Synovial sarcoma of the kidney: A clinicopathologic, immunohistochemical, and molecular genetic study of 16 cases

American Journal of Surgical Pathology

Volumn 38, Issue 1, 2014, Pages 60-65

  Schoolmeester, John Kenneth ^a   Cheville, John C ^a   Folpe, Andrew L ^a  

^a MAYO CLINIC   (United States)

Author keywords

immunohistochemistry; molecular genetics; renal neoplasms; synovial sarcoma

Indexed keywords

ONCOPROTEIN; PROTEIN BCL 2; REPRESSOR PROTEIN; SS18 PROTEIN, HUMAN; SYNOVIAL SARCOMA X BREAKPOINT PROTEINS; SYT SSX FUSION PROTEIN; SYT-SSX FUSION PROTEIN; TLE1 PROTEIN, HUMAN; TUMOR MARKER; TUMOR PROTEIN;

ADOLESCENT; ADULT; AGED; ARTICLE; BIOPSY; CHEMISTRY; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; GENETICS; HUMAN; IMMUNOHISTOCHEMISTRY; KIDNEY TUMOR; MALE; METASTASIS; MIDDLE AGED; MOLECULAR DIAGNOSIS; NEPHRECTOMY; PATHOLOGY; PREDICTIVE VALUE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SURVIVAL; SYNOVIAL SARCOMA; TIME; TREATMENT OUTCOME; TUMOR VOLUME; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; BIOPSY; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION, FLUORESCENCE; KIDNEY NEOPLASMS; MALE; MIDDLE AGED; MOLECULAR DIAGNOSTIC TECHNIQUES; NEOPLASM PROTEINS; NEPHRECTOMY; ONCOGENE PROTEINS, FUSION; PREDICTIVE VALUE OF TESTS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; REPRESSOR PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SARCOMA, SYNOVIAL; SURVIVAL ANALYSIS; TIME FACTORS; TREATMENT OUTCOME; TUMOR BURDEN; TUMOR MARKERS, BIOLOGICAL; YOUNG ADULT;

EID: 84891628288     PISSN: 01475185     EISSN: 15320979     Source Type: Journal    
DOI: 10.1097/PAS.0b013e31829b2d0d     Document Type: Article

References (31)

