-
1
-
-
84871818807
-
A phase II study of conventional radiation therapy and thalidomide for supratentorial, newly-diagnosed glioblastoma (RTOG 9806)
-
Alexander, B. M., Wang, M., Yung, W. K., Fine, H. A., Donahue, B. A., Tremont, I. W., et al. (2013). A phase II study of conventional radiation therapy and thalidomide for supratentorial, newly-diagnosed glioblastoma (RTOG 9806). J. Neurooncol. 111, 33-39.
-
(2013)
J. Neurooncol.
, vol.111
, pp. 33-39
-
-
Alexander, B.M.1
Wang, M.2
Yung, W.K.3
Fine, H.A.4
Donahue, B.A.5
Tremont, I.W.6
-
2
-
-
84859373470
-
Activation of alternative pathways of angiogenesis and involvement of stem cells following anti-angiogenesis treatment in glioma
-
Arbab, A. S. (2012). Activation of alternative pathways of angiogenesis and involvement of stem cells following anti-angiogenesis treatment in glioma. Histol. Histopathol. 27, 549-557.
-
(2012)
Histol. Histopathol.
, vol.27
, pp. 549-557
-
-
Arbab, A.S.1
-
3
-
-
80051590039
-
Preclinical characterization of OSI-027, a potent and selective inhibitor of mTORC1 and mTORC2: distinct from rapamycin
-
Bhagwat, S. V., Gokhale, P. C., Crew, A. P., Cooke, A., Yao, Y., Mantis, C., et al. (2011). Preclinical characterization of OSI-027, a potent and selective inhibitor of mTORC1 and mTORC2: distinct from rapamycin. Mol. Cancer Ther. 10, 1394-1406.
-
(2011)
Mol. Cancer Ther.
, vol.10
, pp. 1394-1406
-
-
Bhagwat, S.V.1
Gokhale, P.C.2
Crew, A.P.3
Cooke, A.4
Yao, Y.5
Mantis, C.6
-
4
-
-
79960681594
-
Anti-angiogenic therapy in glioma
-
Butowski, N. (2011). Anti-angiogenic therapy in glioma. Clin. Transl. Oncol. 13, 294-300.
-
(2011)
Clin. Transl. Oncol.
, vol.13
, pp. 294-300
-
-
Butowski, N.1
-
5
-
-
79959795786
-
Improved survival with vemurafenib in melanoma with BRAF V600E mutation
-
Chapman, P. B., Hauschild, A., Robert, C., Haanen, J. B., Ascierto, P., Larkin, J., et al. (2011). Improved survival with vemurafenib in melanoma with BRAF V600E mutation. N. Engl. J. Med. 364, 2507-2516.
-
(2011)
N. Engl. J. Med.
, vol.364
, pp. 2507-2516
-
-
Chapman, P.B.1
Hauschild, A.2
Robert, C.3
Haanen, J.B.4
Ascierto, P.5
Larkin, J.6
-
6
-
-
84861203795
-
Bevacizumab and irinotecan in children with recurrent or refractory brain tumors: toxicity and efficacy trends
-
Couec, M. L., André, N., Thebaud, E., Minckes, O., Rialland, X., Corradini, N., et al. (2012). Bevacizumab and irinotecan in children with recurrent or refractory brain tumors: toxicity and efficacy trends. Pediatr. Blood Cancer 59, 34-38.
-
(2012)
Pediatr. Blood Cancer
, vol.59
, pp. 34-38
-
-
Couec, M.L.1
André, N.2
Thebaud, E.3
Minckes, O.4
Rialland, X.5
Corradini, N.6
-
7
-
-
84891077836
-
Survival advantage with Everolimus (RAD001) combined with a selective BRAFV600E Inhibitor in a Xenograft Model of BRAFV600E-mutated Pediatric Glioma
-
Dasgupta, T., Olow, A., Yang, X., Nicolaides, T., and Haas-Kogan, D. A. (2013). Survival advantage with Everolimus (RAD001) combined with a selective BRAFV600E Inhibitor in a Xenograft Model of BRAFV600E-mutated Pediatric Glioma. Oncology 27(Suppl. 1), 1.
-
(2013)
Oncology
, vol.27
, Issue.SUPPL. 1
, pp. 1
-
-
Dasgupta, T.1
Olow, A.2
Yang, X.3
Nicolaides, T.4
Haas-Kogan, D.A.5
-
8
-
-
84886746361
-
Survival advantage with radiation combined with a selective BRAFV600E inhibitor in an orthotopic, intracranial model of BRAFV600E-mutated high-grade gliomas
-
Dasgupta, T., Yang, X., Hashizume, R., Olow, A., Kolkowitz, I., Weiss, W., et al. (2012). Survival advantage with radiation combined with a selective BRAFV600E inhibitor in an orthotopic, intracranial model of BRAFV600E-mutated high-grade gliomas. Int. J. Radiat. Oncol. Biol. Phys. 83(Suppl. 3), S125.
-
(2012)
Int. J. Radiat. Oncol. Biol. Phys.
, vol.83
, Issue.SUPPL. 3
-
-
Dasgupta, T.1
Yang, X.2
Hashizume, R.3
Olow, A.4
Kolkowitz, I.5
Weiss, W.6
-
9
-
-
77949264282
-
Microvascular leakage and contrast enhancement as prognostic factors for recurrence in unfavorable low-grade gliomas
-
Dhermain, F., Saliou, G., Parker, F., Page, P., Hoang-Xuan, K., Lacroix, C., et al. (2010). Microvascular leakage and contrast enhancement as prognostic factors for recurrence in unfavorable low-grade gliomas. J. Neurooncol. 97, 81-88.
