Development of functional biomaterials with micro- and nanoscale technologies for tissue engineering and drug delivery applications

Journal of Tissue Engineering and Regenerative Medicine

Volumn 8, Issue 1, 2014, Pages 1-14

  Bae, Hojae ^a,b,c   Chu, Hunghao ^d   Edalat, Faramarz ^a,b   Cha, Jae Min ^a,b   Sant, Shilpa ^a,b   Kashyap, Aditya ^a,b,e   Ahari, Amir F ^a,b   Kwon, Cheong Hoon ^a,b   Nichol, Jason W ^a,b   Manoucheri, Sam ^a,b   Zamanian, Behnam ^a,b   Wang, Yadong ^d   Khademhosseini, Ali ^a,b,c,f  

^a HARVARD MEDICAL SCHOOL   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c Kyung Hee University   (South Korea)

^d University of Pittsburgh   (United States)

^e ETH ZURICH   (Switzerland)

^f HARVARD UNIVERSITY   (United States)

Author keywords

Biomaterials; Drug delivery; High throughput screening; Microtechnology; Nanotechnology; Tissue engineering

Indexed keywords

BIOCHEMISTRY; BIOMATERIALS; CELL ENGINEERING; CELLS; CONTROLLED DRUG DELIVERY; CYTOLOGY; LITHOGRAPHY; SCAFFOLDS (BIOLOGY); SURFACE CHEMISTRY; TARGETED DRUG DELIVERY; THROUGHPUT; TISSUE;

DRUG DELIVERY APPLICATIONS; FABRICATION TECHNIQUE; FABRICATION TOOL; HIGH THROUGHPUT SCREENING; MICRO TECHNOLOGY; MICROSCALE AND NANOSCALE; MICROSCALE TECHNOLOGY; NANOSCALE TECHNOLOGIES; POLYMERIC BIOMATERIALS; TISSUES ENGINEERINGS;

NANOTECHNOLOGY;

BIOMATERIAL; DRUG CARRIER; NANOMATERIAL; NANOPARTICLE; POLYMER;

CELL CULTURE; CELL ENGINEERING; CELL INTERACTION; CELL SPECIFICITY; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; ELECTRON BEAM; GEOMETRY; HIGH THROUGHPUT SCREENING; HUMAN; MATHEMATICAL MODEL; MICROARRAY ANALYSIS; MICROTECHNOLOGY; MOLECULAR IMPRINTING; NANOFABRICATION; NANOTECHNOLOGY; PARTICLE SIZE; PRIORITY JOURNAL; REVIEW; SURFACE PROPERTY; TISSUE ENGINEERING; TOPOGRAPHY; ARTICLE; CHEMISTRY; PHOTOLITHOGRAPHY; POLYMERIZATION; SOFT LITHOGRAPHY;

BIOMATERIALS; DRUG DELIVERY; HIGH-THROUGHPUT SCREENING; MICROTECHNOLOGY; NANOTECHNOLOGY; TISSUE ENGINEERING;

BIOCOMPATIBLE MATERIALS; DRUG DELIVERY SYSTEMS; HIGH-THROUGHPUT SCREENING ASSAYS; TISSUE ENGINEERING; TISSUE SCAFFOLDS;

EID: 84891631759     PISSN: 19326254     EISSN: 19327005     Source Type: Journal    
DOI: 10.1002/term.1494     Document Type: Review

References (156)

