A novel interaction between sympathetic overactivity and aberrant regulation of renin by miR-181a in BPH/2J genetically hypertensive mice

Hypertension

Volumn 62, Issue 4, 2013, Pages 775-781

  Jackson, Kristy L ^a,b   Marques, Francine Z ^c   Watson, Anna M D ^a   Palma Rigo, Kesia ^a   Nguyen Huu, Thu Phuc ^a   Morris, Brian J ^d   Charchar, Fadi J ^c   Davern, Pamela J ^a   Head, Geoffrey A ^a,b  

^a BAKER IDI HEART AND DIABETES INSTITUTE   (Australia)

^b MONASH UNIVERSITY   (Australia)

^c UNIVERSITY OF BALLARAT   (Australia)

^d UNIVERSITY OF SYDNEY   (Australia)

Author keywords

Hypertension; Kidney; microRNAs; Renin angiotensin system; Sympathetic nervous system

Indexed keywords

ENALAPRILAT; MESSENGER RNA; MICRORNA; MICRORNA 181A; PENTOLONIUM TARTRATE; RENIN; TYROSINE 3 MONOOXYGENASE; UNCLASSIFIED DRUG; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; MIRN181 MICRORNA, MOUSE; NICOTINIC RECEPTOR BLOCKING AGENT;

ADRENERGIC SYSTEM; ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE MEASUREMENT; COMPARATIVE STUDY; CONTROLLED STUDY; DARKNESS; DEPRESSOR RESPONSE; DRUG EFFECT; HEART RATE; HYPERTENSION; KIDNEY TUBULE; LIGHT; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; SYMPATHETIC INNERVATION; TELEMETRY; ANIMAL; BLOOD; BLOOD PRESSURE; DRUG EFFECTS; GENETICS; MOTOR ACTIVITY; PATHOPHYSIOLOGY; PHYSIOLOGY; KIDNEY;

ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; ANIMALS; BLOOD PRESSURE; ENALAPRILAT; HEART RATE; HYPERTENSION; MICE; MICRORNAS; MOTOR ACTIVITY; NICOTINIC ANTAGONISTS; PENTOLINIUM TARTRATE; RENIN; RENIN-ANGIOTENSIN SYSTEM; SYMPATHETIC NERVOUS SYSTEM;

HYPERTENSION; KIDNEY; MICRORNAS; RENIN-ANGIOTENSIN SYSTEM; SYMPATHETIC NERVOUS SYSTEM;

EID: 84891518721     PISSN: 0194911X     EISSN: 15244563     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.113.01701     Document Type: Article

References (12)

1. Schlager G, Sides J. Characterization of hypertensive and hypotensive inbred strains of mice. Lab Anim Sci, 1997;47:288-292.
2. Butz GM, Davisson RL. Long-term telemetric measurement of cardiovascular parameters in awake mice: a physiological genomics tool. Physiol Genomics, 2001;5:89-97.
3. Jackson K, Head GA, Morris BJ, Chin-Dusting J, Jones E, La Greca L, Mayorov DN. Reduced cardiovascular reactivity to stress but not feeding in renin enhancer knockout mice. Am J Hypertens, 2007;20:893-899.
4. Head GA, Lukoshkova EV, Burke SL, Malpas SC, Lambert EA, Janssen BJ. Comparing spectral and invasive estimates of baroreflex gain. IEEE Eng Med Biol Mag, 2001;20:43-52.
5. Palma-Rigo K, Jackson KL, Davern PJ, Nguyen-Huu T-P, Elghozi J-L, Head GA. Renin-angiotensin and sympathetic nervous system contribution to high blood pressure in Schlager mice. Journal of hypertension, 2011;29:2156-2166.
6. Tibirica E, Feldman J, Mermet C, Monassier L, Gonon F, Bousquet P. Selectivity of rilmenidine for the nucleus reticularis lateralis, a ventrolateral medullary structure containing imidazoline-preferring receptors. Eur J Pharmacol, 1991;209:213-221.
7. Di Paola Eugenio D, Pietro G, Rosario M, De Sarro G. Effects of enalapril in rats with pressure overload cardiac hypertrophy. Gen Pharmacol, 1997;28:531-533.
8. Snedecor GW, Cochran WG. Statistical Methods. 7th ed. Ames, Iowa: Iowa State University Press; 1980.
9. Korner PI, Badoer E, Head GA. Cardiovascular role of the major noradrenergic cell groups in the rabbit: analysis based on 6-hydroxydopamine-induced transmitter release. Brain Res, 1987;435:258-272.
10. Marques FZ, Campain AE, Davern PJ, Yang YHI, Head GA, Morris BJ. Genes influencing circadian differences in blood pressure in hypertensive mice. PloS one, 2011;6:e19203 19201-19209.
11. Davern PJ, Nguyen-Huu T, La Greca L, Head GA. Role of the sympathetic nervous system in Schlager genetically hypertensive mice. Hypertension, 2009;54:852-859.
12. Watson AM, Li J, Schumacher C, de Gasparo M, Feng B, Thomas MC, Allen TJ, Cooper ME, Jandeleit-Dahm KA. The endothelin receptor antagonist avosentan ameliorates nephropathy and atherosclerosis in diabetic apolipoprotein E knockout mice. Diabetologia, 2010;53:192-203.