Differential healing of full thickness rabbit skin wound by fibroblast loaded chitosan sponge

Journal of Biomaterials and Tissue Engineering

Volumn 3, Issue 3, 2013, Pages 261-272

  Deepa, R ^a   Paul, Willi ^a   Anilkumar, T V ^a   Sharma, Chandra P ^a  

^a SREE CHITRA TIRUNAL INSTITUTE FOR MEDICAL SCIENCES AND TECHNOLOGY   (India)

Author keywords

Cell proliferation; Chitosan skin graft; Histomorphometry; Re epithelialisation; Wound healing

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; CHITOSAN; COLLAGEN; FIBROBLAST GROWTH FACTOR; VIMENTIN;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL COUNT; CELL PROLIFERATION; CONTROLLED STUDY; DERMIS; EPIDERMIS; EPITHELIZATION; FULL THICKNESS SKIN GRAFT; IMMUNOHISTOCHEMISTRY; INFRARED SPECTROSCOPY; MORPHOMETRICS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; RABBIT; SCANNING ELECTRON MICROSCOPY; SKIN INJURY; TENSILE STRENGTH; TISSUE REACTION; TISSUE REGENERATION; WOUND HEALING;

EID: 84891616385     PISSN: 21579083     EISSN: 21579091     Source Type: Journal    
DOI: 10.1166/jbt.2013.1094     Document Type: Article

References (42)

