE MAGGIORE POLICLINICO   (Italy)

Author keywords

Acute otitis media; Complicated acute otitis media; Otitis media with effusion; Recurrent acute otitis media; Vitamin D; Vitamin D supplementation

Indexed keywords

PLACEBO; VITAMIN D;

ACUTE OTITIS MEDIA; ARTICLE; BEHAVIOR DISORDER; BLOOD SAMPLING; CHILD; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE PREDISPOSITION; DOUBLE BLIND PROCEDURE; DRUG FEVER; EARDRUM; FEMALE; FOLLOW UP; HAZARD RATIO; HUMAN; INFANT; MAJOR CLINICAL STUDY; MALE; MEDICAL HISTORY; OTORRHEA; OUTPATIENT CARE; PATIENT MONITORING; PHYSICAL EXAMINATION; PRESCHOOL CHILD; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; RISK MANAGEMENT; RISK REDUCTION; TYMPANOMETRY; VITAMIN BLOOD LEVEL; VITAMIN SUPPLEMENTATION;

ACUTE DISEASE; CHI-SQUARE DISTRIBUTION; CHILD, PRESCHOOL; DOUBLE-BLIND METHOD; FEMALE; HUMANS; INFANT; KAPLAN-MEIER ESTIMATE; MALE; OTITIS MEDIA; PLACEBOS; PROSPECTIVE STUDIES; TREATMENT OUTCOME; VITAMIN D;

EID: 84891824482     PISSN: 08913668     EISSN: 15320987     Source Type: Journal    
DOI: 10.1097/INF.0b013e31829be0b0     Document Type: Article

References (40)

