A traditional herbal formula, Hyangsa-Pyeongwi san (HPS), improves quality of life (QoL) of the patient with functional dyspepsia (FD): Randomized double-blinded controlled trial

Journal of Ethnopharmacology

Volumn 151, Issue 1, 2014, Pages 279-286

  Kim, Jeung Bae ^a   Shin, Jang Woo ^a   Kang, Ji Young ^a   Son, Chang Gue ^a   Kang, Weechang ^a   Lee, Hye Won ^b   Lee, Dong Soo ^c   Park, Yang Chun ^a   Cho, Jung Hyo ^a  

^a Daejeon University   (South Korea)

^b Korea Institute of Oriental Medicine (KIOM)   (South Korea)

^c Daejeon St Mary's Hospital   (South Korea)

Author keywords

Complementary and alternative medicine; Functional dyspepsia; Hyang Sa Pyeong Wi San; Quality of Life

Indexed keywords

CHINESE DRUG; HERBACEOUS AGENT; HYANGSA PYEONGWI SAN; PLACEBO; UNCLASSIFIED DRUG;

ABDOMINAL CRAMP; ABDOMINAL DISCOMFORT; ABDOMINAL PRESSURE; ADULT; AGED; ARTICLE; BITTER TASTE; BLOATING; BURNING SENSATION; CHINESE MEDICINE; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG HYPERSENSITIVITY; DYSPEPSIA; EPIGASTRIC FULLNESS; FEMALE; FOLLOW UP; FUNCTIONAL DYSPEPSIA QUALITY OF LIFE; HALITOSIS; HEARTBURN; HUMAN; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; NAMED INVENTORIES, QUESTIONNAIRES AND RATING SCALES; NAUSEA; NEPEAN DYSPEPSIA INDEX; QUALITY OF LIFE; QUANTITATIVE ANALYSIS; RANDOMIZED CONTROLLED TRIAL; THORAX PAIN; UPPER ABDOMINAL PAIN; URTICARIA; VOMITING; YOUNG ADULT;

COMPLEMENTARY AND ALTERNATIVE MEDICINE; FUNCTIONAL DYSPEPSIA; HYANG-SA-PYEONG-WI-SAN; QUALITY OF LIFE;

ADULT; AGED; DOUBLE-BLIND METHOD; DYSPEPSIA; FEMALE; HUMANS; MALE; MEDICINE, EAST ASIAN TRADITIONAL; MIDDLE AGED; PHYTOTHERAPY; PLANT PREPARATIONS; QUALITY OF LIFE; YOUNG ADULT;

EID: 84891489933     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2013.10.033     Document Type: Article

References (34)