1. Albrecht DR, Underhill GH, Wassermann TB, et al. 2006; Probing the role of multicellular organization in three-dimensional microenvironments. Nat Methods 3: 369-375.
2. Anderson DG, Putnam D, Lavik EB, et al. 2005; Biomaterial microarrays: rapid, microscale screening of polymer-cell interaction. Biomaterials 26: 4892-4897.
3. Aubin H, Nichol JW, Hutson CB, et al. 2010; Directed 3D cell alignment and elongation in microengineered hydrogels. Biomaterials 31: 6941-6951.
4. Bae H, Ahari AF, Shin H, et al. 2011; Cell-laden microengineered pullulan methacrylate hydrogels promote cell proliferation and 3D cluster formation. Soft Matter 7: 1903-1911.
5. Bauwens CL, Peerani R, Niebruegge S, et al. 2008; Control of human embryonic stem cell colony and aggregate size heterogeneity influences differentiation trajectories. Stem Cells 26: 2300-2310.
6. Berkland C, Kim K, Pack DW. 2001; Fabrication of PLG microspheres with precisely controlled and monodisperse size distributions. J Control Release 73: 59-74.
7. Bettinger C, Langer R, Borenstein J. 2009; Engineering substrate topography at the micro- and nanoscale to control cell function. Angew Chem Int Ed Engl 48: 5406-5415.
8. Bhaskar S, Pollock KM, Yoshida M, et al. 2010; Towards designer microparticles: simultaneous control of anisotropy, shape, and size. Small 6: 404-411.
9. Burdick JA, Khademhosseini A, Langer R. 2004; Fabrication of gradient hydrogels using a microfluidics/photopolymerization process. Langmuir 20: 5153-5156.
10. Champion JA, Katare YK, Mitragotri S. 2007; Particle shape: a new design parameter for micro- and nanoscale drug delivery carriers. J Control Release 121: 3-9.
11. Champion JA, Mitragotri S. 2006; Role of target geometry in phagocytosis. Proc Natl Acad Sci USA 103: 4930-4934.
12. Champion JA, Walker A, Mitragotri S. 2008; Role of particle size in phagocytosis of polymeric microspheres. Pharm Res 25: 1815-1821.
13. Chan V, Jeong JH, Bajaj P, et al. 2012; Multi-material bio-fabrication of hydrogel cantilevers and actuators with stereolithography. Lab Chip 12: 88-98.
14. Chen CS, Mrksich M, Huang S, et al. 1997; Geometric control of cell life and death. Science 276: 1425-1428.
15. Chou SY, Krauss PR, Renstrom PJ. 1996; Imprint lithography with 25 nm resolution. Science 272: 85-87.
16. Christman KL, Schopf E, Broyer RM, et al. 2009; Positioning multiple proteins at the nanoscale with electron beam cross-linked functional polymers. J Am Chem Soc 131: 521-527.
17. Chung BG, Kang L, Khademhosseini A. 2007; Micro- and nanoscale approaches for tissue engineering and drug discovery. Expert Opin Drug Dis 2: 1653-1668.
18. Clark HA, Kopelman R, Tjalkens R, et al. 1999; Optical nanosensors for chemical analysis inside single living cells. 2. Sensors for pH and calcium and the intracellular application of PEBBLE sensors. Anal Chem 71: 4837-4843.
19. Cukierman E, Pankov R, Stevens DR, et al. 2001; Taking cell-matrix adhesions to the third dimension. Science 294: 1708-1712.
20. Das G, Mecarini F, Gentile F, et al. 2009; Nano-patterned SERS substrate: application for protein analysis vs temperature. Biosens Bioelectron 24: 1693-1699.
21. Decuzzi P, Ferrari M. 2006; The adhesive strength of non-spherical particles mediated by specific interactions. Biomaterials 27: 5307-5314.
