메뉴 건너뛰기




Volumn 16, Issue , 2013, Pages

Increases in regimen durability associated with the introduction of tenofovir at a large public-sector clinic in Johannesburg, South Africa

Author keywords

Antiretroviral therapy; Drug side effects; Drug toxicities; Regimen durability; Resource limited setting; Single drug substitution

Indexed keywords

EFAVIRENZ; LAMIVUDINE; NEVIRAPINE; NONNUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR; RNA DIRECTED DNA POLYMERASE INHIBITOR; STAVUDINE; TENOFOVIR; ZIDOVUDINE;

EID: 84891504093     PISSN: None     EISSN: 17582652     Source Type: Journal    
DOI: 10.7448/IAS.16.1.18794     Document Type: Article
Times cited : (18)

References (48)
  • 3
    • 78149477676 scopus 로고    scopus 로고
    • National Department of Health, Republic of South Africa. [cited 2013 Aug 1]. Available from
    • National Department of Health, Republic of South Africa. The South African antiretroviral treatment guidelines. 2010. [cited 2013 Aug 1]. Available from: http://www.doh.gov.za/docs/factsheets/guidelines/art.pdf
    • (2010) The South African Antiretroviral Treatment Guidelines
  • 4
    • 37349126951 scopus 로고    scopus 로고
    • Positive outcomes of HAART at 24 months in HIV-infected patients in Cambodia
    • Ferradini L, Laureillard D, Prak N, Ngeth C, Fernandez M, Pinoges L, et al. Positive outcomes of HAART at 24 months in HIV-infected patients in Cambodia. AIDS. 2007;21:2293-301.
    • (2007) AIDS , vol.21 , pp. 2293-2301
    • Ferradini, L.1    Laureillard, D.2    Prak, N.3    Ngeth, C.4    Fernandez, M.5    Pinoges, L.6
  • 5
    • 3042848853 scopus 로고    scopus 로고
    • Efficacy and safety of tenofovir DF vs stavudine in combination therapy in antiretroviral-naive patients: A 3-year randomized trial
    • Gallant JE, Staszewski S, Pozniak AL, DeJesus E, Suleiman JMAH, Miller MD, et al. Efficacy and safety of tenofovir DF vs stavudine in combination therapy in antiretroviral-naive patients: a 3-year randomized trial. JAMA. 2004;292:191-201.
    • (2004) JAMA , vol.292 , pp. 191-201
    • Gallant, J.E.1    Staszewski, S.2    Pozniak, A.L.3    DeJesus, E.4    Suleiman, J.M.A.H.5    Miller, M.D.6
  • 7
    • 75449111630 scopus 로고    scopus 로고
    • Stavudine- and nevirapine-related drug toxicity while on generic fixed-dose antiretroviral treatment: Incidence, timing and risk factors in a three-year cohort in Kigali, Rwanda
    • van Griensven J, Zachariah R, Rasschaert F, Mugabo J, Atté EF, Reid T. Stavudine- and nevirapine-related drug toxicity while on generic fixed-dose antiretroviral treatment: incidence, timing and risk factors in a three-year cohort in Kigali, Rwanda. Trans R Soc Trop Med Hyg. 2010;104:148-53.
    • (2010) Trans R Soc Trop Med Hyg , vol.104 , pp. 148-153
    • Van Griensven, J.1    Zachariah, R.2    Rasschaert, F.3    Mugabo, J.4    Atté, E.F.5    Reid, T.6
  • 8
    • 39549111889 scopus 로고    scopus 로고
    • Antiretroviral therapy-associated toxicities in the resource-poor world: The challenge of a limited formulary
    • Murphy R, Sunpath H, Kuritzkes DR, Venter F, Gandhi RT. Antiretroviral therapy-associated toxicities in the resource-poor world: the challenge of a limited formulary. J Infect Dis. 2007;196(Suppl 3):S449-56.
    • (2007) J Infect Dis , vol.196 , Issue.SUPPL. 3
    • Murphy, R.1    Sunpath, H.2    Kuritzkes, D.R.3    Venter, F.4    Gandhi, R.T.5
  • 9
    • 54049107692 scopus 로고    scopus 로고
    • Viral efficacy maintained and safety parameters improved with a reduced dose of stavudine: A pilot study
    • Ait-Mohand H, Bonmarchand M, Guiguet M, Slama L, Marguet F, Behin A, et al. Viral efficacy maintained and safety parameters improved with a reduced dose of stavudine: a pilot study. HIV Med. 2008;9:738-46.