1. L. Agreus, K. Svardsudd, O. Nyren, and G. Tibblin Irritable bowel syndrome and dyspepsia in the general population: overlap and lack of stability over time Gastroenterology 109 1995 671 680
2. M. Camilleri, B. Coulie, and J.F. Tack Visceral hypersensitivity: facts, speculations, and challenges Gut 48 2001 125 131
3. J.H. Cho Review on effects of hyangsapyeongwisan in gastrointestinal diseases Korean J. Orient. Physiol. Pathol. 4 2010 22 25
4. H.M. Choi, and S.W. Lim The effects of Hyangsapyeongwisan on gastric mucosal lesions induced by indomethacin Korean J. Orient. Intern. Med. 25 2004 518 528
5. P. Enck, B. Horing, K. Weimer, and S. Klosterhalfen Placebo responses and placebo effects infunctional bowel disorders Eur. J. Gastroenterol. Hepatol. 24 2012 1 8
6. B.F. Filipovic, T. Randjelovic, T. Ille, O. Markovic, B. Milovanovic, N. Kovacevic, and B.R. Filipovic Anxiety, personality traits and quality of life in functional dyspepsia-suffering patients Eur. J. Intern. Med. 24 2013 83 86
7. F. Froehlich, J.J. Gonvers, V. Wietlisbach, B. Burnand, P. Hildebrand, C. Schneider, E. Saraga, C. Beglinger, and J.P. Vader Helicobacter pylori eradication treatment does not benefit patients with nonulcer dyspepsia Am. J. Gastroenterol. 96 2001 2329 2336
8. G. Holtmann, B. Adam, S. Haag, W. Collet, E. Grunewald, and T. Windeck Efficacy of artichoke leaf extract in the treatment of patients with functional dyspepsia: a six-week placebocontrolled,double-blind, multicentre trial Aliment. Pharmacol. Ther. 18 2003 1099 1105
9. G. Holtmann, J. Gschossmann, P. Mayr, and N.J. Talley A randomized placebo-controlled trial of simethicone and cisapride for the treatment of patients with functional dyspepsia Aliment. Pharmacol. Ther. 16 2002 1641 1648
10. W.H. Hu, and N.J. Talley Functional (non-ulcer) dyspepsia: unexplained but not unmanageable Med. J. Aust. 168 1998 507 512
11. M. Jones, and N.J. Talley Minimum clinically important difference for the Nepean Dyspepsia Index, a validated quality of life scale for functional dyspepsia Am. J. Gastroenterol. 104 2009 1483 1488
12. J.H. Kleibeuker, and J.C. Thijs Functional dyspepsia Curr. Opin. Gastroenterol. 20 2004 546 550
13. E.H. Lee, K.B. Hahm, J.H. Lee, J.J. Park, D.H. Lee, S.K. Kim, S.R. Choi, and S.T. Lee Development and validation of a functional dyspepsia-related quality of life (FD-QOL) scale in South Korea J. Gastroenterol. Hepatol. 21 2006 268 274
14. S.H. Lim, H.S. Yi, and J.Y. Moon Free radical scavenging activity of hyangsapyungwisan extract for herbal-acupuncture and protective effects against oxidative damage of HUVECs J. Meridian Acupoint 25 2008 113 130
15. P.L. Lu, S. Teich, C.D. Lorenzo, B. Skaggs, M. Alhajj, and H.M. Mousa Improvement of quality of life and symptoms after gastric electrical stimulation in children with functional dyspepsia Neurogastroenterol. Motil.: Off. J. Eur. Gastrointest. Motil. Soc. 2013
16. A. Madisch, S. Miehlke, and J. Labenz Management of functional dyspepsia: unsolved problems and new perspectives World J. Gastroenterol.: WJG 11 2005 6577 6581
17. A. Morris-Yates, N.J. Talley, P.M. Boyce, S. Nandurkar, and G. Andrews Evidence of a genetic contribution to functional bowel disorder Am. J. Gastroenterol. 93 1998 1311 1317
18. F. Musial, S. Klosterhalfen, and P. Enck Placebo responses in patients with gastrointestinaldisorders World J. Gastroenterol. 13 2007 3425 3429
19. K.R. Raveendra, Jayachandra, V. Srinivasa, K.R. Sushma, J.J. Allan, K.S. Goudar, H.N. Shivaprasad, K. Venkateshwarlu, P. Geetharani, G. Sushma, and A. Agarwal An extract of Glycyrrhiza glabra (GutGard) alleviates symptoms of functional dyspepsia: a randomized, double-blind, placebo-controlled study Evid.-Based Complement. Altern. Med.: eCAM 2012 2012 216970
20. W.D. Rees, L.J. Miller, and J.R. Malagelada Dyspepsia, antral motor dysfunction, and gastric stasis of solids Gastroenterology 78 1980 360 365
21. Y. Shaib, and H.B. El-Serag The prevalence and risk factors of functional dyspepsia in a multiethnic population in the United States Am. J. Gastroenterol. 99 2004 2210 2216
22. R. Spector, and E.S. Vesell Pharmacology and statistics: recommendations to strengthen a productive partnership Pharmacology 78 2006 113 122
23. J. Tack, and K.J. Lee Pathophysiology and treatment of functional dyspepsia J. Clin. Gastroenterol. 39 2005 S211 S216
24. J. Tack, N.J. Talley, M. Camilleri, G. Holtmann, P. Hu, J.R. Malagelada, and V. Stanghellini Functional gastroduodenal disorders Gastroenterology 130 2006 1466 1479
25. N.J. Talley Non-ulcer dyspepsia: myths and realities Aliment. Pharmacol. Ther. 5 Suppl. 1 1991 145 162
26. N.J. Talley Spectrum of chronic dyspepsia in the presence of the irritable bowel syndrome Scand. J. Gastroenterol. 182 Suppl. 1991 7 10
27. N.J. Talley Scope of the problem of functional digestive disorders Eur. J. Surg.: Acta Chir. 582 Suppl. 1998 35 41
28. N.J. Talley, M. Haque, J.W. Wyeth, N.H. Stace, G.N. Tytgat, V. Stanghellini, G. Holtmann, M. Verlinden, and M. Jones Development of a new dyspepsia impact scale: the Nepean Dyspepsia Index Aliment. Pharmacol. Ther. 13 1999 225 235
29. N.J. Talley, G.R. Locke 3rd, L.M. Herrick, V.M. Silvernail, C.M. Prather, B.E. Lacy, J.K. DiBaise, C.W. Howden, D.M. Brenner, E.P. Bouras, H.B. El-Serag, B.P. Abraham, P. Moayyedi, and A.R. Zinsmeister Functional dyspepsia treatment trial (FDTT): a double-blind,randomized, placebo-controlled trial of antidepressants in functional dyspepsia, evaluating symptoms, psychopathology, pathophysiology and pharmacogenetics Contemp. Clin. Trials 33 2012 523 533
30. N.J. Talley, V. Meineche-Schmidt, P. Pare, M. Duckworth, P. Raisanen, A. Pap, H. Kordecki, and V. Schmid Efficacy of omeprazole in functional dyspepsia: double-blind, randomized, placebo-controlled trials (the Bond and Opera studies) Aliment. Pharmacol. Ther. 12 1998 1055 1065
31. N.J. Talley, V. Stanghellini, R.C. Heading, K.L. Koch, J.R. Malagelada, and G.N. Tytgat Functional gastroduodenal disorders Gut 45 Suppl. 2 1999 II37 II42
32. J. Thompson Coon, and E. Ernst Systematic review: herbal medicinal products for non-ulcer dyspepsia Aliment. Pharmacol. Ther. 16 2002 1689 1699
33. UNESCO, 2009. http://www.unesco.org/new/en/communication-and-information/ flagship-project-activities/memory-of-the-world/register/.
34. H. Zheng, X. Tian, Y. Li, F.R. Liang, S.G. Yu, X.G. Liu, Y. Tang, X.G. Yang, J. Yan, G.J. Sun, X.R. Chang, H.X. Zhang, T.T. Ma, and S.Y. Yu Acupuncture as a treatment for functional dyspepsia: design and methods of a randomized controlled trial Trials 10 2009 10 75