Platelet endothelial cell adhesion molecule 1 deficiency misguides venous thrombus resolution

Blood

Volumn 122, Issue 19, 2013, Pages 3376-3384

  Kellermair, Joerg ^a   Redwan, Bassam ^b   Alias, Sherin ^c   Jabkowski, Joerg ^a   Panzenboeck, Adelheid ^c   Kellermair, Lukas ^c   Winter, Max P ^c   Weltermann, Ansgar ^a   Lang, Irene M ^c  

^a ELISABETHINEN HOSPITAL   (Austria)

^b UNIVERSITY HOSPITAL MÜNSTER   (Germany)

^c MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

CD31 ANTIGEN; DABIGATRAN; LOW MOLECULAR WEIGHT HEPARIN;

AGED; ANIMAL EXPERIMENT; ANTIBODY SPECIFICITY; ANTICOAGULANT THERAPY; ARTICLE; CELL INVASION; CELL SURFACE; COMPRESSION STOCKING; CONTROLLED STUDY; CORRELATIONAL STUDY; DEEP VEIN THROMBOSIS; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; IMMUNOHISTOCHEMISTRY; LEUKOCYTE FUNCTION; MACROPHAGE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SMOOTH MUSCLE CELL; ANIMAL; BLOOD; CELL MOTION; FIBRINOLYSIS; GENE DELETION; GENE EXPRESSION; GENETICS; METABOLISM; MIDDLE AGED; PATHOLOGY; PHYSIOLOGY; POSTTHROMBOSIS SYNDROME; PROTEIN DEGRADATION; PROTEIN TERTIARY STRUCTURE; VEIN; VEIN THROMBOSIS;

AGED; ANIMALS; ANTIGENS, CD31; CELL MOVEMENT; FEMALE; FIBRINOLYSIS; GENE DELETION; GENE EXPRESSION; HUMANS; MACROPHAGES; MALE; MICE; MIDDLE AGED; POSTTHROMBOTIC SYNDROME; PROTEIN STRUCTURE, TERTIARY; PROTEOLYSIS; VEINS; VENOUS THROMBOSIS;

EID: 84891716127     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2013-04-499558     Document Type: Article

References (39)