22. Decuzzi P, Ferrari M. 2008; The receptor-mediated endocytosis of nonspherical particles. Biophys J 94: 3790-3797.
23. Decuzzi P, Pasqualini R, Arap W, et al. 2009; Intravascular delivery of particulate systems: does geometry really matter? Pharm Res 26: 235-243.
24. del Campo A, Arzt E. 2008; Fabrication approaches for generating complex micro- and nanopatterns on polymeric surfaces. Chem Rev 108: 911-945.
25. Dendukuri D, Pregibon DC, Collins J, et al. 2006; Continuous-flow lithography for high-throughput microparticle synthesis. Nat Mater 5: 365-369.
26. Dolatshahi-Pirouz A, Nikkhah M, Kolind K, et al. 2011; Micro- and nanoengineering approaches to control stem cell-biomaterial interactions. J Funct Biomater 2: 88-106.
27. Doyle AD, Wang FW, Matsumoto K, et al. 2009; One-dimensional topography underlies three-dimensional fibrillar cell migration. J Cell Biol 184: 481-490.
28. Dvir T, Timko BP, Kohane DS, et al. 2011; Nanotechnological strategies for engineering complex tissues. Nat Nanotechnol 6: 13-22.
29. Edalat F, Bae H, Manoucheri S, et al. 2011; Engineering approaches toward deconstructing and controlling the stem cell environment. Ann Biomed Eng 10.1007/s10439-011-0452-9.
30. Egerton RF, Li P, Malac M. 2004; Radiation damage in the TEM and SEM. Micron 35: 399-409.
31. Engler AJ, Carag-Krieger C, Johnson CP, et al. 2008; Embryonic cardiomyocytes beat best on a matrix with heart-like elasticity: scar-like rigidity inhibits beating. J Cell Sci 121: 3794-3802.
32. Engler AJ, Humbert PO, Wehrle-Haller B, et al. 2009; Multiscale modeling of form and function. Science 324: 208-212.
33. Fernandes TG, Diogo MM, Clark DS, et al. 2009; High-throughput cellular microarray platforms: applications in drug discovery, toxicology and stem cell research. Trends Biotechnol 27: 342-349.
34. Fernandes TG, Kwon SJ, Bale SS, et al. 2010; Three-dimensional cell culture microarray for high-throughput studies of stem cell fate. Biotechnol Bioeng 106: 106-118.
35. Flaim CJ, Chien S, Bhatia SN. 2005; An extracellular matrix microarray for probing cellular differentiation. Nat Methods 2: 119-125.
36. Flaim CJ, Teng D, Chien S, et al. 2008; Combinatorial signaling microenvironments for studying stem cell fate. Stem Cells Dev 17: 29-39.
37. Folch A, Jo BH, Hurtado O, et al. 2000; Microfabricated elastomeric stencils for micropatterning cell cultures. J Biomed Mater Res 52: 346-353.
38. Fu AY, Chou HP, Spence C, et al. 2002; An integrated microfabricated cell sorter. Anal Chem 74: 2451-2457.
39. Gao H, Shi W, Freund LB. 2005; Mechanics of receptor-mediated endocytosis. Proc Natl Acad Sci USA 102: 9469-9474.
40. Gates BD, Xu Q, Stewart M, et al. 2005; New approaches to nanofabrication: molding, printing, and other techniques. Chem Rev 105: 1171-1196.
41. Gauvin R, Khademhosseini A. 2011; Microscale technologies and modular approaches for tissue engineering: moving toward the fabrication of complex functional structures. ACS Nano 5: 4258-4264.
42. Gauvin R, Parenteau-Bareil R, Dokmeci MR, et al. 2011; Hydrogels and microtechnologies for engineering the cellular microenvironment. Wiley Interdiscip Rev Nanomed Nanobiotechnol 10.1002/wnan.171.
43. Geiger B, Spatz JP, Bershadsky AD. 2009; Environmental sensing through focal adhesions. Nat Rev Mol Cell Bio 10: 21-33.
44. Gentile F, Chiappini C, Fine D, et al. 2008; The effect of shape on the margination dynamics of non-neutrally buoyant particles in two-dimensional shear flows. J Biomech 41: 2312-2318.