-
(2010)
J. Neurooncol.
, vol.97
, pp. 81-88
-
-
Dhermain, F.1
Saliou, G.2
Parker, F.3
Page, P.4
Hoang-Xuan, K.5
Lacroix, C.6
-
10
-
-
84867539766
-
Efficacy of the novel dual PI3-kinase/mTOR inhibitor NVP-BEZ235 in a preclinical model of adrenocortical carcinoma
-
Doghman, M., and Lalli, E. (2012). Efficacy of the novel dual PI3-kinase/mTOR inhibitor NVP-BEZ235 in a preclinical model of adrenocortical carcinoma. Mol. Cell. Endocrinol. 364, 101-104.
-
(2012)
Mol. Cell. Endocrinol.
, vol.364
, pp. 101-104
-
-
Doghman, M.1
Lalli, E.2
-
11
-
-
78149467927
-
Activating mutations in BRAF characterize a spectrum of pediatric low-grade gliomas
-
Dougherty, M. J., Santi, M., Brose, M. S., Ma, C., Resnick, A. C., Sievert, A. J., et al. (2010). Activating mutations in BRAF characterize a spectrum of pediatric low-grade gliomas. Neuro-oncology 12, 621-630.
-
(2010)
Neuro-oncology
, vol.12
, pp. 621-630
-
-
Dougherty, M.J.1
Santi, M.2
Brose, M.S.3
Ma, C.4
Resnick, A.C.5
Sievert, A.J.6
-
12
-
-
79960983264
-
Phase I and pharmacokinetic study of sunitinib in pediatric patients with refractory solid tumors: a children's oncology group study
-
Dubois, S. G., Shusterman, S., Ingle, A. M., Ahern, C. H., Reid, J. M., Wu, B., et al. (2011). Phase I and pharmacokinetic study of sunitinib in pediatric patients with refractory solid tumors: a children's oncology group study. Clin. Cancer Res. 17, 5113-5122.
-
(2011)
Clin. Cancer Res.
, vol.17
, pp. 5113-5122
-
-
Dubois, S.G.1
Shusterman, S.2
Ingle, A.M.3
Ahern, C.H.4
Reid, J.M.5
Wu, B.6
-
13
-
-
0036094711
-
Dysregulation of PTEN and protein kinase B is associated with glioma histology and patient survival
-
Ermoian, R. P., Furniss, C. S., Lamborn, K. R., Basila, D., Berger, M. S., Gottschalk, A. R., et al. (2002). Dysregulation of PTEN and protein kinase B is associated with glioma histology and patient survival. Clin. Cancer Res. 8, 1100-1106.
-
(2002)
Clin. Cancer Res.
, vol.8
, pp. 1100-1106
-
-
Ermoian, R.P.1
Furniss, C.S.2
Lamborn, K.R.3
Basila, D.4
Berger, M.S.5
Gottschalk, A.R.6
-
14
-
-
84861083983
-
Dabrafenib in patients with melanoma, untreated brain metastases, and other solid tumours: a phase I dose-escalation trial
-
Falchook, G. S., Long, G. V., Kurzrock, R., Kim, K. B., Arkenau, T. H., Brown, M. P., et al. (2012). Dabrafenib in patients with melanoma, untreated brain metastases, and other solid tumours: a phase I dose-escalation trial. Lancet 379, 1893-1901.
-
(2012)
Lancet
, vol.379
, pp. 1893-1901
-
-
Falchook, G.S.1
Long, G.V.2
Kurzrock, R.3
Kim, K.B.4
Arkenau, T.H.5
Brown, M.P.6
-
15
-
-
84862528335
-
Targeting mTOR pathways in human malignancies
-
Fasolo, A., and Sessa, C. (2012). Targeting mTOR pathways in human malignancies. Curr. Pharm. Des. 18, 2766-2777.
-
(2012)
Curr. Pharm. Des.
, vol.18
, pp. 2766-2777
-
-
Fasolo, A.1
Sessa, C.2
-
16
-
-
37249075870
-
A phase I trial of lenalidomide in patients with recurrent primary central nervous system tumors
-
Fine, H. A., Kim, L., Albert, P. S., Duic, J. P., Ma, H., Zhang, W., et al. (2007). A phase I trial of lenalidomide in patients with recurrent primary central nervous system tumors. Clin. Cancer Res. 13, 7101-7106.
-
(2007)
Clin. Cancer Res.
, vol.13
, pp. 7101-7106
-
-
Fine, H.A.1
Kim, L.2
Albert, P.S.3
Duic, J.P.4
Ma, H.5
Zhang, W.6
-
17
-
-
0034470391
-
Descriptive analysis and quantification of angiogenesis in human brain tumors
-
Folkerth, R. D. (2000). Descriptive analysis and quantification of angiogenesis in human brain tumors. J. Neurooncol. 50, 165-172.
-
(2000)
J. Neurooncol.
, vol.50
, pp. 165-172
-
-
Folkerth, R.D.1
-
18
-
-
63149084589
-
p53-Mediated inhibition of angiogenesis in diffuse low-grade astrocytomas
-
Gaiser, T., Becker, M. R., Meyer, J., Habel, A., and Siegelin, M. D. (2009). p53-Mediated inhibition of angiogenesis in diffuse low-grade astrocytomas. Neurochem. Int. 54, 458-463.
-
(2009)
Neurochem. Int.
, vol.54
, pp. 458-463
-
-
Gaiser, T.1
Becker, M.R.2
Meyer, J.3
Habel, A.4
Siegelin, M.D.5
-
19
-
-
84863321033
-
Puduvalli VK, phase 2 trial of irinotecan and thalidomide in adults with recurrent anaplastic glioma
-
Giglio, P., Dhamne, M., Hess, K. R., Gilbert, M. R., Groves, M. D., Levin, V. A., et al. (2012). Puduvalli VK, phase 2 trial of irinotecan and thalidomide in adults with recurrent anaplastic glioma. Cancer 118, 3599-3606.
