Prevalence of antiphospholipid antibodies in psychiatric patients users and non-users of antipsychotics

British Journal of Haematology

Volumn 164, Issue 2, 2014, Pages 272-279

  Delluc, Aurélien ^a,b   Rousseau, Aurélie ^c   Le Galudec, Mickael ^a,d   Canceil, Olivier ^e   Woodhams, Barry ^c   Etienne, Sylvie ^e   Walter, Michel ^a,d   Mottier, Dominique ^a,f   Van Dreden, Patrick ^c   Lacut, Karine ^a,f  

^a UNIVERSITÉ DE BRETAGNE OCCIDENTALE   (France)

^b BREST UNIVERSITY HOSPITAL   (France)

^c PAE Parispace 3   (France)

^d CHRU Brest   (France)

^e CENTRE HOSPITALIER SAINTE ANNE   (France)

^f Centre d'Investigation Clinique   (France)

Author keywords

Antiphospholipid antibodies; Antipsychotics

Indexed keywords

BETA2 GLYCOPROTEIN 1 ANTIBODY; CARDIOLIPIN ANTIBODY; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN M ANTIBODY; LUPUS ANTICOAGULANT; NEUROLEPTIC AGENT; PHOSPHOLIPID ANTIBODY;

ADULT; AGED; ANTIBODY DETECTION; ANTIBODY PRODUCTION; ANTIBODY TITER; ARTICLE; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DRUG USE; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MENTAL PATIENT; PRIORITY JOURNAL; VERY ELDERLY;

ANTIPHOSPHOLIPID ANTIBODIES; ANTIPSYCHOTICS;

ADULT; AGED; AGED, 80 AND OVER; ANTIBODIES, ANTIPHOSPHOLIPID; ANTIPSYCHOTIC AGENTS; CROSS-SECTIONAL STUDIES; FEMALE; HUMANS; MALE; MIDDLE AGED; PREVALENCE; PSYCHOTIC DISORDERS; SEROEPIDEMIOLOGIC STUDIES; YOUNG ADULT;

EID: 84891625757     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/bjh.12627     Document Type: Article

References (33)

