Overexpression of stearoyl-CoA desaturase 1 in bone-marrow mesenchymal stem cells increases osteogenesis

Panminerva Medica

Volumn 55, Issue 3, 2013, Pages 283-289

  Tao, J ^a   Shi, J ^b   Lu, Y ^a   Dou, B ^a   Zhou, Z ^a   Gao, M ^a   Zhu, Z ^c  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

^b NANJING MEDICAL UNIVERSITY   (China)

^c SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Mesenchymal stem cells; Mouse 1; Osteogenesis.; Scd1 protein

Indexed keywords

ACYL COENZYME A DESATURASE; ALKALINE PHOSPHATASE; OSTEOCALCIN; SCD1 PROTEIN, MOUSE;

ANIMAL; ARTICLE; BONE DEVELOPMENT; BONE MARROW CELL; CELL STRAIN HEK293; ENZYMOLOGY; GENE VECTOR; GENETIC TRANSDUCTION; GENETIC TRANSFECTION; GENETICS; HUMAN; LENTIVIRINAE; MESENCHYMAL STROMA CELL; METABOLISM; MOUSE; OSTEOBLAST; TIME; UPREGULATION;

ALKALINE PHOSPHATASE; ANIMALS; BONE MARROW CELLS; GENETIC VECTORS; HEK293 CELLS; HUMANS; LENTIVIRUS; MESENCHYMAL STROMAL CELLS; MICE; OSTEOBLASTS; OSTEOCALCIN; OSTEOGENESIS; STEAROYL-COA DESATURASE; TIME FACTORS; TRANSDUCTION, GENETIC; TRANSFECTION; UP-REGULATION;

