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Volumn 94, Issue 1, 2014, Pages 98-106

Quantitative assessment Ki-67 score for prediction of response to neoadjuvant chemotherapy in breast cancer

Author keywords

breast cancer; field of view; hotspot; neoadjuvant chemotherapy; pathological complete response; predictive biomarkers; quantitative immunofluorescence

Indexed keywords

BEVACIZUMAB; CARBOPLATIN; CYCLOPHOSPHAMIDE; DOXORUBICIN; EPIDERMAL GROWTH FACTOR RECEPTOR 2; ESTROGEN RECEPTOR; KI 67 ANTIGEN; PACLITAXEL; TAXANE DERIVATIVE; TRASTUZUMAB;

EID: 84891506225     PISSN: 00236837     EISSN: 15300307     Source Type: Journal    
DOI: 10.1038/labinvest.2013.128     Document Type: Article
Times cited : (85)

References (51)
  • 1
    • 33646375742 scopus 로고    scopus 로고
    • Recommendations from an international expert panel on the use of neoadjuvant (primary) systemic treatment of operable breast cancer: An update
    • Kaufmann M, Hortobagyi GN, Goldhirsch A, et al. Recommendations from an international expert panel on the use of neoadjuvant (primary) systemic treatment of operable breast cancer: An update. J Clin Oncol 2006;24:1940-1949
    • (2006) J Clin Oncol , vol.24 , pp. 1940-1949
    • Kaufmann, M.1    Hortobagyi, G.N.2    Goldhirsch, A.3
  • 2
    • 39149103121 scopus 로고    scopus 로고
    • Statement of the science concerning locoregional treatments after preoperative chemotherapy for breast cancer: A National Cancer Institute conference
    • Buchholz TA, Lehman CD, Harris JR, et al. Statement of the science concerning locoregional treatments after preoperative chemotherapy for breast cancer: A National Cancer Institute conference. J Clin Oncol 2008;26:791-797
    • (2008) J Clin Oncol , vol.26 , pp. 791-797
    • Buchholz, T.A.1    Lehman, C.D.2    Harris, J.R.3
  • 3
    • 21344442673 scopus 로고    scopus 로고
    • Neo-Adjuvant therapy in breast cancer
    • Bafaloukos D. Neo-Adjuvant therapy in breast cancer. Ann Oncol 2005;16(Suppl 2):ii174-ii181
    • (2005) Ann Oncol , vol.16 , Issue.SUPPL. 2
    • Bafaloukos, D.1
  • 4
    • 0038013982 scopus 로고    scopus 로고
    • International expert panel on the use of primary (preoperative) systemic treatment of operable breast cancer: Review and recommendations
    • Kaufmann M, von Minckwitz G, Smith R, et al. International expert panel on the use of primary (preoperative) systemic treatment of operable breast cancer: Review and recommendations. J Clin Oncol 2003;21:2600-2608
    • (2003) J Clin Oncol , vol.21 , pp. 2600-2608
    • Kaufmann, M.1    Von Minckwitz, G.2    Smith, R.3
  • 5
    • 33646445341 scopus 로고    scopus 로고
    • Sequential preoperative or postoperative docetaxel added to preoperative doxorubicin plus cyclophosphamide for operable breast cancer: National Surgical Adjuvant Breast and Bowel Project Protocol B-27
    • Bear HD, Anderson S, Smith RE, et al. Sequential preoperative or postoperative docetaxel added to preoperative doxorubicin plus cyclophosphamide for operable breast cancer: National Surgical Adjuvant Breast and Bowel Project Protocol B-27. J Clin Oncol 2006;24: 2019-2027
    • (2006) J Clin Oncol , vol.24 , pp. 2019-2027
    • Bear, H.D.1    Anderson, S.2    Smith, R.E.3
  • 6
    • 0642347622 scopus 로고    scopus 로고
    • The effect on tumor response of adding sequential preoperative docetaxel to preoperative doxorubicin and cyclophosphamide: Preliminary results from national surgical adjuvant breast and bowel project protocol b-27
