메뉴 건너뛰기




Volumn 3 JUN, Issue , 2013, Pages

Improving drug uptake and penetration into tumors: Current and forthcoming opportunities

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; BEVACIZUMAB; IPILIMUMAB;

EID: 84891638533     PISSN: None     EISSN: 2234943X     Source Type: Journal    
DOI: 10.3389/fonc.2013.00161     Document Type: Editorial
Times cited : (6)

References (28)
  • 1
    • 84862514374 scopus 로고    scopus 로고
    • Co-administration of epithelial junction opener JO-1 improves the efficacy and safety of chemotherapeutic drugs
    • doi:10.1158/1078-0432.CCR-11-3213
    • Beyer, I., Cao, H., Persson, J., Song, H., Richter, M., Feng, Q., et al. (2012). Co-administration of epithelial junction opener JO-1 improves the efficacy and safety of chemotherapeutic drugs. Clin. Cancer Res. 18, 3340-3351. doi:10.1158/1078-0432.CCR-11-3213.
    • (2012) Clin. Cancer Res. , vol.18 , pp. 3340-3351
    • Beyer, I.1    Cao, H.2    Persson, J.3    Song, H.4    Richter, M.5    Feng, Q.6
  • 2
    • 81155132185 scopus 로고    scopus 로고
    • Epithelial junction opener JO-1 improves monoclonal antibody therapy of cancer
    • doi:10.1158/0008-5472.CAN-11-2009
    • Beyer, I., van Rensburg, R., Strauss, R., Li, Z. Y., Wang, H., Persson, J., et al. (2011). Epithelial junction opener JO-1 improves monoclonal antibody therapy of cancer. Cancer Res. 71, 7080-7090. doi:10.1158/0008-5472.CAN-11-2009.
    • (2011) Cancer Res. , vol.71 , pp. 7080-7090
    • Beyer, I.1    van Rensburg, R.2    Strauss, R.3    Li, Z.Y.4    Wang, H.5    Persson, J.6
  • 3
    • 84857829255 scopus 로고    scopus 로고
    • Targeting TNF-α to neoangiogenic vessels enhances lymphocyte infiltration in tumors and increases the therapeutic potential of immunotherapy
    • doi:10.4049/jimmunol.1101877
    • Calcinotto, A., Grioni, M., Jachetti, E., Curnis, F., Mondino, A., Parmiani, G., et al. (2012). Targeting TNF-α to neoangiogenic vessels enhances lymphocyte infiltration in tumors and increases the therapeutic potential of immunotherapy. J. Immunol. 188, 2687-2694. doi:10.4049/jimmunol.1101877.
    • (2012) J. Immunol. , vol.188 , pp. 2687-2694
    • Calcinotto, A.1    Grioni, M.2    Jachetti, E.3    Curnis, F.4    Mondino, A.5    Parmiani, G.6
  • 4
    • 0031740227 scopus 로고    scopus 로고
    • Tumour necrosis factor: strategies for improving the therapeutic index
    • doi:10.3109/10611869808997869
    • Corti, A., and Marcucci, F. (1998). Tumour necrosis factor: strategies for improving the therapeutic index. J. Drug Target. 5, 403-413. doi:10.3109/10611869808997869.
    • (1998) J. Drug Target. , vol.5 , pp. 403-413
    • Corti, A.1    Marcucci, F.2
  • 5
    • 0033764170 scopus 로고    scopus 로고
    • Enhancement of tumor necrosis factor α antitumor immunotherapeutic properties by targeted delivery to aminopeptidase N (CD13)
    • doi:10.1038/81183
    • Curnis, F., Sacchi, A., Borgna, L., Magni, F., Gasparri, A., and Corti, A. (2000). Enhancement of tumor necrosis factor α antitumor immunotherapeutic properties by targeted delivery to aminopeptidase N (CD13). Nat. Biotechnol. 18, 1185-1190. doi:10.1038/81183.
