Pirfenidone inhibits migration, differentiation, and proliferation of human retinal pigment epithelial cells in vitro

Molecular Vision

Volumn 19, Issue , 2013, Pages 2626-2635

  Wang, Jing ^a   Yang, Yangfan ^a   Xu, Jiangang ^a   Lin, Xianchai ^a   Wu, Kaili ^a   Yu, Minbin ^a  

^a SUN YAT SEN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

COFILIN; COLLAGEN TYPE 1; F ACTIN; FIBRONECTIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PIRFENIDONE; SMAD2 PROTEIN; SMAD3 PROTEIN; STRESS ACTIVATED PROTEIN KINASE; TRANSFORMING GROWTH FACTOR BETA1;

ARTICLE; CELL ASSAY; CELL LINE; CELL MIGRATION; CELL STRAIN ARPE 19; COLLAGEN SYNTHESIS; COMPLEX FORMATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; EXTRACELLULAR MATRIX; FIBROGENESIS; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOCYTOCHEMISTRY; PHENOTYPIC VARIATION; PIGMENT EPITHELIUM; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN NUCLEAR TRANSLOCATION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; STRESS FIBER;

ACTINS; APOPTOSIS; CELL DIFFERENTIATION; CELL LINE; CELL MOVEMENT; CELL PROLIFERATION; CELL SURVIVAL; CONNECTIVE TISSUE GROWTH FACTOR; DOSE-RESPONSE RELATIONSHIP, DRUG; EPITHELIAL CELLS; FIBRONECTINS; GENE EXPRESSION; HUMANS; PYRIDONES; RETINAL PIGMENT EPITHELIUM; SIGNAL TRANSDUCTION; SMAD PROTEINS; SMAD1 PROTEIN; TRANSCRIPTION FACTORS;

EID: 84891684134     PISSN: None     EISSN: 10900535     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

