-
1
-
-
84886429265
-
Push back to respond better: Regulatory inhibition of the DNA double-strand break response
-
Panier S, Durocher D (2013) Push back to respond better: Regulatory inhibition of the DNA double-strand break response. Nat Rev Mol Cell Biol 14(10): 661-672.
-
(2013)
Nat Rev Mol Cell Biol
, vol.14
, Issue.10
, pp. 661-672
-
-
Panier, S.1
Durocher, D.2
-
2
-
-
36749029369
-
RIDDLE immunodeficiency syndrome is linked to defects in 53BP1-mediated DNA damage signaling
-
Stewart GS, et al. (2007) RIDDLE immunodeficiency syndrome is linked to defects in 53BP1-mediated DNA damage signaling. Proc Natl Acad Sci USA 104(43): 16910-16915.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, Issue.43
, pp. 16910-16915
-
-
Stewart, G.S.1
-
3
-
-
59049103900
-
The RIDDLE syndrome protein mediates a ubiquitindependent signaling cascade at sites of DNA damage
-
Stewart GS, et al. (2009) The RIDDLE syndrome protein mediates a ubiquitindependent signaling cascade at sites of DNA damage. Cell 136(3): 420-434.
-
(2009)
Cell
, vol.136
, Issue.3
, pp. 420-434
-
-
Stewart, G.S.1
-
4
-
-
80051717220
-
Homozygous deficiency of ubiquitin-ligase ring-finger protein RNF168 mimics the radiosensitivity syndrome of ataxia-telangiectasia
-
Devgan SS, et al. (2011) Homozygous deficiency of ubiquitin-ligase ring-finger protein RNF168 mimics the radiosensitivity syndrome of ataxia-telangiectasia. Cell Death Differ 18(9): 1500-1506.
-
(2011)
Cell Death Differ
, vol.18
, Issue.9
, pp. 1500-1506
-
-
Devgan, S.S.1
-
5
-
-
59049091728
-
RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins
-
Doil C, et al. (2009) RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins. Cell 136(3): 435-446.
-
(2009)
Cell
, vol.136
, Issue.3
, pp. 435-446
-
-
Doil, C.1
-
6
-
-
78751682842
-
UMI, a novel RNF168 ubiquitin binding domain involved in the DNA damage signaling pathway
-
Pinato S, Gatti M, Scandiuzzi C, Confalonieri S, Penengo L (2011) UMI, a novel RNF168 ubiquitin binding domain involved in the DNA damage signaling pathway. Mol Cell Biol 31(1): 118-126.
-
(2011)
Mol Cell Biol
, vol.31
, Issue.1
, pp. 118-126
-
-
Pinato, S.1
Gatti, M.2
Scandiuzzi, C.3
Confalonieri, S.4
Penengo, L.5
-
7
-
-
84866388311
-
RNF168 ubiquitinates K13-15 on H2A/H2AX to drive DNA damage signaling
-
Mattiroli F, et al. (2012) RNF168 ubiquitinates K13-15 on H2A/H2AX to drive DNA damage signaling. Cell 150(6): 1182-1195.
-
(2012)
Cell
, vol.150
, Issue.6
, pp. 1182-1195
-
-
Mattiroli, F.1
-
8
-
-
74049095565
-
MRE11-RAD50-NBS1 complex dictates DNA repair independent of H2AX
-
Yuan J, Chen J (2010) MRE11-RAD50-NBS1 complex dictates DNA repair independent of H2AX. J Biol Chem 285(2): 1097-1104.
-
(2010)
J Biol Chem
, vol.285
, Issue.2
, pp. 1097-1104
-
-
Yuan, J.1
Chen, J.2
-
9
-
-
0037711771
-
Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks
-
Celeste A, et al. (2003) Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks. Nat Cell Biol 5(7): 675-679.
-
(2003)
Nat Cell Biol
, vol.5
, Issue.7
, pp. 675-679
-
-
Celeste, A.1
-
10
-
-
33646117239
-
Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks
-
Bekker-Jensen S, et al. (2006) Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks. J Cell Biol 173(2): 195-206.