1. S. P. Zhong, Y. Z. Zhang, and C. T. Lim, Tissue scaffolds for skin wound healing and dermal reconstruction. Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology 2, 510 (2010).
2. E. A. Woodroof, R. P. Phipps, J. E. Greenwood, W. Hickerson, and D. Herndon, The search for an ideal temporary skin substitute: AWBAT plus, a combination product wound dressing medical device. Eplasty 10, e60 (2010).
3. G. P. Chen, T. Ushida, and T. Tateishi, Scaffold design for tissue engineering. Macromolecular Bioscience 2, 67 (2002).
4. A. Francesko and T. Tzanov, Chitin, chitosan and derivatives for wound healing and tissue engineering. Adv. Biochem. Eng. Biotechnol. 125, 1 (2011).
5. C. I. W. Lauder, G. Garcea, A. Strickland, and G. J. Maddern, Use of a modified chitosan-dextran gel to prevent peritoneal adhesions in a rat model. Journal of Surgical Research 171, 877 (2011).
6. C. Alemdaroglu, Z. Degim, N. Celebi, F. Zor, S. Ozturk, and D. Erdogan, An investigation on burn wound healing in rats with chitosan gel formulation containing epidermal growth factor. Burns 32, 319 (2006).
7. F. Cui, G. Li, J. Huang, J. Zhang, M. Lu, W. Lu, J. Huan, and Q. Huang, Development of chitosan-collagen hydrogel incorporated with lysostaphin (CCHL) burn dressing with anti-methicillinresistant Staphylococcus aureus and promotion wound healing properties. Drug Deliv. 18, 173 (2011).
8. J. S. Choi and H. S. Yoo, Pluronic/chitosan hydrogels containing epidermal growth factor with wound-adhesive and photo-crosslinkable properties. Journal of Biomedical Materials Research Part A 95A, 564 (2010).
9. W. Paul, M. R. Rekha, P. V. Mohanan, and C. P. Sharma, Bioactive chitosan scaffold co cultured with keratinocyte and fibroblast cells. Trends in Biomaterials and Artificial Organs. 26, 3 (2012).
10. I. V. Yannas, Facts and theories of induced organ regeneration. Adv. Biochem. Eng. Biotechnol. 93, 1 (2005).
11. W. C. Hsieh, C. P. Chang, and S. M. Lin, Morphology and characterization of 3D micro-porous structured chitosan scaffolds for tissue engineering. Colloids Surf B Biointerfaces 57, 250 (2007).
12. T. Minagawa, Y. Okamura, Y. Shigemasa, S. Minami, and Y. Okamoto, Effects of molecular weight and deacetylation degree of chitin/chitosan on wound healing. Carbohydrate Polymers 67, 640 (2007).
13. P. Rieck, C. Hartmann, C. Jacob, Y. Pouliquen, and Y. Courtois, Human recombinant bFGF stimulates corneal endothelial wound healing in rabbits. Curr. Eye. Res. 11, 1161 (1992).
14. V. C. Sandulache, Z. Zhou, A. Sherman, J. E. Dohar, and P. A. Hebda, Impact of transplanted fibroblasts on rabbit skin wounds. Arch. Otolaryngol. Head. Neck. Surg. 129, 345 (2003).
15. J. D. Bancroft and M. Gamble, Theory and Practice of Histological Techniques, Elsevier, Philadelphia (2007).
16. P. Tayalia and D. J. Mooney, Controlled growth factor delivery for tissue engineering. Advanced Materials 21, 3269 (2009).
17. S. Schreml, R. M. Szeimies, L. Prantl, M. Landthaler, and P. Babilas, Wound healing in the 21st century. Journal of the American Academy of Dermatology 63, 866 (2010).
18. S. Ejaz, M. Ashraf, M. Nawaz, and C. W. Lim, Total particulate matter and wound healing: An in vivo study with histological insights. Biomedical and Environmental Sciences 22, 278 (2009).
19. T. V. Anilkumar, J. Muhamed, A. Jose, A. Jyothi, P. V. Mohanan, and L. K. Krishnan, Advantages of hyaluronic acid as a component of fibrin sheet for care of acute wound. Biologicals 39, 81 (2011).
20. L. Braiman-Wiksman, I. Solomonik, R. Spira, and T. Tennenbaum, Novel insights into wound healing sequence of events. Toxicol. Pathol. 35, 767 (2007).
21. C. Alemdaroglu, Z. Degim, N. Celebi, M. Sengezer, M. Alomeroglu, and A. Nacar, Investigation of epidermal growth factor containing liposome formulation effects on burn wound healing. J. Biomed. Mater. Res. A 85, 271 (2008).
22. H. Nakagawa, S. Akita, M. Fukui, T. Fujii, and K. Akino, Human mesenchymal stem cells successfully improve skin-substitute wound healing. Br. J. Dermatol. 153, 29 (2005).
23. B. Eckes, E. Colucci-Guyon, H. Smola, S. Nodder, C. Babinet, T. Krieg, and P. Martin, Impaired wound healing in embryonic and adult mice lacking vimentin. J. Cell. Sci. 113, 2455 (2000).
24. B. Hinz, G. Celetta, J. J. Tomasek, G. Gabbiani, and C. Chaponnier, Alpha-smooth muscle actin expression upregulates fibroblast contractile activity. Mol. Biol. Cell. 12, 2730 (2001).
25. R. V. Shevchenko, S. L. James, and S. E. James, A review of tissueengineered skin bioconstructs available for skin reconstruction. Journal of the Royal Society Interface 7, 229 (2010).
26. W. R. Lee, J. H. Park, K. H. Kim, S. J. Kim, D. H. Park, M. H. Chae, S. H. Suh, S. W. Jeong, and K. K. Park, The biological effects of topical alginate treatment in an animal model of skin wound healing. Wound Repair and Regeneration 17, 505 (2009).
27. Y. M. Qin, Absorption characteristics of alginate wound dressings. Journal of Applied Polymer Science 91, 953 (2004).
28. P. Mignatti, T. Morimoto, and D. B. Rifkin, Basic fibroblast growthfactor released by single, isolated cells stimulates their migration in an autocrine manner, Proceedings of the National Academy of Sciences of the United States of America 88, 11007 (1991).
29. S. Kanazawa, T. Fujiwara, S. Matsuzaki, K. Shingaki, M. Taniguchi, S. Miyata, M. Tohyama, Y. Sakai, K. Yano, K. Hosokawa, and T. Kubo, bFGF regulates PI3-kinase-rac1-JNK pathway and promotes fibroblast migration in wound healing. Plos One 5 (2010).
30. S. Werner and R. Grose, Regulation of wound healing by growth factors and cytokines. Physiological Reviews 83, 835 (2003).
31. H. P. Lorentz and M. T. Longaker, Wounds: Biology, pathology and management, Surgery: Basic Science and Clinical Evidence, edited by J. A. Norton, P. S. Barie, R. R. Bollinger, A. E. Chang, S. Lowry, S. J. Mulvihill, and H. I. Pass, Springer, New York (2008), p. 191.
32. J. M. Sorrell, M. A. Baber, and A. I. Caplan, A self-assembled fibroblast-endothelial cell co-culture system that supports in vitro vasculogenesis by both human umbilical vein endothelial cells and human dermal microvascular endothelial cells. Cells Tissues Organs 186, 157 (2007).
33. C. M. Ghajar, S. Kachgal, E. Kniazeva, H. Mori, S. V. Costes, S. C. George, and A. J. Putnam, Mesenchymal cells stimulate capillary morphogenesis via distinct proteolytic mechanisms. Experimental Cell Research 316, 813 (2010).
34. S. Mujaj, K. Manton, Z. Upton, and S. Richards, Serum-free primary human fibroblast and keratinocyte coculture. Tissue Engineering Part A 16, 1407 (2010).
35. P. P. Parnigotto, V. Bassani, S. Pastore, F. Valenti, and M. T. Conconi, Fibroblast-keratinocyte co-cultures in vitro: Growth, morphometry and nutrient exchange. Ital. J. Anat. Embryol. 99, 17 (1994).
36. T. L. Tuan, L. C. Keller, D. Sun, M. E. Nimni, and D. Cheung, Dermal fibroblasts activate keratinocyte outgrowth on collagen gels. Journal of Cell Science 107, 2285 (1994).
37. T. Barisic-Dujmovic, I. Boban, and S. H. Clark, Fibroblasts/ myofibroblasts that participate in cutaneous wound healing are not derived from circulating progenitor cells. Journal of Cellular Physiology 222, 703 (2010).
38. A. S. Pearson and R. W. Wolford, Management of skin trauma. Primary Care 27, 475 (2000).
39. R. A. F. Clark, Regulation of fibroplasia in cutaneous wound repair. American Journal of the Medical Sciences 306, 42 (1993).
40. I. A. Darby and T. D. Hewitson, Fibroblast differentiation in wound healing and fibrosis. International Review of Cytology-a Survey of Cell Biology 257, 143 (2007).
41. P. de la Puente, D. Ludena, A. Fernandez, J. L. Aranda, G. Varela, and J. Iglesias, Autologous fibrin scaffolds cultured dermal fibroblasts and enriched with encapsulated bFGF for tissue engineering. Journal of Biomedical Materials Research Part A 99A, 648 (2011).
42. G. G. Gauglitz, H. C. Korting, T. Pavicic, T. Ruzicka, and M. G. Jeschke, Hypertrophic scarring and keloids: Pathomechanisms and current and emerging treatment strategies. Molecular Medicine 17, 113 (2011).