Combination of BRAF inhibitors and brain radiotherapy in patients with metastatic melanoma shows minimal acute toxicity

Journal of Clinical Oncology

Volumn 31, Issue 30, 2013, Pages 3844-3845

  Rompoti, Natalia ^a   Schilling, Bastian ^a   Livingstone, Elisabeth ^a   Griewank, Klaus ^a   Hillen, Uwe ^a   Sauerwein, Wolfgang ^a   Pöttgen, Christoph ^a   Stuschke, Martin ^a   Schadendorf, Dirk ^a   Zimmer, Lisa ^a  

^a UNIVERSITY HOSPITAL ESSEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

DABRAFENIB; IPILIMUMAB; VEMURAFENIB; B RAF KINASE; IMIDAZOLE DERIVATIVE; INDOLE DERIVATIVE; OXIME; PROTEIN KINASE INHIBITOR; SULFONAMIDE;

ADULT; AGED; BRAIN DAMAGE; BRAIN METASTASIS; CANCER RADIOTHERAPY; CANCER REGRESSION; CLINICAL ARTICLE; DISEASE COURSE; DISEASE SEVERITY; FEMALE; HUMAN; LETTER; MALE; METASTATIC MELANOMA; MIDDLE AGED; MULTIMODALITY CANCER THERAPY; NEUROTOXICITY; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; RADIATION DERMATITIS; RADIATION DOSE; STEREOTAXIC SURGERY; TREATMENT RESPONSE; CONTACT DERMATITIS; DRUG ANTAGONISM; MELANOMA; NOTE; RADIATION INJURY; ANTAGONISTS AND INHIBITORS; DERMATITIS, CONTACT; RADIATION INJURIES;

DERMATITIS, CONTACT; FEMALE; HUMANS; IMIDAZOLES; INDOLES; MALE; MELANOMA; OXIMES; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS B-RAF; RADIATION INJURIES; SULFONAMIDES;

EID: 84891535435     PISSN: 0732183X     EISSN: 15277755     Source Type: Journal    
DOI: 10.1200/JCO.2013.50.8473     Document Type: Letter

References (6)

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2. Long GV, Trefzer U, Davies MA, et al: Dabrafenib in patients with Val600Glu or Val600Lys BRAF-mutant melanoma metastatic to the brain (BREAK-MB): A multicentre, open-label, phase 2 trial. Lancet Oncol 13:1087-1095, 2012
3. Margolin K, Ernstoff MS, Hamid O, et al: Ipilimumab in patients with melanoma and brain metastases: An open-label, phase 2 trial. Lancet Oncol 13:459-465, 2012
4. Sambade MJ, Peters EC, Thomas NE, et al: Melanoma cells show a heterogeneous range of sensitivity to ionizing radiation and are radiosensitized by inhibition of B-RAF with PLX-4032. Radiother Oncol 98:394-399, 2011
5. Narayana A, Mathew M, Tam M, et al: Vemurafenib and radiation therapy in melanoma brain metastases. J Neurooncol 113:411-416, 2013
6. Sak A, Stuschke M: Use of γH2AX and other biomarkers of double-strand breaks during radiotherapy. Semin Radiat Oncol 20:223-231, 2010