Fc gamma receptor 3B (FCGR3B-c.233C>A-rs5030738) polymorphism modifies the protective effect of malaria specific antibodies in ghanaian children

Journal of Infectious Diseases

Volumn 209, Issue 2, 2014, Pages 285-289

  Adu, Bright ^a,b   Jepsen, Micha Phill Grønholm ^a,b   Gerds, Thomas A ^c   Kyei Baafour, Eric ^d   Christiansen, Michael ^a   Dodoo, Daniel ^d   Theisen, Michael ^a,b  

^a STATENS SERUM INSTITUT   (Denmark)

^b Rigshospitalet   (Denmark)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

^d University of Ghana   (Ghana)

Author keywords

Effect modification; Fc RIIIB; FCGR3B c.233C>A; GLURP; Malaria; Neutrophils; Plasmodium falciparum

Indexed keywords

ADENINE; ANTIBODY; ANTIGEN; CD16 ANTIGEN; CYTOSINE; DNA; FC GAMMA RECEPTOR 3B; GLUTAMATE RICH PROTEIN; GLUTAMATE RICH PROTEIN ANTIBODY; IMMUNOGLOBULIN G ANTIBODY; MALARIA ANTIGEN; UNCLASSIFIED DRUG;

AGE DISTRIBUTION; ANTIBODY BLOOD LEVEL; ANTIBODY DETECTION; ANTIGEN ANTIBODY REACTION; ARTICLE; ASYMPTOMATIC DISEASE; BLOOD GROUP ABO SYSTEM; CHILD; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE CARRIER; DNA MODIFICATION; EXPOSURE; FEVER; GENE FREQUENCY; GENOTYPE; GHANA; HUMAN; IMMUNITY; INFECTION RISK; MAJOR CLINICAL STUDY; MALARIA FALCIPARUM; PARASITEMIA; PRESCHOOL CHILD; PREVALENCE; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN POLYMORPHISM; SCHOOL CHILD; SEROEPIDEMIOLOGY; SICKLE CELL TRAIT;

EID: 84891512092     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1093/infdis/jit422     Document Type: Article

References (15)

1. Dodoo D, Theisen M, Kurtzhals JA, et al. Naturally acquired antibodies to the glutamate-rich protein are associated with protection against Plasmodium falciparum malaria. J Infect Dis 2000; 181:1202-5
2. Dodoo D, Atuguba F, Bosomprah S, et al. Antibody levels to multiple malaria vaccine candidate antigens in relation to clinical malaria episodes in children in the Kasena-Nankana district of Northern Ghana. Malar J 2011; 10:108
3. Adu B, Dodoo D, Adukpo S, et al. Fc gamma receptor IIIB (FcgammaRIIIB) polymorphisms are associated with clinical malaria in Ghanaian children. PLoS One 2012; 7:e46197
4. Schuldt K, Kretz CC, Timmann C, et al. A-436C>A polymorphism in the human FAS gene promoter associated with severe childhood malaria. PLoS Genet 2011; 7:e1002066
5. Joos C, Marrama L, Polson HE, et al. Clinical protection from falciparum malaria correlates with neutrophil respiratory bursts induced by merozoites opsonized with human serum antibodies. PLoS One 2010; 5:e9871
6. Perussia B, Dayton ET, Lazarus R, Fanning V, Trinchieri G. Immune interferon induces the receptor for monomeric IgG1 on human monocytic and myeloid cells. J Exp Med 1983; 158:1092-113
7. Salmon JE, Millard SS, Brogle NL, Kimberly RP. Fc gamma receptor IIIb enhances Fc gamma receptor IIa function in an oxidant-dependent and allele-sensitive manner. J Clin Invest 1995; 95:2877-85
8. Clark IA, Hunt NH. Evidence for reactive oxygen intermediates causing hemolysis and parasite death in malaria. Infect Immun 1983; 39:1-6
9. Theisen M, Vuust J, Gottschau A, Jepsen S, Hogh B. Antigenicity and immunogenicity of recombinant glutamate-rich protein of Plasmodium falciparum expressed in Escherichia coli. Clin Diagn Lab Immunol 1995; 2:30-4
10. Jepsen MP, Roser D, Christiansen M, et al. Development and evaluation of a multiplex screening assay for Plasmodium falciparum exposure. J Immunol Methods 2012; 384:62-70
11. Boross P, van de Poel K, Van de Winkel JGJ, Leusen JHW. Fc Receptors. Encyclopedia of Life Sciences (ELS). Chichester, UK: JohnWiley & Sons, 2008:1-8
12. Allison AC, Eugui EM. The role of cell-mediated immune responses in resistance to malaria, with special reference to oxidant stress. Annu Rev Immunol 1983; 1:361-92
13. Oeuvray C, Theisen M, Rogier C, Trape JF, Jepsen S, Druilhe P. Cytophilic immunoglobulin responses to Plasmodium falciparum glutamaterich protein are correlated with protection against clinical malaria in Dielmo, Senegal. Infect Immun 2000; 68:2617-20
14. Koene HR, Kleijer M, Roos D, de Haas M, dem Borne AE. Fc gamma RIIIB gene duplication: Evidence for presence and expression of three distinct Fc gamma RIIIB genes in NA(1+,2+)SH(+) individuals. Blood 1998; 91:673-9
15. Kinyanjui SM, Conway DJ, Lanar DE, Marsh K. IgG antibody responses to Plasmodium falciparum merozoite antigens in Kenyan children have a short half-life. Malar J 2007; 6:82 Partnership