    • Bear HD, Anderson S, Brown A, et al. The effect on tumor response of adding sequential preoperative docetaxel to preoperative doxorubicin and cyclophosphamide: Preliminary results from National Surgical Adjuvant Breast and Bowel Project Protocol B-27. J Clin Oncol 2003;21:4165-4174
    • (2003) J Clin Oncol , vol.21 , pp. 4165-4174
    • Bear, H.D.1    Anderson, S.2    Brown, A.3
  • 7
    • 2942715244 scopus 로고    scopus 로고
    • Breast conservation after neoadjuvant chemotherapy: The MD Anderson cancer center experience
    • Chen AM, Meric-Bernstam F, Hunt KK, et al. Breast conservation after neoadjuvant chemotherapy: The MD Anderson cancer center experience. J Clin Oncol 2004;22:2303-2312
    • (2004) J Clin Oncol , vol.22 , pp. 2303-2312
    • Chen, A.M.1    Meric-Bernstam, F.2    Hunt, K.K.3
  • 8
    • 0035890633 scopus 로고    scopus 로고
    • Preoperative chemotherapy in primary operable breast cancer: Results from the European Organization for Research and Treatment of Cancer trial 10902
    • van der Hage JA, van de Velde CJ, Julien JP, et al. Preoperative chemotherapy in primary operable breast cancer: Results from the European Organization for Research and Treatment of Cancer trial 10902. J Clin Oncol 2001;19:4224-4237
    • (2001) J Clin Oncol , vol.19 , pp. 4224-4237
    • Van Der Hage, J.A.1    Van De Velde, C.J.2    Julien, J.P.3
  • 9
    • 0033058219 scopus 로고    scopus 로고
    • Neoadjuvant chemotherapy for operable breast carcinoma larger than 3 cm: A unicentre randomized trial with a 124-month median follow-up. Institut bergonie bordeaux groupe sein (ibbgs)
    • Mauriac L, MacGrogan G, Avril A, et al. Neoadjuvant chemotherapy for operable breast carcinoma larger than 3 cm: A unicentre randomized trial with a 124-month median follow-up. Institut Bergonie Bordeaux Groupe Sein (IBBGS). Ann Oncol 1999;10:47-52
    • (1999) Ann Oncol , vol.10 , pp. 47-52
    • Mauriac, L.1    MacGrogan, G.2    Avril, A.3
  • 10
    • 0037103104 scopus 로고    scopus 로고
    • Pathobiology of preoperative chemotherapy: Findings from the national surgical adjuvant breast and bowel (nsabp) protocol b-18
    • Fisher ER, Wang J, Bryant J, et al. Pathobiology of preoperative chemotherapy: Findings from the National Surgical Adjuvant Breast and Bowel (NSABP) protocol B-18. Cancer 2002;95:681-695
    • (2002) Cancer , vol.95 , pp. 681-695
    • Fisher, E.R.1    Wang, J.2    Bryant, J.3
  • 11
    • 0036814394 scopus 로고    scopus 로고
    • Neoadjuvant docetaxel in breast cancer: 3-year survival results from the Aberdeen trial
    • Heys SD, Hutcheon AW, Sarkar TK, et al. Neoadjuvant docetaxel in breast cancer: 3-year survival results from the Aberdeen trial. Clin Breast Cancer 2002;3(Suppl 2):S69-S74
    • (2002) Clin Breast Cancer , vol.3 , Issue.SUPPL. 2
    • Heys, S.D.1    Hutcheon, A.W.2    Sarkar, T.K.3
  • 12
    • 0028357653 scopus 로고
    • Neoadjuvant versus adjuvant chemotherapy in premenopausal patients with tumours considered too large for breast conserving surgery: Preliminary results of a randomised trial S6
    • Scholl SM, Fourquet A, Asselain B, et al. Neoadjuvant versus adjuvant chemotherapy in premenopausal patients with tumours considered too large for breast conserving surgery: Preliminary results of a randomised trial: S6. Eur J Cancer 1994;30A:645-652
    • (1994) Eur J Cancer , vol.30 , pp. 645-652
    • Scholl, S.M.1    Fourquet, A.2    Asselain, B.3
  • 13
    • 0031926839 scopus 로고    scopus 로고
    • Effect of preoperative chemotherapy on the outcome of women with operable breast cancer