1. Asherson, R.A., Mercey, D., Phillips, G., Sheehan, N., Gharavi, A.E., Harris, E.N. & Hughes, G.R. (1987) Recurrent stroke and multi-infarct dementia in systemic lupus erythematosus: association with antiphospholipid antibodies. Annals of the Rheumatic Diseases, 46, 605-611.
2. Brandt, J.T., Triplett, D.A., Alving, B. & Scharrer, I. (1995) Criteria for the diagnosis of lupus anticoagulants: an update. On behalf of the Subcommittee on Lupus Anticoagulant/Antiphospholipid Antibody of the Scientific and Standardisation Committee of the ISTH. Thrombosis and Haemostasis, 74, 1185-1190.
3. Brey, R.L. (2000) Differential diagnosis of central nervous system manifestations of the antiphospholipid antibody syndrome. Journal of Autoimmunity, 15, 133-138.
4. Brey, R.L. & Coull, B.M. (1992) Antiphospholipid antibodies: origin, specificity, and mechanism of action. Stroke; a Journal of Cerebral Circulation, 23, I15-I18.
5. Canoso, R.T. & de Oliveira, R.M. (1988) Chlorpromazine-induced anticardiolipin antibodies and lupus anticoagulant: absence of thrombosis. American Journal of Hematology, 27, 272-275.
6. Canoso, R.T. & Sise, H.S. (1982) Chlorpromazine-induced lupus anticoagulant and associated immunologic abnormalities. American Journal of Hematology, 13, 121-129.
7. Canoso, R.T., de Oliveira, R.M. & Nixon, R.A. (1990) Neuroleptic-associated autoantibodies. A prevalence study. Biological Psychiatry, 27, 863-870.
8. Caronti, B., Calderaro, C., Alessandri, C., Conti, F., Tinghino, R., Pini, C., Palladini, G. & Valesini, G. (1998a) Serum anti-beta2-glycoprotein I antibodies from patients with antiphospholipid antibody syndrome bind central nervous system cells. Journal of Autoimmunity, 11, 425-429.
9. Caronti, B., Pittoni, V., Palladini, G. & Valesini, G. (1998b) Anti-beta 2-glycoprotein I antibodies bind to central nervous system. Journal of the Neurological Sciences, 156, 211-219.
10. Chengappa, K.N., Carpenter, A.B., Keshavan, M.S., Yang, Z.W., Kelly, R.H., Rabin, B.S. & Ganguli, R. (1991) Elevated IGG and IGM anticardiolipin antibodies in a subgroup of medicated and unmedicated schizophrenic patients. Biological Psychiatry, 30, 731-735.
11. Davis, S., Kern, H.B. & Asokan, R. (1994) Antiphospholipid antibodies associated with clozapine treatment. American Journal of Hematology, 46, 166-167.
12. Delluc, A., Montavon, S., Canceil, O., Carpentier, M., Nowak, E., Mercier, B., Bressollette, L., Etienne, S., Walter, M., Mottier, D. & Lacut, K. (2012) Incidence of venous thromboembolism in psychiatric units. Thrombosis Research, 130, e283-e288.
13. Denburg, S.D., Carbotte, R.M., Ginsberg, J.S. & Denburg, J.A. (1997) The relationship of antiphospholipid antibodies to cognitive function in patients with systemic lupus erythematosus. Journal of the International Neuropsychological Society: JINS, 3, 377-386.
14. Firer, M., Sirota, P., Schild, K., Elizur, A. & Slor, H. (1994) Anticardiolipin antibodies are elevated in drug-free, multiply affected families with schizophrenia. Journal of Clinical Immunology, 14, 73-78.
15. Freedman, R. (2003) Schizophrenia. The New England Journal of Medicine, 349, 1738-1749.
16. Hughes, G.R. (1983) Thrombosis, abortion, cerebral disease, and the lupus anticoagulant. British Medical Journal (Clinical Research Ed), 287, 1088-1089.
17. Infante-Rivard, C., David, M., Gauthier, R. & Rivard, G.E. (1991) Lupus anticoagulants, anticardiolipin antibodies, and fetal loss. A case-control study. The New England Journal of Medicine, 325, 1063-1066.
18. Kanjolia, A., Valigorsky, J.M. & Joson-Pasion, M.L. (1997) Clozaril-induced lupus anticoagulant. American Journal of Hematology, 54, 345-346.
19. Keeling, D., Mackie, I., Moore, G.W., Greer, I.A. & Greaves, M. (2012) Guidelines on the investigation and management of antiphospholipid syndrome. British Journal of Haematology, 157, 47-58.
20. Lillicrap, D.P., Pinto, M., Benford, K., Ford, P.M. & Ford, S. (1990) Heterogeneity of laboratory test results for antiphospholipid antibodies in patients treated with chlorpromazine and other phenothiazines. American Journal of Clinical Pathology, 93, 771-775.
21. Lockwood, C.J., Romero, R., Feinberg, R.F., Clyne, L.P., Coster, B. & Hobbins, J.C. (1989) The prevalence and biologic significance of lupus anticoagulant and anticardiolipin antibodies in a general obstetric population. American Journal of Obstetrics and Gynecology, 161, 369-373.
22. Manoussakis, M.N., Tzioufas, A.G., Silis, M.P., Pange, P.J., Goudevenos, J. & Moutsopoulos, H.M. (1987) High prevalence of anti-cardiolipin and other autoantibodies in a healthy elderly population. Clinical and Experimental Immunology, 69, 557-565.
23. Miyakis, S., Lockshin, M.D., Atsumi, T., Branch, D.W., Brey, R.L., Cervera, R., Derksen, R.H.W.M., De Groot, P.G., Koike, T., Meroni, P.L., Reber, G., Shoenfeld, Y., Tincani, A., Vlachoyiannopoulos, P.G. & Krilis, S.A. (2006) International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). Journal of Thrombosis and Haemostasis: JTH, 4, 295-306.
24. Pattison, N.S., Chamley, L.W., McKay, E.J., Liggins, G.C. & Butler, W.S. (1993) Antiphospholipid antibodies in pregnancy: prevalence and clinical associations. British Journal of Obstetrics and Gynaecology, 100, 909-913.
25. Raza, H., Epstein, S.A., Pao, M. & Rosenstein, D.L. (2008) Mania: psychiatric manifestations of the antiphospholipid syndrome. Psychosomatics, 49, 438-441.
26. Ruiz-Irastorza, G., Crowther, M., Branch, W. & Khamashta, M.A. (2010) Antiphospholipid syndrome. Lancet, 376, 1498-1509.
27. Schmidt, R., Auer-Grumbach, P., Fazekas, F., Offenbacher, H. & Kapeller, P. (1995) Anticardiolipin antibodies in normal subjects. Neuropsychological correlates and MRI findings. Stroke; a Journal of Cerebral Circulation, 26, 749-754.
28. Schwartz, M., Rochas, M., Weller, B., Sheinkman, A., Tal, I., Golan, D., Toubi, N., Eldar, I., Sharf, B. & Attias, D. (1998) High association of anticardiolipin antibodies with psychosis. The Journal of Clinical Psychiatry, 59, 20-23.
29. Schwartz, M., Rochas, M., Toubi, E. & Sharf, B. (1999) The presence of lupus anticoagulant and anticardiolipin antibodies in patients undergoing long-term neuroleptic treatment. Journal of Psychiatry and Neuroscience, 24, 351-352.
30. Schwartz, M., Kormilachev, M., Kushnir, M., Weller, B., Rochas, M. & Toubi, E. (2009) Lupus anticoagulant and anticardiolipin antibodies in serum of patients treated with risperidone. The Journal of Clinical Psychiatry, 70, 769-771.
31. Shi, W., Krilis, S.A., Chong, B.H., Gordon, S. & Chesterman, C.N. (1990) Prevalence of lupus anticoagulant and anticardiolipin antibodies in a healthy population. Australian and New Zealand Journal of Medicine, 20, 231-236.
32. Vargas-Alarcon, G., Yamamoto-Furusho, J.K., Zuniga, J., Canoso, R. & Granados, J. (1997) HLA-DR7 in association with chlorpromazine-induced lupus anticoagulant (LA). Journal of Autoimmunity, 10, 579-583.
33. Zarrabi, M.H., Zucker, S., Miller, F., Derman, R.M., Romano, G.S., Hartnett, J.A. & Varma, A.O. (1979) Immunologic and coagulation disorders in chlorpromazine-treated patients. Annals of Internal Medicine, 91, 194-199.