Treatment considerations for HIV-infected individuals with severe mental illness

Current HIV/AIDS Reports

Volumn 10, Issue 4, 2013, Pages 371-379

  Blank, Michael B ^a   Himelhoch, Seth ^b   Walkup, James ^c   Eisenberg, Marlene M ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^c RUTGERS UNIVERSITY   (United States)

Author keywords

Anxiety disorder; Bipolar disorder; Depression; Drug drug interactions; HIV; PATH+; PTSD; Schizophrenia; Severe mental illness; Substance abuse; Syndemics; Treatment guidelines; Triply diagnosed

Indexed keywords

BENZODIAZEPINE DERIVATIVE; HERBACEOUS AGENT; METHADONE; NON PRESCRIPTION DRUG; NONNUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR; PROTEINASE INHIBITOR;

ADVANCED PRACTICE NURSE; ANXIETY DISORDER; ARTICLE; BIPOLAR DISORDER; DRUG MONITORING; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MAJOR DEPRESSION; MENTAL DISEASE; NURSE; PATHOPHYSIOLOGY; POSTTRAUMATIC STRESS DISORDER; PRACTICE GUIDELINE; QUALITY OF LIFE; SCHIZOPHRENIA; SUBSTANCE ABUSE;

ANTI-RETROVIRAL AGENTS; ANTIDEPRESSIVE AGENTS; ANTIPSYCHOTIC AGENTS; DRUG THERAPY, COMBINATION; HIV INFECTIONS; HUMANS; MENTAL DISORDERS; PRACTICE GUIDELINES AS TOPIC;

EID: 84891149830     PISSN: 15483568     EISSN: 15483576     Source Type: Journal    
DOI: 10.1007/s11904-013-0179-3     Document Type: Article

References (52)

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52. Blank M, Hennessy M, Eisenberg M. Increasing Quality of Life and Reducing HIV Burden: The PATH+ Intervention. AIDS & Behavior. 2013 Sep 3. [Epub ahead of print]. The heightened risk of persons with a serious mental illness (SMI) to contract and transmit human immunodeficiency virus is a public health problem. In order to test the effectiveness of a community-based advanced practice nurses intervention to promote adherence to HIV and psychiatric treatment regimens, 238 HIV-positive participants who also were in treatment for a serious mental illness were randomized to an nurse led intervention, Preventing AIDS Through Health for Positives (PATH+), or treatment-as-usual. The study examined viral load and CD4 count at baseline, 12 and 24 months, and health-related quality of life measures (SF-12 Mental and Physical Health) at baseline, 3, 6, 12, and 24 months. Participants were followed for 12 months after PATH ended in order to examine any radiating effects of decay of the intervention. Latent growth curve model using three data points for biomarkers (baseline, 12 & 24 months) and five data points for health related quality of life (baseline, 3, 6, 12, & 24 months) shows moderate to excellent fit for modeling changes in CD4, viral load, and mental SF-12 subscales. This project demonstrates the effectiveness of PATH+ and its community-based, individually-tailored intervention cascade, to improve outcomes of individuals with HIV/SMI. With appropriate support, persons with SMI and HIV can successfully adhere to treatment and achieve improvements in health-related quality of life and biomarker health status indicators.