Frequency analysis of atrial action potential alternans: A sensitive clinical index of individual propensity to atrial fibrillation

Circulation: Arrhythmia and Electrophysiology

Volumn 6, Issue 5, 2013, Pages 859-867

  Lalani, Gautam G ^a   Schricker, Amir A ^a   Clopton, Paul ^a   Krummen, David E ^a   Narayan, Sanjiv M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Action potential duration; Action potentials; Alternans; Atrial fibrillation; Spectral analysis

Indexed keywords

ACTION POTENTIAL; ACTION POTENTIAL DURATION; ADULT; AGED; ARTICLE; ATRIAL ACTION POTENTIAL ALTERNANS; CLINICAL ARTICLE; CONTROLLED STUDY; ELECTRICAL POTENTIAL PARAMETERS; FEMALE; FREQUENCY ANALYSIS; HEART ATRIUM FIBRILLATION; HEART REPOLARIZATION; HUMAN; MALE; MIDDLE AGED; PRIORITY JOURNAL; PROSPECTIVE STUDY; SINUS RHYTHM; SPECTROSCOPY; HEART FUNCTION TEST; HEART MUSCLE CONDUCTION SYSTEM; PATHOPHYSIOLOGY; PHYSIOLOGY; PREDICTIVE VALUE; RISK FACTOR; ALTERNANS;

ACTION POTENTIALS; ATRIAL FIBRILLATION; ELECTROPHYSIOLOGIC TECHNIQUES, CARDIAC; FEMALE; HEART CONDUCTION SYSTEM; HUMANS; MALE; MIDDLE AGED; PREDICTIVE VALUE OF TESTS; PROSPECTIVE STUDIES; RISK FACTORS;

ACTION POTENTIAL DURATION; ACTION POTENTIALS; ALTERNANS; ATRIAL FIBRILLATION; SPECTRAL ANALYSIS;

EID: 84891537588     PISSN: 19413149     EISSN: 19413084     Source Type: Journal    
DOI: 10.1161/CIRCEP.113.000204     Document Type: Article

References (34)