1. Oger E. Incidence of venous thromboembolism: a community-based study in Western France. EPI-GETBP Study Group. Groupe d’Etude de la Thrombose de Bretagne Occidentale. Thromb Haemost. 2000;83(5):657-660.
2. Becattini C, Agnelli G, Pesavento R, Silingardi M, Poggio R, Taliani MR, Ageno W. Incidence of chronic thromboembolic pulmonary hypertension after a first episode of pulmonary embolism. Chest. 2006;130(1):172-175.
3. Kahn SR. Post-thrombotic syndrome after deep venous thrombosis: risk factors, prevention, and therapeutic options. Clin Adv Hematol Oncol. 2009;7(7):433-435.
4. Stewart GJ. Neutrophils and deep venous thrombosis. Haemostasis. 1993;23(Suppl 1): 127-140.
5. Henke PK, Varma MR, Deatrick KB, et al. Neutrophils modulate post-thrombotic vein wall remodeling but not thrombus neovascularization. Thromb Haemost. 2006;95(2):272-281.
6. Humphries J, McGuinness CL, Smith A, Waltham M, Poston R, Burnand KG. Monocyte chemotactic protein-1 (MCP-1) accelerates the organization and resolution of venous thrombi. J Vasc Surg. 1999;30(5):894-899.
7. Henke PK, Wakefield TW, Kadell AM, et al. Interleukin-8 administration enhances venous thrombosis resolution in a rat model. J Surg Res. 2001;99(1):84-91.
8. Ley K, Laudanna C, Cybulsky MI, Nourshargh S. Getting to the site of inflammation: the leukocyte adhesion cascade updated. Nat Rev Immunol. 2007;7(9):678-689.
9. Muller WA, Weigl SA, Deng X, Phillips DM. PECAM-1 is required for transendothelial migration of leukocytes. J Exp Med. 1993;178(2): 449-460.
10. Privratsky JR, Newman DK, Newman PJ. PECAM-1: conflicts of interest in inflammation. Life Sci. 2010;87(3-4):69-82.
11. Xie Y, Muller WA. Molecular cloning and adhesive properties of murine platelet/endothelial cell adhesion molecule 1. Proc Natl Acad Sci USA. 1993;90(12):5569-5573.
12. O’Brien CD, Cao G, Makrigiannakis A, DeLisser HM. Role of immunoreceptor tyrosine-based inhibitory motifs of PECAM-1 in PECAM-1-dependent cell migration. Am J Physiol Cell Physiol. 2004;287(4): C1103-C1113.
13. Privratsky JR, Tilkens SB, Newman DK, Newman PJ. PECAM-1 dampens cytokine levels during LPS-induced endotoxemia by regulating leukocyte trafficking. Life Sci. 2012;90(5-6): 177-184.
14. Dimaio TA, Wang S, Huang Q, Scheef EA, Sorenson CM, Sheibani N. Attenuation of retinal vascular development and neovascularization in PECAM-1-deficient mice. Dev Biol. 2008;315(1): 72-88.
15. Rathore V, Stapleton MA, Hillery CA, et al. PECAM-1 negatively regulates GPIb/V/IX signaling in murine platelets. Blood. 2003; 102(10):3658-3664.
16. Woodfin A, Voisin MB, Imhof BA, Dejana E, Engelhardt B, Nourshargh S. Endothelial cell activation leads to neutrophil transmigration as supported by the sequential roles of ICAM-2, JAM-A, and PECAM-1. Blood. 2009;113(24): 6246-6257.
17. Jackson DE. The unfolding tale of PECAM-1. FEBS Lett. 2003;540(1-3):7-14.
18. Saha P, Humphries J, Modarai B, et al. Leukocytes and the natural history of deep vein thrombosis: current concepts and future directions. Arterioscler Thromb Vasc Biol. 2011; 31(3):506-512.
19. Fornasa G, Groyer E, Clement M, et al. TCR stimulation drives cleavage and shedding of the ITIM receptor CD31. J Immunol. 2010;184(10): 5485-5492.
20. Goldberger A, Middleton KA, Oliver JA, et al. Biosynthesis and processing of the cell adhesion molecule PECAM-1 includes production of a soluble form. J Biol Chem. 1994;269(25): 17183-17191.
21. Schenkel AR, Chew TW, Chlipala E, Harbord MW, Muller WA. Different susceptibilities of PECAM-deficient mouse strains to spontaneous idiopathic pneumonitis. Exp Mol Pathol. 2006; 81(1):23-30.
22. Schenkel AR, Chew TW, Muller WA. Platelet endothelial cell adhesion molecule deficiency or blockade significantly reduces leukocyte emigration in a majority of mouse strains. J Immunol. 2004;173(10):6403-6408.
23. Garvey W, Fathi A, Bigelow F, Carpenter B, Jimenez C. A combined elastic, fibrin and collagen stain. Stain Technol. 1987;62(6):365-368.
24. Lang IM, Marsh JJ, Olman MA, Moser KM, Loskutoff DJ, Schleef RR. Expression of type 1 plasminogen activator inhibitor in chronic pulmonary thromboemboli. Circulation. 1994; 89(6):2715-2721.
25. López-De León A, Rojkind M. A simple micromethod for collagen and total protein determination in formalin-fixed paraffin-embedded sections. J Histochem Cytochem. 1985;33(8): 737-743.
26. Agnelli G, Gallus A, Goldhaber SZ, et al; ODIXa-DVT Study Investigators. Treatment of proximal deep-vein thrombosis with the oral direct factor Xa inhibitor rivaroxaban (BAY 59-7939): the ODIXa-DVT (Oral Direct Factor Xa Inhibitor BAY 59-7939 in Patients With Acute Symptomatic Deep-Vein Thrombosis) study. Circulation. 2007; 116(2):180-187.
27. Shbaklo H, Holcroft CA, Kahn SR. Levels of inflammatory markers and the development of the post-thrombotic syndrome. Thromb Haemost. 2009;101(3):505-512.
28. Eugenin EA, Gamss R, Buckner C, et al. Shedding of PECAM-1 during HIV infection: a potential role for soluble PECAM-1 in the pathogenesis of NeuroAIDS. J Leukoc Biol. 2006;79(3):444-452.
29. Engelmann B, Massberg S. Thrombosis as an intravascular effector of innate immunity. Nat Rev Immunol. 2013;13(1):34-45.
30. von Brühl ML, Stark K, Steinhart A, et al. Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo. J Exp Med. 2012;209(4):819-835.
31. Falati S, Patil S, Gross PL, et al. Platelet PECAM-1 inhibits thrombus formation in vivo. Blood. 2006;107(2):535-541.
32. Jones KL, Hughan SC, Dopheide SM, Farndale RW, Jackson SP, Jackson DE. Platelet endothelial cell adhesion molecule-1 is a negative regulator of platelet-collagen interactions. Blood. 2001;98(5):1456-1463.
33. Cao G, Fehrenbach ML, Williams JT, Finklestein JM, Zhu JX, Delisser HM. Angiogenesis in platelet endothelial cell adhesion molecule-1-null mice. Am J Pathol. 2009;175(2):903-915.
34. Varma MR, Moaveni DM, Dewyer NA, et al. Deep vein thrombosis resolution is not accelerated with increased neovascularization. J Vasc Surg. 2004; 40(3):536-542.
35. Kalinowska A, Losy J. PECAM-1, a key player in neuroinflammation. Eur J Neurol. 2006;13(12): 1284-1290.
36. Liao F, Ali J, Greene T, Muller WA. Soluble domain 1 of platelet-endothelial cell adhesion molecule (PECAM) is sufficient to block transendothelial migration in vitro and in vivo. J Exp Med. 1997;185(7):1349-1357.
37. Yamaki T, Hamahata A, Soejima K, Kono T, Nozaki M, Sakurai H. Factors predicting development of post-thrombotic syndrome in patients with a first episode of deep vein thrombosis: preliminary report. Eur J Vasc Endovasc Surg. 2011;41(1):126-133.
38. Tick LW, Doggen CJ, Rosendaal FR, et al. Predictors of the post-thrombotic syndrome with non-invasive venous examinations in patients 6 weeks after a first episode of deep vein thrombosis. J Thromb Haemost. 2010;8(12): 2685-2692.
39. Bucek RA, Reiter M, Quehenberger P, Minar E, Baghestanian M. The role of soluble cell adhesion molecules in patients with suspected deep vein thrombosis. Blood Coagul Fibrinolysis. 2003; 14(7):653-657.