Chloride channels are necessary for full platelet phosphatidylserine exposure and procoagulant activity

Cell Death and Disease

Volumn 4, Issue 12, 2013, Pages

  Harper, M T ^a   Poole, A W ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

chloride channels; coagulation; necrosis; platelets; thrombosis

Indexed keywords

CHLORIDE CHANNEL; IONOPHORE; PHOSPHATIDYLSERINE; PROCOAGULANT;

ARTICLE; CALCIUM CONDUCTANCE; CELL DEATH; CELL MEMBRANE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HYPERPOLARIZATION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; THROMBOCYTE; THROMBOCYTE MEMBRANE;

BLOOD PLATELETS; CALCIUM; CARRIER PROTEINS; CELLS, CULTURED; CHLORIDE CHANNELS; FLOW CYTOMETRY; HUMANS; NECROSIS; PEPTIDES; PHOSPHATIDYLSERINES; PHOSPHOLIPID TRANSFER PROTEINS; THROMBIN; THROMBOSIS;

EID: 84891778834     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2013.495     Document Type: Article

References (28)

1. Jackson SP. Arterial thrombosis-insidious, unpredictable and deadly. Nat Med 2011; 17: 1423-1436
2. Jackson SP, Schoenwaelder SM. Procoagulant platelets: Are they necrotic? Blood 2010; 116: 2011-2018
3. Suzuki J, Umeda M, Sims PJ, Nagata S. Calcium-dependent phospholipid scrambling by TMEM16F. Nature 2010; 468: 834-838
4. Castoldi E, Collins PW, Williamson PL, Bevers EM. Compound heterozygosity for 2 novel TMEM16F mutations in a patient with Scott syndrome. Blood 2011; 117: 4399-4400
5. Zwaal RF, Comfurius P, Bevers EM. Scott syndrome, a bleeding disorder caused by defective scrambling of membrane phospholipids. Biochem Biophys Acta 2004; 1636: 119-128
6. Kunzelmann K, Nilius B, Owsianik G, Schreiber R, Ousingsawat J, Sirianant L et al. Molecular functions of anoctamin 6 (TMEM16F): A chloride channel, cation channel, or phospholipid scramblase? Pflugers Arch; e-pub ahead of print 8 June 2013; doi:10.1007/ s00424-013-1305-1
7. Martins JR, Faria D, Kongsuphol P, Reisch B, Schreiber R, Kunzelmann K. Anoctamin 6 is an essential component of the outwardly rectifying chloride channel. Proc Natl Acad Sci USA 2011; 108: 18168-18172
8. Tian Y, Schreiber R, Kunzelmann K. Anoctamins are a family of Ca2+-Activated Cl-channels. J Cell Sci 2012; 125: 4991-4998
9. Owsianik G, Prenen J, Hermans C, Eggermont J, Nilius B. Functional characterization of TMEM16 anion channels. FASEB J (Abstract) 2010; 608: 12
10. Szteyn K, Schmid E, Nurbaeva MK, Yang W, Münzer P, Kunzelmann K et al. Expression and functional significance of the Ca(2+)-Activated Cl(-) channel ANO6 in dendritic cells. Cell Physiol Biochem 2012; 30: 1319-1332
11. Okada Y, Shimizu T, Maeno E, Tanabe S, Wang X, Takahashi N. Volume-sensitive chloride channels involved in apoptotic volume decrease and cell death. J Membr Biol 2006; 209: 21-29
12. Namkung W, Phuan PW, Verkman AS. TMEM16A inhibitors reveal TMEM16A as a minor component of calcium-Activated chloride channel conductance in airway and intestinal epithelial cells. J Biol Chem 2011; 286: 2365-2374
13. De La Fuente R, Namkung W, Mills A, Verkman AS. Small-molecule screen identifies inhibitors of a human intestinal calcium-Activated chloride channel. Mol Pharmacol 2008; 73: 758-768
14. Kmit A, van Kruchten R, Ousingsawat J, Mattheij NJ, Senden-Gijsbers B, Heemskerk JWet al. Calcium-Activated and apoptotic phospholipid scrambling induced by Ano6 can occur independently of Ano6 ion currents. Cell Death Dis 2013; 4: E611
15. Hemker HC, Giesen PL, Ramjee M, Wagenvoord R, Béguin S. The thrombogram: Monitoring thrombin generation in platelet-rich plasma. Thromb Haemost 2000; 83: 589-591
16. van der Meijden PE, Feijge MA, Swieringa F, Gilio K, Nergiz-Unal R, Hamulyák K et al. Key role of integrin a(IIb)b (3) signaling to Syk kinase in tissue factor-induced thrombin generation. Cell Mol Life Sci 2012; 69: 3481-3492
17. Jones ML, Harper MT, Aitken EW, Williams CM, Poole AW. RGD-ligand mimetic antagonists of integrin alphaIIbbeta3 paradoxically enhance GPVI-induced human platelet activation. J Thromb Haemost 2010; 8: 567-576
18. Weiss HJ, Lages B. Platelet prothrombinase activity and intracellular calcium responses in patients with storage pool deficiency, glycoprotein IIb-IIIa deficiency, or impaired platelet coagulant activity-A comparison with Scott syndrome. Blood 1997; 89: 1599-1611
19. Harper MT, Poole AW. Store-operated calcium entry and non-capacitative calcium entry have distinct roles in thrombin-induced calcium signalling in human platelets. Cell Calcium 2011; 50: 351-358
20. Bergmeier W, Oh-Hora M, McCarl CA, Roden RC, Bray PF, Feske S. R93W mutation in Orai1 causes impaired calcium influx in platelets. Blood 2009; 113: 675-678
21. Braun A, Varga-Szabo D, Kleinschnitz C, Pleines I, Bender M, Austinat M et al. Orai1 (CRACM1) is the platelet SOC channel and essential for pathological thrombus formation. Blood 2009; 113: 2056-2063
22. Ramanathan G, Gupta S, Thielmann I, Pleines I, Varga-Szabo D, May F et al. Defective diacylglycerol-induced Ca2+ entry but normal agonist-induced activation responses in TRPC6-deficient mouse platelets. J Thromb Haemost 2012; 10: 419-429
23. Harper MT, Londono JEC, Quick K, Londono JC, Flockerzi V, Philipp SE et al. Transient receptor potential channels function as a coincidence signal detector mediating phosphatidylserine exposure. Sci Signal 2013; 6: Ra50
24. Estacion M, Sinkins WG, Jones SW, Applegate MA, Schilling WP. Human TRPC6 expressed in HEK 293 cells forms non-selective cation channels with limited Ca2+ permeability. J Physiol 2006; 572: 359-377
25. Feske S, Gwack Y, Prakriya M, Srikanth S, Puppel SH, Tanasa B et al. A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function. Nature 2006; 441: 179-185
26. Epps DE, Wolfe ML, Groppi V. Characterization of the steady-state and dynamic fluorescence properties of the potential-sensitive dye bis-(1,3-dibutylbarbituric acid)trimethine oxonol (Dibac4(3)) in model systems and cells. Chem Phys Lipids 1994; 69: 137-150
27. Yang H, Kim A, David T, Palmer D, Jin T, Tien J et al. TMEM16F forms a Ca2+-Activated cation channel required for lipid scrambling in platelets during blood coagulation. Cell 2012; 151: 111-122
28. Grynkiewicz G, Poenie M, Tsien RY. A new generation of Ca2+ indicators with greatly improved fluorescence properties. J Biol Chem 1985; 260: 3440-3450