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Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 1, 2014, Pages 152-155

Replacement of amide with bioisosteres led to a new series of potent adenosine A2A receptor antagonists

(6) Yang, Zhaohui a Li, Xuan a Ma, Haikuo a Zheng, Jiyue a Zhen, Xuechu a Zhang, Xiaohu a

a SOOCHOW UNIVERSITY (China)

Author keywords

Adenosine receptor; Antagonist; Bioisostere; GPCR; Parkinson's disease

Indexed keywords

ACETAMIDE; ADENOSINE A2 RECEPTOR; ISTRADEFYLLINE; PRELADENANT; PYRIMIDINE DERIVATIVE; TETRAHYDROISOQUINOLINE; TOZADENANT; VIPADENANT; ADENOSINE A2A RECEPTOR ANTAGONIST; AMIDE;

ARTICLE; DRUG ANTAGONISM; DRUG EFFICACY; DRUG HALF LIFE; DRUG POTENCY; DRUG STABILITY; HALOPERIDOL-INDUCED CATALEPSY; DRUG STRUCTURE; DRUG SYNTHESIS; HYDROLYSIS; STRUCTURE ACTIVITY RELATION;

ADENOSINE RECEPTOR; ANTAGONIST; BIOISOSTERE; GPCR; PARKINSON'S DISEASE;

ACETAMIDES; ADENOSINE A2 RECEPTOR ANTAGONISTS; DOSE-RESPONSE RELATIONSHIP, DRUG; HEK293 CELLS; HUMANS; MOLECULAR STRUCTURE; PYRIMIDINES; RECEPTOR, ADENOSINE A2A; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84891492152 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2013.11.051 Document Type: Article

Times cited : (16)

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