45. Glangchai LC, Caldorera-Moore M, Shi L, et al. 2008; Nanoimprint lithography based fabrication of shape-specific, enzymatically-triggered smart nanoparticles. J Control Release 125: 263-272.
46. Gobaa S, Hoehnel S, Roccio M, et al. 2011; Artificial niche microarrays for probing single stem cell fate in high throughput. Nat Methods 8: 949-955.
47. Goldsmith HL, Turitto VT. 1986; Rheological aspects of thrombosis and haemostasis: basic principles and applications. ICTH Report - Subcommittee on Rheology of the International Committee on Thrombosis and Haemostasis. Thromb Haemost 55: 415-435.
48. Grant MR, Kim SH, Hunt CA. 2006; Simulating in vitro epithelial morphogenesis in multiple environments. In Comput Syst Bioinformatics Con; 381-384.
49. Gratton SE, Napier ME, Ropp PA, et al. 2008a; Microfabricated particles for engineered drug therapies: elucidation into the mechanisms of cellular internalization of PRINT particles. Pharm Res 25: 2845-2852.
50. Gratton SE, Pohlhaus PD, Lee J, et al. 2007; Nanofabricated particles for engineered drug therapies: a preliminary biodistribution study of PRINT nanoparticles. J Control Release 121: 10-18.
51. Gratton SE, Ropp PA, Pohlhaus PD, et al. 2008b; The effect of particle design on cellular internalization pathways. Proc Natl Acad Sci USA 105: 11613-11618.
52. Gratton SE, Williams SS, Napier ME, et al. 2008c; The pursuit of a scalable nanofabrication platform for use in material and life science applications. Acc Chem Res 41: 1685-1695.
53. Guo LJ. 2007; Nanoimprint lithography: methods and material requirements. Adv Mater 19: 495-513.
54. Guo LJ, Cheng X, Chou CF. 2004; Fabrication of size-controllable nanofluidic channels by nanoimprinting and its application for DNA stretching. Nano Lett 4: 69-73.
55. Hahn MS, Miller JS, West JL. 2006; Three dimensional biochemical and biomechanical patterning of hydrogels for guiding cell behavior. Adv Mater 18: 2679-2684.
56. Hansen CL, Skordalakes E, Berger JM, et al. 2002; A robust and scalable microfluidic metering method that allows protein crystal growth by free interface diffusion. Proc Natl Acad Sci USA 99: 16531-16536.
57. Hobbs SK, Monsky WL, Yuan F, et al. 1998; Regulation of transport pathways in tumor vessels: role of tumor type and microenvironment. Proc Natl Acad Sci USA 95: 4607-4612.
58. Hoff JD, Cheng LJ, Meyhöfer E, et al. 2004; Nanoscale protein patterning by imprint lithography. Nano Lett 4: 853-857.
59. Hong JW, Studer V, Hang G, et al. 2004; A nanoliter-scale nucleic acid processor with parallel architecture. Nat Biotechnol 22: 435-439.
60. Hook AL, Anderson DG, Langer R, et al. 2010; High throughput methods applied in biomaterial development and discovery. Biomaterials 31: 187-198.
61. Hove JR, Koster RW, Forouhar AS, et al. 2003; Intracardiac fluid forces are an essential epigenetic factor for embryonic cardiogenesis. Nature 421: 172-177.
62. Hua F, Sun Y, Gaur A, et al. 2004; Polymer imprint lithography with molecular-scale resolution. Nano Lett 4: 2467-2471.
63. Huang J, Gräter SV, Corbellini F, et al. 2009; Impact of order and disorder in RGD nanopatterns on cell adhesion. Nano Lett 9: 1111-1116.
64. Huh D, Matthews BD, Mammoto A, et al. 2010; Reconstituting organ-level lung functions on a chip. Science 328: 1662-1668.