    • (2008) HIV Med , vol.9 , pp. 738-746
    • Ait-Mohand, H.1    Bonmarchand, M.2    Guiguet, M.3    Slama, L.4    Marguet, F.5    Behin, A.6
  • 13
    • 58149472999 scopus 로고    scopus 로고
    • Campaign for Access to Essential Medicines 11th ed. Geneva: Médecins sans Frontières. Available from
    • Campaign for Access to Essential Medicines. 2008. Untangling the Web of Antiretroviral Price Reductions, 11th ed. Geneva: Médecins sans Frontières. Available from: http://d2pd3b5abq75bb.cloudfront.net/2012/07/ 16/14/49/04/691/UTW-11-ENG-Jul2008.pdf.
    • (2008) Untangling the Web of Antiretroviral Price Reductions
  • 14
    • 84862777618 scopus 로고    scopus 로고
    • Association of tenofovir exposure with kidney disease risk in HIV infection
    • Scherzer R, Estrella M, Li Y, Choi AI, Deeks SG, Grunfeld C, et al. Association of tenofovir exposure with kidney disease risk in HIV infection. AIDS. 2012;26(7):867-75.
    • (2012) AIDS , vol.26 , Issue.7 , pp. 867-875
    • Scherzer, R.1    Estrella, M.2    Li, Y.3    Choi, A.I.4    Deeks, S.G.5    Grunfeld, C.6
  • 15
    • 0037306630 scopus 로고    scopus 로고
    • HIV-related renal disease: A clinical and practical approach in the South African context
    • Bihl G. HIV-related renal disease: a clinical and practical approach in the South African context. SAMJ. 2003:11-14.
    • (2003) SAMJ , pp. 11-14
    • Bihl, G.1
  • 16
    • 0037447180 scopus 로고    scopus 로고
    • Tenofovir-related nephrotoxicity in human immunodeficiency virus-infected patients: Three cases of renal failure, Fanconi syndrome and nephrogenic diabetes insipidus
    • Karras A, Lafaurie M, Furco A, Bourgarit A, Droz D, Sereni D, et al. Tenofovir-related nephrotoxicity in human immunodeficiency virus-infected patients: three cases of renal failure, Fanconi syndrome and nephrogenic diabetes insipidus. Clin Infect Dis. 2003;36:1070-3.
    • (2003) Clin Infect Dis , vol.36 , pp. 1070-1073
    • Karras, A.1    Lafaurie, M.2    Furco, A.3    Bourgarit, A.4    Droz, D.5    Sereni, D.6
  • 17
    • 23344433003 scopus 로고    scopus 로고
    • Low frequency of renal function impairment during one-year of therapy with tenofovir-containing regimens in the real-world: A case-control study
    • Padilla S, Gutierrez F, Masia M, Canovas V, Orozco C. Low frequency of renal function impairment during one-year of therapy with tenofovir-containing regimens in the real-world: a case-control study. AIDS Patient Care STDS. 2005;19:421-4.
    • (2005) AIDS Patient Care STDS , vol.19 , pp. 421-424
    • Padilla, S.1    Gutierrez, F.2    Masia, M.3    Canovas, V.4    Orozco, C.5
  • 18
    • 10044236429 scopus 로고    scopus 로고
    • Renal dysfunction with tenofovir disoproxil fumarate containing highly active antiretroviral therapy regimes is not observed more frequently: A cohort and case-control study
    • Jones R, Stebbing J, Nelson M, Moyle G, Bower M, Sundhiya M, et al. Renal dysfunction with tenofovir disoproxil fumarate containing highly active antiretroviral therapy regimes is not observed more frequently: a cohort and case-control study. JAIDS. 2004;37:1489-95.
    • (2004) JAIDS , vol.37 , pp. 1489-1495
    • Jones, R.1    Stebbing, J.2    Nelson, M.3    Moyle, G.4    Bower, M.5    Sundhiya, M.6
  • 19
    • 80051798090 scopus 로고    scopus 로고
    • Relationship between renal dysfunction, nephrotoxicity and death among HIV adults on tenofovir
    • Brennan A, Evans D, Maskew M, Naicker S, Ive P, Sanne I, et al. Relationship between renal dysfunction, nephrotoxicity and death among HIV adults on tenofovir. AIDS. 2011;25(13):1603-9.
