Improvement in insulin sensitivity during mifepristone treatment of cushing syndrome: Early and late effects

Diabetes Care

Volumn 36, Issue 9, 2013, Pages

  Wallia, Amisha ^a   Colleran, Kathleen ^b   Purnell, Jonathan Q ^c   Gross, Coleman ^d   Molitch, Mark E ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b UNIVERSITY OF NEW MEXICO   (United States)

^c OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^d Corcept Therapeutics ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPONECTIN; GLUCOCORTICOID; MIFEPRISTONE;

CELL FUNCTION; COMPARATIVE STUDY; CUSHING SYNDROME; HUMAN; IMPAIRED GLUCOSE TOLERANCE; INSULIN RELEASE; INSULIN SENSITIVITY; LETTER; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; ORAL GLUCOSE TOLERANCE TEST; WAIST CIRCUMFERENCE; WEIGHT; WEIGHT REDUCTION;

CUSHING SYNDROME; GLUCOSE TOLERANCE TEST; HORMONE ANTAGONISTS; HUMANS; INSULIN RESISTANCE; MIFEPRISTONE;

EID: 84891821126     PISSN: 01495992     EISSN: 19355548     Source Type: Journal    
DOI: 10.2337/dc13-0246     Document Type: Letter

References (5)

1. Pivonello R, De Leo M, Vitale P, et al. Pathophysiology of diabetes mellitus in Cushing's syndrome. Neuroendocrinology 2010;92 (Suppl. 1): 77-81
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3. Fleseriu M, Biller BM, Findling JW, Molitch ME, Schteingart DE, Gross C; SEISMIC Study Investigators. Mifepristone, a glucocorticoid receptor antagonist, produces clinical and metabolic benefits in patients with Cushing's syndrome. J Clin Endocrinol Metab 2012;97: 2039-2049
4. Albareda M, Rodríguez-Espinosa J, Murugo M, de Leiva A, Corcoy R. Assessment of insulin sensitivity and beta-cell function from measurements in the fasting state and during an oral glucose tolerance test. Diabetologia 2000;43: 1507-1511
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