-
(2012)
Cancer
, vol.118
, pp. 3599-3606
-
-
Giglio, P.1
Dhamne, M.2
Hess, K.R.3
Gilbert, M.R.4
Groves, M.D.5
Levin, V.A.6
-
20
-
-
78650148102
-
A phase I factorial design study of dose-dense temozolomide alone and in combination with thalidomide, isotretinoin, and/or celecoxib as postchemoradiation adjuvant therapy for newly diagnosed glioblastoma
-
Gilbert, M. R., Gonzalez, J., Hunter, K., Hess, K., Giglio, P., Chang, E., et al. (2010). A phase I factorial design study of dose-dense temozolomide alone and in combination with thalidomide, isotretinoin, and/or celecoxib as postchemoradiation adjuvant therapy for newly diagnosed glioblastoma. Neuro-oncology 12, 1167-1172.
-
(2010)
Neuro-oncology
, vol.12
, pp. 1167-1172
-
-
Gilbert, M.R.1
Gonzalez, J.2
Hunter, K.3
Hess, K.4
Giglio, P.5
Chang, E.6
-
21
-
-
84861721417
-
Differences in molecular genetics between pediatric and adult malignant astrocytomas: age matters
-
Gilheeney, S. W., and Kieran, M. W. (2012). Differences in molecular genetics between pediatric and adult malignant astrocytomas: age matters. Future Oncol. 8, 549-558.
-
(2012)
Future Oncol.
, vol.8
, pp. 549-558
-
-
Gilheeney, S.W.1
Kieran, M.W.2
-
22
-
-
84891046866
-
Imaging parameters and molecular correlates as predictive markers of treatment response to mTOR inhibitor in adults with recurrent low-grade gliomas
-
Washington.
-
Haas-Kogan, D. A., Phillips, J. J., Molinaro, A., Wahl, M., Mueller, S., Weiss, W. A., et al. (2013). "Imaging parameters and molecular correlates as predictive markers of treatment response to mTOR inhibitor in adults with recurrent low-grade gliomas," in American Association for Cancer Research (AACR), Washington.
-
(2013)
American Association for Cancer Research (AACR)
-
-
Haas-Kogan, D.A.1
Phillips, J.J.2
Molinaro, A.3
Wahl, M.4
Mueller, S.5
Weiss, W.A.6
-
23
-
-
84864285704
-
Dabrafenib in BRAF-mutated metastatic melanoma: a multicentre, open-label, phase 3 randomised controlled trial
-
Hauschild, A., Grob, J. J., Demidov, L. V., Jouary, T., Gutzmer, R., Millward, M., et al. (2012). Dabrafenib in BRAF-mutated metastatic melanoma: a multicentre, open-label, phase 3 randomised controlled trial. Lancet 380, 358-365.
-
(2012)
Lancet
, vol.380
, pp. 358-365
-
-
Hauschild, A.1
Grob, J.J.2
Demidov, L.V.3
Jouary, T.4
Gutzmer, R.5
Millward, M.6
-
24
-
-
79960388615
-
BRAF-KIAA1549 fusion predicts better clinical outcome in pediatric low-grade astrocytoma
-
Hawkins, C., Walker, E., Mohamed, N., Zhang, C., Jacob, K., Shirinian, M., et al. (2011). BRAF-KIAA1549 fusion predicts better clinical outcome in pediatric low-grade astrocytoma. Clin. Cancer Res. 17, 4790-4798.
-
(2011)
Clin. Cancer Res.
, vol.17
, pp. 4790-4798
-
-
Hawkins, C.1
Walker, E.2
Mohamed, N.3
Zhang, C.4
Jacob, K.5
Shirinian, M.6
-
25
-
-
84862703623
-
The PP242 mammalian target of rapamycin (mTOR) inhibitor activates extracellular signal-regulated kinase (ERK) in multiple myeloma cells via a target of rapamycin complex 1 (TORC1)/eukaryotic translation initiation factor 4E (eIF-4E)/RAF pathway and activation is a mechanism of resistance
-
Hoang, B., Benavides, A., Shi, Y., Yang, Y., Frost, P., Gera, J., et al. (2012). The PP242 mammalian target of rapamycin (mTOR) inhibitor activates extracellular signal-regulated kinase (ERK) in multiple myeloma cells via a target of rapamycin complex 1 (TORC1)/eukaryotic translation initiation factor 4E (eIF-4E)/RAF pathway and activation is a mechanism of resistance. J. Biol. Chem. 287, 21796-21805.
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 21796-21805
-
-
Hoang, B.1
Benavides, A.2
Shi, Y.3
Yang, Y.4
Frost, P.5
Gera, J.6
-
26
-
-
77953020697
-
Association of molecular alterations, including BRAF, with biology and outcome in pilocytic astrocytomas
-
Horbinski, C., Hamilton, R. L., Nikiforov, Y., and Pollack, I. F. (2010). Association of molecular alterations, including BRAF, with biology and outcome in pilocytic astrocytomas. Acta Neuropathol. 119, 641-649.
-
(2010)
Acta Neuropathol.
, vol.119
, pp. 641-649
-
-
Horbinski, C.1
Hamilton, R.L.2
Nikiforov, Y.3
Pollack, I.F.4
-
27
-
-
84862193195
-
Interplay among BRAF, p16, p53, and MIB1 in pediatric low-grade gliomas
-
Horbinski, C., Nikiforova, M. N., Hagenkord, J. M., Hamilton, R. L., and Pollack, I. F. (2012). Interplay among BRAF, p16, p53, and MIB1 in pediatric low-grade gliomas. Neuro-oncology 14, 777-789.
-
(2012)
Neuro-oncology
, vol.14
, pp. 777-789
-
-
Horbinski, C.1
Nikiforova, M.N.2
Hagenkord, J.M.3
Hamilton, R.L.4
Pollack, I.F.5
-
28
-
-
84862840727
-
BRAF alterations are frequent in cerebellar low-grade astrocytomas with diffuse growth pattern
-
Ida, C. M., Lambert, S. R., Rodriguez, F. J., Voss, J. S., Mc Cann, B. E., Seys, A. R., et al. (2012). BRAF alterations are frequent in cerebellar low-grade astrocytomas with diffuse growth pattern. J. Neuropathol. Exp. Neurol. 71, 631-639.