1. Paradise JL, Rockette HE, Colborn DK, et al. Otitis media in 2253 Pittsburgh-area infants: prevalence and risk factors during the first two years of life. Pediatrics. 1997;99: 318-333.
2. Gravel JS, Karma P, Casselbrant ML, et al. Recent advances in otitis media. 7. Diagnosis and screening. Ann Otol Rhinol Laryngol Suppl. 2005;194: 104-113.
3. Leach AJ, Morris PS. Antibiotics for the prevention of acute and chronic suppurative otitis media in children. Cochrane Database Syst Rev 2006;4:CD004401.
4. Rosenfeld RM, Lous J, Bluestone CD, et al. Recent advances in otitis media. 8. Treatment. Ann Otol Rhinol Laryngol Suppl. 2005;194: 114-139.
5. Meropol SB. Valuing reduced antibiotic use for pediatric acute otitis media. Pediatrics. 2008;121: 669-673.
6. American Academy of Pediatrics Subcommittee on Management of Acute Otitis Media Diagnosis and management of acute otitis media. Pediatrics. 2004;113: 1451-1465.
7. Grevers G; First International Roundtable ENT Meeting Group. Challenges in reducing the burden of otitis media disease: an ENT perspective on improving management and prospects for prevention. Int J Pediatr Otorhinolaryngol. 2010;74: 572-577.
8. Marchisio P, Bellussi L, Di Mauro G, et al. Acute otitis media: from diagnosis to prevention. Summary of the Italian guideline. Int J Pediatr Otorhinolaryngol. 2010;74: 1209-1216.
9. Subcommittee of Clinical Practice Guideline for Diagnosis and Management of Acute Otitis Media in Children (Japan Otological Society, Japan Society for Pediatric Otorhinolaryngology, Japan Society for Infectious Diseases in Otolaryngology. Clinical practice guidelines for the diagnosis and management of acute otitis media (AOM) in children in Japan. Auris Nasus Larynx. 2012;39: 1-8.
10. Esposito S, Marchisio P, Tenconi R, et al. Antibiotic treatment of acute otitis media in pediatrics. Future Microbiol. 2011;6: 485-488.
11. Dhooge IJ. Risk factors for the development of otitis media. Curr Allergy Asthma Rep. 2003;3: 321-325.
12. Morris PS, Leach AJ. Antibiotics for persistent nasal discharge (rhinosinusitis) in children. Cochrane Database Syst Rev. 2008;2:CD001094.
13. Principi N, Baggi E, Esposito S. Prevention of acute otitis media using currently available vaccines. Future Microbiol. 2012;7: 457-465.
14. Lous J, Ryborg CT, Thomsen JL. A systematic review of the effect of tympanostomy tubes in children with recurrent acute otitis media. Int J Pediatr Otorhinolaryngol. 2011;75: 1058-1061.
15. Blazek-O'Neill B. Complementary and alternative medicine in allergy, otitis media, and asthma. Curr Allergy Asthma Rep. 2005;5: 313-318.
16. Lim A, Cranswick N, South M. Adverse events associated with the use of complementary and alternative medicine in children. Arch Dis Child. 2011;96: 297-300.
17. Adams JS, Hewison M. Unexpected actions of vitamin D: new perspectives on the regulation of innate and adaptive immunity. Nat Clin Pract Endocrinol Metab. 2008;4: 80-90.
18. Carlberg C, Molnar F. Current status of vitamin D signaling and its therapeutic applications. Curr Top Med Chem. 2012;12: 528-547.
19. Morcos MM, Gabr AA, Samuel S, et al. Vitamin D administration to tuberculous children and its value. Boll Chim Farm. 1998;137: 157-164.
20. Williams B, Williams AJ, Anderson ST. Vitamin D deficiency and insufficiency in children with tuberculosis. Pediatr Infect Dis J. 2008;27: 941-942.
21. Oduwole AO, Renner JK, Disu E, et al. Relationship between vitamin D levels and outcome of pneumonia in children. West Afr J Med. 2010;29: 373-378.
22. Urashima M, Segawa T, Okazaki M, et al. Randomized trial of vitamin D supplementation to prevent seasonal influenza A in schoolchildren. Am J Clin Nutr. 2010;91: 1255-1260.
23. Roth DE, Shah R, Black RE, et al. Vitamin D status and acute lower respiratory infection in early childhood in Sylhet, Bangladesh. Acta Paediatr. 2010;99: 389-393.
24. Inamo Y, Hasegawa M, Saito K, et al. Serum vitamin D concentrations and associated severity of acute lower respiratory tract infections in Japanese hospitalized children. Pediatr Int. 2011;53: 199-201.
25. Bozzetto S, Carraro S, Giordano G, et al. Asthma, allergy and respiratory infections: the vitamin D hypothesis. Allergy. 2012;67: 10-17.
26. Bluestone CD, Klein JO. Microbiology. Bacteriology of relapse and recurrence. In: Otitis Media in Infants and Children., 4th edition. Hamilton, Canada: BC Decker; 2007: 117.
27. Armitage P, Berry G, Matthews JNS. Statistical Methods in Medical Research. 4th ed. Oxford: Blackwell Science; 2002.
28. Therneau TM, Grambsch PM. Modeling Survival Data: Extending the Cox Model. New York: Springer; 2000.
29. Segal N, Givon-Lavi N, Leibovitz E, et al. Acute otitis media caused by Streptococcus pyogenes in children. Clin Infect Dis. 2005;41: 35-41.
30. Marchisio P, Bianchini S, Baggi E, et al. A retrospective evaluation of microbiology of acute otitis media complicated by spontaneous otorrhea in children living in Milan, Italy. Infection. 2013;41: 629-635.
31. Love JF, Tran-Winkler HJ, Wessels MR. Vitamin D and the human antimicrobial peptide LL-37 enhance group a streptococcus resistance to killing by human cells. MBio. 2012;3:e00394-e00412.
32. Muehleisen B, Bikle DD, Aguilera C, et al. PTH/PTHrP and vitamin D control antimicrobial peptide expression and susceptibility to bacterial skin infection. Sci Transl Med. 2012;4: 135ra66.
33. Vieth R, Bischoff-Ferrari H, Boucher BJ, et al. The urgent need to recommend an intake of vitamin D that is effective. Am J Clin Nutr. 2007;85: 649-650.
34. Levin GP, Robinson-Cohen C, de Boer IH, et al. Genetic variants and associations of 25-hydroxyvitamin D concentrations with major clinical outcomes. JAMA. 2012;308: 1898-1905.
35. Camargo CA Jr, Ganmaa D, Frazier AL, et al. Randomized trial of vitamin D supplementation and risk of acute respiratory infection in Mongolia. Pediatrics. 2012;130:e561-e567.
36. Tolppanen AM, Fraser A, Fraser WD, et al. Risk factors for variation in 25-hydroxyvitamin D3 and D2 concentrations and vitamin D deficiency in children. J Clin Endocrinol Metab. 2012;97: 1202-1210.
37. Major JM, Graubard BI, Dodd KW, et al. Variability and reproducibility of circulating vitamin D in a nationwide U.S. population. J Clin Endocrinol Metab. 2013;98: 97-104.
38. Holick MF, Binkley NC, Bischoff-Ferrari HA, et al. Guidelines for preventing and treating vitamin D deficiency and insufficiency revisited. J Clin Endocrinol Metab. 2012;97: 1153-1158.
39. Principi N, Bianchini S, Baggi E, et al. Implications of maternal vitamin D deficiency for the fetus, the neonate and the young infant. Eur J Nutr. 2013;52: 859-867.
40. Ross AC, Manson JE, Abrams SA, et al. The 2011 dietary reference intakes for calcium and vitamin D: what dietetics practitioners need to know. J Am Diet Assoc. 2011;111: 524-527.