Taking the STING out of cytosolic DNA sensing

Trends in Immunology

Volumn 35, Issue 1, 2014, Pages 1-2

  Diner, Elie J ^a   Vance, Russell E ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; DOUBLE STRANDED DNA;

AUTOIMMUNE DISEASE; AUTOPHAGY; CYTOSOL; DNA BINDING; GENE; SHORT SURVEY; STIMULATOR OF INTERFERON GENE;

HUMANS; IMMUNITY, INNATE; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MEMBRANE PROTEINS; PROTEIN-SERINE-THREONINE KINASES; SIGNAL TRANSDUCTION;

EID: 84891373738     PISSN: 14714906     EISSN: 14714981     Source Type: Journal    
DOI: 10.1016/j.it.2013.10.011     Document Type: Short Survey

References (8)

1. Sun L., et al. Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway. Science 2013, 339:786-791.
2. Wu J., et al. Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA. Science 2013, 339:826-830.
3. Ablasser A., et al. Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP. Nature 2013, 10.1038/nature12640.
4. Ahn J., et al. STING manifests self DNA-dependent inflammatory disease. Proc. Natl. Acad. Sci. U.S.A. 2012, 109:19386-19391.
5. Gall A., et al. Autoimmunity initiates in nonhematopoietic cells and progresses via lymphocytes in an interferon-dependent autoimmune disease. Immunity 2012, 36:120-131.
6. Konno H., et al. Cyclic dinucleotides trigger ULK1 (ATG1) phosphorylation of STING to prevent sustained innate immune signaling. Cell 2013, 10.1016/j.cell.2013.09.049.
7. Saitoh T., et al. Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response. Proc. Natl. Acad. Sci. U.S.A. 2009, 106:20842-20846.
8. Tanaka Y., Chen Z.J. STING specifies IRF3 phosphorylation by TBK1 in the cytosolic DNA signaling pathway. Sci. signal. 2012, 5:ra20.