-
(2006)
J Cell Biol
, vol.173
, Issue.2
, pp. 195-206
-
-
Bekker-Jensen, S.1
-
11
-
-
77952318450
-
Rnf8 deficiency impairs class switch recombination, spermatogenesis, and genomic integrity and predisposes for cancer
-
Li L, et al. (2010) Rnf8 deficiency impairs class switch recombination, spermatogenesis, and genomic integrity and predisposes for cancer. J Exp Med 207(5): 983-997.
-
(2010)
J Exp Med
, vol.207
, Issue.5
, pp. 983-997
-
-
Li, L.1
-
12
-
-
79955627875
-
Genomic instability, defective spermatogenesis, immunodeficiency, and cancer in a mouse model of the RIDDLE syndrome
-
Bohgaki T, et al. (2011) Genomic instability, defective spermatogenesis, immunodeficiency, and cancer in a mouse model of the RIDDLE syndrome. PLoS Genet 7(4): e1001381.
-
(2011)
PLoS Genet
, vol.7
, Issue.4
-
-
Bohgaki, T.1
-
13
-
-
57049124828
-
53BP1 facilitates long-range DNA end-joining during v (D)J recombination
-
Difilippantonio S, et al. (2008) 53BP1 facilitates long-range DNA end-joining during V (D)J recombination. Nature 456(7221): 529-533.
-
(2008)
Nature
, vol.456
, Issue.7221
, pp. 529-533
-
-
Difilippantonio, S.1
-
14
-
-
79955502009
-
Regulation of DNA end joining, resection, and immunoglobulin class switch recombination by 53BP1
-
Bothmer A, et al. (2011) Regulation of DNA end joining, resection, and immunoglobulin class switch recombination by 53BP1. Mol Cell 42(3): 319-329.
-
(2011)
Mol Cell
, vol.42
, Issue.3
, pp. 319-329
-
-
Bothmer, A.1
-
15
-
-
77952294873
-
Class switching and meiotic defects in mice lacking the E3 ubiquitin ligase RNF8
-
Santos MA, et al. (2010) Class switching and meiotic defects in mice lacking the E3 ubiquitin ligase RNF8. J Exp Med 207(5): 973-981.
-
(2010)
J Exp Med
, vol.207
, Issue.5
, pp. 973-981
-
-
Santos, M.A.1
-
16
-
-
33845666681
-
Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair
-
Botuyan MV, et al. (2006) Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair. Cell 127(7): 1361-1373.
-
(2006)
Cell
, vol.127
, Issue.7
, pp. 1361-1373
-
-
Botuyan, M.V.1
-
17
-
-
79551665780
-
MMSET regulates histone H4K20 methylation and 53BP1 accumulation at DNA damage sites
-
Pei H, et al. (2011) MMSET regulates histone H4K20 methylation and 53BP1 accumulation at DNA damage sites. Nature 470(7332): 124-128.
-
(2011)
Nature
, vol.470
, Issue.7332
, pp. 124-128
-
-
Pei, H.1
-
18
-
-
0141815630
-
Potential role for 53BP1 in DNA end-joining repair through direct interaction with DNA
-
Iwabuchi K, et al. (2003) Potential role for 53BP1 in DNA end-joining repair through direct interaction with DNA. J Biol Chem 278(38): 36487-36495.
-
(2003)
J Biol Chem
, vol.278
, Issue.38
, pp. 36487-36495
-
-
Iwabuchi, K.1
-
19
-
-
0037468192
-
MDC1 is a mediator of the mammalian DNA damage checkpoint
-
Stewart GS, Wang B, Bignell CR, Taylor AM, Elledge SJ (2003) MDC1 is a mediator of the mammalian DNA damage checkpoint. Nature 421(6926): 961-966.
