Amitriptyline, clomipramine, and maprotiline attenuate the inflammatory response by inhibiting neutrophil migration and mast cell degranulation

Revista Brasileira de Psiquiatria

Volumn 35, Issue 4, 2013, Pages 387-392

  Gurgel, José Alves ^a   Lima Júnior, Roberto César Pereira ^a   Rabelo, Cristiano Oliveira ^a   Pessoa, Breno Bezerra Gomes Pinho ^a   Brito, Gerly Anne Castro ^a   Ribeiro, Ronaldo Albuquerque ^a,b  

^a FEDERAL UNIVERSITY OF CEARÁ   (Brazil)

^b Instituto do Cancer do Ceara   (Brazil)

Author keywords

Antidepressant agents; Inflammation; Mast cells; Neutrophil; Rats

Indexed keywords

AMITRIPTYLINE; CARRAGEENAN; CLOMIPRAMINE; COMPOUND 48-80; DEXTRAN; FORMYLMETHIONYLLEUCYLPHENYLALANINE; MAPROTILINE; PRODOME; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL COUNTING; CELL MIGRATION; CONTROLLED STUDY; INFLAMMATION; MALE; MAST CELL DEGRANULATION; MESENTERY; NEUTROPHIL; NONHUMAN; PAW EDEMA; PLETHYSMOGRAPHY; RAT;

AMITRIPTYLINE; ANIMALS; ANTI-INFLAMMATORY AGENTS; CARRAGEENAN; CELL DEGRANULATION; CELL MOVEMENT; CLOMIPRAMINE; DISEASE MODELS, ANIMAL; EDEMA; MALE; MAPROTILINE; MAST CELLS; NEUTROPHIL INFILTRATION; RATS; RATS, WISTAR;

EID: 84891544519     PISSN: 15164446     EISSN: None     Source Type: Journal    
DOI: 10.1590/1516-4446-2012-0977     Document Type: Article

References (27)

1. Brunton L, Parker K, Blumenthal D, Buxton I. Goodman & Gilman's Manual of Pharmacology and Therapeutics. New York: McGraw Hill; 2008.
2. Mitra R, Jones S. Adjuvant analgesics in cancer pain: a review. Am J Hosp Palliat Care. 2012; 29: 70-9.
3. Magni G. The use of antidepressants in the treatment of chronic pain. A review of the current evidence. Drugs. 1991; 42: 730-48.
4. Bianchi M, Panerai AE. Antidepressant drugs and experimental inflammation. Pharmacol Res. 1996; 33: 235-8.
5. Fishbain D. Evidence-based data on pain relief with antidepressants. Ann Med. 2000; 32: 305-16.
6. Vorobeychik Y, Gordin V, Mao J, Chen L. Combination therapy for neuropathic pain: a review of current evidence. CNS Drugs. 2011; 25: 1023-34.
7. Littrell JL. Taking the Perspective that a Depressive State Reflects Inflammation: Implications for the Use of Antidepressants. Front Psychol. 2012; 3: 297.
8. Vismari L, Alves GJ, Palermo-Neto J. Amitriptyline and acute inflammation: a study using intravital microscopy and the carrageenan-induced paw edema model. Pharmacology. 2010; 86: 231-9.
9. Sacerdote P, Bianchi M, Panerai AE. Chlorimipramine and nortriptyline but not fluoxetine and fluvoxamine inhibit human polymorphonuclear cell chemotaxis in vitro. Gen Pharmacol. 1994; 25: 409-12.
10. Capuron L, Hauser P, Hinze-Selch D, Miller AH, Neveu PJ. Treatment of cytokine-induced depression. Brain Behav Immun. 2002; 16: 575-80.
11. Corcos M, Guilbaud O, Hjalmarsson L, Chambry J, Jeammet P. Cytokines and depression: an analogic approach. Biomed Pharmacother. 2002; 56: 105-10.
12. Kulmatycki KM, Jamali F. Drug disease interactions: role of inflammatory mediators in depression and variability in antidepressant drug response. J Pharm Pharm Sci. 2006; 9: 292-306.
13. Bianchi M, Rossoni G, Sacerdote P, Panerai AE, Berti F. Effects of chlomipramine and fluoxetine on subcutaneous carrageenin-induced inflammation in the rat. Inflamm Res. 1995; 44: 466-9.
14. Abdel-Salam OM, Nofal SM, El-Shenawy SM. Evaluation of the antiinflammatory and anti-nociceptive effects of different antidepressants in the rat. Pharmacol Res. 2003; 48: 157-65.
15. Hajhashemi V, Sadeghi H, MinaiyanM, Movahedian A, Talebi A. Central and peripheral anti-inflammatory effects of maprotiline on carrageenaninduced paw edema in rats. Inflamm Res. 2010; 59: 1053-9.
16. Sadeghi H, Hajhashemi V, Minaiyan M, Movahedian A, Talebi A. A study on the mechanisms involving the anti-inflammatory effect of amitriptyline in carrageenan-induced paw edema in rats. Eur J Pharmacol. 2011; 667: 396-401.
17. Ribeiro RA, Flores CA, Cunha FQ, Ferreira SH. IL-8 causes in vivo neutrophil migration by a cell-dependent mechanism. Immunology. 1991; 73: 472-7.
18. Oliveira FA, Lima-Junior RC, Cordeiro WM, Vieira-Jú nior GM, Chaves MH, Almeida FR, et al. Pentacyclic triterpenoids, alpha,-beta-amyrins, suppress the scratching behavior in a mouse model of pruritus. Pharmacol Biochem Behav. 2004; 78: 719-25.
19. Lo TN, Almeida AP, Beaven MA. Dextran and carrageenan evoke different inflammatory responses in rat with respect to composition of infiltrates and effect of indomethacin. J Pharmacol Exp Ther. 1982; 221: 261-7.
20. Vinegar R, Schreiber W, Hugo R. Biphasic development of carrageenin edema in rats. J Pharmacol Exp Ther. 1969; 166: 96-103.
21. Morris CJ. Carrageenan-induced paw edema in the rat and mouse. Methods Mol Biol. 2003; 225: 115-21.
22. Cunha TM, Verri WA Jr, Schivo IR, Napimoga MH, Parada CA, Poole S, et al. Crucial role of neutrophils in the development of mechanical inflammatory hypernociception. J Leukoc Biol. 2008; 83: 824-32.
23. Kowanko IC, Gordon TP, Rozenbilds MA, Brooks PM, Roberts-Thomson PJ. The subcutaneous air pouch model of synovium and the inflammatory response to heat aggregated gammaglobulin. Agents Actions. 1986; 18: 421-8.
24. Sacerdote P, Bianchi M, Panerai AE. In vivo and in vitro clomipramine treatment decreases the migration of macrophages in the rat. Eur J Pharmacol. 1997; 319: 287-90.
25. Hajhashemi V, Minaiyan M, Efthekhari M. Anti-Inflammatory activity of a selection of antidepressant drugs. IJPR. 2008; 4: 225-30.
26. Clemons A, Vasiadi M, Kempuraj D, Kourelis T, Vandoros G, Theoharides TC. Amitriptyline and prochlorperazine inhibit proinflammatory mediator release from human mast cells: possible relevance to chronic fatigue syndrome. J Clin Psychopharmacol. 2011; 31: 385-7.
27. Ferjan I, Erjavec F. Changes in histamine and serotonin secretion from rat peritoneal mast cells caused by antidepressants. Inflamm Res. 1996; 45: 141-4.