    • (2011) AIDS , vol.25 , Issue.13 , pp. 1603-1609
    • Brennan, A.1    Evans, D.2    Maskew, M.3    Naicker, S.4    Ive, P.5    Sanne, I.6
  • 20
    • 80055067605 scopus 로고    scopus 로고
    • Glomerular dysfunction and associated risk factors over 4-5 years following antiretroviral therapy initiation in Africa
    • Stöhr W, Reid A, Walker AS, Ssali F, Munderi P, Mambule I, et al. Glomerular dysfunction and associated risk factors over 4-5 years following antiretroviral therapy initiation in Africa. Antivir Ther. 2011;16(7):1011-20.
    • (2011) Antivir Ther , vol.16 , Issue.7 , pp. 1011-1020
    • Stöhr, W.1    Reid, A.2    Walker, A.S.3    Ssali, F.4    Munderi, P.5    Mambule, I.6
  • 23
    • 84877733753 scopus 로고    scopus 로고
    • Comparison of tenofovir, zidovudine, or stavudine as part of first-line antiretroviral therapy in a resource-limited-setting: A cohort study
    • Velen K, Lewis JJ, Charalambous S, Grant AD, Churchyard GJ, Hoffmann CJ. Comparison of tenofovir, zidovudine, or stavudine as part of first-line antiretroviral therapy in a resource-limited-setting: a cohort study. PLoS One. 2013;8(5):64459.
    • (2013) PLoS One , vol.8 , Issue.5 , pp. 64459
    • Velen, K.1    Lewis, J.J.2    Charalambous, S.3    Grant, A.D.4    Churchyard, G.J.5    Hoffmann, C.J.6
  • 25
  • 26
    • 84878052800 scopus 로고    scopus 로고
    • Rates of switching antiretroviral drugs in a primary care service in South Africa before and after introduction of tenofovir
    • Njuguna C, Orrell C, Kaplan R, Bekker LG, Wood R, Lawn SD. Rates of switching antiretroviral drugs in a primary care service in South Africa before and after introduction of tenofovir. PLoS One. 2013;8(5):63596.
    • (2013) PLoS One , vol.8 , Issue.5 , pp. 63596
    • Njuguna, C.1    Orrell, C.2    Kaplan, R.3    Bekker, L.G.4    Wood, R.5    Lawn, S.D.6
  • 27
    • 84891507744 scopus 로고    scopus 로고
    • An investigation into the frequency and reasons why patients switch antiretroviral therapy and which antiretrovirals are commonly implicated in toxicity
    • 18th Annual Conference of the British HIV Association, abstract, 2012 Oct 28; Birmingham
    • Boyle A, Sonecha S, Mandalia S, Nelson M. An investigation into the frequency and reasons why patients switch antiretroviral therapy and which antiretrovirals are commonly implicated in toxicity. 18th Annual Conference of the British HIV Association, abstract, 2012 Oct 28; Birmingham: Journal of the International AIDS Society. 2012;15(Suppl 4):18121.
    • (2012) Journal of the International AIDS Society , vol.15 , Issue.SUPPL. 4 , pp. 18121
    • Boyle, A.1    Sonecha, S.2    Mandalia, S.3    Nelson, M.4
  • 30
    • 0003597577 scopus 로고    scopus 로고
    • (Chapter). SAS Institute Inc., Cary, NC, USA. Available from
    • SAS/STAT® 9.3 User's Guide: The MI Procedure (Chapter). SAS Institute Inc., Cary, NC, USA. Available from: http://support.sas.com/documentation/ onlinedoc/stat/930/mi.pdf
    • SAS/STAT® 9.3 User's Guide: The MI Procedure
  • 32
    • 0003597577 scopus 로고    scopus 로고
    • (Chapter). SAS Institute Inc., Cary, NC, USA. Available from
    • SAS/STAT® 9.3 User's Guide: The MIANALYZE Procedure (Chapter). SAS Institute Inc., Cary, NC, USA. Available from: http://support.sas.com/rnd/app/ papers/mianalyzev802.pdf
    • SAS/STAT® 9.3 User's Guide: The MIANALYZE Procedure
  • 33
    • 84856377951 scopus 로고    scopus 로고
    • Incidence of treatment-limiting toxicity with stavudine-based antiretroviral therapy in Cambodia: A retrospective cohort study
    • Phan V, Thai S, Choun K, Lynen L, van Griensven J. Incidence of treatment-limiting toxicity with stavudine-based antiretroviral therapy in Cambodia: a retrospective cohort study. PLoS One. 2012;7(1):e30647.