EID: 84891787655     PISSN: 00310808     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Parhami F, Morrow AD, Balucan J, Leitinger N, Watson AD, Tintut Y et al. Lipid oxidation products have opposite effects on calcifying vascular cell and bone cell differentiation. A possible explanation for the paradox of arterial calcification in osteoporotic patients. Arterioscler Thromb Vasc Biol 1997;17:680-7. (Pubitemid 27169128)
2. Akune T, Ohba S, Kamekura S, Yamaguchi M, Chung UI, Kubota N et al. PPARgamma insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors. J Clin Invest 2004;113:846-55. (Pubitemid 38544143)
3. Man WC, Miyazaki M, Chu K, Ntambi JM. Membrane topology of mouse stearoyl-CoA desaturase 1. J Biol Chem 2006;281:1251-60.
4. Ntambi JM, Miyazaki M. Regulation of stearoyl-CoA desaturases and role in metabolism. Prog Lipid Res 2004;43:91-104. (Pubitemid 37487985)
5. Insull W, Jr., Bartsch GE. Fatty acid composition of human adipose tissue related to age, sex, and race. Am J Clin Nutr 1967;20:13-23.
6. Dobrzyn P, Jazurek M, Dobrzyn A. Stearoyl-CoA desaturase and insulin signaling-what is the molecular switch? Biochim Biophys Acta 2010;1797:1189-94.
7. Sampath H, Miyazaki M, Dobrzyn A, Ntambi JM. Stearoyl-CoA desaturase-1 mediates the pro-lipogenic effects of dietary saturated fat. J Biol Chem 2007;282:2483-93. (Pubitemid 47076774)
8. Melhus H, Riserus U, Warensjo E, Wemroth L, Jensevik K, Berglund L et al. A high activity index of stearoyl-CoA desaturase is associated with increased risk of fracture in men. Osteoporos Int 2008;19:929-34.
9. Halleux C, Sottile V, Gasser JA, Seuwen K. Multi-lineage potential of human mesenchymal stem cells following clonal expansion. J Muscuioskelet Neuronal Interact 2001;2:71-6.
10. Lee RH, Kim B, Choi I, Kim H, Choi HS, Suh K et al. Characterization and expression analysis of mesenchymal stem cells from human bone marrow and adipose tissue. Cell Physiol Biochem 2004;14:311-24. (Pubitemid 39179200)
11. Lee OK, Kuo TK, Chen WM, Lee KD, Hsieh SL, Chen TH. Isolation of multipotent mesenchymal stem cells from umbilical cord blood. Blood 2004;103:1669-75. (Pubitemid 38268958)
12. Yen BL, Huang HI, Chien CC, Jui HY, Ko BS, Yao M et al. Isolation of multipotent cells from human term placenta. Stem Cells 2005;23:3-9. (Pubitemid 40105287)
13. Matsuzawa Y. Adipocytokines and metabolic syndrome. Semin Vase Med 2005;5:34-9. (Pubitemid 40721043)
14. Tontonoz P, Spiegelman BM. Fat and beyond: the diverse biology of PPARgamma. Annu Rev Biochem 2008;77:289-312.
15. O'Donoghue K, Choolani M, Chan J, de la Fuente J, Kumar S, Campagnoli C et al. Identification of fetal mesenchymal stem cells in maternal blood: implications for non-invasive prenatal diagnosis. Mol Hum Reprod 2003;9:497-502. (Pubitemid 36874308)
16. Liew CF, Groves CJ, Wiltshire S, Zeggini E, Frayling TM, Owen KR et al. Analysis of the contribution to type 2 diabetes susceptibility of sequence variation in the gene encoding stearoyl-CoA desaturase, a key regulator of lipid and carbohydrate metabolism. Diabetologia 2004;47:2168-75. (Pubitemid 40174690)
17. Ntambi JM, Miyazaki M, Stoehr JP, Lan H, Kendziorski CM, Yandell BS et al. Loss of stearoyl-CoA desaturase-1 function protects mice against adiposity. Proc Natl Acad Sci USA 2002;99:11482-6. (Pubitemid 34920951)
18. Kunesova M, Hainer V, Tvrzicka E, Phinney SD, Stich V, Parizkova J et al. Assessment of dietary and genetic factors influencing serum and adipose fatty acid composition in obese female identical twins. Lipids 2002;37:27-32. (Pubitemid 34137449)
19. Okada T, Furuhashi N, Kuromori Y, Miyashita M, Iwata F, Harada K. Plasma palmitoleic acid content and obesity in children. Am J Clin Nutr 2005;82:747-50. (Pubitemid 43779686)
20. Attie AD, Krauss RM, Gray-Keller MP, Brownlie A, Miyazaki M, Kastelein JJ et al. Relationship between stearoyl-CoA desaturase activity and plasma triglycerides in human and mouse hypertriglyceridemia. J Lipid Res 2002;43:1899-907. (Pubitemid 35315808)
21. Riserus U, Tan GD, Fielding BA, Neville MJ, Currie J, Savage DB et al. Rosiglitazone increases indexes of stearoyl-CoA desaturase activity in humans: link to insulin sensitization and the role of dominant-negative mutation in peroxisome proliferator activated receptor-gamma. Diabetes 2005;54:1379-84. (Pubitemid 40586667)
22. Warensjo E, Ohrvall M, Vessby B. Fatty acid composition and estimated desaturase activities are associated with obesity and lifestyle variables in men and women. Nutr Metab Cardiovasc Dis 2006;16:128-36. (Pubitemid 43384710)
23. Ali AA, Weinstein RS, Stewart SA, Parfitt AM, Manolagas SC, Jilka RL. Rosiglitazone causes bone loss in mice by suppressing osteoblast differentiation and bone formation. Endocrinology 2005;146:1226-35. (Pubitemid 40289310)
24. Botolin S, Faugere MC, Malluche H, Orth M, Meyer R, McCabe LR. Increased bone adiposity and peroxisomal proliferator-activated receptor-gamma2 expression in type I diabetic mice. Endocrinology 2005;146:3622-31. (Pubitemid 41058134)
25. Kawaguchi H, Akune T, Yamaguchi M, Ohba S, Ogata N, Chung UI et al. Distinct effects of PPARgamma insufficiency on bone marrow cells, osteoblasts, and osteoclastic cells. J Bone Miner Metab 2005;23:275-9. (Pubitemid 40875085)
26. Hamerman D. Osteoporosis and atherosclerosis: biological linkages. and the emergence of dual-purpose therapies. QJM 2005;98:467-84. (Pubitemid 41430104)
27. Dobrzyn A, Dobrzyn P, Lee SH, Miyazaki M, Cohen P, Asilmaz E et al. Stearoyl-CoA desaturase-1 deficiency reduces ceramide synthesis by downregulating serine palmitoyltransferase and increasing beta-oxidation in skeletal muscle. Am J Physiol Endocrinol Metab 2005;288:E599-E607. (Pubitemid 40250556)
28. Dobrzyn P, Dobrzyn A, Miyazaki M, Cohen P, Asilmaz E, Hardie DG et al. Stearoyl-CoA desaturase 1 deficiency increases fatty acid oxidation by activating AMP-activated protein kinase in liver. Proc Natl Acad Sci U S A 2004;101:6409-14. (Pubitemid 38585987)
29. Peter A, Weigert C, Staiger H, Machicao F, Schick F, Machann J et al. Individual stearoyl-coa desaturase 1 expression modulates endoplasmic reticulum stress and inflammation in human myotubes and is associated with skeletal muscle lipid storage and insulin sensitivity in vivo. Diabetes 2009;58:1757-65.
30. Li ZZ, Berk M, McIntyre TM, Feldstein AE. Hepatic lipid partitioning and liver damage in nonalcoholic fatty liver disease: role of stearoyl-CoA desaturase. J Biol Chem 2009;284:5637-44.
31. Hess D, Chisholm JW, Igal RA. Inhibition of stearoylCoA desaturase activity blocks cell cycle progression and induces programmed cell death in lung cancer cells. PLoS One 2010;5:e11394.