-
(2003)
Nature
, vol.421
, Issue.6926
, pp. 961-966
-
-
Stewart, G.S.1
Wang, B.2
Bignell, C.R.3
Taylor, A.M.4
Elledge, S.J.5
-
20
-
-
0141780833
-
NFBD1/MDC1 regulates ionizing radiation-induced focus formation by DNA checkpoint signaling and repair factors
-
Xu X, Stern DF (2003) NFBD1/MDC1 regulates ionizing radiation-induced focus formation by DNA checkpoint signaling and repair factors. FASEB J 17(13):1842- 1848.
-
(2003)
FASEB J
, vol.17
, Issue.13
, pp. 1842-1848
-
-
Xu, X.1
Stern, D.F.2
-
21
-
-
58649094213
-
The direct interaction between 53BP1 and MDC1 is required for the recruitment of 53BP1 to sites of damage
-
Eliezer Y, Argaman L, Rhie A, Doherty AJ, Goldberg M (2009) The direct interaction between 53BP1 and MDC1 is required for the recruitment of 53BP1 to sites of damage. J Biol Chem 284(1): 426-435.
-
(2009)
J Biol Chem
, vol.284
, Issue.1
, pp. 426-435
-
-
Eliezer, Y.1
Argaman, L.2
Rhie, A.3
Doherty, A.J.4
Goldberg, M.5
-
22
-
-
65549143757
-
RAD18 promotes DNA double-strand break repair during G1 phase through chromatin retention of 53BP1
-
Watanabe K, et al. (2009) RAD18 promotes DNA double-strand break repair during G1 phase through chromatin retention of 53BP1. Nucleic Acids Res 37(7): 2176-2193.
-
(2009)
Nucleic Acids Res
, vol.37
, Issue.7
, pp. 2176-2193
-
-
Watanabe, K.1
-
23
-
-
33748991453
-
Ubiquitin and ubiquitin-like proteins in cancer pathogenesis
-
Hoeller D, Hecker CM, Dikic I (2006) Ubiquitin and ubiquitin-like proteins in cancer pathogenesis. Nat Rev Cancer 6(10): 776-788.
-
(2006)
Nat Rev Cancer
, vol.6
, Issue.10
, pp. 776-788
-
-
Hoeller, D.1
Hecker, C.M.2
Dikic, I.3
-
24
-
-
59449094470
-
An oligomerized 53BP1 tudor domain suffices for recognition of DNA double-strand breaks
-
Zgheib O, Pataky K, Brugger J, Halazonetis TD (2009) An oligomerized 53BP1 tudor domain suffices for recognition of DNA double-strand breaks. Mol Cell Biol 29(4): 1050-1058.
-
(2009)
Mol Cell Biol
, vol.29
, Issue.4
, pp. 1050-1058
-
-
Zgheib, O.1
Pataky, K.2
Brugger, J.3
Halazonetis, T.D.4
-
25
-
-
84859895529
-
RNF8- and RNF168-dependent degradation of KDM4A/ JMJD2A triggers 53BP1 recruitment to DNA damage sites
-
Mallette FA, et al. (2012) RNF8- and RNF168-dependent degradation of KDM4A/ JMJD2A triggers 53BP1 recruitment to DNA damage sites. EMBO J 31(8): 1865-1878.
-
(2012)
EMBO J
, vol.31
, Issue.8
, pp. 1865-1878
-
-
Mallette, F.A.1
-
26
-
-
9244251125
-
Cell-cycle checkpoints and cancer
-
Kastan MB, Bartek J (2004) Cell-cycle checkpoints and cancer. Nature 432(7015): 316-323.
-
(2004)
Nature
, vol.432
, Issue.7015
, pp. 316-323
-
-
Kastan, M.B.1
Bartek, J.2
-
27
-
-
0037378527
-
P53 Binding protein 53BP1 is required for DNA damage responses and tumor suppression in mice
-
Ward IM, Minn K, van Deursen J, Chen J (2003) p53 Binding protein 53BP1 is required for DNA damage responses and tumor suppression in mice. Mol Cell Biol 23(7): 2556-2563.