65. Hui EE, Bhatia SN. 2007; Micromechanical control of cell-cell interactions. Proc Natl Acad Sci USA 104: 5722-5726.
66. Hwang YS, Chung BG, Ortmann D, et al. 2009; Microwell-mediated control of embryoid body size regulates embryonic stem cell fate via differential expression of WNT5a and WNT11. Proc Natl Acad Sci USA 106: 16978-16983.
67. Hynes RO. 2009; The extracellular matrix: not just pretty fibrils. Science 326: 1216-1219.
68. Idota N, Tsukahara T, Sato K, et al. 2009; The use of electron beam lithographic graft-polymerization on thermoresponsive polymers for regulating the directionality of cell attachment and detachment. Biomaterials 30: 2095-2101.
69. Ito T, Okazaki S. 2000; Pushing the limits of lithography. Nature 406: 1027-1031.
70. Kaji H, Camci-Unal G, Langer R, et al. 2011; Engineering systems for the generation of patterned co-cultures for controlling cell-cell interactions. Biochim Biophys Acta 1810: 239-250.
71. Karp J, Yeo Y, Geng W, et al. 2006; A photolithographic method to create cellular micropatterns. Biomaterials 27: 4755-4764.
72. Karp JM, Yeh J, Eng G, et al. 2007; Controlling size, shape and homogeneity of embryoid bodies using poly(ethylene glycol) microwells. Lab Chip 7: 786-794.
73. Kaufmann T, Ravoo BJ. 2010; Stamps, inks and substrates: polymers in microcontact printing. Polym Chem 1: 371-387.
74. Ker EDF, Chu B, Phillippi JA, et al. 2011; Engineering spatial control of multiple differentiation fates within a stem cell population. Biomaterials 32: 3413-3422.
75. Khademhosseini A, Eng G, Yeh J, et al. 2006a; Micromolding of photocrosslinkable hyaluronic acid for cell encapsulation and entrapment. J Biomed Mater Res A 79: 522-532.
76. Khademhosseini A, Eng G, Yeh J, et al. 2007; Microfluidic patterning for fabrication of contractile cardiac organoids. Biomed Microdevices 9: 149-157.
77. Khademhosseini A, Ferreira L, Blumling J III, et al. 2006b; Co-culture of human embryonic stem cells with murine embryonic fibroblasts on microwell-patterned substrates. Biomaterials 27: 5968-5977.
78. Khademhosseini A, Langer R, Borenstein J, et al. 2006c; Microscale technologies for tissue engineering and biology. Proc Natl Acad Sci USA 103: 2480-2487.
79. Kilian KA, Bugarija B, Lahn BT, et al. 2010; Geometric cues for directing the differentiation of mesenchymal stem cells. Proc Natl Acad Sci USA 107: 4872-4877.
80. Kim D-H, Lipke EA, Kim P, et al. 2010a; Nanoscale cues regulate the structure and function of macroscopic cardiac tissue constructs. Proc Natl Acad Sci 107: 565-570.
81. Kim JD, Choi JS, Kim BS, et al. 2010b; Piezoelectric inkjet printing of polymers: stem cell patterning on polymer substrates. Polymer 51: 2147-2154.
82. Kwon CH, Wheeldon I, Kachouie NN, et al. 2011; Drug-eluting microarrays for cell-based screening of chemical-induced apoptosis. Anal Chem 83: 4118-4125.
83. Lamprecht A, Schafer U, Lehr CM. 2001; Size-dependent bioadhesion of micro- and nanoparticulate carriers to the inflamed colonic mucosa. Pharm Res 18: 788-793.
84. Langer R, Vacanti JP. 1993; Tissue engineering. Science 260: 920-926.
85. Lee K-S, Kim RH, Yang D-Y, et al. 2008; Advances in 3D nano/microfabrication using two-photon initiated polymerization. Prog Polym Sci 33: 631-681.
86. Li HW, Muir BVO, Fichet G, et al. 2003; Nanocontact printing: a route to sub-50 nm-scale chemical and biological patterning. Langmuir 19: 1963-1965.
