Interaction of microbes with mucus and mucins recent developments

Gut Microbes

Volumn 5, Issue 1, 2013, Pages

  Naughton, Julie ^a   Duggan, Gina ^a   Bourke, Billy ^a,b   Clyne, Marguerite ^a  

^a UNIVERSITY COLLEGE DUBLIN   (Ireland)

^b OUR LADY S CHILDREN S HOSPITAL   (Ireland)

Author keywords

Campylobacter jejuni; Helicobacter pylori; Microarray; Mucin; Mucus

Indexed keywords

MUCIN; MUCIN 2; MUCIN 5AC; MUCIN 5B; MUCIN 6;

ARTICLE; CLOSTRIDIUM INFECTION; DOWN REGULATION; GENE EXPRESSION; HELICOBACTER INFECTION; HOST PATHOGEN INTERACTION; INTESTINE EPITHELIUM CELL; MICROARRAY ANALYSIS; MICROFLORA; MICROORGANISM; MUCUS; NONHUMAN; ANIMAL; CAMPYLOBACTER JEJUNI; GASTRIC MUCOSA; HELICOBACTER PYLORI; HUMAN; INTESTINE MUCOSA; METABOLISM; MICROBIOLOGY; PATHOGENICITY;

ANIMALS; CAMPYLOBACTER JEJUNI; GASTRIC MUCOSA; HELICOBACTER PYLORI; HUMANS; INTESTINAL MUCOSA; MUCINS; MUCUS;

EID: 84891789225     PISSN: 19490976     EISSN: 19490984     Source Type: Journal    
DOI: 10.4161/gmic.26680     Document Type: Article

References (40)