1. Sadaka A, Giuliari GP. Proliferative vitreoretinopathy: current and emerging treatments. Clin Ophthalmol 2012; 6:1325-33. [PMID: 22942638].
2. Pastor JC. Proliferative vitreoretinopathy: An Overview. Surv Ophthalmol 1998; 43:3-18. [PMID: 9716190].
3. Chen W, Chen H, Hou P, Fok A, Hu Y, Lam DS. Midterm results of low-dose intravitreal triamcinolone as adjunctive treatment for proliferative vitreoretinopathy. Retina 2011; 31:1137-42. [PMID: 21317835].
4. Blumenkranz M, Hernadez E, Ophir A, Norton EW. 5-fluorouracil: new applications in complicated retinal detachment for an established antimetabolite. Ophthalmology 1984; 91:122-30. [PMID: 6709326].
5. Wickham L, Bunce C, Wong D, McGurn D, Charteris DG. A randomized controlled trial of combined 5-fluorouracil and low-molecular-weight heparin in the management of unselected rhegmatogenous retinal detachments undergoing primary vitrectomy. Ophthalmology 2007; 114:698-704. [PMID: 17398320].
6. Creten O, Spileers W, Stalmans P. Systemic resportion of 5-fluorouracil used in infusion fliud during vitrectomy. Bull Soc Belge Ophtalmol 2007; 303:37-41. [PMID: 17894285].
7. Iyer SN, Gurujeyalakshmi G, Giri SN. Effects of pirfenidone on procollagen gene expression at the transcriptional level in bleomycin hamster model of lung fibrosis. Pharmacol Exp Ther 1999; 289:211-8. [PMID: 10087006].
8. Suga H, Teraoka S, Ota K, Komemushi S, Furutani S, Yamauchi S. Margolin s. Preventive effect of pirfenidone against experimental sclerosing peritonitis in rats. Exp Toxicol Pathol 1995; 47:287-91. [PMID: 8855123].
9. Miric G, Dallemagne C, Endre Z, Margolin S, Taylor SM, Brown L. Reversal of cardiac and renal fibrosis by pirfenidone and spironolactone in streptozotocin-diabetic rats. Br J Pharmacol 2001; 133:687-94. [PMID: 11429393].
10. Walker JE, Margolin SB. Pirfenidone for chronic progressive multiple sclerosis. Mult Scler 2001; 7:305-12. [PMID: 11724446].
11. Azuma A, Nukiwa T, Tsuboi E, Suga M, Nakata K, Taguchi Y, Nagai S, Itoh H, Ochi M, Sato A, Kudoh S. Double-blind, placebo-controlled trial of pirfenidone in patients with idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 2005; 171:1040-7. [PMID: 15665326].
12. Azuma A, Nukiwa T, Tsuboi E, Suga M, Abe S, Nakata K, Taguchi Y, Nagai S, Itoh H, Ohi M, Sato A, Kudoh S. Double-blind, placebo-controlled trial of pirfenidone in patients with idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 2005; 171:1040-7. [PMID: 15665326].
13. th, 2013.
14. Lin X, Yu M, Wu K, Yuan H, Zhong H. Effects of pirfenidone on proliferation, migration, and collagen contraction of human Tenon's fibroblasts in vitro. Invest Ophthalmol Vis Sci 2009; 50:3763-70. [PMID: 19264889].
15. Zhong H, Sun G, Lin X, Wu K, Yu M. Evaluation of pirfenidone as a new postoperative antiscarring agent in experimental glaucoma surgery. Invest Ophthalmol Vis Sci 2011; 52:3136-42. [PMID: 21330661].
16. Sun G, Lin X, Zhong H, Yang Y, Qiu X, Ye C, Wu K, Yu M. Pharmacokinetics of pirfenidone after topical administration in rabbit eye. Mol Vis 2011; 17:2191-6. [PMID: 21866212].
17. Choi K, Lee K, Ryu S-W, Im M, Kook KH, Choi C. Pirfenidone inhibits transforming growth factor-β1-induced fibrogenesis by blocking nuclear translocation of Smads in human retinal pigment epithelial cell line ARPE-19. Mol Vis 2012; 18:1010-20. [PMID: 22550395].
18. Fromme HG, Voss B, Pfautsch M, Grote M, von Figura K, Beeck H. Immunoelectron-microscopic study on the location of fibronectin in human fibroblast cultures. Ultrastruct Res 1982; 80:264-9. [PMID: 6752438].
19. Saika S. TGF beta pathobiology in the eye. Lab Invest 2006; 86:106-15. [PMID: 16341020].
20. Saika S, Yamanaka O, Okada Y, Tanaka S, Miyamoto T, Sumioka T, Kitano A, Shirai K, Ikeda K. TGF beta in fibroproliferative diseases in the eye. Front Biosci 2009; 1:376-90. Schol Ed[PMID: 19482708].
21. Pennison M, Pasche B. Targeting transforming growth factor beta signaling. Curr Opin Oncol 2007; 19:579-85. [PMID: 17906455].
22. Pastor JC, de la Rúa ER, Martín F. Proliferative vitreoretinopathy: risk factors and pathobiology. Prog Retin Eye Res 2002; 21:127-44. [PMID: 11906814].
23. Di Sario A, Bendia E, Baroni GS, Ridolfi F, Casini A, Ceni E, Saccomanno S, Marzioni M, Trozzi L, Sterpetti P, Taffetani S, Benedetti A. Effect of pirfenidone on rat hepatic stellate cell proliferation and collagen production. J Hepatol 2002; 37:584-91. [PMID: 12399223].
24. Wang Y, Wu Y, Chen J, Zhan S, Li H. Pirfenidone Attenuates Cardiac Fibrosis in a Mouse Model of TAC-Induced Left Ventricular Remodeling by Suppressing NLRP3 Inflammasome Formation. Cardiology 2013; 126:1-11. [PMID: 23839341].
25. Laqua H, Machemer R. Clinical-pathological correlation in massive periretinal proliferation. Am J Ophthalmol 1975; 80:913-29. [PMID: 811122].
26. Kirchhof B, Kirchhof E, Ryan SJ, Sorgente N. Vitreous modulation of migration and proliferation of retinal pigment epithelial cells in vitro. Invest Ophthalmol Vis Sci 1989; 30:1951-7. [PMID: 2777515].
27. Olmeda D, Jordá M, Peinado H, Fabra A, Cano A. Snail silencing effectively suppresses tumour growth and invasiveness. Oncogene 2007; 26:1862-74. [PMID: 17043660].
28. Hinton DR, He S, Jin ML, Barron E, Ryan SJ. Novel growth factors involved in the pathogenesis of proliferative vitreoretinopathy. Eye (Lond) 2002; 16:422-8. [PMID: 12101449].
29. Wang Q, Usinger W, Nichols B, Gray J, Xu L, Seeley TW, Brenner M, Guo G, Zhang W, Oliver N, Lin A, Yeowell D. Cooperative interaction of CTGF and TGF-beta in animal models of fibrotic disease. Fibrogenesis Tissue Repair 2011; 4:4-[PMID: 21284856].
30. Pennison M, Pasche B. Targeting transforming growth factor beta signaling. Curr Opin Oncol 2007; 19:579-85. [PMID: 17906455].
31. Parapuram SK, Chang B, Li L, Hartung RA, Chalam KV, Nair-Menon JU, Hunt DM, Hunt RC. Differential Effects of TGFβ and Vitreous on the Transformation of Retinal Pigment Epithelial Cells. IVOS 2009; 50:5965-74.
32. Kita T, Hata Y, Arita R, Kawahara S, Miura M, Nakao S, Mochizuki Y, Enaida H, Goto Y, Shimokawa H, Hafezi-Moghadam A, Ishibashi T. Role of TGF-β in proliferative vitreoretinal diseases and ROCK as a therapeutic target. Proc Natl Acad Sci USA 2008; 105:17504-9. [PMID: 18952846].
33. Tada S, Nakamuta M, Enjoji M, Sugimoto R, Iwamoto H, Kato M, Nakashima Y, Nawata H. Pirfenidone inhibits dimethylnitrosamine induced hepatic fibrosis in rat. Clin Exp Pharmacol Physiol 2001; 28:522-7. [PMID: 11422218].
34. Kaibori M, Yanagida H, Uchida Y, Yokoigawa N, Kwon AH, Okumura T, Kamiyama Y. Pirfenidone protects endotoxin-induced liver injury after hepatic ischemia in rats. Transplant Proc 2004; 36:1973-4. [PMID: 15518715].