1. Chugh SS, Blackshear JL, Shen WK, Hammill SC, Gersh BJ. Epidemiology and natural history of atrial fibrillation: clinical implications. J Am Coll Cardiol. 2001;37:371-378.
2. Lloyd-Jones DM, Wang TJ, Leip EP, Larson MG, Levy D, Vasan RS, D'Agostino RB, Massaro JM, Beiser A, Wolf PA, Benjamin EJ. Lifetime risk for development of atrial fibrillation: the Framingham Heart Study. Circulation. 2004;110:1042-1046.
3. Lip GY, Nieuwlaat R, Pisters R, Lane DA, Crijns HJ. Refining clinical risk stratification for predicting stroke and thromboembolism in atrial fibrillation using a novel risk factor-based approach: the euro heart survey on atrial fibrillation. Chest. 2010;137:263-272.
4. Moe GK, Rheinboldt WC, Abildskov JA. A computer model of atrial fibrillation. Am Heart J. 1964;67:200-220.
5. Allessie MA, De Groot NM, Houben RP, Schotten U, Boersma E, Smeets JL, Crijns HJ. Electropathological substrate of long-standing persistent atrial fibrillation in patients with structural heart disease: longitudinal dissociation. Circ Arrhythm Electrophysiol. 2010;3:606-615.
6. Narayan SM, Krummen DE, Shivkumar K, Clopton P, Rappel WJ, Miller JM. Treatment of atrial fibrillation by the ablation of localized sources: CONFIRM (Conventional Ablation for Atrial Fibrillation With or Without Focal Impulse and Rotor Modulation) trial. J Am Coll Cardiol. 2012;60:628-636.
7. Gong Y, Xie F, Stein KM, Garfinkel A, Culianu CA, Lerman BB, Christini DJ. Mechanism underlying initiation of paroxysmal atrial flutter/atrial fibrillation by ectopic foci: a simulation study. Circulation. 2007;115:2094-2102.
8. Narayan SM, Kazi D, Krummen DE, Rappel WJ. Repolarization and activation restitution near human pulmonary veins and atrial fibrillation initiation: a mechanism for the initiation of atrial fibrillation by premature beats. J Am Coll Cardiol. 2008;52:1222-1230.
9. Kim BS, Kim YH, Hwang GS, Pak HN, Lee SC, Shim WJ, Oh DJ, Ro YM. Action potential duration restitution kinetics in human atrial fibrillation. J Am Coll Cardiol. 2002;39:1329-1336.
10. Narayan SM, Bode F, Karasik PL, Franz MR. Alternans of atrial action potentials during atrial flutter as a precursor to atrial fibrillation. Circulation. 2002;106:1968-1973.
11. Hiromoto K, Shimizu H, Furukawa Y, Kanemori T, Mine T, Masuyama T, Ohyanagi M. Discordant repolarization alternans-induced atrial fibrillation is suppressed by verapamil. Circ J. 2005;69:1368-1373.
12. Narayan SM, Franz MR, Clopton P, Pruvot EJ, Krummen DE. Repolarization alternans reveals vulnerability to human atrial fibrillation. Circulation. 2011;123:2922-2930.
13. Franz MR, Kirchhof PF, Fabritz CL, Zabel M. Computer analysis of monophasic action potentials: manual validation and clinically pertinent applications. Pacing Clin Electrophysiol. 1995;18(9 Pt 1):1666-1678.
14. Wilson LD, Jeyaraj D, Wan X, Hoeker GS, Said TH, Gittinger M, Laurita KR, Rosenbaum DS. Heart failure enhances susceptibility to arrhythmogenic cardiac alternans. Heart Rhythm. 2009;6:251-259.
15. Narayan SM, Bayer JD, Lalani G, Trayanova NA. Action potential dynamics explain arrhythmic vulnerability in human heart failure: a clinical and modeling study implicating abnormal calcium handling. J Am Coll Cardiol. 2008;52:1782-1792.
16. Bayer JD, Narayan SM, Lalani GG, Trayanova NA. Rate-dependent action potential alternans in human heart failure implicates abnormal intracellular calcium handling. Heart Rhythm. 2010;7:1093-1101.
17. Lalani GG, Schricker A, Gibson M, Rostamian A, Krummen DE, Narayan SM. Atrial conduction slows immediately before the onset of human atrial fibrillation: a bi-atrial contact mapping study of transitions to atrial fibrillation. J Am Coll Cardiol. 2012;59:595-606.
18. Ritzenberg AL, Adam DR, Cohen RJ. Period multupling-evidence for nonlinear behaviour of the canine heart. Nature. 1984;307:159-161.
19. Nearing BD, Verrier RL. Progressive increases in complexity of T-wave oscillations herald ischemia-induced ventricular fibrillation. Circ Res. 2002;91:727-732.
20. Narayan SM, Lindsay BD, Smith JM. Demonstration of the proarrhythmic preconditioning of single premature extrastimuli by use of the magnitude, phase, and distribution of repolarization alternans. Circulation. 1999;100:1887-1893.
21. Bloomfield DM, Hohnloser SH, Cohen RJ. Interpretation and classification of microvolt T wave alternans tests. J Cardiovasc Electrophysiol. 2002;13:502-512.
22. Verrier RL, Nearing BD, La Rovere MT, Pinna GD, Mittleman MA, Bigger JT Jr, Schwartz PJ; ATRAMI Investigators. Ambulatory electrocardiogrambased tracking of T wave alternans in postmyocardial infarction patients to assess risk of cardiac arrest or arrhythmic death. J Cardiovasc Electrophysiol. 2003;14:705-711.
23. Weiss JN, Karma A, Shiferaw Y, Chen P-S, Garfinkel A, Qu Z. From pulsus to pulseless: the saga of cardiac alternans (review). Circ Res. 2006;98:1244-1253.
24. Pruvot EJ, Katra RP, Rosenbaum DS, Laurita KR. Role of calcium cycling versus restitution in the mechanism of repolarization alternans. Circ Res. 2004;94:1083-1090.
25. 2+ handling in human chronic atrial fibrillation. Circulation. 2006;114:670-680.
26. Krummen DE, Bayer JD, Ho J, Ho G, Smetak MR, Clopton P, Trayanova NA, Narayan SM. Mechanisms of human atrial fibrillation initiation: clinical and computational studies of repolarization restitution and activation latency. Circ Arrhythm Electrophysiol. 2012;5:1149-1159.
27. Weiss JN, Nivala M, Garfinkel A, Qu Z. Alternans and arrhythmias: from cell to heart. Circ Res. 2011;108:98-112.
28. Nattel S, Dobrev D. The multidimensional role of calcium in atrial fibrillation pathophysiology: mechanistic insights and therapeutic opportunities. Eur Heart J. 2012;33:1870-1877.
29. Tsai CT, Chiang FT, Tseng CD, Yu CC, Wang YC, Lai LP, Hwang JJ, Lin JL. Mechanical stretch of atrial myocyte monolayer decreases sarcoplasmic reticulum calcium adenosine triphosphatase expression and increases susceptibility to repolarization alternans. J Am Coll Cardiol. 2011;58:2106-2115.
30. Kalifa J, Yamazaki M. Repolarization alternans in dilated pulsing atria: a preventable "prelude" to atrial fibrillation? J Am Coll Cardiol. 2011;58:2116-2117.
31. Li Q, O'Neill SC, Tao T, Li Y, Eisner D, Zhang H. Mechanisms by which cytoplasmic calcium wave propagation and alternans are generated in cardiac atrial myocytes lacking T-tubules-insights from a simulation study. Biophys J. 2012;102:1471-1482.
32. Jousset F, Tenkorang J, Vesin JM, Pascale P, Ruchat P, Rollin AG, Fromer M, Narayan SM, Pruvot E. Kinetics of atrial repolarization alternans in a free-behaving ovine model. J Cardiovasc Electrophysiol. 2012;23:1003-1012.
33. Comtois P, Nattel S. Atrial repolarization alternans as a path to atrial fibrillation. J Cardiovasc Electrophysiol. 2012;23:1013-1015.
34. Charitos EI, Stierle U, Ziegler PD, Baldewig M, Robinson DR, Sievers HH, Hanke T. A comprehensive evaluation of rhythm monitoring strategies for the detection of atrial fibrillation recurrence: insights from 647 continuously monitored patients and implications for monitoring after therapeutic interventions. Circulation. 2012;126:806-814.