-
(2012)
J. Neuropathol. Exp. Neurol.
, vol.71
, pp. 631-639
-
-
Ida, C.M.1
Lambert, S.R.2
Rodriguez, F.J.3
Voss, J.S.4
Mc Cann, B.E.5
Seys, A.R.6
-
29
-
-
84873819555
-
Which drug, and when, for patients with BRAF-mutant melanoma?
-
Jang, S., and Atkins, M. B. (2013). Which drug, and when, for patients with BRAF-mutant melanoma? Lancet Oncol. 14, e60-e69.
-
(2013)
Lancet Oncol.
, vol.14
-
-
Jang, S.1
Atkins, M.B.2
-
30
-
-
0032005359
-
Growth factor-mediated angiogenesis in the malignant progression of glial tumors: a review
-
discussion 196
-
Jensen, R. L. (1998). Growth factor-mediated angiogenesis in the malignant progression of glial tumors: a review. Surg. Neurol. 49, 189-195; discussion 196.
-
(1998)
Surg. Neurol.
, vol.49
, pp. 189-195
-
-
Jensen, R.L.1
-
31
-
-
79955081038
-
Phenotypic variations in NF1-associated low grade astrocytomas: possible role for increased mTOR activation in a subset
-
Jentoft, M., Giannini, C., Cen, L., Scheithauer, B. W., Hoesley, B., Sarkaria, J. N., et al. (2010). Phenotypic variations in NF1-associated low grade astrocytomas: possible role for increased mTOR activation in a subset. Int. J. Clin. Exp. Pathol. 4, 43-57.
-
(2010)
Int. J. Clin. Exp. Pathol.
, vol.4
, pp. 43-57
-
-
Jentoft, M.1
Giannini, C.2
Cen, L.3
Scheithauer, B.W.4
Hoesley, B.5
Sarkaria, J.N.6
-
33
-
-
84870506967
-
Pediatric glioma-associated KIAA1549:BRAF expression regulates neuroglial cell growth in a cell type-specific and mTOR-dependent manner
-
Kaul, A., Chen, Y. H., Emnett, R. J., Dahiya, S., and Gutmann, D. H. (2012). Pediatric glioma-associated KIAA1549:BRAF expression regulates neuroglial cell growth in a cell type-specific and mTOR-dependent manner. Genes Dev. 26, 2561-2566.
-
(2012)
Genes Dev.
, vol.26
, pp. 2561-2566
-
-
Kaul, A.1
Chen, Y.H.2
Emnett, R.J.3
Dahiya, S.4
Gutmann, D.H.5
-
34
-
-
55849093794
-
Phase II study of temozolomide, thalidomide, and celecoxib for newly diagnosed glioblastoma in adults
-
Kesari, S., Schiff, D., Henson, J. W., Muzikansky, A., Gigas, D. C., Doherty, L., et al. (2008). Phase II study of temozolomide, thalidomide, and celecoxib for newly diagnosed glioblastoma in adults. Neuro-oncology 10, 300-308.
-
(2008)
Neuro-oncology
, vol.10
, pp. 300-308
-
-
Kesari, S.1
Schiff, D.2
Henson, J.W.3
Muzikansky, A.4
Gigas, D.C.5
Doherty, L.6
-
35
-
-
79952188499
-
A prospective study of temozolomide plus thalidomide during and after radiation therapy for pediatric diffuse pontine gliomas: preliminary results of the Korean Society for Pediatric Neuro-Oncology study
-
Kim, C. Y., Kim, S. K., Phi, J. H., Lee, M. M., Kim, I. A., Kim, I. H., et al. (2010). A prospective study of temozolomide plus thalidomide during and after radiation therapy for pediatric diffuse pontine gliomas: preliminary results of the Korean Society for Pediatric Neuro-Oncology study. J. Neurooncol. 100, 193-198.
-
(2010)
J. Neurooncol.
, vol.100
, pp. 193-198
-
-
Kim, C.Y.1
Kim, S.K.2
Phi, J.H.3
Lee, M.M.4
Kim, I.A.5
Kim, I.H.6
-
36
-
-
78049510428
-
Everolimus for subependymal giant-cell astrocytomas in tuberous sclerosis
-
Krueger, D. A., Care, M. M., Holland, K., Agricola, K., Tudor, C., Mangeshkar, P., et al. (2010). Everolimus for subependymal giant-cell astrocytomas in tuberous sclerosis. N. Engl. J. Med. 363, 1801-1811.
-
(2010)
N. Engl. J. Med.
, vol.363
, pp. 1801-1811
-
-
Krueger, D.A.1
Care, M.M.2
Holland, K.3
Agricola, K.4
Tudor, C.5
Mangeshkar, P.6
-
37
-
-
84858990965
-
Thalidomide: an old drug with new action
-
Kumar, V., and Chhibber, S. (2011). Thalidomide: an old drug with new action. J. Chemother. 23, 326-334.
-
(2011)
J. Chemother.
, vol.23
, pp. 326-334
-
-
Kumar, V.1
Chhibber, S.2
-
38
-
-
84891079236
-
Development of pediatric glioma models for BRAF-targeted therapy
-
Lang, S.-S., Sievert, A. L., Boucher, K. L., Madsen, P. J., Slaunwhite, E., Brewington, D., et al. (2012). Development of pediatric glioma models for BRAF-targeted therapy. Neurosurgery 71, E575.
-
(2012)
Neurosurgery
, vol.71
-
-
Lang, S.-S.1
Sievert, A.L.2
Boucher, K.L.3
Madsen, P.J.4
Slaunwhite, E.5
Brewington, D.6
-
39
-
-
84859778293
-
mTOR signaling in growth control and disease
-
Laplante, M., and Sabatini, D. M. (2012). mTOR signaling in growth control and disease. Cell 149, 274-293.