    • (2000) Nat. Biotechnol. , vol.18 , pp. 1185-1190
    • Curnis, F.1    Sacchi, A.2    Borgna, L.3    Magni, F.4    Gasparri, A.5    Corti, A.6
  • 6
    • 0036678474 scopus 로고    scopus 로고
    • Improving chemotherapeutic drug penetration in tumors by vascular targeting and barrier alteration
    • doi:10.1172/JCI200215223
    • Curnis, F., Sacchi, A., and Corti, A. (2002). Improving chemotherapeutic drug penetration in tumors by vascular targeting and barrier alteration. J. Clin. Invest. 110, 475-482. doi:10.1172/JCI200215223.
    • (2002) J. Clin. Invest. , vol.110 , pp. 475-482
    • Curnis, F.1    Sacchi, A.2    Corti, A.3
  • 7
    • 0032532318 scopus 로고    scopus 로고
    • Tumor microenvironment can restrict the effectiveness of activated antitumor lymphocytes
    • Ganss, R., and Hanahan, D. (1998). Tumor microenvironment can restrict the effectiveness of activated antitumor lymphocytes. Cancer Res. 58, 4673-4681.
    • (1998) Cancer Res. , vol.58 , pp. 4673-4681
    • Ganss, R.1    Hanahan, D.2
  • 8
    • 77954801079 scopus 로고    scopus 로고
    • Improved survival with ipilimumab in patients with metastatic melanoma
    • doi:10.1056/NEJMoa1003466
    • Hodi, F. S., O'Day, S. J., McDermott, D. F., Weber, R. W., Sosman, J. A., Haanen, J. B., et al. (2010). Improved survival with ipilimumab in patients with metastatic melanoma. N. Engl. J. Med. 363, 711-723. doi:10.1056/NEJMoa1003466.
    • (2010) N. Engl. J. Med. , vol.363 , pp. 711-723
    • Hodi, F.S.1    O'Day, S.J.2    McDermott, D.F.3    Weber, R.W.4    Sosman, J.A.5    Haanen, J.B.6
  • 9
    • 2542561964 scopus 로고    scopus 로고
    • Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
    • doi:10.1056/NEJMoa032691
    • Hurwitz, H., Fehrenbacher, L., Novotny, W., Cartwright, T., Hainsworth, J., Heim, W., et al. (2004). Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N. Engl. J. Med. 350, 2335-2342. doi:10.1056/NEJMoa032691.
    • (2004) N. Engl. J. Med. , vol.350 , pp. 2335-2342
    • Hurwitz, H.1    Fehrenbacher, L.2    Novotny, W.3    Cartwright, T.4    Hainsworth, J.5    Heim, W.6
  • 10
    • 11844254414 scopus 로고    scopus 로고
    • Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy
    • doi:10.1126/science.1104819
    • Jain, R. K. (2005). Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science 307, 58-62. doi:10.1126/science.1104819.
    • (2005) Science , vol.307 , pp. 58-62
    • Jain, R.K.1
  • 11
    • 84863911486 scopus 로고    scopus 로고
    • Ipilimumab in combination with paclitaxel and carboplatin as first-line treatment in stage IIIB/IV non-small-cell lung cancer: results from a randomized, double-blind, multicenter phase II study
    • doi:10.1200/JCO.2011.38.4032
    • Lynch, T. J., Bondarenko, I., Luft, A., Serwatowski, P., Barlesi, F., Chacko, R., et al. (2012). Ipilimumab in combination with paclitaxel and carboplatin as first-line treatment in stage IIIB/IV non-small-cell lung cancer: results from a randomized, double-blind, multicenter phase II study. J. Clin. Oncol. 30, 2046-2054. doi:10.1200/JCO.2011.38.4032.