-
(2003)
Mol Cell Biol
, vol.23
, Issue.7
, pp. 2556-2563
-
-
Ward, I.M.1
Minn, K.2
Van Deursen, J.3
Chen, J.4
-
28
-
-
37349096996
-
Distinct roles of chromatin-associated proteins MDC1 and 53BP1 in mammalian double-strand break repair
-
Xie A, et al. (2007) Distinct roles of chromatin-associated proteins MDC1 and 53BP1 in mammalian double-strand break repair. Mol Cell 28(6): 1045-1057.
-
(2007)
Mol Cell
, vol.28
, Issue.6
, pp. 1045-1057
-
-
Xie, A.1
-
29
-
-
57049132043
-
53BP1 promotes non-homologous end joining of telomeres by increasing chromatin mobility
-
Dimitrova N, Chen YC, Spector DL, de Lange T (2008) 53BP1 promotes non-homologous end joining of telomeres by increasing chromatin mobility. Nature 456(7221): 524-528.
-
(2008)
Nature
, vol.456
, Issue.7221
, pp. 524-528
-
-
Dimitrova, N.1
Chen, Y.C.2
Spector, D.L.3
De Lange, T.4
-
30
-
-
77951057068
-
53BP1 regulates DNA resection and the choice between classical and alternative end joining during class switch recombination
-
Bothmer A, et al. (2010) 53BP1 regulates DNA resection and the choice between classical and alternative end joining during class switch recombination. J Exp Med 207(4): 855-865.
-
(2010)
J Exp Med
, vol.207
, Issue.4
, pp. 855-865
-
-
Bothmer, A.1
-
31
-
-
77953291328
-
53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers
-
Bouwman P, et al. (2010) 53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers. Nat Struct Mol Biol 17(6): 688-695.
-
(2010)
Nat Struct Mol Biol
, vol.17
, Issue.6
, pp. 688-695
-
-
Bouwman, P.1
-
32
-
-
77950958141
-
53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks
-
Bunting SF, et al. (2010) 53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks. Cell 141(2): 243-254.
-
(2010)
Cell
, vol.141
, Issue.2
, pp. 243-254
-
-
Bunting, S.F.1
-
33
-
-
2542463148
-
53BP1 is required for class switch recombination
-
Ward IM, et al. (2004) 53BP1 is required for class switch recombination. J Cell Biol 165(4): 459-464.
-
(2004)
J Cell Biol
, vol.165
, Issue.4
, pp. 459-464
-
-
Ward, I.M.1
-
34
-
-
77951980886
-
Differential requirement for H2AX and 53BP1 in organismal development and genome maintenance in the absence of poly(ADP)ribosyl polymerase 1
-
Orsburn B, et al. (2010) Differential requirement for H2AX and 53BP1 in organismal development and genome maintenance in the absence of poly(ADP)ribosyl polymerase 1. Mol Cell Biol 30(10): 2341-2352.
-
(2010)
Mol Cell Biol
, vol.30
, Issue.10
, pp. 2341-2352
-
-
Orsburn, B.1
-
35
-
-
0037112212
-
53BP1, a mediator of the DNA damage checkpoint
-
Wang B, Matsuoka S, Carpenter PB, Elledge SJ (2002) 53BP1, a mediator of the DNA damage checkpoint. Science 298(5597): 1435-1438.
-
(2002)
Science
, vol.298
, Issue.5597
, pp. 1435-1438
-
-
Wang, B.1
Matsuoka, S.2
Carpenter, P.B.3
Elledge, S.J.4
-
36
-
-
4344660051
-
Effect of Ku86 and DNA-PKcs deficiency on non-homologous end-joining and homologous recombination using a transient transfection assay
-
Secretan MB, et al. (2004) Effect of Ku86 and DNA-PKcs deficiency on non-homologous end-joining and homologous recombination using a transient transfection assay. Mutat Res 554(1-2): 351-364.
-
(2004)
Mutat Res
, vol.554
, Issue.1-2
, pp. 351-364
-
-
Secretan, M.B.1
-
37
-
-
67650477223
-
DNA repair by homologous recombination, but not by nonhomologous end joining, is elevated in breast cancer cells
-
Mao Z, Jiang Y, Liu X, Seluanov A, Gorbunova V (2009) DNA repair by homologous recombination, but not by nonhomologous end joining, is elevated in breast cancer cells. Neoplasia 11(7): 683-691.
