Transformation of Althaea officinalis L. by Agrobacterium rhizogenes for the production of transgenic roots expressing the anti-HIV microbicide cyanovirin-N

Transgenic Research

Volumn 22, Issue 6, 2013, Pages 1225-1229

  Drake, Pascal M W ^a   de Moraes Madeira, Luisa ^a   Szeto, Tim H ^a   Ma, Julian K C ^a  

^a ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Althaea officinalis; Cyanovirin N; Genetic transformation Agrobacterium rhizogenes; HIV AIDS; Marshmallow; Pharmaceutical; Recombinant; Transgenic roots

Indexed keywords

AGROBACTERIUM RHIZOGENES; ALTHAEA; ALTHAEA OFFICINALIS; HUMAN IMMUNODEFICIENCY VIRUS;

ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; ANTIINFECTIVE AGENT; BACTERIAL PROTEIN; CARRIER PROTEIN; CYANOVIRIN N;

AGROBACTERIUM; ALTHAEA; ARTICLE; BIOREACTOR; BIOSYNTHESIS; CHEMISTRY; CULTURE MEDIUM; CULTURE TECHNIQUE; GENE EXPRESSION REGULATION; GENETICS; HUMAN; METABOLISM; PLANT ROOT; TRANSGENIC PLANT;

AGROBACTERIUM; ALTHAEA; ANTI-HIV AGENTS; ANTI-INFECTIVE AGENTS; BACTERIAL PROTEINS; BIOREACTORS; CARRIER PROTEINS; CELL CULTURE TECHNIQUES; CULTURE MEDIA; GENE EXPRESSION REGULATION, PLANT; HUMANS; PLANT ROOTS; PLANTS, GENETICALLY MODIFIED;

EID: 84891663738     PISSN: 09628819     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11248-013-9730-7     Document Type: Article

References (20)

1. Basch E, Ulbricht C, Hammerness P, Vora M (2003) Marshmallow (Althaea officinalis L.) monograph. J Herbal Pharmacother 3: 71-81.
2. Boyd MR, Gustafson KR, McMahon JB, Shoemaker RH, Okeefe BR, Mori T, Gulakowski RJ, Wu L, Rivera MI, Laurencot CM, Currens MJ, Cardellina JH, Buckheit RW, Nara PL, Pannell LK, Sowder RC, Henderson LE (1997) Discovery of cyanovirin-N, a novel human immunodeficiency virus-inactivating protein that binds viral surface envelope glycoprotein gp120: potential applications to microbicide development. Antimicrob Agents Ch 41: 1521-1530.
3. Buffa V, Stieh D, Mamhood N, Hu Q, Fletcher P, Shattock RJ (2009) Cyanovirin-N potently inhibits human immunodeficiency virus type 1 infection in cellular and cervical explant models. J Gen Virol 90: 234-243.
4. Drake PMW, Barbi T, Sexton A, McGowan E, Stadlmann J, Navarre C, Ma J-K (2009) Development of rhizosecretion as a production system for recombinant proteins from hydroponic cultivated tobacco. FASEB J 23: 3581-3589.
5. Elghabi Z, Karcher D, Zhou F, Ruf S, Bock R (2011) Optimization of the expression of the HIV fusion inhibitor cyanovirin-N from the tobacco plastid genome. Plant Biotechnol J 9: 599-608.
6. Ghanem ME, Han RM, Classen B, Quetin-Leclerq J, Mahy G, Ruan CJ, Qin P, Perez-Alfocea F, Lutts S (2010) Mucilage and polysaccharides in the halophyte plant species Kosteletzkya virginica: localization and composition in relation to salt stress. J Plant Physiol 167: 382-392.
7. Horsch RB, Fry JE, Hoffmann NL, Eichholtz D, Rogers SG, Fraley RT (1985) A simple and general-method for transferring genes into plants. Science 227: 1229-1231.
8. Hu Q, Mahmood N, Shattock RJ (2007) High-mannose-specific deglycosylation of HIV-1 gp120 induced by resistance to cyanovirin-N and the impact on antibody neutralization. Virology 368: 145-154.
9. Ionkova I (1992) Alternative ways for the production of biologically active substances from Althaea officinalis var. russalka. CR Acad Bulg Sci 45: 137-140.
10. Ionkova I, Hu Z, Alfermann A (1993) Polysaccharide production by hairy root cultures of some higher medicinal plants. Planta Med 59: A658-A659.
11. Khidyrova N, van EV, Shakhidoyatov R, Bobakulov K, Abdullaev N, Shakhidoyatov K (2012) Polyprenols from leaves and stems of the plant Althaea officinalis. Chem Nat Compd 48: 358-360.
12. Mori T, Barrientos LG, Han ZZ, Gronenborn AM, Turpin JA, Boyd MR (2002) Functional homologs of cyanovirin-N amenable to mass production in prokaryotic and eukaryotic hosts. Protein Express Purif 26: 42-49.
13. Murashige T, Skoog F (1962) A revised medium for rapid growth bioassays with tobacco tissue cultures. Plant Physiol 15: 473-497.
14. Naz R, Anis M (2012) Acceleration of adventitious shoots by interaction between exogenous hormone and adenine sulphate in Althaea Officinalis L. Appl Biochem Biotech 168: 1239-1255.
15. Sexton A, Drake PM, Mahmood N, Harman SJ, Shattock RJ, Ma JK-C (2005) Transgenic plant production of cyanovirin-N, an HIV microbicide. FASEB J 20: 356-358.
16. Shah S, Akhtar N, Akram M, Shah PA, Saeed T, Ahmed K, Asif H (2011) Pharmacological activity of Althaea officinalis L. J Med Plants Res 5: 5662-5666.
17. Shenoy SR, O'Keefe BR, Bolmstedt AJ, Cartner LK, Boyd MR (2001) Selective interactions of the human immunodeficiency virus-inactivating protein cyanovirin-N with high-mannose oligosaccharides on gp120 and other glycoproteins. J Pharmacol Exp Ther 297: 704-710.
18. Tsai CC, Emau P, Jiang YH, Tian BP, Morton WR, Gustafson KR, Boyd MR (2003) Cyanovirin-N gel as a topical microbicide prevents rectal transmission of SHIV89. 6P in macaques. Aids Res Human Retrovir 19: 535-541.
19. Tsai CC, Emau P, Jiang YH, Agy MB, Shattock RJ, Schmidt A, Morton WR, Gustafson KR, Boyd MR (2004) Cyanovirin-N inhibits AIDS virus infections in vaginal transmission models. Aids Res Human Retrovir 20: 11-18.
20. Witvrouw M, Fikkert V, Hantson A, Pannecouque C, O'Keefe BR, McMahon J, Stamatatos L, de Clercq E, Bolmstedt A (2005) Resistance of human immunodeficiency virus type 1 to the high-mannose binding agents cyanovirin N and concanavalin A. J Virol 79: 7777-7784.