    • (2012) PLoS One , vol.7 , Issue.1
    • Phan, V.1    Thai, S.2    Choun, K.3    Lynen, L.4    Van Griensven, J.5
  • 34
    • 0028898503 scopus 로고
    • Design and implementation of the d4T parallel-track program
    • Bristol-Myers Squibb Co., Pharmaceutical Research Institute, Wallingford, Connecticut
    • Anderson RE, Dunkle LM, Smaldone L, Adler M, Wirtz C, Kriesel D, et al. Bristol-Myers Squibb Co., Pharmaceutical Research Institute, Wallingford, Connecticut. Design and implementation of the d4T parallel-track program. J Infect Dis. 1995;171(Suppl 2):S118-22.
    • (1995) J Infect Dis , vol.171 , Issue.SUPPL. 2
    • Anderson, R.E.1    Dunkle, L.M.2    Smaldone, L.3    Adler, M.4    Wirtz, C.5    Kriesel, D.6
  • 35
    • 42549113615 scopus 로고    scopus 로고
    • Effect of reducing the dose of stavudine on body composition, bone density, and markers of mitochondrial toxicity in HIV-infected subjects: A randomized, controlled study
    • McComsey GA, Lo Re V 3rd, O'Riordan M,Walker UA, Lebrecht D, Baron E, et al. Effect of reducing the dose of stavudine on body composition, bone density, and markers of mitochondrial toxicity in HIV-infected subjects: a randomized, controlled study. Clin Infect Dis. 2008;46(8):1290-6.
    • (2008) Clin Infect Dis , vol.46 , Issue.8 , pp. 1290-1296
    • McComsey, G.A.1    Lo Re III, V.2    O'Riordan, M.3    Walker, U.A.4    Lebrecht, D.5    Baron, E.6
  • 37
    • 0033941723 scopus 로고    scopus 로고
    • A randomized, dose-finding study with ddI plus d4T versus ddI alone in antiviral-naive, HIV-infected Thai patients
    • Ruxrungtham K, Kroon ED, Ungsedhapand C, Teeratakulpisarn S, Ubolyam S, Buranapraditkun S, et al. A randomized, dose-finding study with ddI plus d4T versus ddI alone in antiviral-naive, HIV-infected Thai patients. AIDS. 2000;14:1375-82.
    • (2000) AIDS , vol.14 , pp. 1375-1382
    • Ruxrungtham, K.1    Kroon, E.D.2    Ungsedhapand, C.3    Teeratakulpisarn, S.4    Ubolyam, S.5    Buranapraditkun, S.6
  • 38
    • 69449104971 scopus 로고    scopus 로고
    • HIV suppression with stavudine 30 mg versus 40 mg in adults over 60 kg on antiretroviral therapy in South Africa
    • Hoffmann CJ, Charalambous S, Fielding KL, Innes C, Chaisson RE, Grant AD, et al. HIV suppression with stavudine 30 mg versus 40 mg in adults over 60 kg on antiretroviral therapy in South Africa. AIDS. 2009;23(13):1784-6.
    • (2009) AIDS , vol.23 , Issue.13 , pp. 1784-1786
    • Hoffmann, C.J.1    Charalambous, S.2    Fielding, K.L.3    Innes, C.4    Chaisson, R.E.5    Grant, A.D.6
  • 40
    • 84857947110 scopus 로고    scopus 로고
    • Effectiveness and safety of 30 mg versus 40 mg stavudine regimens: A cohort study among HIV-infected adults initiating HAART in South Africa
    • Maskew M, Westreich D, Fox MP, Maotoe T, Sanne IM. Effectiveness and safety of 30 mg versus 40 mg stavudine regimens: a cohort study among HIV-infected adults initiating HAART in South Africa. J Int AIDS Soc. 2012;15(1):13.
    • (2012) J Int AIDS Soc , vol.15 , Issue.1 , pp. 13
    • Maskew, M.1    Westreich, D.2    Fox, M.P.3    Maotoe, T.4    Sanne, I.M.5
  • 41
    • 80054860864 scopus 로고    scopus 로고
    • In silico study supports the efficacy of a reduced dose regimen for stavudine
    • Hurwitz SJ, Schinazi RF. In silico study supports the efficacy of a reduced dose regimen for stavudine. Antiviral Res. 2011;92(2):372-7.