    • Fisher B, Bryant J, Wolmark N, et al. Effect of preoperative chemotherapy on the outcome of women with operable breast cancer. J Clin Oncol 1998;16:2672-2685
    • (1998) J Clin Oncol , vol.16 , pp. 2672-2685
    • Fisher, B.1    Bryant, J.2    Wolmark, N.3
  • 14
    • 14644394275 scopus 로고    scopus 로고
    • Good clinical response of breast cancers to neoadjuvant chemoendocrine therapy is associated with improved overall survival
    • Cleator SJ, Makris A, Ashley SE, et al. Good clinical response of breast cancers to neoadjuvant chemoendocrine therapy is associated with improved overall survival. Ann Oncol 2005;16:267-272
    • (2005) Ann Oncol , vol.16 , pp. 267-272
    • Cleator, S.J.1    Makris, A.2    Ashley, S.E.3
  • 15
    • 84862303759 scopus 로고    scopus 로고
    • Definition and impact of pathologic complete response on prognosis after neoadjuvant chemotherapy in various intrinsic breast cancer subtypes
    • von Minckwitz G, Untch M, Blohmer JU, et al. Definition and impact of pathologic complete response on prognosis after neoadjuvant chemotherapy in various intrinsic breast cancer subtypes. J Clin Oncol 2012;30:1796-1804
    • (2012) J Clin Oncol , vol.30 , pp. 1796-1804
    • Von Minckwitz, G.1    Untch, M.2    Blohmer, J.U.3
  • 16
    • 39149083784 scopus 로고    scopus 로고
    • Preoperative therapy in invasive breast cancer: Pathologic assessment and systemic therapy issues in operable disease
    • Gralow JR, Burstein HJ, Wood W, et al. Preoperative therapy in invasive breast cancer: Pathologic assessment and systemic therapy issues in operable disease. J Clin Oncol 2008;26:814-819
    • (2008) J Clin Oncol , vol.26 , pp. 814-819
    • Gralow, J.R.1    Burstein, H.J.2    Wood, W.3
  • 17
    • 39149111633 scopus 로고    scopus 로고
    • Preoperative chemotherapy: Updates of National Surgical Adjuvant Breast and Bowel Project Protocols B-18 and B-27
    • Rastogi P, Anderson SJ, Bear HD, et al. Preoperative chemotherapy: Updates of National Surgical Adjuvant Breast and Bowel Project Protocols B-18 and B-27. J Clin Oncol 2008;26:778-785
    • (2008) J Clin Oncol , vol.26 , pp. 778-785
    • Rastogi, P.1    Anderson, S.J.2    Bear, H.D.3
  • 18
    • 0034823009 scopus 로고    scopus 로고
    • Doxorubicin and taxane combination regimens for metastatic breast cancer: Focus on cardiac effects
    • Valero V, Perez E, Dieras V. Doxorubicin and taxane combination regimens for metastatic breast cancer: Focus on cardiac effects. Semin Oncol 2001;28(4 Suppl 12):15-23
    • (2001) Semin Oncol , vol.28 , Issue.4 SUPPL. 12 , pp. 15-23
    • Valero, V.1    Perez, E.2    Dieras, V.3
  • 19
    • 0036965771 scopus 로고    scopus 로고
    • Phase II trial of doxorubicin/ docetaxel/cyclophosphamide for locally advanced and metastatic breast cancer: Results from NSABP trial BP-58
    • Smith RE, Anderson SJ, Brown A, et al. Phase II trial of doxorubicin/ docetaxel/cyclophosphamide for locally advanced and metastatic breast cancer: Results from NSABP trial BP-58. Clin Breast Cancer 2002;3:333-340
    • (2002) Clin Breast Cancer , vol.3 , pp. 333-340
    • Smith, R.E.1    Anderson, S.J.2    Brown, A.3
  • 20
    • 33644973070 scopus 로고    scopus 로고
    • Prognostic value of pathologic complete response after primary chemotherapy in relation to hormone receptor status and other factors
    • Guarneri V, Broglio K, Kau SW, et al. Prognostic value of pathologic complete response after primary chemotherapy in relation to hormone receptor status and other factors. J Clin Oncol 2006;24: 1037-1044
