I don't know the question, but sex is definitely the answer! Focus on "In pursuit of scientific excellence: Sex matters" and "Do you know the sex of your cells?"

American Journal of Physiology - Cell Physiology

Volumn 306, Issue 1, 2014, Pages

  Fuller, Catherine M ^a   Insel, Paul A ^b  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

G PROTEIN COUPLED RECEPTOR;

CELL FUNCTION; CELL SEXUAL IDENTITY; DUCHENNE MUSCULAR DYSTROPHY; EDITORIAL; FIBROBLAST; GENDER IDENTITY; GENE EXPRESSION; HEMOPHILIA; HUMAN; KARYOTYPE 46,XX; KARYOTYPE 46,XY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; SEX DIFFERENCE; SOMATIC CELL; STEM CELL; STEM CELL TRANSPLANTATION; X CHROMOSOME; Y CHROMOSOME;

EID: 84891505342     PISSN: 03636143     EISSN: 15221563     Source Type: Journal    
DOI: 10.1152/ajpcell.00342.2013     Document Type: Editorial

References (7)

1. Beyer C, Pilgrim C, Reisert I. Dopamine content and metabolism in mesencephalic and diencephalic cell cultures: sex differences and effects of sex steroids. J Neurosci 11: 1325-1333, 1991.
2. Carruth LL, Reisert I, Arnold AP. Sex chromosome genes directly affect brain sexual differentiation. Nat Neurosci 5: 933-934, 2002.
3. Dewing P, Shi T, Horvath S, Vilain E. Sexually dimorphic gene expression in mouse brain precedes gonadal differentiation. Brain Res Mol Brain Res 118: 82-90, 2003.
4. Miller VM. In pursuit of scientific excellence: sex matters. Am J Physiol Cell Physiol 302: C1269-C1270, 2012.
5. Pollitzer E. Biology: cell sex matters. Nature 500: 23-24, 2013.
6. Shah K, McCormack CE, Bradbury NA. Do you know the sex of your cells? Am J Physiol Cell Physiol (November 6, 2013). doi:10.1152/ ajpcell.00281.2013.
7. Taylor KE, Vallejo-Giraldo C, Schaible NS, Zakeri R, Miller VM. Reporting of sex as a variable in cardiovascular studies using cultured cells. Biol Sex Differ 2: 11, 2011.