87. Lim JY, Donahue HJ. 2007; Cell sensing and response to micro- and nanostructured surfaces produced by chemical and topographic patterning. Tissue Eng 13: 1879-1891.
88. Liu J, Enzelberger M, Quake S. 2002; A nanoliter rotary device for polymerase chain reaction. Electrophoresis 23: 1531-1536.
89. Lutolf MP. 2009; Integration column. Artificial ECM: expanding the cell biology toolbox in 3D. Integr Biol 1: 235-241.
90. Lutolf MP, Gilbert PM, Blau HM. 2009; Designing materials to direct stem-cell fate. Nature 462: 433-441.
91. Lutolf MP, Hubbell JA. 2005; Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering. Nat Biotechnol 23: 47-55.
92. Ma PX. 2008; Biomimetic materials for tissue engineering. Adv Drug Deliv Rev 60: 184-198.
93. Manoharan VN, Elsesser MT, Pine DJ. 2003; Dense packing and symmetry in small clusters of microspheres. Science 301: 483-487.
94. Matsumura Y, Maeda H. 1986; A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs. Cancer Res 46: 6387-6392.
95. McMurray RJ, Gadegaard N, Tsimbouri PM, et al. 2011; Nanoscale surfaces for the long-term maintenance of mesenchymal stem cell phenotype and multipotency. Nat Mater 10: 637-644.
96. Mei Y, Saha K, Bogatyrev SR, et al. 2010; Combinatorial development of biomaterials for clonal growth of human pluripotent stem cells. Nat Mater 9: 768-778.
97. Mironov V, Kasyanov V, Markwald RR. 2011; Organ printing: from bioprinter to organ biofabrication line. Curr Opin Biotech 22: 1-7.
98. Mitragotri S. 2009; In drug delivery, shape does matter. Pharm Res 26: 232-234.
99. Mitragotri S, Lahann J. 2009; Physical approaches to biomaterial design. Nat Mater 8: 15-23.
100. Moeller HC, Mian MK, Shrivastava S, et al. 2008; A microwell array system for stem cell culture. Biomaterials 29: 752-763.
101. Moghimi SM, Hunter AC, Murray JC. 2005; Nanomedicine: current status and future prospects. FASEB J 19: 311-330.
102. Mueller-Klieser W. 2000; Tumor biology and experimental therapeutics. Crit Rev Oncol Hematol 36: 123-139.
103. Murtuza B, Nichol JW, Khademhosseini A. 2009; Micro- and nanoscale control of the cardiac stem cell niche for tissue fabrication. Tissue Eng Part B Rev 15: 443-454.
104. Naderi H, Matin MM, Bahrami AR. 2011; Review paper: critical issues in tissue engineering: Biomaterials, cell sources, angiogenesis, and drug delivery systems. J Biomater Appl 26: 383-417.
105. Nelson CM, Chen CS. 2003; VE-cadherin simultaneously stimulates and inhibits cell proliferation by altering cytoskeletal structure and tension. J Cell Sci 116: 3571-3581.
106. Nichol JW, Koshy ST, Bae H, et al. 2010; Cell-laden microengineered gelatin methacrylate hydrogels. Biomaterials 31: 5536-5544.
107. Nie Z, Kumacheva E. 2008; Patterning surfaces with functional polymers. Nat Mater 7: 277-290.
108. Norman JJ, Desai TA. 2006; Methods for fabrication of nanoscale topography for tissue engineering scaffolds. Ann Biomed Eng 34: 89-101.
109. Park J-U, Hardy M, Kang SJ, et al. 2007; High-resolution electrohydrodynamic jet printing. Nat Mater 6: 782-789.
110. Patil VRS, Campbell CJ, Yun YH, et al. 2001; Particle diameter influences adhesion under flow. Biophys J 80: 1733-1743.
111. Peng CY, Nam WJ, Fonash SJ, et al. 2003; Formation of nanostructured polymer filaments in nanochannels. J Am Chem Soc 125: 9298-9299.