    • (2006) J Clin Oncol , vol.24 , pp. 1037-1044
    • Guarneri, V.1    Broglio, K.2    Kau, S.W.3
  • 21
    • 34548799629 scopus 로고    scopus 로고
    • A strategy for predicting the chemosensitivity of human cancers and its application to drug discovery
    • Lee JK, Havaleshko DM, Cho H, et al. A strategy for predicting the chemosensitivity of human cancers and its application to drug discovery. Proc Natl Acad Sci USA 2007;104:13086-13091
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 13086-13091
    • Lee, J.K.1    Havaleshko, D.M.2    Cho, H.3
  • 22
    • 2942729848 scopus 로고    scopus 로고
    • Gene expression profiles predict complete pathologic response to neoadjuvant paclitaxel and fluorouracil, doxorubicin, and cyclophosphamide chemotherapy in breast cancer
    • Ayers M, Symmans WF, Stec J, et al. Gene expression profiles predict complete pathologic response to neoadjuvant paclitaxel and fluorouracil, doxorubicin, and cyclophosphamide chemotherapy in breast cancer. J Clin Oncol 2004;22:2284-2293
    • (2004) J Clin Oncol , vol.22 , pp. 2284-2293
    • Ayers, M.1    Symmans, W.F.2    Stec, J.3
  • 23
    • 60849097255 scopus 로고    scopus 로고
    • Gene-expression signatures in breast cancer
    • Sotiriou C, Pusztai L. Gene-expression signatures in breast cancer. N Engl J Med 2009;360:790-800
    • (2009) N Engl J Med , vol.360 , pp. 790-800
    • Sotiriou, C.1    Pusztai, L.2
  • 24
    • 0035845531 scopus 로고    scopus 로고
    • Chemosensitivity prediction by transcriptional profiling
    • Staunton JE, Slonim DK, Coller HA, et al. Chemosensitivity prediction by transcriptional profiling. Proc Natl Acad Sci USA 2001;98: 10787-10792
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 10787-10792
    • Staunton, J.E.1    Slonim, D.K.2    Coller, H.A.3
  • 25
    • 79955798310 scopus 로고    scopus 로고
    • A genomic predictor of response and survival following taxane-Anthracycline chemotherapy for invasive breast cancer
    • Hatzis C, Pusztai L, Valero V, et al. A genomic predictor of response and survival following taxane-Anthracycline chemotherapy for invasive breast cancer. JAMA 2011;305:1873-1881
    • (2011) JAMA , vol.305 , pp. 1873-1881
    • Hatzis, C.1    Pusztai, L.2    Valero, V.3
  • 26
    • 77954168391 scopus 로고    scopus 로고
    • Effect of training-sample size and classification difficulty on the accuracy of genomic predictors
    • Popovici V, Chen W, Gallas BG, et al. Effect of training-sample size and classification difficulty on the accuracy of genomic predictors. Breast Cancer Res 2010;12:R5
    • (2010) Breast Cancer Res , vol.12
    • Popovici, V.1    Chen, W.2    Gallas, B.G.3
  • 27
    • 0021212003 scopus 로고
    • Cell cycle analysis of a cell proliferation-Associated human nuclear antigen defined by the monoclonal antibody Ki-67
    • Gerdes J, Lemke H, Baisch H, et al. Cell cycle analysis of a cell proliferation-Associated human nuclear antigen defined by the monoclonal antibody Ki-67. J Immunol 1984;133:1710-1715
    • (1984) J Immunol , vol.133 , pp. 1710-1715
    • Gerdes, J.1    Lemke, H.2    Baisch, H.3
  • 28
    • 0024643202 scopus 로고
    • Ki-67 detects a nuclear matrix-Associated proliferation-related antigen. II. Localization in mitotic cells and association with chromosomes
    • Verheijen R, Kuijpers HJ, van Driel R, et al. Ki-67 detects a nuclear matrix-Associated proliferation-related antigen. II. Localization in mitotic cells and association with chromosomes. J Cell Sci 1989; 92(Pt 4):531-540