1. Johansson ME, Phillipson M, Petersson J, Velcich A, Holm L, Hansson GC. The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria. Proc Natl Acad Sci U S A 2008; 105:15064-9; PMID:18806221; http://dx.doi.org/10.1073/pnas.0803124105
2. Ermund A, Schütte A, Johansson ME, Gustafsson JK, Hansson GC. Studies of mucus in mouse stomach, small intestine, and colon. I. Gastrointestinal mucus layers have different properties depending on location as well as over the Peyer's patches. Am J Physiol Gastrointest Liver Physiol 2013; 305:G341-7; PMID:23832518; http://dx.doi.org/10.1152/ajpgi.00046.2013
3. Johansson ME, Gustafsson JK, Holmén-Larsson J, Jabbar KS, Xia L, Xu H, Ghishan FK, Carvalho FA, Gewirtz AT, Sjövall H, et al. Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and patients with ulcerative colitis. Gut 2013; PMID:23426893; http://dx.doi.org/10.1136/gutjnl-2012-303207
4. Palmer C, Bik EM, DiGiulio DB, Relman DA, Brown PO. Development of the human infant intestinal microbiota. PLoS Biol 2007; 5:e177; PMID:17594176; http://dx.doi.org/10.1371/journal.pbio.0050177
5. Nanthakumar NN, Dai D, Meng D, Chaudry N, Newburg DS, Walker WA. Regulation of intestinal ontogeny: effect of glucocorticoids and luminal microbes on galactosyltransferase and trehalase induction in mice. Glycobiology 2005; 15:221-32; PMID:15483270; http://dx.doi.org/10.1093/glycob/cwi004
6. Leser TD, Mølbak L. Better living through microbial action: the benefits of the mammalian gastro-intestinal microbiota on the host. Environ Microbiol 2009; 11:2194-206; PMID:19737302; http://dx.doi.org/10.1111/j.1462-2920.2009.01941.x
7. Sudo N, Sawamura S, Tanaka K, Aiba Y, Kubo C, Koga Y. The requirement of intestinal bacterial flora for the development of an IgE production system fully susceptible to oral tolerance induction. J Immunol 1997; 159:1739-45; PMID:9257835
8. Ley RE. Obesity and the human microbiome. Curr Opin Gastroenterol 2010; 26:5-11; PMID:19901833; http://dx.doi.org/10.1097/MOG.0b013e328333d751
9. Manichanh C, Borruel N, Casellas F, Guarner F. The gut microbiota in IBD. Nat Rev Gastroenterol Hepatol 2012; 9:599-608; PMID:22907164; http://dx.doi.org/10.1038/nrgastro.2012.152
10. Karlsson FH, Tremaroli V, Nookaew I, Bergström G, Behre CJ, Fagerberg B, Nielsen J, Bäckhed F. Gut metagenome in European women with normal, impaired and diabetic glucose control. Nature 2013; 498:99-103; PMID:23719380; http://dx.doi.org/10.1038/nature12198
11. Longman RJ, Douthwaite J, Sylvester PA, Poulsom R, Corfield AP, Thomas MG, Wright NA. Coordinated localisation of mucins and trefoil peptides in the ulcer associated cell lineage and the gastrointestinal mucosa. Gut 2000; 47:792-800; PMID:11076877; http://dx.doi.org/10.1136/gut.47.6.792
12. Corfield AP, Myerscough N, Longman R, Sylvester P, Arul S, Pignatelli M. Mucins and mucosal protection in the gastrointestinal tract: new prospects for mucins in the pathology of gastrointestinal disease. Gut 2000; 47:589-94; PMID:10986224; http://dx.doi.org/10.1136/gut.47.4.589
13. Hooper LV, Gordon JI. Commensal host-bacterial relationships in the gut. Science 2001; 292:1115-8; PMID:11352068; http://dx.doi.org/10.1126/science.1058709
14. Corfield AP, Wiggins R, Edwards C, Myerscough N, Warren BF, Soothill P, Millar MR, Horner P. A sweet coating-how bacteria deal with sugars. Adv Exp Med Biol 2003; 535:3-15; PMID:14714885; http://dx.doi.org/10.1007/978-1-4615-0065-0_1
15. Moran AP, Gupta A, Joshi L. Sweet-talk: role of host glycosylation in bacterial pathogenesis of the gastrointestinal tract. Gut 2011; 60:1412-25; PMID:21228430; http://dx.doi.org/10.1136/gut.2010.212704
16. Bouckaert J, Berglund J, Schembri M, De Genst E, Cools L, Wuhrer M, Hung CS, Pinkner J, Slättegård R, Zavialov A, et al. Receptor binding studies disclose a novel class of high-affinity inhibitors of the Escherichia coli FimH adhesin. Mol Microbiol 2005; 55:441-55; PMID:15659162; http://dx.doi.org/10.1111/j.1365-2958.2004.04415.x
17. Borén T, Falk P, Roth KA, Larson G, Normark S. Attachment of Helicobacter pylori to human gastric epithelium mediated by blood group antigens. Science 1993; 262:1892-5; PMID:8018146; http://dx.doi.org/10.1126/science.8018146
18. Corfield AP, Wagner SA, Clamp JR, Kriaris MS, Hoskins LC. Mucin degradation in the human colon: production of sialidase, sialate O-acetylesterase, N-acetylneuraminate lyase, arylesterase, and glycosulfatase activities by strains of fecal bacteria. Infect Immun 1992; 60:3971-8; PMID:1398908
19. Corfield AP, Wagner SA, O'Donnell LJ, Durdey P, Mountford RA, Clamp JR. The roles of enteric bacterial sialidase, sialate O-acetyl esterase and glycosulfatase in the degradation of human colonic mucin. Glycoconj J 1993; 10:72-81; PMID:8358229; http://dx.doi.org/10.1007/BF00731190
20. Haider K, Hossain A, Wanke C, Qadri F, Ali S, Nahar S. Production of mucinase and neuramini-dase and binding of Shigella to intestinal mucin. J Diarrhoeal Dis Res 1993; 11:88-92; PMID:8409287
21. Homer KA, Whiley RA, Beighton D. Production of specific glycosidase activities by Streptococcus intermedius strain UNS35 grown in the presence of mucin. J Med Microbiol 1994; 41:184-90; PMID:8064838; http://dx.doi.org/10.1099/00222615-41-3-184