    • (2012) J. Clin. Oncol. , vol.30 , pp. 2046-2054
    • Lynch, T.J.1    Bondarenko, I.2    Luft, A.3    Serwatowski, P.4    Barlesi, F.5    Chacko, R.6
  • 12
    • 84872867897 scopus 로고    scopus 로고
    • Approaches to improve tumor accumulation and interactions between monoclonal antibodies and immune cells
    • doi:10.4161/mabs.22775
    • Marcucci, F., Bellone, M., Rumio, C., and Corti, A. (2013). Approaches to improve tumor accumulation and interactions between monoclonal antibodies and immune cells. MAbs 5, 36-46. doi:10.4161/mabs.22775.
    • (2013) MAbs , vol.5 , pp. 36-46
    • Marcucci, F.1    Bellone, M.2    Rumio, C.3    Corti, A.4
  • 13
    • 84858447459 scopus 로고    scopus 로고
    • How to improve exposure of tumor cells to drugs-promoter drugs increase tumor uptake and penetration of effector drugs
    • doi:10.1016/j.addr.2011.09.007
    • Marcucci, F., and Corti, A. (2012a). How to improve exposure of tumor cells to drugs-promoter drugs increase tumor uptake and penetration of effector drugs. Adv. Drug Deliv. Rev. 64, 53-68. doi:10.1016/j.addr.2011.09.007.
    • (2012) Adv. Drug Deliv. Rev. , vol.64 , pp. 53-68
    • Marcucci, F.1    Corti, A.2
  • 14
    • 84866742980 scopus 로고    scopus 로고
    • Improving drug penetration to curb tumor drug resistance
    • doi:10.1016/j.drudis.2012.06.004
    • Marcucci, F., and Corti, A. (2012b). Improving drug penetration to curb tumor drug resistance. Drug Discov. Today 17, 1139-1147. doi:10.1016/j.drudis.2012.06.004.
    • (2012) Drug Discov. Today , vol.17 , pp. 1139-1147
    • Marcucci, F.1    Corti, A.2
  • 15
    • 84859402603 scopus 로고    scopus 로고
    • Paclitaxel enhances therapeutic efficacy of the F8-IL2 immunocytokine to EDA-fibronectin-positive metastatic human melanoma xenografts
    • doi:10.1158/0008-5472.CAN-11-1919
    • Moschetta, M., Pretto, F., Berndt, A., Galler, K., Richter, P., Bassi, A., et al. (2012). Paclitaxel enhances therapeutic efficacy of the F8-IL2 immunocytokine to EDA-fibronectin-positive metastatic human melanoma xenografts. Cancer Res. 72, 1814-1824. doi:10.1158/0008-5472.CAN-11-1919.
    • (2012) Cancer Res. , vol.72 , pp. 1814-1824
    • Moschetta, M.1    Pretto, F.2    Berndt, A.3    Galler, K.4    Richter, P.5    Bassi, A.6
  • 16
    • 70449374917 scopus 로고    scopus 로고
    • Elevating blood pressure as a strategy to increase tumor-targeted delivery of macromolecular drug SMANCS: cases of advanced solid tumors
    • doi:10.1093/jjco/hyp074
    • Nagamitsu, A., Greish, K., and Maeda, H. (2009). Elevating blood pressure as a strategy to increase tumor-targeted delivery of macromolecular drug SMANCS: cases of advanced solid tumors. Jpn. J. Clin. Oncol. 39, 756-766. doi:10.1093/jjco/hyp074.
    • (2009) Jpn. J. Clin. Oncol. , vol.39 , pp. 756-766
    • Nagamitsu, A.1    Greish, K.2    Maeda, H.3
  • 17
    • 1542320497 scopus 로고    scopus 로고
    • Pathology: cancer cells compress intratumour vessels
    • doi:10.1038/427695a
    • Padera, T. P., Stoll, B. R., Tooredman, J. B., Capen, D., di Tomaso, E., and Jain, R. K. (2004). Pathology: cancer cells compress intratumour vessels. Nature 427, 695. doi:10.1038/427695a.
