Constitutively active CaMKKα stimulates skeletal muscle glucose uptake in insulin-resistant mice in vivo

Diabetes

Volumn 63, Issue 1, 2014, Pages 142-151

  Hinkley, J Matthew ^a,b   Ferey, Jeremie L ^a,b   Brault, Jeffrey J ^a,b   Smith, Cheryl A S ^a,b   Gilliam, Laura A A ^a,b   Witczak, Carol A ^a,b  

^a EAST CAROLINA UNIVERSITY   (United States)

^b EAST CAROLINA UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

[3H] 2 DEOXYGLUCOSE; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE KINASE; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE KINASE ALPHA; DEOXYGLUCOSE; INSULIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; ELECTROPORATION; GLUCOSE TRANSPORT; INSULIN RESISTANCE; LIPID DIET; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SKELETAL MUSCLE;

EID: 84891797191     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db13-0452     Document Type: Article

References (26)

1. DeFronzo RA, Gunnarsson R, Björkman O, Olsson M, Wahren J. Effects of insulin on peripheral and splanchnic glucose metabolism in noninsulindependent (type II) diabetes mellitus. J Clin Invest 1985;76:149-155
2. Björnholm M, Kawano Y, Lehtihet M, Zierath JR. Insulin receptor substrate-1 phosphorylation and phosphatidylinositol 3-kinase activity in skeletal muscle from NIDDM subjects after in vivo insulin stimulation. Diabetes 1997;46:524-527
3. Kennedy JW, Hirshman MF, Gervino EV, et al. Acute exercise induces GLUT4 translocation in skeletal muscle of normal human subjects and subjects with type 2 diabetes. Diabetes 1999;48:1192-1197
4. Youn JH, Gulve EA, Holloszy JO. Calcium stimulates glucose transport in skeletal muscle by a pathway independent of contraction. Am J Physiol 1991;260:C555-C561
5. Wright DC, Hucker KA, Holloszy JO, Han DH. Ca2+ and AMPK both mediate stimulation of glucose transport by muscle contractions. Diabetes 2004; 53:330-335
6. Jensen TE, Rose AJ, Hellsten Y, Wojtaszewski JF, Richter EA. Caffeineinduced Ca(2+) release increases AMPK-dependent glucose uptake in rodent soleus muscle. Am J Physiol Endocrinol Metab 2007;293:E286-E292
7. Witczak CA, Fujii N, Hirshman MF, Goodyear LJ. Ca2+/calmodulindependent protein kinase kinase-alpha regulates skeletal muscle glucose uptake independent of AMP-activated protein kinase and Akt activation. Diabetes 2007;56:1403-1409
8. Jensen TE, Rose AJ, Jørgensen SB, et al. Possible CaMKK-dependent regulation of AMPK phosphorylation and glucose uptake at the onset of mild tetanic skeletal muscle contraction. Am J Physiol Endocrinol Metab 2007;292:E1308-E1317
9. Witczak CA, Jessen N, Warro DM, et al. CaMKII regulates contraction- but not insulin-induced glucose uptake in mouse skeletal muscle. Am J Physiol Endocrinol Metab 2010;298:E1150-E1160
10. Enslen H, Tokumitsu H, Stork PJ, Davis RJ, Soderling TR. Regulation of mitogen-activated protein kinases by a calcium/calmodulin-dependent protein kinase cascade. Proc Natl Acad Sci USA 1996;93:10803-10808
11. Ferré P, Leturque A, Burnol AF, Penicaud L, Girard J. A method to quantify glucose utilization in vivo in skeletal muscle and white adipose tissue of the anaesthetized rat. Biochem J 1985;228:103-110
12. Kramer HF, Witczak CA, Taylor EB, Fujii N, Hirshman MF, Goodyear LJ. AS160 regulates insulin- and contraction-stimulated glucose uptake in mouse skeletal muscle. J Biol Chem 2006;281:31478-31485
13. Towbin H, Staehelin T, Gordon J. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci USA 1979;76:4350-4354
14. Sakamoto K, Holman GD. Emerging role for AS160/TBC1D4 and TBC1D1 in the regulation of GLUT4 traffic. Am J Physiol Endocrinol Metab 2008;295: E29-E37
15. McGee SL, Mustard KJ, Hardie DG, Baar K. Normal hypertrophy accompanied by phosphoryation and activation of AMP-activated protein kinase alpha1 following overload in LKB1 knockout mice. J Physiol 2008;586: 1731-1741
16. Surwit RS, Kuhn CM, Cochrane C, McCubbin JA, Feinglos MN. Dietinduced type II diabetes in C57BL/6J mice. Diabetes 1988;37:1163-1167
17. Surwit RS, Feinglos MN, Rodin J, et al. Differential effects of fat and sucrose on the development of obesity and diabetes in C57BL/6J and A/J mice. Metabolism 1995;44:645-651
18. Jorgensen SB, O'Neill HM, Sylow L, et al. Deletion of skeletal muscle SOCS3 prevents insulin resistance in obesity. Diabetes 2013;62:56-64
19. Beck Jørgensen S, O'Neill HM, Hewitt K, Kemp BE, Steinberg GR. Reduced AMP-activated protein kinase activity in mouse skeletal muscle does not exacerbate the development of insulin resistance with obesity. Diabetologia 2009;52:2395-2404
20. Augusto V, Padovani CR, Campos GER. Skeletal muscle fiber types in C57BL6J mice. Braz J Morphol Sci 2004;21:89-94
21. Yano S, Tokumitsu H, Soderling TR. Calcium promotes cell survival through CaM-K kinase activation of the protein-kinase-B pathway. Nature 1998; 396:584-587
22. Taylor EB, An D, Kramer HF, et al. Discovery of TBC1D1 as an insulin-, AICAR-, and contraction-stimulated signaling nexus in mouse skeletal muscle. J Biol Chem 2008;283:9787-9796
23. Vichaiwong K, Purohit S, An D, et al. Contraction regulates site-specific phosphorylation of TBC1D1 in skeletal muscle. Biochem J 2010;431: 311-320
24. Kramer HF, Witczak CA, Fujii N, et al. Distinct signals regulate AS160 phosphorylation in response to insulin, AICAR, and contraction in mouse skeletal muscle. Diabetes 2006;55:2067-2076
25. Treebak JT, Taylor EB, Witczak CA, et al. Identification of a novel phosphorylation site on TBC1D4 regulated by AMP-activated protein kinase in skeletal muscle. Am J Physiol Cell Physiol 2010;298:C377-C385
26. Treebak JT, Glund S, Deshmukh A, et al. AMPK-mediated AS160 phosphorylation in skeletal muscle is dependent on AMPK catalytic and regulatory subunits. Diabetes 2006;55:2051-2058 and Skin Diseases and Skin Diseases