-
(2012)
Cell
, vol.149
, pp. 274-293
-
-
Laplante, M.1
Sabatini, D.M.2
-
40
-
-
0030059969
-
Microvessel density is a prognostic indicator for patients with astroglial brain tumors
-
Leon, S. P., Folkert, R. D., and Black, P. M. (1996). Microvessel density is a prognostic indicator for patients with astroglial brain tumors. Cancer 77, 362-372.
-
(1996)
Cancer
, vol.77
, pp. 362-372
-
-
Leon, S.P.1
Folkert, R.D.2
Black, P.M.3
-
41
-
-
84655167688
-
BRAF alterations in primary glial and glioneuronal neoplasms of the central nervous system with identification of 2 novel KIAA1549:BRAF fusion variants
-
Lin, A., Rodriguez, F. J., Karajannis, M. A., Williams, S. C., Legault, G., Zagzag, D., et al. (2012). BRAF alterations in primary glial and glioneuronal neoplasms of the central nervous system with identification of 2 novel KIAA1549:BRAF fusion variants. J. Neuropathol. Exp. Neurol. 71, 66-72.
-
(2012)
J. Neuropathol. Exp. Neurol.
, vol.71
, pp. 66-72
-
-
Lin, A.1
Rodriguez, F.J.2
Karajannis, M.A.3
Williams, S.C.4
Legault, G.5
Zagzag, D.6
-
42
-
-
84868120907
-
Dabrafenib in patients with Val600Glu or Val600Lys BRAF-mutant melanoma metastatic to the brain (BREAK-MB): a multicentre, open-label, phase 2 trial
-
Long, G. V., Trefzer, U., Davies, M. A., Kefford, R. F., Ascierto, P. A., Chapman, P. B., et al. (2012). Dabrafenib in patients with Val600Glu or Val600Lys BRAF-mutant melanoma metastatic to the brain (BREAK-MB): a multicentre, open-label, phase 2 trial. Lancet Oncol. 13, 1087-1095.
-
(2012)
Lancet Oncol.
, vol.13
, pp. 1087-1095
-
-
Long, G.V.1
Trefzer, U.2
Davies, M.A.3
Kefford, R.F.4
Ascierto, P.A.5
Chapman, P.B.6
-
43
-
-
84862555221
-
Relation between bevacizumab dose intensity and high-grade glioma survival: a retrospective study in two large cohorts
-
Lorgis, V., Maura, G., Coppa, G., Hassani, K., Taillandierm, L., Chauffert, B., et al. (2012). Relation between bevacizumab dose intensity and high-grade glioma survival: a retrospective study in two large cohorts. J. Neurooncol. 107, 351-358.
-
(2012)
J. Neurooncol.
, vol.107
, pp. 351-358
-
-
Lorgis, V.1
Maura, G.2
Coppa, G.3
Hassani, K.4
Taillandierm, L.5
Chauffert, B.6
-
44
-
-
84869505566
-
Phase I pharmacokinetic and pharmacodynamic study of the pan-PI3K/mTORC vascular targeted pro-drug SF1126 in patients with advanced solid tumours and B-cell malignancies
-
Mahadevan, D., Chiorean, E. G., Harris, W. B., Von Hoff, D. D., Stejskal-Barnett, A., Qi, W., et al. (2012). Phase I pharmacokinetic and pharmacodynamic study of the pan-PI3K/mTORC vascular targeted pro-drug SF1126 in patients with advanced solid tumours and B-cell malignancies. Eur. J. Cancer. 48, 3319-3327.
-
(2012)
Eur. J. Cancer.
, vol.48
, pp. 3319-3327
-
-
Mahadevan, D.1
Chiorean, E.G.2
Harris, W.B.3
Von Hoff, D.D.4
Stejskal-Barnett, A.5
Qi, W.6
-
45
-
-
34250788809
-
AKT/PKB signaling: navigating downstream
-
Manning, B. D., and Cantley, L. C. (2007). AKT/PKB signaling: navigating downstream. Cell 129, 1261-1274.
-
(2007)
Cell
, vol.129
, pp. 1261-1274
-
-
Manning, B.D.1
Cantley, L.C.2
-
46
-
-
34447335394
-
A randomized, double-blind, placebo-controlled trial of lenalidomide in the treatment of moderately severe active Crohn's disease
-
Mansfield, J. C., Parkes, M., Hawthorne, A. B., Forbes, A., Probert, C. S., Perowne, R. C., et al. (2007). A randomized, double-blind, placebo-controlled trial of lenalidomide in the treatment of moderately severe active Crohn's disease. Aliment. Pharmacol. Ther. 26, 421-430.
-
(2007)
Aliment. Pharmacol. Ther.
, vol.26
, pp. 421-430
-
-
Mansfield, J.C.1
Parkes, M.2
Hawthorne, A.B.3
Forbes, A.4
Probert, C.S.5
Perowne, R.C.6
-
47
-
-
77949265515
-
Activation of PI3K/mTOR pathway occurs in most adult low-grade gliomas and predicts patient survival
-
McBride, S. M., Perez, D. A., Polley, M. Y., Vandenberg, S. R., Smith, J. S., Zheng, S., et al. (2010). Activation of PI3K/mTOR pathway occurs in most adult low-grade gliomas and predicts patient survival. J. Neurooncol. 97, 33-40.
-
(2010)
J. Neurooncol.
, vol.97
, pp. 33-40
-
-
McBride, S.M.1
Perez, D.A.2
Polley, M.Y.3
Vandenberg, S.R.4
Smith, J.S.5
Zheng, S.6
-
48
-
-
84868628069
-
Mutations and deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascades which alter therapy response
-
McCubrey, J. A., Steelman, L. S., Chappell, W. H., Abrams, S. L., Montalto, G., Cervello, M., et al. (2012). Mutations and deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascades which alter therapy response. Oncotarget 3, 954-987.
