Absence of ductal hyper-keratinization in mouse age-related meibomian gland dysfunction (ARMGD)

Aging

Volumn 5, Issue 11, 2013, Pages 825-834

  Parfitt, Geraint J ^a   Xie, Yilu ^a   Geyfman, Mikhail ^a   Brown, Donald J ^a   Jester, James V ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

3 D reconstruction; Dry eye disease; ICT; Immunofluorescence; Meibomian gland

Indexed keywords

KERATIN;

AGING; ANIMAL; ARTICLE; DRY EYE; FLUORESCENT ANTIBODY TECHNIQUE; MEIBOMIAN GLAND; METABOLISM; MOUSE; PATHOLOGY; THREE DIMENSIONAL IMAGING;

AGING; ANIMALS; DRY EYE SYNDROMES; FLUORESCENT ANTIBODY TECHNIQUE; IMAGING, THREE-DIMENSIONAL; KERATINS; MEIBOMIAN GLANDS; MICE;

EID: 84891509506     PISSN: 19454589     EISSN: None     Source Type: Journal    
DOI: 10.18632/aging.100615     Document Type: Article

References (50)

1. Hykin PG and Bron AJ. Age-related morphological changes in lid margin and meibomian gland anatomy. Cornea. 1992; 11:334-342.
2. Schaumberg DA, Dana R, Buring JE and Sullivan DA. Prevalence of dry eye disease among US men: estimates from the Physicians' Health Studies. Archives of ophthalmology. 2009; 127:763-768.
3. Lemp MA, Crews LA, Bron AJ, Foulks GN and Sullivan BD. Distribution of aqueous-deficient and evaporative dry eye in a clinic-based patient cohort: a retrospective study. Cornea. 2012; 31:472-478.
4. Schaumberg DA, Nichols JJ, Papas EB, Tong L, Uchino M and Nichols KK. The international workshop on meibomian gland dysfunction: report of the subcommittee on the epidemiology of, and associated risk factors for, MGD. Investigative ophthalmology & visual science. 2011; 52:1994-2005.
5. Nichols JJ and Sinnott LT. Tear film, contact lens, and patientrelated factors associated with contact lens-related dry eye. Investigative ophthalmology & visual science. 2006; 47:1319- 1328.
6. Tsubota K and Nakamori K. Dry eyes and video display terminals. The New England journal of medicine. 1993; 328:584.
7. Miljanovic B, Dana R, Sullivan DA and Schaumberg DA. Impact of dry eye syndrome on vision-related quality of life. American journal of ophthalmology. 2007; 143:409-415.
8. Narayanan S, Redfern RL, Miller WL, Nichols KK and McDermott AM. Dry eye disease and microbial keratitis: is there a connection? The ocular surface. 2013; 11:75-92.
9. Horwath-Winter J, Berghold A, Schmut O, Floegel I, Solhdju V, Bodner E, Schwantzer G and Haller-Schober EM. Evaluation of the clinical course of dry eye syndrome. Archives of ophthalmology. 2003; 121:1364-1368.
10. Lemp MA and Nichols KK. Blepharitis in the United States 2009: a survey-based perspective on prevalence and treatment. The ocular surface. 2009; 7:S1-S14.
11. Knop E, Knop N, Millar T, Obata H and Sullivan DA. The international workshop on meibomian gland dysfunction: report of the subcommittee on anatomy, physiology, and pathophysiology of the meibomian gland. Investigative ophthalmology & visual science. 2011; 52:1938-1978.
12. Bron AJ, Tiffany JM, Gouveia SM, Yokoi N and Voon LW. Functional aspects of the tear film lipid layer. Experimental eye research. 2004; 78:347-360.
13. Craig JP and Tomlinson A. Importance of the lipid layer in human tear film stability and evaporation. Optometry and vision science: official publication of the American Academy of Optometry. 1997; 74:8-13.
14. Mishima S and Maurice DM. The oily layer of the tear film and evaporation from the corneal surface. Experimental eye research. 1961; 1:39-45.
15. Mathers WD and Lane JA. Meibomian gland lipids, evaporation, and tear film stability. Advances in experimental medicine and biology. 1998; 438:349-360.
16. Gilbard JP, Rossi SR and Heyda KG. Tear film and ocular surface changes after closure of the meibomian gland orifices in the rabbit. Ophthalmology. 1989; 96:1180-1186.
17. Foulks GN and Bron AJ. Meibomian gland dysfunction: a clinical scheme for description, diagnosis, classification, and grading. The ocular surface. 2003; 1:107-126.
18. Jester JV, Nicolaides N, Kiss-Palvolgyi I and Smith RE. Meibomian gland dysfunction. II. The role of keratinization in a rabbit model of MGD. Investigative ophthalmology & visual science. 1989; 30:936-945.
19. Jester JV, Rife L, Nii D, Luttrull JK, Wilson L and Smith RE. In vivo biomicroscopy and photography of meibomian glands in a rabbit model of meibomian gland dysfunction. Investigative ophthalmology & visual science. 1982; 22:660-667.
20. Jester JV, Rajagopalan S and Rodrigues M. Meibomian gland changes in the rhino (hrrhhrrh) mouse. Investigative ophthalmology & visual science. 1988; 29:1190-1194.
21. Ohnishi Y and Kohno T. Polychlorinated biphenyls poisoning in monkey eye. Investigative ophthalmology & visual science. 1979; 18:981-984.
22. Korb DR and Henriquez AS. Meibomian gland dysfunction and contact lens intolerance. Journal of the American Optometric Association. 1980; 51:243-251.
23. Gutgesell VJ, Stern GA and Hood CI. Histopathology of meibomian gland dysfunction. American journal of ophthalmology. 1982; 94:383-387.