    • (1989) J Cell Sci , vol.92 , Issue.PART 4 , pp. 531-540
    • Verheijen, R.1    Kuijpers, H.J.2    Van Driel, R.3
  • 29
    • 27244443082 scopus 로고    scopus 로고
    • Proliferation marker Ki-67 in early breast cancer
    • Urruticoechea A, Smith IE, Dowsett M. Proliferation marker Ki-67 in early breast cancer. J Clin Oncol 2005;23:7212-7220
    • (2005) J Clin Oncol , vol.23 , pp. 7212-7220
    • Urruticoechea, A.1    Smith, I.E.2    Dowsett, M.3
  • 30
    • 81555208345 scopus 로고    scopus 로고
    • Assessment of Ki67 in breast cancer: Recommendations from the International Ki67 in Breast Cancer working group
    • Dowsett M, Nielsen TO, A'Hern R, et al. Assessment of Ki67 in breast cancer: Recommendations from the International Ki67 in Breast Cancer working group. J Natl Cancer Inst 2011;103:1656-1664
    • (2011) J Natl Cancer Inst , vol.103 , pp. 1656-1664
    • Dowsett, M.1    Nielsen, T.O.2    A'Hern, R.3
  • 31
    • 84865171628 scopus 로고    scopus 로고
    • Ki-67: Level of evidence and methodological considerations for its role in the clinical management of breast cancer: Analytical and critical review
    • Luporsi E, Andre F, Spyratos F, et al. Ki-67: Level of evidence and methodological considerations for its role in the clinical management of breast cancer: Analytical and critical review. Breast Cancer Res Treat 2012;132:895-915
    • (2012) Breast Cancer Res Treat , vol.132 , pp. 895-915
    • Luporsi, E.1    Andre, F.2    Spyratos, F.3
  • 32
    • 75249083420 scopus 로고    scopus 로고
    • Ki67 in breast cancer: Prognostic and predictive potential
    • Yerushalmi R, Woods R, Ravdin PM, et al. Ki67 in breast cancer: Prognostic and predictive potential. Lancet Oncol 2010;11: 174-183
    • (2010) Lancet Oncol , vol.11 , pp. 174-183
    • Yerushalmi, R.1    Woods, R.2    Ravdin, P.M.3
  • 33
    • 58749085047 scopus 로고    scopus 로고
    • Changes and predictive and prognostic value of the mitotic index, Ki-67, cyclin D1, and cyclooxygenase-2 in 710 operable breast cancer patients treated with neoadjuvant chemotherapy
    • Penault-Llorca F, Abrial C, Raoelfils I, et al. Changes and predictive and prognostic value of the mitotic index, Ki-67, cyclin D1, and cyclooxygenase-2 in 710 operable breast cancer patients treated with neoadjuvant chemotherapy. Oncologist 2008;13:1235-1245
    • (2008) Oncologist , vol.13 , pp. 1235-1245
    • Penault-Llorca, F.1    Abrial, C.2    Raoelfils, I.3
  • 34
    • 33645779551 scopus 로고    scopus 로고
    • Evaluation of HER-2/neu amplification and other biological markers as predictors of response to neoadjuvant anthracycline-based chemotherapy in primary breast cancer: The role of anthracycline dose intensity
    • Bozzetti C, Musolino A, Camisa R, et al. Evaluation of HER-2/neu amplification and other biological markers as predictors of response to neoadjuvant anthracycline-based chemotherapy in primary breast cancer: The role of anthracycline dose intensity. Am J Clin Oncol 2006;29:171-177
    • (2006) Am J Clin Oncol , vol.29 , pp. 171-177
    • Bozzetti, C.1    Musolino, A.2    Camisa, R.3
  • 35
    • 84860390436 scopus 로고    scopus 로고
    • Ki-67 can be used for further classification of triple negative breast cancer into two subtypes with different response and prognosis
    • Keam B, Im SA, Lee KH, et al. Ki-67 can be used for further classification of triple negative breast cancer into two subtypes with different response and prognosis. Breast Cancer Res 2011;13:R22
    • (2011) Breast Cancer Res , vol.13