-
(2012)
Oncotarget
, vol.3
, pp. 954-987
-
-
McCubrey, J.A.1
Steelman, L.S.2
Chappell, W.H.3
Abrams, S.L.4
Montalto, G.5
Cervello, M.6
-
49
-
-
84860295237
-
Clinical experience with thalidomide and lenalidomide in multiple myeloma
-
Moehler, T. (2012). Clinical experience with thalidomide and lenalidomide in multiple myeloma. Curr. Cancer Drug Targets 12, 372-390.
-
(2012)
Curr. Cancer Drug Targets
, vol.12
, pp. 372-390
-
-
Moehler, T.1
-
50
-
-
62549160588
-
First-in-class, first-in-human phase I results of targeted agents: highlights of the 2008 American society of clinical oncology meeting
-
Molckovsky, A., and Siu, L. L. (2008). First-in-class, first-in-human phase I results of targeted agents: highlights of the 2008 American society of clinical oncology meeting. J. Hematol. Oncol. 1, 20.
-
(2008)
J. Hematol. Oncol.
, vol.1
, pp. 20
-
-
Molckovsky, A.1
Siu, L.L.2
-
51
-
-
48649107474
-
Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled phase III trial
-
Motzer, R. J., Escudier, B., Oudard, S., Hutson, T. E., Porta, C., Bracarda, S., et al. (2008). Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled phase III trial. Lancet 372, 449-456.
-
(2008)
Lancet
, vol.372
, pp. 449-456
-
-
Motzer, R.J.1
Escudier, B.2
Oudard, S.3
Hutson, T.E.4
Porta, C.5
Bracarda, S.6
-
52
-
-
34147205832
-
Molecular pathogenesis of pediatric astrocytic tumors
-
Nakamura, M., Shimada, K., Ishida, E., Higuchi, T., Nakase, H., Sakaki, T., et al. (2007). Molecular pathogenesis of pediatric astrocytic tumors. Neuro-oncology 9, 113-123.
-
(2007)
Neuro-oncology
, vol.9
, pp. 113-123
-
-
Nakamura, M.1
Shimada, K.2
Ishida, E.3
Higuchi, T.4
Nakase, H.5
Sakaki, T.6
-
53
-
-
79951617158
-
A phase I safety and pharmacokinetic study of XL765 (SAR245409), a novel PI3K/TORC1/TORC2 inhibitor, in combination with temozolomide (TMZ) in patients (pts) with newly diagnosed malignant glioma
-
abstr
-
Nghiemphu, P. L., Omuro, A. M., Cloughesy, T., Mellinghoff, I. K., Norden, A. D., Nguyen, L. T., et al. (2010). A phase I safety and pharmacokinetic study of XL765 (SAR245409), a novel PI3K/TORC1/TORC2 inhibitor, in combination with temozolomide (TMZ) in patients (pts) with newly diagnosed malignant glioma. J. Clin. Oncol. 28, abstr. 3085.
-
(2010)
J. Clin. Oncol.
, vol.28
, pp. 3085
-
-
Nghiemphu, P.L.1
Omuro, A.M.2
Cloughesy, T.3
Mellinghoff, I.K.4
Norden, A.D.5
Nguyen, L.T.6
-
54
-
-
84055212088
-
Targeted therapy for BRAFV600E malignant astrocytoma
-
Nicolaides, T. P., Li, H., Solomon, D. A., Hariono, S., Hashizume, R., Barkovich, K., et al. (2011). Targeted therapy for BRAFV600E malignant astrocytoma. Clin. Cancer Res. 17, 7595-7604.
-
(2011)
Clin. Cancer Res.
, vol.17
, pp. 7595-7604
-
-
Nicolaides, T.P.1
Li, H.2
Solomon, D.A.3
Hariono, S.4
Hashizume, R.5
Barkovich, K.6
-
55
-
-
79959781204
-
Treatment of children with recurrent high grade gliomas with a bevacizumab containing regimen
-
Parekh, C., Jubran, R., Erdreich-Epstein, A., Panigrahy, A., Bluml, S., Finlay, J., et al. (2011). Treatment of children with recurrent high grade gliomas with a bevacizumab containing regimen. J. Neurooncol. 103, 673-680.
-
(2011)
J. Neurooncol.
, vol.103
, pp. 673-680
-
-
Parekh, C.1
Jubran, R.2
Erdreich-Epstein, A.3
Panigrahy, A.4
Bluml, S.5
Finlay, J.6
-
56
-
-
0023254170
-
Observations on the current treatment of low-grade astrocytic tumors of the cerebral hemispheres
-
Piepmeier, J. M. (1987). Observations on the current treatment of low-grade astrocytic tumors of the cerebral hemispheres. J. Neurosurg. 67, 177-181.
-
(1987)
J. Neurosurg.
, vol.67
, pp. 177-181
-
-
Piepmeier, J.M.1
-
57
-
-
84857675728
-
The mTOR signalling pathway in human cancer
-
Populo, H., Lopes, J. M., and Soares, P. (2012). The mTOR signalling pathway in human cancer. Int. J. Mol. Sci. 13, 1886-1918.
-
(2012)
Int. J. Mol. Sci.
, vol.13
, pp. 1886-1918
-
-
Populo, H.1
Lopes, J.M.2
Soares, P.3
-
58
-
-
84863230465
-
Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR
-
Prahallad, A., Sun, C., Huang, S., Di Nicolantonio, F., Salazar, R., Zecchin, D., et al. (2012). Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR. Nature 483, 100-103.