24. Liu S, Richards SM, Lo K, Hatton M, Fay A and Sullivan DA. Changes in gene expression in human meibomian gland dysfunction. Investigative ophthalmology & visual science. 2011; 52:2727-2740.
25. Ong BL, Hodson SA, Wigham T, Miller F and Larke JR. Evidence for keratin proteins in normal and abnormal human meibomian fluids. Current eye research. 1991; 10:1113-1119.
26. Jester BE, Nien CJ, Winkler M, Brown DJ and Jester JV. Volumetric reconstruction of the mouse meibomian gland using high-resolution nonlinear optical imaging. Anatomical record. 2011; 294:185-192.
27. Nien CJ, Paugh JR, Massei S, Wahlert AJ, Kao WW and Jester JV. Age-related changes in the meibomian gland. Experimental eye research. 2009; 89:1021-1027.
28. Den S, Shimizu K, Ikeda T, Tsubota K, Shimmura S and Shimazaki J. Association between meibomian gland changes and aging, sex, or tear function. Cornea. 2006; 25:651-655.
29. Sullivan BD, Evans JE, Dana MR and Sullivan DA. Influence of aging on the polar and neutral lipid profiles in human meibomian gland secretions. Archives of ophthalmology. 2006; 124:1286-1292.
30. Nien CJ, Massei S, Lin G, Nabavi C, Tao J, Brown DJ, Paugh JR and Jester JV. Effects of age and dysfunction on human meibomian glands. Archives of ophthalmology. 2011; 129:462- 469.
31. Parfitt GJ, Xie Y, Reid KM, Dervillez X, Brown DJ and Jester JV. A novel immunofluorescent computed tomography (ICT) method to localise and quantify multiple antigens in large tissue volumes at high resolution. PloS one. 2012; 7:e53245.
32. Riau AK, Barathi VA and Beuerman RW. Mucocutaneous junction of eyelid and lip: a study of the transition zone using epithelial cell markers. Current eye research. 2008; 33:912-922.
33. Norn M. Meibomian orifices and Marx's line. Studied by triple vital staining. Acta Ophthalmol (Copenh). 1985; 63 698- 700.
34. Bron AJ, Yokoi N, Gaffney EA and Tiffany JM. A solute gradient in the tear meniscus. I. A hypothesis to explain Marx's line. The ocular surface. 2011; 9:70-91.
35. Doughty MJ, Naase T, Donald C, Hamilton L and Button NF. Visualisation of "Marx's line" along the marginal eyelid conjunctiva of human subjects with lissamine green dye. Ophthalmic & physiological optics: the journal of the British College of Ophthalmic Opticians. 2004; 24:1-7.
36. Yamaguchi M, Kutsuna M, Uno T, Zheng X, Kodama T and Ohashi Y. Marx line: fluorescein staining line on the inner lid as indicator of meibomian gland function. American journal of ophthalmology. 2006; 141:669-675.
37. Wang J, Palakuru JR and Aquavella JV. Correlations among upper and lower tear menisci, noninvasive tear break-up time, and the Schirmer test. American journal of ophthalmology. 2008; 145:795-800.
38. Yokoi N, Bron AJ, Tiffany JM and Kinoshita S. Reflective meniscometry: a new field of dry eye assessment. Cornea. 2000; 19:S37-43.
39. Olami Y, Zajicek G, Cogan M, Gnessin H and Pe'er J. Turnover and migration of meibomian gland cells in rats' eyelids. Ophthalmic research. 2001; 33:170-175.
40. Lavker Rea. IOVS ARVO e-abstract 3781. 2003; 44.
41. Cotsarelis G, Sun TT and Lavker RM. Label-retaining cells reside in the bulge area of pilosebaceous unit: implications for follicular stem cells, hair cycle, and skin carcinogenesis. Cell. 1990; 61:1329-1337.
42. Tumbar T, Guasch G, Greco V, Blanpain C, Lowry WE, Rendl M and Fuchs E. Defining the epithelial stem cell niche in skin. Science. 2004; 303:359-363.
43. Cotsarelis G, Cheng SZ, Dong G, Sun TT and Lavker RM. Existence of slow-cycling limbal epithelial basal cells that can be preferentially stimulated to proliferate: implications on epithelial stem cells. Cell. 1989; 57:201-209.
44. Ghazizadeh S and Taichman LB. Multiple classes of stem cells in cutaneous epithelium: a lineage analysis of adult mouse skin. The EMBO journal. 2001; 20:1215-1222.
45. Horsley V, O'Carroll D, Tooze R, Ohinata Y, Saitou M, Obukhanych T, Nussenzweig M, Tarakhovsky A and Fuchs E. Blimp1 defines a progenitor population that governs cellular input to the sebaceous gland. Cell. 2006; 126:597-609.
46. Ruzankina Y and Brown EJ. Relationships between stem cell exhaustion, tumour suppression and ageing. British journal of cancer. 2007; 97:1189-1193.
47. Nakajima T, Inui S, Fushimi T, Noguchi F, Kitagawa Y, Reddy JK and Itami S. Roles of MED1 in quiescence of hair follicle stem cells and maintenance of normal hair cycling. The Journal of investigative dermatology. 2013; 133:354-360.
48. Castilho RM, Squarize CH, Chodosh LA, Williams BO and Gutkind JS. mTOR mediates Wnt-induced epidermal stem cell exhaustion and aging. Cell stem cell. 2009; 5:279-289.
49. Ahmad S. Concise review: limbal stem cell deficiency, dysfunction, and distress. Stem cells translational medicine. 2012; 1:110-115.
50. Schneider CA, Rasband WS and Eliceiri KW. NIH Image to ImageJ: 25 years of image analysis. Nature Methods. 2012; 9:671-675.