    • (2004) Nature , vol.427 , pp. 695
    • Padera, T.P.1    Stoll, B.R.2    Tooredman, J.B.3    Capen, D.4    di Tomaso, E.5    Jain, R.K.6
  • 18
    • 0028924988 scopus 로고
    • Endothelial vascular cell adhesion molecule 1 expression is suppressed by melanoma and carcinoma
    • doi:10.1084/jem.181.2.811
    • Piali, L., Fichtel, A., Terpe, H.-J., Imhof, B. A., and Gisler, R. H. (1995). Endothelial vascular cell adhesion molecule 1 expression is suppressed by melanoma and carcinoma. J. Exp. Med. 181, 811-816. doi:10.1084/jem.181.2.811.
    • (1995) J. Exp. Med. , vol.181 , pp. 811-816
    • Piali, L.1    Fichtel, A.2    Terpe, H.-J.3    Imhof, B.A.4    Gisler, R.H.5
  • 19
    • 84858602107 scopus 로고    scopus 로고
    • Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma
    • doi:10.1016/j.ccr.2012.01.007
    • Provenzano, P. P., Cuevas, C., Chang, A. E., Goel, V. K., Von Hoff, D. D., and Hingorani, S. R. (2012). Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma. Cancer Cell 21, 418-429. doi:10.1016/j.ccr.2012.01.007.
    • (2012) Cancer Cell , vol.21 , pp. 418-429
    • Provenzano, P.P.1    Cuevas, C.2    Chang, A.E.3    Goel, V.K.4    Von Hoff, D.D.5    Hingorani, S.R.6
  • 20
    • 31544436380 scopus 로고    scopus 로고
    • Synergistic antitumor activity of cisplatin, paclitaxel, and gemcitabine with tumor vasculature-targeted tumor necrosis factor-α
    • doi:10.1158/1078-0432.CCR-05-1147
    • Sacchi, A., Gasparri, A., Gallo-Stampino, C., Toma, S., Curnis, F., and Corti, A. (2006). Synergistic antitumor activity of cisplatin, paclitaxel, and gemcitabine with tumor vasculature-targeted tumor necrosis factor-α. Clin. Cancer Res. 2, 175-182. doi:10.1158/1078-0432.CCR-05-1147.
    • (2006) Clin. Cancer Res. , vol.2 , pp. 175-182
    • Sacchi, A.1    Gasparri, A.2    Gallo-Stampino, C.3    Toma, S.4    Curnis, F.5    Corti, A.6
  • 21
    • 79957928543 scopus 로고    scopus 로고
    • Mild elevation of body temperature reduces tumor interstitial fluid pressure and hypoxia and enhances efficacy of radiotherapy in murine tumor models
    • doi:10.1158/0008-5472.CAN-10-4482
    • Sen, A., Capitano, M. L., Spernyak, J. A., Schueckler, J. T., Thomas, S., Singh, A. K., et al. (2011). Mild elevation of body temperature reduces tumor interstitial fluid pressure and hypoxia and enhances efficacy of radiotherapy in murine tumor models. Cancer Res. 71, 3872-3880. doi:10.1158/0008-5472.CAN-10-4482.
    • (2011) Cancer Res. , vol.71 , pp. 3872-3880
    • Sen, A.1    Capitano, M.L.2    Spernyak, J.A.3    Schueckler, J.T.4    Thomas, S.5    Singh, A.K.6
  • 22
    • 0027982876 scopus 로고
    • Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm
    • doi:10.1016/0092-8674(94)90337-9
    • Springer, T. A. (1994). Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell 76, 301-314. doi:10.1016/0092-8674(94)90337-9.
    • (1994) Cell , vol.76 , pp. 301-314
    • Springer, T.A.1
  • 23
    • 84862859820 scopus 로고    scopus 로고
    • Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
    • doi:10.1056/NEJMoa1200690
    • Topalian, S. L., Hodi, F. S., Brahmer, J. R., Gettinger, S. N., Smith, D. C., McDermott, D. F., et al. (2012). Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N. Engl. J. Med. 366, 2443-2454. doi:10.1056/NEJMoa1200690.