22. Cooke CL, An HJ, Kim J, Canfield DR, Torres J, Lebrilla CB, Solnick JV. Modification of gastric mucin oligosaccharide expression in rhesus macaques after infection with Helicobacter pylori. Gastroenterology 2009; 137:1061-71, e1-8; PMID:19375420; http://dx.doi.org/10.1053/j.gastro.2009.04.014
23. Skoog EC, Sjöling A, Navabi N, Holgersson J, Lundin SB, Lindén SK. Human gastric mucins differently regulate Helicobacter pylori proliferation, gene expression and interactions with host cells. PLoS One 2012; 7:e36378; PMID:22563496; http://dx.doi.org/10.1371/journal.pone.0036378
24. Tu QV, McGuckin MA, Mendz GL. Campylobacter jejuni response to human mucin MUC2: modulation of colonization and pathogenicity determinants. J Med Microbiol 2008; 57:795-802; PMID:18566135; http://dx.doi.org/10.1099/jmm.0.47752-0
25. Buchon N, Broderick NA, Poidevin M, Pradervand S, Lemaitre B. Drosophila intestinal response to bacterial infection: activation of host defense and stem cell proliferation. Cell Host Microbe 2009; 5:200-11; PMID:19218090; http://dx.doi.org/10.1016/j. chom.2009.01.003
26. Naughton JA, Mariño K, Dolan B, Reid C, Gough R, Gallagher ME, Kilcoyne M, Gerlach JQ, Joshi L, Rudd P, et al. Divergent mechanisms of interaction of Helicobacter pylori and Campylobacter jejuni with mucus and mucins. Infect Immun 2013; 81:2838-50; PMID:23716616; http://dx.doi.org/10.1128/IAI.00415-13
27. Favre-Bonté S, Licht TR, Forestier C, Krogfelt KA. Klebsiella pneumoniae capsule expression is necessary for colonization of large intestines of streptomycin-treated mice. Infect Immun 1999; 67:6152-6; PMID:10531279
28. Alemka A, Clyne M, Shanahan F, Tompkins T, Corcionivoschi N, Bourke B. Probiotic colonization of the adherent mucus layer of HT29MTXE12 cells attenuates Campylobacter jejuni virulence properties. Infect Immun 2010; 78:2812-22; PMID:20308300; http://dx.doi.org/10.1128/IAI.01249-09
29. Gagnon M, Zihler Berner A, Chervet N, Chassard C, Lacroix C. Comparison of the Caco-2, HT-29 and the mucus-secreting HT29-MTX intestinal cell models to investigate Salmonella adhesion and invasion. J Microbiol Methods 2013; 94:274-9; PMID:23835135; http://dx.doi.org/10.1016/j. mimet.2013.06.027
30. Mahdavi J, Sondén B, Hurtig M, Olfat FO, Forsberg L, Roche N, Angstrom J, Larsson T, Teneberg S, Karlsson KA, et al. Helicobacter pylori SabA adhesin in persistent infection and chronic inflammation. Science 2002; 297:573-8; PMID:12142529; http://dx.doi.org/10.1126/science.1069076
31. Schüller S, Lucas M, Kaper JB, Girón JA, Phillips AD. The ex vivo response of human intestinal mucosa to enteropathogenic Escherichia coli infection. Cell Microbiol 2009; 11:521-30; PMID:19134113; http://dx.doi.org/10.1111/j.1462-5822.2008.01275.x
32. Corcionivoschi N, Alvarez LA, Sharp TH, Strengert M, Alemka A, Mantell J, Verkade P, Knaus UG, Bourke B. Mucosal reactive oxygen species decrease virulence by disrupting Campylobacter jejuni phosphotyrosine signaling. Cell Host Microbe 2012; 12:47-59; PMID:22817987; http://dx.doi.org/10.1016/j.chom.2012.05.018
33. Godl K, Johansson ME, Lidell ME, Mörgelin M, Karlsson H, Olson FJ, Gum JR Jr., Kim YS, Hansson GC. The N terminus of the MUC2 mucin forms trimers that are held together within a trypsin-resistant core fragment. J Biol Chem 2002; 277:47248-56; PMID:12374796; http://dx.doi.org/10.1074/jbc.M208483200
34. Lidell ME, Johansson ME, Mörgelin M, Asker N, Gum JR Jr., Kim YS, Hansson GC. The recombinant C-terminus of the human MUC2 mucin forms dimers in Chinese-hamster ovary cells and heterodimers with full-length MUC2 in LS 174T cells. Biochem J 2003; 372:335-45; PMID:12597771; http://dx.doi.org/10.1042/BJ20030003
35. Lidell ME, Hansson GC. Cleavage in the GDPH sequence of the C-terminal cysteine-rich part of the human MUC5AC mucin. Biochem J 2006; 399:121-9; PMID:16787389; http://dx.doi.org/10.1042/BJ20060443
36. Lidell ME, Moncada DM, Chadee K, Hansson GC. Entamoeba histolytica cysteine proteases cleave the MUC2 mucin in its C-terminal domain and dissolve the protective colonic mucus gel. Proc Natl Acad Sci U S A 2006; 103:9298-303; PMID:16754877; http://dx.doi.org/10.1073/pnas.0600623103
37. Ehre C, Worthington EN, Liesman RM, Grubb BR, Barbier D, O'Neal WK, Sallenave JM, Pickles RJ, Boucher RC. Overexpressing mouse model demonstrates the protective role of Muc5ac in the lungs. Proc Natl Acad Sci U S A 2012; 109:16528-33; PMID:23012413; http://dx.doi.org/10.1073/pnas.1206552109
38. Kilcoyne M, Gerlach JQ, Gough R, Gallagher ME, Kane M, Carrington SD, Joshi L. Construction of a natural mucin microarray and interrogation for biologically relevant glyco-epitopes. Anal Chem 2012; 84:3330-8; PMID:22390135; http://dx.doi.org/10.1021/ac203404n
39. Alemka A, Whelan S, Gough R, Clyne M, Gallagher ME, Carrington SD, Bourke B. Purified chicken intestinal mucin attenuates Campylobacter jejuni pathogenicity in vitro. J Med Microbiol 2010; 59:898-903; PMID:20466838; http://dx.doi.org/10.1099/jmm.0.019315-0
40. Barr JJ, Auro R, Furlan M, Whiteson KL, Erb ML, Pogliano J, Stotland A, Wolkowicz R, Cutting AS, Doran KS, et al. Bacteriophage adhering to mucus provide a non-host-derived immunity. Proc Natl Acad Sci U S A 2013; 110:10771-6; PMID:23690590; http://dx.doi.org/10.1073/pnas.1305923110