    • Keam, B.1    Im, S.A.2    Lee, K.H.3
  • 36
    • 79952100114 scopus 로고    scopus 로고
    • Prognostic value of estrogen receptor and Ki-67 index after neoadjuvant chemotherapy in locally advanced breast cancer expressing high levels of proliferation at diagnosis
    • Miglietta L, Vanella P, Canobbio L, et al. Prognostic value of estrogen receptor and Ki-67 index after neoadjuvant chemotherapy in locally advanced breast cancer expressing high levels of proliferation at diagnosis. Oncology 2010;79:255-261
    • (2010) Oncology , vol.79 , pp. 255-261
    • Miglietta, L.1    Vanella, P.2    Canobbio, L.3
  • 37
    • 81055148214 scopus 로고    scopus 로고
    • Ki67, chemotherapy response, and prognosis in breast cancer patients receiving neoadjuvant treatment
    • Fasching PA, Heusinger K, Haeberle L, et al. Ki67, chemotherapy response, and prognosis in breast cancer patients receiving neoadjuvant treatment. BMC Cancer 2011;11:486
    • (2011) BMC Cancer , vol.11 , pp. 486
    • Fasching, P.A.1    Heusinger, K.2    Haeberle, L.3
  • 38
    • 0035914249 scopus 로고    scopus 로고
    • Relationship between tumour shrinkage and reduction in Ki67 expression after primary chemotherapy in human breast cancer
    • Bottini A, Berruti A, Bersiga A, et al. Relationship between tumour shrinkage and reduction in Ki67 expression after primary chemotherapy in human breast cancer. Br J Cancer 2001;85:1106-1112
    • (2001) Br J Cancer , vol.85 , pp. 1106-1112
    • Bottini, A.1    Berruti, A.2    Bersiga, A.3
  • 39
    • 74849113750 scopus 로고    scopus 로고
    • Relationship between oestrogen receptor status and proliferation in predicting response and long-Term outcome to neoadjuvant chemotherapy for breast cancer
    • Jones RL, Salter J, A'Hern R, et al. Relationship between oestrogen receptor status and proliferation in predicting response and long-Term outcome to neoadjuvant chemotherapy for breast cancer. Breast Cancer Res Treat 2010;119:315-323
    • (2010) Breast Cancer Res Treat , vol.119 , pp. 315-323
    • Jones, R.L.1    Salter, J.2    A'Hern, R.3
  • 40
    • 79251598806 scopus 로고    scopus 로고
    • Prognostic significance of Ki6& index after neoadjuvant chemotherapy in breast cancer
    • Tanei T, Shimomura A, Shimazu K, et al. Prognostic significance of Ki6& index after neoadjuvant chemotherapy in breast cancer. Eur J Surg Oncol 2011;37:155-161
    • (2011) Eur J Surg Oncol , vol.37 , pp. 155-161
    • Tanei, T.1    Shimomura, A.2    Shimazu, K.3
  • 41
    • 0027057589 scopus 로고
    • Monoclonal antibodies against recombinant parts of the Ki-67 antigen (MIB 1 and MIB 3) detect proliferating cells in microwave-processed formalin-fixed paraffin sections
    • Cattoretti G, Becker MH, Key G, et al. Monoclonal antibodies against recombinant parts of the Ki-67 antigen (MIB 1 and MIB 3) detect proliferating cells in microwave-processed formalin-fixed paraffin sections. J Pathol 1992;168:357-363
    • (1992) J Pathol , vol.168 , pp. 357-363
    • Cattoretti, G.1    Becker, M.H.2    Key, G.3
  • 42
    • 84870873727 scopus 로고    scopus 로고
    • Quantitative assessment of effect of preanalytic cold ischemic time on protein expression in breast cancer tissues
    • Neumeister VM, Anagnostou V, Siddiqui S, et al. Quantitative assessment of effect of preanalytic cold ischemic time on protein expression in breast cancer tissues. J Natl Cancer Inst 2012;104: 1815-1824
    • (2012) J Natl Cancer Inst , vol.104 , pp. 1815-1824
    • Neumeister, V.M.1    Anagnostou, V.2    Siddiqui, S.3