-
(2009)
Neoplasia
, vol.11
, Issue.7
, pp. 683-691
-
-
Mao, Z.1
Jiang, Y.2
Liu, X.3
Seluanov, A.4
Gorbunova, V.5
-
38
-
-
0033569684
-
XRCC3 promotes homologydirected repair of DNA damage in mammalian cells
-
Pierce AJ, Johnson RD, Thompson LH, Jasin M (1999) XRCC3 promotes homologydirected repair of DNA damage in mammalian cells. Genes Dev 13(20): 2633-2638.
-
(1999)
Genes Dev
, vol.13
, Issue.20
, pp. 2633-2638
-
-
Pierce, A.J.1
Johnson, R.D.2
Thompson, L.H.3
Jasin, M.4
-
39
-
-
35548978945
-
The impact of a negligent G2/M checkpoint on genomic instability and cancer induction
-
Löbrich M, Jeggo PA (2007) The impact of a negligent G2/M checkpoint on genomic instability and cancer induction. Nat Rev Cancer 7(11): 861-869.
-
(2007)
Nat Rev Cancer
, vol.7
, Issue.11
, pp. 861-869
-
-
Löbrich, M.1
Jeggo, P.A.2
-
40
-
-
2442707746
-
53BP1 links DNA damage-response pathways to immunoglobulin heavy chain class-switch recombination
-
Manis JP, et al. (2004) 53BP1 links DNA damage-response pathways to immunoglobulin heavy chain class-switch recombination. Nat Immunol 5(5): 481-487.
-
(2004)
Nat Immunol
, vol.5
, Issue.5
, pp. 481-487
-
-
Manis, J.P.1
-
41
-
-
3342915628
-
Mdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retention
-
Lukas C, et al. (2004) Mdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retention. EMBO J 23(13): 2674-2683.
-
(2004)
EMBO J
, vol.23
, Issue.13
, pp. 2674-2683
-
-
Lukas, C.1
-
42
-
-
30744465308
-
MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals
-
Lou Z, et al. (2006) MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals. Mol Cell 21(2): 187-200.
-
(2006)
Mol Cell
, vol.21
, Issue.2
, pp. 187-200
-
-
Lou, Z.1
-
43
-
-
80052697814
-
The ubiquitin- and SUMO-dependent signaling response to DNA double-strand breaks
-
Bekker-Jensen S, Mailand N (2011) The ubiquitin- and SUMO-dependent signaling response to DNA double-strand breaks. FEBS Lett 585(18): 2914-2919.
-
(2011)
FEBS Lett
, vol.585
, Issue.18
, pp. 2914-2919
-
-
Bekker-Jensen, S.1
Mailand, N.2
-
44
-
-
84879888213
-
53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark
-
Fradet-Turcotte A, et al. (2013) 53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark. Nature 499(7456): 50-54.
-
(2013)
Nature
, vol.499
, Issue.7456
, pp. 50-54
-
-
Fradet-Turcotte, A.1
-
45
-
-
82955233157
-
The AAA-ATPase VCP/p97 promotes 53BP1 recruitment by removing L3MBTL1 from DNA double-strand breaks
-
Acs K, et al. (2011) The AAA-ATPase VCP/p97 promotes 53BP1 recruitment by removing L3MBTL1 from DNA double-strand breaks. Nat Struct Mol Biol 18(12): 1345-1350.
-
(2011)
Nat Struct Mol Biol
, vol.18
, Issue.12
, pp. 1345-1350
-
-
Acs, K.1
-
46
-
-
67349168142
-
RAD18 transmits DNA damage signalling to elicit homologous recombination repair
-
Huang J, et al. (2009) RAD18 transmits DNA damage signalling to elicit homologous recombination repair. Nat Cell Biol 11(5): 592-603.
-
(2009)
Nat Cell Biol
, vol.11
, Issue.5
, pp. 592-603
-
-
Huang, J.1
|