-
(2012)
Nature
, vol.483
, pp. 100-103
-
-
Prahallad, A.1
Sun, C.2
Huang, S.3
Di Nicolantonio, F.4
Salazar, R.5
Zecchin, D.6
-
59
-
-
79953052206
-
Inhibition of PI3K/mTOR pathways in glioblastoma and implications for combination therapy with temozolomide
-
Prasad, G., Sottero, T., Yang, X., Mueller, S., James, C. D., Weiss, W. A., et al. (2011). Inhibition of PI3K/mTOR pathways in glioblastoma and implications for combination therapy with temozolomide. Neuro-oncology 13, 384-392.
-
(2011)
Neuro-oncology
, vol.13
, pp. 384-392
-
-
Prasad, G.1
Sottero, T.2
Yang, X.3
Mueller, S.4
James, C.D.5
Weiss, W.A.6
-
60
-
-
77953201344
-
Expression of KIT receptor tyrosine kinase in endothelial cells of juvenile brain tumors
-
Puputti, M., Tynninen, O., Pernilä, P., Salmi, M., Jalkanen, S., Paetau, A., et al. (2010). Expression of KIT receptor tyrosine kinase in endothelial cells of juvenile brain tumors. Brain Pathol. 20, 763-770.
-
(2010)
Brain Pathol.
, vol.20
, pp. 763-770
-
-
Puputti, M.1
Tynninen, O.2
Pernilä, P.3
Salmi, M.4
Jalkanen, S.5
Paetau, A.6
-
61
-
-
34247171422
-
Temozolomide and thalidomide in the treatment of glioblastoma multiforme
-
Riva, M., Imbesi, F., Beghi, E., Galli, C., Citterio, A., Trapani, P., et al. (2007). Temozolomide and thalidomide in the treatment of glioblastoma multiforme. Anticancer Res. 27, 1067-1071.
-
(2007)
Anticancer Res.
, vol.27
, pp. 1067-1071
-
-
Riva, M.1
Imbesi, F.2
Beghi, E.3
Galli, C.4
Citterio, A.5
Trapani, P.6
-
62
-
-
79954447261
-
PI3K/AKT pathway alterations are associated with clinically aggressive and histologically anaplastic subsets of pilocytic astrocytoma
-
Rodriguez, E. F., Scheithauer, B. W., Giannini, C., Rynearson, A., Cen, L., Hoesley, B., et al. (2011). PI3K/AKT pathway alterations are associated with clinically aggressive and histologically anaplastic subsets of pilocytic astrocytoma. Acta Neuropathol. 121, 407-420.
-
(2011)
Acta Neuropathol.
, vol.121
, pp. 407-420
-
-
Rodriguez, E.F.1
Scheithauer, B.W.2
Giannini, C.3
Rynearson, A.4
Cen, L.5
Hoesley, B.6
-
63
-
-
84857036020
-
A phase II trial of thalidomide and procarbazine in adult patients with recurrent or progressive malignant gliomas
-
Ruiz, J., Case, D., Enevold, G., Rosdhal, R., Tatter, S. B., Ellis, T. L., et al. (2012). A phase II trial of thalidomide and procarbazine in adult patients with recurrent or progressive malignant gliomas. J. Neurooncol. 106, 611-617.
-
(2012)
J. Neurooncol.
, vol.106
, pp. 611-617
-
-
Ruiz, J.1
Case, D.2
Enevold, G.3
Rosdhal, R.4
Tatter, S.B.5
Ellis, T.L.6
-
64
-
-
84876098212
-
Brainstem ganglioglioma successfully treated with vemurafenib
-
Rush, S., Foreman, N., and Liu, A. (2013). Brainstem ganglioglioma successfully treated with vemurafenib. J. Clin. Oncol. 31, e159-e160.
-
(2013)
J. Clin. Oncol.
, vol.31
-
-
Rush, S.1
Foreman, N.2
Liu, A.3
-
65
-
-
84869235067
-
Targeting the PI3K pathway in the brain-efficacy of a PI3K inhibitor optimized to cross the blood-brain barrier
-
Salphati, L., Heffron, T. P., Alicke, B., Nishimura, M., Barck, K., Carano, R. A., et al. (2012). Targeting the PI3K pathway in the brain-efficacy of a PI3K inhibitor optimized to cross the blood-brain barrier. Clin. Cancer Res. 18, 6239-6248.
-
(2012)
Clin. Cancer Res.
, vol.18
, pp. 6239-6248
-
-
Salphati, L.1
Heffron, T.P.2
Alicke, B.3
Nishimura, M.4
Barck, K.5
Carano, R.A.6
-
66
-
-
82255186836
-
Temsirolimus in the treatment of relapsed or refractory mantle cell lymphoma
-
Samad, N., and Younes, A. (2010). Temsirolimus in the treatment of relapsed or refractory mantle cell lymphoma. Onco Targets Ther. 3, 167-178.
-
(2010)
Onco Targets Ther.
, vol.3
, pp. 167-178
-
-
Samad, N.1
Younes, A.2
-
67
-
-
76549137130
-
Oncogenic BRAF mutation with CDKN2A inactivation is characteristic of a subset of pediatric malignant astrocytomas
-
Schiffman, J. D., Hodgson, J. G., VandenBerg, S. R., Flaherty, P., Polley, M. Y., Yu, M., et al. (2010). Oncogenic BRAF mutation with CDKN2A inactivation is characteristic of a subset of pediatric malignant astrocytomas. Cancer Res. 70, 512-519.
-
(2010)
Cancer Res.
, vol.70
, pp. 512-519
-
-
Schiffman, J.D.1
Hodgson, J.G.2
VandenBerg, S.R.3
Flaherty, P.4
Polley, M.Y.5
Yu, M.6
-
68
-
-
79954441895
-
Analysis of BRAF V600E mutation in 1,320 nervous system tumors reveals high mutation frequencies in pleomorphic xanthoastrocytoma, ganglioglioma and extra-cerebellar pilocytic astrocytoma
-
Schindler, G., Capper, D., Meyer, J., Janzarik, W., Omran, H., Herold-Mende, C., et al. (2011). Analysis of BRAF V600E mutation in 1,320 nervous system tumors reveals high mutation frequencies in pleomorphic xanthoastrocytoma, ganglioglioma and extra-cerebellar pilocytic astrocytoma. Acta Neuropathol. 121, 397-405.