    • (2012) N. Engl. J. Med. , vol.366 , pp. 2443-2454
    • Topalian, S.L.1    Hodi, F.S.2    Brahmer, J.R.3    Gettinger, S.N.4    Smith, D.C.5    McDermott, D.F.6
  • 24
    • 35148881028 scopus 로고    scopus 로고
    • Drug resistance and the solid tumor microenvironment
    • doi:10.1093/jnci/djm135
    • Trédan, O., Galmarini, C. M., Patel, K., and Tannock, I. F. (2007). Drug resistance and the solid tumor microenvironment. J. Natl. Cancer Inst. 99, 1441-1454. doi:10.1093/jnci/djm135.
    • (2007) J. Natl. Cancer Inst. , vol.99 , pp. 1441-1454
    • Trédan, O.1    Galmarini, C.M.2    Patel, K.3    Tannock, I.F.4
  • 25
    • 84855931910 scopus 로고    scopus 로고
    • Rapid decrease in delivery of chemotherapy to tumors after anti-VEGF therapy: implications for scheduling of anti-angiogenic drugs
    • doi:10.1016/j.ccr.2011.11.023
    • Van der Veldt, A. A. M., Lubberink, M., Bahce, I., Walraven, M., de Boer, M. P., Greuter, H. N. J. M., et al. (2012). Rapid decrease in delivery of chemotherapy to tumors after anti-VEGF therapy: implications for scheduling of anti-angiogenic drugs. Cancer Cell 21, 82-91. doi:10.1016/j.ccr.2011.11.023.
    • (2012) Cancer Cell , vol.21 , pp. 82-91
    • Van der Veldt, A.A.M.1    Lubberink, M.2    Bahce, I.3    Walraven, M.4    de Boer, M.P.5    Greuter, H.N.J.M.6
  • 26
    • 78651260394 scopus 로고    scopus 로고
    • Desmoglein 2 is a receptor for adenovirus serotypes 3, 7, 11 and 14
    • doi:10.1038/nm.2270
    • Wang, H., Li, Z.-Y., Liu, Y., Persson, J., Beyer, I., Möller, T., et al. (2011). Desmoglein 2 is a receptor for adenovirus serotypes 3, 7, 11 and 14. Nat. Med. 17, 96-105. doi:10.1038/nm.2270.
    • (2011) Nat. Med. , vol.17 , pp. 96-105
    • Wang, H.1    Li, Z.-Y.2    Liu, Y.3    Persson, J.4    Beyer, I.5    Möller, T.6
  • 27
    • 84863229509 scopus 로고    scopus 로고
    • Ultrasound increases nanoparticle delivery by reducing intratumoral pressure and increasing transport in epithelial and epithelial-mesenchymal transition tumors
    • doi:10.1158/0008-5472.CAN-11-3232
    • Watson, K. D., Lai, C.-Y., Qin, S., Kruse, D. E., Lin, Y.-C., Seo, J. W., et al. (2012). Ultrasound increases nanoparticle delivery by reducing intratumoral pressure and increasing transport in epithelial and epithelial-mesenchymal transition tumors. Cancer Res. 72, 1485-1493. doi:10.1158/0008-5472.CAN-11-3232.
    • (2012) Cancer Res. , vol.72 , pp. 1485-1493
    • Watson, K.D.1    Lai, C.-Y.2    Qin, S.3    Kruse, D.E.4    Lin, Y.-C.5    Seo, J.W.6
  • 28
    • 11144354392 scopus 로고    scopus 로고
    • Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer
    • doi:10.1038/nm988
    • Willett, C. G., Boucher, Y., di Tomaso, E., Duda, D. G., Munn, L. L., Tong, R. T., et al. (2004). Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer. Nat. Med. 10, 145-147. doi:10.1038/nm988.
    • (2004) Nat. Med. , vol.10 , pp. 145-147
    • Willett, C.G.1    Boucher, Y.2    di Tomaso, E.3    Duda, D.G.4    Munn, L.L.5    Tong, R.T.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.