1. Fletcher CDM, Bridge JA, Hogendoorn PCW. WHO Classification of Tumours of Soft Tissue and Bone. Lyons: IARC Press; 2013.
2. Weiss SW, Goldblum JR. Enzinger & Weiss's Soft Tissue Tumors. Philadelphia: Mosby, Elsevier; 2008.
3. Dimitriadis E, Rontogianni D, Kyriazoglou A, et al. Novel SYTSSX fusion transcript variants in synovial sarcoma. Cancer Genet Cytogenet. 2009;195:54-58.
4. Takenaka S, Ueda T, Naka N, et al. Prognostic implication of SYTSSX fusion type in synovial sarcoma: a multi-institutional retrospective analysis in Japan. Oncol Rep. 2008;19:467-476.
5. Sun B, Sun Y, Wang J, et al. The diagnostic value of SYT-SSX detected by reverse transcriptase-polymerase chain reaction (RTPCR) and fluorescence in situ hybridization (FISH) for synovial sarcoma: a review and prospective study of 255 cases. Cancer Sci. 2008;99:1355-1361.
6. Amary MF, Berisha F, Bernardi Fdel C, et al. Detection of SS18-SSX fusion transcripts in formalin-fixed paraffin-embedded neoplasms: analysis of conventional RT-PCR, qRT-PCR and dual color FISH as diagnostic tools for synovial sarcoma. Mod Pathol. 2007; 20:482-496.
7. Guillou L, Benhattar J, Bonichon F, et al. Histologic grade, but not SYT-SSX fusion type, is an important prognostic factor in patients with synovial sarcoma: a multicenter, retrospective analysis. J Clin Oncol. 2004;22:4040-4050.
8. Ladanyi M, Antonescu CR, Leung DH, et al. Impact of SYT-SSX fusion type on the clinical behavior of synovial sarcoma: a multiinstitutional retrospective study of 243 patients. Cancer Res. 2002; 62:135-140.
9. Antonescu CR, Kawai A, Leung DH, et al. Strong association of SYT-SSX fusion type and morphologic epithelial differentiation in synovial sarcoma. Diagn Mol Pathol. 2000;9:1-8.
10. Skytting B, Nilsson G, Brodin B, et al. A novel fusion gene, SYTSSX4, in synovial sarcoma. J Natl Cancer Inst. 1999;91:974-975.
11. Nilsson G, Skytting B, Xie Y, et al. The SYT-SSX1 variant of synovial sarcoma is associated with a high rate of tumor cell proliferation and poor clinical outcome. Cancer Res. 1999;59:3180-3184.
12. Bahrami A, Folpe AL. Adult-type fibrosarcoma: a reevaluation of 163 putative cases diagnosed at a single institution over a 48-year period. Am J Surg Pathol. 2010;34:1504-1513.
13. Argani P, Faria PA, Epstein JI, et al. Primary renal synovial sarcoma: molecular and morphologic delineation of an entity previously included among embryonal sarcomas of the kidney. Am J Surg Pathol. 2000;24:1087-1096.
14. Iacovelli R, Altavilla A, Ciardi A, et al. Clinical and pathological features of primary renal synovial sarcoma: analysis of 64 cases from 11 years of medical literature. BJU Int. 2012;110:1449-1454.
15. Jin L, Majerus J, Oliveira A, et al. Detection of fusion gene transcripts in fresh-frozen and formalin-fixed paraffin-embedded tissue sections of soft-tissue sarcomas after laser capture microdissection and RT-PCR. Diagn Mol Pathol. 2003;12:224-230.
16. Jagdis A, Rubin BP, Tubbs RR, et al. Prospective evaluation of TLE1 as a diagnostic immunohistochemical marker in synovial sarcoma. Am J Surg Pathol. 2009;33:1743-1751.
17. Kosemehmetoglu K, Vrana JA, Folpe AL. TLE1 expression is not specific for synovial sarcoma: a whole section study of 163 soft tissue and bone neoplasms. Mod Pathol. 2009;22:872-878.
18. Terry J, Saito T, Subramanian S, et al. TLE1 as a diagnostic immunohistochemical marker for synovial sarcoma emerging from gene expression profiling studies. Am J Surg Pathol. 2007;31:240-246.
19. Kawai A, Woodruff J, Healey JH, et al. SYT-SSX gene fusion as a determinant of morphology and prognosis in synovial sarcoma. N Engl J Med. 1998;338:153-160.
20. Ladanyi M. Correlates of SYT-SSX fusion type in synovial sarcoma: getting more complex but also more interesting? J Clin Oncol. 2005;23:3638-3639; author reply 3639-3640.
21. Cheville JC, Lohse CM, Zincke H, et al. Sarcomatoid renal cell carcinoma: an examination of underlying histologic subtype and an analysis of associations with patient outcome. Am J Surg Pathol. 2004;28:435-441.
22. Messer J, Drabick J, KaagM. Rational therapy for renal cell carcinoma based on its genetic targets. Adv Exp Med Biol. 2013;779:291-308.
23. Fine SW, McCarthy DM, Chan TY, et al. Malignant solitary fibrous tumor of the kidney: report of a case and comprehensive review of the literature. Arch Pathol Lab Med. 2006;130:857-861.
24. Magro G, Cavallaro V, Torrisi A, et al. Intrarenal solitary fibrous tumor of the kidney report of a case with emphasis on the differential diagnosis in the wide spectrum of monomorphous spindle cell tumors of the kidney. Pathol Res Pract. 2002; 198:37-43.
25. Wang J, Arber DA, Frankel K, et al. Large solitary fibrous tumor of the kidney: report of two cases and review of the literature. Am J Surg Pathol. 2001;25:1194-1199.
26. Yamada H, Tsuzuki T, Yokoi K, et al. Solitary fibrous tumor of the kidney originating from the renal capsule and fed by the renal capsular artery. Pathol Int. 2004;54:914-917.
27. Yazaki T, Satoh S, Iizumi T, et al. Solitary fibrous tumor of renal pelvis. Int J Urol. 2001;8:504-508.
28. Robinson DR, Wu YM, Kalyana-Sundaram S, et al. Identification of recurrent NAB2-STAT6 gene fusions in solitary fibrous tumor by integrative sequencing. Nat Genet. 2013;45:180-185.
29. Jimenez RE, Folpe AL, Lapham RL, et al. Primary Ewing's sarcoma/primitive neuroectodermal tumor of the kidney: a clinicopathologic and immunohistochemical analysis of 11 cases. Am J Surg Pathol. 2002;26:320-327.
30. Khoury JD. Ewing sarcoma family of tumors: a model for the new era of integrated laboratory diagnostics. Expert Rev Mol Diagn. 2008;8:97-105.
31. Mohanty SK, Parwani AV. Mixed epithelial and stromal tumors of the kidney: an overview. Arch Pathol Lab Med. 2009;133: 1483-1486.