112. Peppas NA, Hilt JZ, Khademhosseini A, et al. 2006; Hydrogels in biology and medicine: from molecular principles to bionanotechnology. Adv Mater 18: 1345-1360.
113. Perl A, Reinhoudt DN, Huskens J. 2009; Microcontact printing: limitations and achievements. Adv Mater 21: 2257-2268.
114. Pesen D, Heinz WF, Werbin JL, et al. 2007; Electron beam patterning of fibronectin nanodots that support focal adhesion formation. Soft Matter 3: 1280-1284.
115. Petrie RJ, Doyle AD, Yamada KM. 2009; Random versus directionally persistent cell migration. Nat Rev Mol Cell Biol 10: 538-549.
116. Petros RA, DeSimone JM. 2010; Strategies in the design of nanoparticles for therapeutic applications. Nat Rev Drug Discov 9: 615-627.
117. Place ES, Evans ND, Stevens MM. 2009; Complexity in biomaterials for tissue engineering. Nat Mater 8: 457-470.
118. Ranzinger J, Krippner-Heidenreich A, Haraszti T, et al. 2009; Nanoscale arrangement of apoptotic ligands reveals a demand for a minimal lateral distance for efficient death receptor activation. Nano Lett 9: 4240-4245.
119. Rejman J, Oberle V, Zuhorn IS, et al. 2004; Size-dependent internalization of particles via the pathways of clathrin- and caveolae-mediated endocytosis. Biochem J 377: 159-169.
120. Rolland JP, Maynor BW, Euliss LE, et al. 2005; Direct fabrication and harvesting of monodisperse, shape-specific nanobiomaterials. J Am Chem Soc 127: 10096-10100.
121. Rothschild M. 2005; Projection optical lithography. Mater Today 8: 18-24.
122. Sant S, Poulin S, Hildgen P. 2008; Effect of polymer architecture on surface properties, plasma protein adsorption, and cellular interactions of pegylated nanoparticles. J Biomed Mater Res A 87: 885-895.
123. Schift H. 2008; Nanoimprint lithography: an old story in modern times? A review. J Vac Sci Technol B 26: 458-480.
124. Sele CW, von Werne T, Friend RH, et al. 2005; Lithography-free, self-aligned inkjet printing with sub-100 nm resolution. Adv Mater 17: 997-1001.
125. Selimovic S, Piraino F, Bae H, et al. 2011; Microfabricated polyester conical microwells for cell culture applications. Lab Chip 11: 2325-2332.
126. Shi J, Votruba AR, Farokhzad OC, et al. 2010; Nanotechnology in drug delivery and tissue engineering: from discovery to applications. Nano Lett 10: 3223-3230.
127. Shin SR, Bae H, Cha JM, et al. 2011; Carbon nanotube reinforced hybrid microgels as scaffold materials for cell encapsulation. ACS Nano 6: 362-372.
128. Sill TJ, von Recum HA. 2008; Electrospinning: applications in drug delivery and tissue engineering. Biomaterials 29: 1989-2006.
129. Slaughter BV, Khurshid SS, Fisher OZ, et al. 2009; Hydrogels in regenerative medicine. Adv Mater 21: 3307-3329.
130. Song W, Lu H, Kawazoe N, et al. 2011; Adipogenic differentiation of individual mesenchymal stem cells on different geometric micropatterns. Langmuir 27: 6155-6162.
131. Stevens MM, George JH. 2005; Exploring and engineering the cell surface interface. Science 310: 1135-1138.
132. Stolnik S, Illum L, Davis SS. 1995; Long circulating microparticulate drug carriers. Adv Drug Deliv Rev 16: 195-214.
133. Stuart MAC, Huck WTS, Genzer J, et al. 2010; Emerging applications of stimuli-responsive polymer materials. Nat Mater 9: 101-113.
134. Subramani C, Cengiz N, Saha K, et al. 2011; Direct fabrication of functional and biofunctional nanostructures through reactive imprinting. Adv Mater 23: 3165-3169.