    • (2011) Antiviral Res , vol.92 , Issue.2 , pp. 372-377
    • Hurwitz, S.J.1    Schinazi, R.F.2
  • 42
    • 79955097122 scopus 로고    scopus 로고
    • Improved antiretroviral treatment outcome in a rural African setting is associated with cART initiation at higher CD4 cell counts and better general health condition
    • Mossdorf E, Stoeckle M, Mwaigomole EG, Chiweka E, Kibatala PL, Geubbels E, et al. Improved antiretroviral treatment outcome in a rural African setting is associated with cART initiation at higher CD4 cell counts and better general health condition. BMC Infect Dis. 2011;11:98.
    • (2011) BMC Infect Dis , vol.11 , pp. 98
    • Mossdorf, E.1    Stoeckle, M.2    Mwaigomole, E.G.3    Chiweka, E.4    Kibatala, P.L.5    Geubbels, E.6
  • 43
    • 34248162966 scopus 로고    scopus 로고
    • Liver toxicity induced by non-nucleoside reverse transcriptase inhibitors
    • Rivero A, Mira JA, Pineda JA. Liver toxicity induced by non-nucleoside reverse transcriptase inhibitors. J Antimicrob Chemother. 2007;59:342-6.
    • (2007) J Antimicrob Chemother , vol.59 , pp. 342-346
    • Rivero, A.1    Mira, J.A.2    Pineda, J.A.3
  • 44
    • 11144357656 scopus 로고    scopus 로고
    • Comparison of first-line antiretroviral therapy with regimens including nevirapine, efavirenz, or both drugs, plus stavudine and lamivudine: A randomized open-label trial, the 2NN Study
    • van Leth F, Phanuphak P, Ruxrungtham K, Baraldi E, Miller S, Gazzard B, et al. Comparison of first-line antiretroviral therapy with regimens including nevirapine, efavirenz, or both drugs, plus stavudine and lamivudine: a randomized open-label trial, the 2NN Study. Lancet. 2004;363:1253-63.
    • (2004) Lancet , vol.363 , pp. 1253-1263
    • Van Leth, F.1    Phanuphak, P.2    Ruxrungtham, K.3    Baraldi, E.4    Miller, S.5    Gazzard, B.6
  • 46
    • 20144370563 scopus 로고    scopus 로고
    • Incidence and risk factors for rash in Thai patients randomized to regimens with nevirapine, efavirenz or both drugs
    • Ananworanich J, Moor Z, Siangphoe U, Chan J, Cardiello P, Duncombe C, et al. Incidence and risk factors for rash in Thai patients randomized to regimens with nevirapine, efavirenz or both drugs. AIDS. 2005;19:185-92.
    • (2005) AIDS , vol.19 , pp. 185-192
    • Ananworanich, J.1    Moor, Z.2    Siangphoe, U.3    Chan, J.4    Cardiello, P.5    Duncombe, C.6
  • 47
    • 84879117069 scopus 로고    scopus 로고
    • Adverse events associated with nevirapine and efavirenz-based first-line antiretroviral therapy: A systematic review and meta-analysis
    • Shubber Z, Calmy A, Andrieux-Meyer I, Vitoria M, Renaud-Thery F, Shaffer N, et al. Adverse events associated with nevirapine and efavirenz-based first-line antiretroviral therapy: a systematic review and meta-analysis. AIDS. 2013;27:1403-12.
    • (2013) AIDS , vol.27 , pp. 1403-1412
    • Shubber, Z.1    Calmy, A.2    Andrieux-Meyer, I.3    Vitoria, M.4    Renaud-Thery, F.5    Shaffer, N.6
  • 48
    • 34547814064 scopus 로고    scopus 로고
    • Substitutions due to antiretroviral toxicity or contraindication in the first 3 years of antiretroviral therapy in a large South African cohort
    • Boulle A, Orrel C, Kaplan R, Van Cutsem G, McNally M, Hilderbrand K, et al. Substitutions due to antiretroviral toxicity or contraindication in the first 3 years of antiretroviral therapy in a large South African cohort. Antivir Ther. 2007;12(5):753-60. Development Development Development
    • (2007) Antivir Ther , vol.12 , Issue.5 , pp. 753-760
    • Boulle, A.1    Orrel, C.2    Kaplan, R.3    Van Cutsem, G.4    McNally, M.5    Hilderbrand, K.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.