  • 44
    • 0036852721 scopus 로고    scopus 로고
    • Automated subcellular localization and quantification of protein expression in tissue microarrays
    • Camp RL, Chung GG, Rimm DL. Automated subcellular localization and quantification of protein expression in tissue microarrays. Nat Med 2002;8:1323-1327
    • (2002) Nat Med , vol.8 , pp. 1323-1327
    • Camp, R.L.1    Chung, G.G.2    Rimm, D.L.3
  • 46
    • 84856432316 scopus 로고    scopus 로고
    • Comparison of visual and automated assessment of Ki-67 proliferative activity and their impact on outcome in primary operable invasive ductal breast cancer
    • Mohammed ZM, McMillan DC, Elsberger B, et al. Comparison of visual and automated assessment of Ki-67 proliferative activity and their impact on outcome in primary operable invasive ductal breast cancer. Br J Cancer 2012;106:383-388
    • (2012) Br J Cancer , vol.106 , pp. 383-388
    • Mohammed, Z.M.1    McMillan, D.C.2    Elsberger, B.3
  • 47
    • 79953143904 scopus 로고    scopus 로고
    • Proliferative activity in human breast cancer: Ki-67 automated evaluation and the influence of different Ki-67 equivalent antibodies
    • Fasanella S, Leonardi E, Cantaloni C, et al. Proliferative activity in human breast cancer: Ki-67 automated evaluation and the influence of different Ki-67 equivalent antibodies. Diagn Pathol 2011;6(Suppl 1):S7
    • (2011) Diagn Pathol , vol.6 , Issue.SUPPL. 1
    • Fasanella, S.1    Leonardi, E.2    Cantaloni, C.3
  • 48
    • 48849096940 scopus 로고    scopus 로고
    • Proliferation markers and survival in early breast cancer: A systematic review and meta-Analysis of 85 studies in 32,825 patients
    • Stuart-Harris R, Caldas C, Pinder SE, et al. Proliferation markers and survival in early breast cancer: A systematic review and meta-Analysis of 85 studies in 32,825 patients. Breast 2008;17:323-334
    • (2008) Breast , vol.17 , pp. 323-334
    • Stuart-Harris, R.1    Caldas, C.2    Pinder, S.E.3
  • 49
    • 84871202260 scopus 로고    scopus 로고
    • An intra- and interobserver reproducibility analysis of the Ki-67 proliferation marker assessment on core biopsies of breast cancer patients and its potential clinical implications
    • Voros A, Csorgo E, Nyari T, et al. An intra- and interobserver reproducibility analysis of the Ki-67 proliferation marker assessment on core biopsies of breast cancer patients and its potential clinical implications. Pathobiology 2012;80:111-118
    • (2012) Pathobiology , vol.80 , pp. 111-118
    • Voros, A.1    Csorgo, E.2    Nyari, T.3
  • 50
    • 79961125059 scopus 로고    scopus 로고
    • Ki67 proliferation in core biopsies versus surgical samples-A model for neo-Adjuvant breast cancer studies
    • Romero Q, Bendahl PO, Klintman M, et al. Ki67 proliferation in core biopsies versus surgical samples-A model for neo-Adjuvant breast cancer studies. BMC Cancer 2011;11:341
    • (2011) BMC Cancer , vol.11 , pp. 341
    • Romero, Q.1    Bendahl, P.O.2    Klintman, M.3
  • 51
    • 84864310664 scopus 로고    scopus 로고
    • Immunohistochemical Ki6& labeling index has similar proliferation predictive power to various gene signatures in breast cancer
    • Niikura N, Iwamoto T, Masuda S, et al. Immunohistochemical Ki6& labeling index has similar proliferation predictive power to various gene signatures in breast cancer. Cancer Sci 2012;103:1508-1512.
    • (2012) Cancer Sci , vol.103 , pp. 1508-1512
    • Niikura, N.1    Iwamoto, T.2    Masuda, S.3


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