135. 2 coating on the biological properties of microroughened titanium. Biomaterials 32: 8374-8384.
136. Teixeira AI, Abrams GA, Bertics PJ, et al. 2003; Epithelial contact guidance on well-defined micro- and nanostructured substrates. J Cell Sci 116: 1881-1892.
137. Tekin H, Anaya M, Brigham MD, et al. 2010; Stimuli-responsive microwells for formation and retrieval of cell aggregates. Lab Chip 10: 2411-2418.
138. Tekin H, Tsinman T, Sanchez JG, et al. 2011; Responsive micromolds for sequential patterning of hydrogel microstructures. J American Chemical Society 133: 12944-12947.
139. Thorsen T, Maerkl SJ, Quake SR. 2002; Microfluidic large-scale integration. Science 298: 580-584.
140. Unger MA, Chou HP, Thorsen T, et al. 2000; Monolithic microfabricated valves and pumps by multilayer soft lithography. Science 288: 113-116.
141. Vieu C, Carcenac F, Pepin A, et al. 2000; Electron beam lithography: resolution limits and applications. Appl Surf Sci 164: 111-117.
142. Weibel DB, DiLuzio WR, Whitesides GM. 2007; Microfabrication meets microbiology. Nat Rev Micro 5: 209-218.
143. Werts MHV, Lambert M, Bourgoin JP, et al. 2002; Nanometer scale patterning of Langmuir-Blodgett films of gold nanoparticles by electron beam lithography. Nano Lett 2: 43-47.
144. Whitesides GM. 2006; The origins and the future of microfluidics. Nature 442: 368-373.
145. Williams C, Tsuda Y, Isenberg BC, et al. 2009; Aligned cell sheets grown on thermo-responsive substrates with microcontact printed protein patterns. Adv Mater 21: 2161-2164.
146. Williams C, Xie AW, Yamato M, et al. 2011; Stacking of aligned cell sheets for layer-by-layer control of complex tissue structure. Biomaterials 32: 5625-5632.
147. Wright D, Rajalingam B, Karp JM, et al. 2008; Reusable, reversibly sealable parylene membranes for cell and protein patterning. J Biomed Mater Res A 85: 530-538.
148. Wright D, Rajalingam B, Selvarasah S, et al. 2007; Generation of static and dynamic patterned co-cultures using microfabricated parylene-C stencils. Lab Chip 7: 1272-1279.
149. Wu J, Wheeldon I, Guo Y, et al. 2010; Sandwiched microarray for bench-top cell-based high throughput screening. Biomaterials 32: 841-848.
150. Xia Y, Whitesides GM. 1998; Soft lithography. Annu Rev Mater Sci 28: 153-184.
151. Yamazoe H, Uemura T, Tanabe T. 2008; Facile cell patterning on an albumin-coated surface. Langmuir 24: 8402-8404.
152. Yang MT, Fu J, Wang Y-K, et al. 2011; Assaying stem cell mechanobiology on microfabricated elastomeric substrates with geometrically modulated rigidity. Nat Protoc 6: 187-213.
153. Young KD. 2010; Bacterial shape: two-dimensional questions and possibilities. Annu Rev Microbiol 64: 223-240.
154. Yuan F, Dellian M, Fukumura D, et al. 1995; Vascular permeability in a human tumor xenograft - molecular-size dependence and cutoff size. Cancer Res 55: 3752-3756.
155. Zhuang L-F, Jiang H-H, Qiao S-C, et al. 2012; The roles of extracellular signal-regulated kinase 1/2 pathway in regulating osteogenic differentiation of murine preosteoblasts MC3T3-E1 cells on roughened titanium surfaces. J Biomed Mater Res A 100A: 125-133.
156. Zorlutuna P, Jeong JH, Kong H, et al. 2011; Stereolithography-based hydrogel microenvironments to examine cellular interactions. Adv Funct Mater 21: 3642-3651.