Prostaglandin E2 enhances long-term repopulation but does not permanently alter inherent stem cell competitiveness

Blood

Volumn 122, Issue 17, 2013, Pages 2997-3000

  Hoggatt, Jonathan ^a,b,c   Mohammad, Khalid S ^a   Singh, Pratibha ^a   Pelus, Louis M ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Harvard University   (United States)

^c HARVARD STEM CELL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROSTAGLANDIN E2;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL HOMING; CELL LINEAGE; CELL PROLIFERATION; CONTROLLED STUDY; CORD BLOOD STEM CELL TRANSPLANTATION; HEMATOPOIETIC STEM CELL TRANSPLANTATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; STEM CELL; ANIMAL; C57BL MOUSE; CELL COUNT; CELL CULTURE; CYTOLOGY; DRUG EFFECTS; GRAFT SURVIVAL; HEMATOPOIETIC STEM CELL; IMMUNOLOGY; DRUG EFFECT;

ANIMALS; CELL COUNT; CELL LINEAGE; CELL PROLIFERATION; CELLS, CULTURED; DINOPROSTONE; GRAFT SURVIVAL; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HEMATOPOIETIC STEM CELLS; MICE; MICE, INBRED C57BL;

EID: 84891689160     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2013-07-515288     Document Type: Article

References (20)

1. Pelus LM, Hoggatt J. Pleiotropic effects of prostaglandin E2 in hematopoiesis; prostaglandin E2 and other eicosanoids regulate hematopoietic stem and progenitor cell function. Prostaglandins Other Lipid Mediat. 2011;96(1-4):3-9.
2. Pelus LM. Prostaglandin E: biphasic control of hematopoiesis. In: Cohen MM, ed. Biological Protection with Prostaglandins. Boca Raton: CRC Press Inc; 1985:45-55.
3. Hoggatt J, Pelus LM. Eicosanoid regulation of hematopoiesis and hematopoietic stem and progenitor trafficking. Leukemia. 2010;24(12): 1993-2002.
4. Pelus LM. Modulation of myelopoiesis by prostaglandin E2: demonstration of a novel mechanism of action in vivo. Immunol Res. 1989; 8(3):176-184.
5. North TE, Goessling W, Walkley CR, et al. Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis. Nature. 2007;447(7147):1007-1011.
6. Verma DS, Spitzer G, Zander AR, McCredie KB, Dicke KA. Prostaglandin E1-mediated augmentation of human granulocyte-macrophage progenitor cell growth in vitro. Leuk Res. 1981; 5(1):65-71.
7. Pelus LM. Association between colony forming units-granulocyte macrophage expression of Ia-like (HLA-DR) antigen and control of granulocyte and macrophage production. A new role for prostaglandin E. J Clin Invest. 1982;70(3): 568-578.
8. Hoggatt J, Singh P, Sampath J, Pelus LM. Prostaglandin E2 enhances hematopoietic stem cell homing, survival, and proliferation. Blood. 2009;113(22):5444-5455.
9. Goessling W, North TE, Loewer S, et al. Genetic interaction of PGE2 and Wnt signaling regulates developmental specification of stem cells and regeneration. Cell. 2009;136(6): 1136-1147.
10. Cutler C, Multani P, Robbins D, et al. Prostaglandin-modulated umbilical cord blood hematopoietic stem cell transplantation [published online ahead of print August 30, 2013]. Blood.
11. Ogden DA, Mickliem HS. The fate of serially transplanted bone marrow cell populations from young and old donors. Transplantation. 1976; 22(3):287-293.
12. Muller-Sieburg CE, Sieburg HB. Clonal diversity of the stem cell compartment. Curr Opin Hematol. 2006;13(4):243-248.
13. Lu R, Neff NF, Quake SR, Weissman IL. Tracking single hematopoietic stem cells in vivo using high-throughput sequencing in conjunction with viral genetic barcoding. Nat Biotechnol. 2011;29(10): 928-933.
14. Verovskaya E, Broekhuis MJ, Zwart E, et al. Heterogeneity of young and aged murine hematopoietic stem cells revealed by quantitative clonal analysis using cellular barcoding. Blood. 2013;122(4):523-532.
15. Hull MA, Ko SC, Hawcroft G. Prostaglandin EP receptors: targets for treatment and prevention of colorectal cancer? Mol Cancer Ther. 2004;3(8): 1031-1039.
16. Murakami M, Kudo I. Prostaglandin E synthase: a novel drug target for inflammation and cancer. Curr Pharm Des. 2006;12(8):943-954.
17. Wang Y, Krivtsov AV, Sinha AU, et al. The Wnt/beta-catenin pathway is required for the development of leukemia stem cells in AML. Science. 2010;327(5973):1650-1653.
18. Araki H, Baluchamy S, Yoshinaga K, et al. Cord blood stem cell expansion is permissive to epigenetic regulation and environmental cues. Exp Hematol. 2009;37(9):1084-1095.
19. Chung YS, Kim HJ, Kim TM, et al. Undifferentiated hematopoietic cells are characterized by a genome-wide undermethylation dip around the transcription start site and a hierarchical epigenetic plasticity. Blood. 2009;114(24):4968-4978.
20. Miller PH, Knapp DJ, Eaves CJ. Heterogeneity in hematopoietic stem cell populations: implications for transplantation. Curr Opin Hematol. 2013; 20(4):257-264.