Longterm effect of delaying combination therapy with tumor necrosis factor inhibitor in patients with aggressive early rheumatoid arthritis: 10-year efficacy and safety of adalimumab from the randomized controlled PREMIER trial with open-label extension

Journal of Rheumatology

Volumn 41, Issue 1, 2014, Pages 5-14

  Keystone, Edward C ^a   Breedveld, Ferdinand C ^b   Van Der Heijde, Désirée ^b   Landewé, Robert ^c   Florentinus, Stefan ^d   Arulmani, Udayasankar ^d   Liu, Shufang ^d   Kupper, Hartmut ^d   Kavanaugh, Arthur ^e  

^a MOUNT SINAI HOSPITAL   (Canada)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^c ACADEMIC MEDICAL CENTER   (Netherlands)

^d ABBVIE INC   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Adalimumab; Longterm treatment; Radiographic progression safety; Rheumatoid arthritis

Indexed keywords

ADALIMUMAB; METHOTREXATE; PLACEBO;

ADULT; ARTICLE; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; DEMYELINATING DISEASE; DISEASE ACTIVITY; DISEASE CONTROL; DISEASE COURSE; DOUBLE BLIND PROCEDURE; DRUG DOSE ESCALATION; DRUG EFFICACY; DRUG FATALITY; DRUG SAFETY; DRUG WITHDRAWAL; FEMALE; HUMAN; INFECTION; INJECTION SITE REACTION; LONG TERM CARE; LYMPHOMA; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; NON MELANOMA SKIN CANCER; OPEN STUDY; OUTCOMES RESEARCH; PHASE 3 CLINICAL TRIAL; PRIORITY JOURNAL; RADIODIAGNOSIS; RANDOMIZED CONTROLLED TRIAL; RHEUMATOID ARTHRITIS; THERAPY DELAY; THRUSH; TREATMENT DURATION; TUBERCULOSIS;

ADALIMUMAB; LONGTERM TREATMENT; RADIOGRAPHIC PROGRESSION; RHEUMATOID ARTHRITIS; SAFETY;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANTIBODIES, MONOCLONAL, HUMANIZED; ANTIRHEUMATIC AGENTS; ARTHRITIS, RHEUMATOID; DISEASE PROGRESSION; DRUG THERAPY, COMBINATION; FEMALE; HUMANS; MALE; METHOTREXATE; MIDDLE AGED; SEVERITY OF ILLNESS INDEX; TIME FACTORS; TREATMENT OUTCOME; TUMOR NECROSIS FACTOR-ALPHA; YOUNG ADULT;

EID: 84891749397     PISSN: 0315162X     EISSN: 14992752     Source Type: Journal    
DOI: 10.3899/jrheum.130543     Document Type: Article

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