-
(2011)
Acta Neuropathol.
, vol.121
, pp. 397-405
-
-
Schindler, G.1
Capper, D.2
Meyer, J.3
Janzarik, W.4
Omran, H.5
Herold-Mende, C.6
-
70
-
-
84876571810
-
Thalidomide-analogue biology: immunological, molecular and epigenetic targets in cancer therapy
-
doi:10.1038/onc.2012.599
-
Shortt, J., Hsu, A. K., and Johnstone, R. W. (2013). Thalidomide-analogue biology: immunological, molecular and epigenetic targets in cancer therapy. Oncogene. doi:10.1038/onc.2012.599
-
(2013)
Oncogene
-
-
Shortt, J.1
Hsu, A.K.2
Johnstone, R.W.3
-
71
-
-
78349242122
-
Tumour vasculature and angiogenic profile of paediatric pilocytic astrocytoma; is it much different from glioblastoma?
-
Sie, M., de Bont, E. S., Scherpen, F. J., Hoving, E. W., and den Dunnen, W. F. (2010). Tumour vasculature and angiogenic profile of paediatric pilocytic astrocytoma; is it much different from glioblastoma? Neuropathol. Appl. Neurobiol. 36, 636-647.
-
(2010)
Neuropathol. Appl. Neurobiol.
, vol.36
, pp. 636-647
-
-
Sie, M.1
de Bont, E.S.2
Scherpen, F.J.3
Hoving, E.W.4
den Dunnen, W.F.5
-
72
-
-
20044366163
-
Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma
-
Stupp, R., Mason, W. P., van den Bent, M. J., Weller, M., Fisher, B., Taphoorn, M. J., et al. (2005). Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N. Engl. J. Med. 352, 987-996.
-
(2005)
N. Engl. J. Med.
, vol.352
, pp. 987-996
-
-
Stupp, R.1
Mason, W.P.2
van den Bent, M.J.3
Weller, M.4
Fisher, B.5
Taphoorn, M.J.6
-
73
-
-
84858592194
-
The role of avastin in the management of recurrent glioblastoma
-
Sweet, J. A., Feinberg, M. L., and Sherman, J. H. (2012). The role of avastin in the management of recurrent glioblastoma. Neurosurg. Clin. N. Am. 23, 331-341, x.
-
(2012)
Neurosurg. Clin. N. Am. x
, vol.23
, pp. 331-341
-
-
Sweet, J.A.1
Feinberg, M.L.2
Sherman, J.H.3
-
74
-
-
82955249323
-
Detection of KIAA1549-BRAF fusion transcripts in formalin-fixed paraffin-embedded pediatric low-grade gliomas
-
Tian, Y., Rich, B. E., Vena, N., Craig, J. M., Macconaill, L. E., Rajaram, V., et al. (2011). Detection of KIAA1549-BRAF fusion transcripts in formalin-fixed paraffin-embedded pediatric low-grade gliomas. J. Mol. Diagn. 13, 669-677.
-
(2011)
J. Mol. Diagn.
, vol.13
, pp. 669-677
-
-
Tian, Y.1
Rich, B.E.2
Vena, N.3
Craig, J.M.4
Macconaill, L.E.5
Rajaram, V.6
-
75
-
-
33846992324
-
Phase II study of thalidomide and radiation in children with newly diagnosed brain stem gliomas and glioblastoma multiforme
-
Turner, C. D., Chi, S., Marcus, K. J., MacDonald, T., Packer, R. J., Poussaint, T. Y., et al. (2007). Phase II study of thalidomide and radiation in children with newly diagnosed brain stem gliomas and glioblastoma multiforme. J. Neurooncol. 82, 95-101.
-
(2007)
J. Neurooncol.
, vol.82
, pp. 95-101
-
-
Turner, C.D.1
Chi, S.2
Marcus, K.J.3
MacDonald, T.4
Packer, R.J.5
Poussaint, T.Y.6
-
76
-
-
33846503808
-
Role of PI3-K/Akt pathway and its effect on glial cell line-derived neurotrophic factor in midbrain dopamine cells
-
Wang, H. J., Cao, J. P., Yu, J. K., and Gao, D. S. (2007). Role of PI3-K/Akt pathway and its effect on glial cell line-derived neurotrophic factor in midbrain dopamine cells. Acta Pharmacol. Sin. 28, 166-172.
-
(2007)
Acta Pharmacol. Sin.
, vol.28
, pp. 166-172
-
-
Wang, H.J.1
Cao, J.P.2
Yu, J.K.3
Gao, D.S.4
-
77
-
-
79951986245
-
Phase I trial of lenalidomide in pediatric patients with recurrent, refractory, or progressive primary CNS tumors: Pediatric Brain Tumor Consortium study PBTC-018
-
Warren, K. E., Goldman, S., Pollack, I. F., Fangusaro, J., Schaiquevich, P., Stewart, C. F., et al. (2011). Phase I trial of lenalidomide in pediatric patients with recurrent, refractory, or progressive primary CNS tumors: Pediatric Brain Tumor Consortium study PBTC-018. J. Clin. Oncol. 29, 324-329.
-
(2011)
J. Clin. Oncol.
, vol.29
, pp. 324-329
-
-
Warren, K.E.1
Goldman, S.2
Pollack, I.F.3
Fangusaro, J.4
Schaiquevich, P.5
Stewart, C.F.6
-
78
-
-
79961131151
-
Patterns of progression in malignant glioma following anti-VEGF therapy: perceptions and evidence
-
Wick, W., Wick, A., Weiler, M., and Weller, M. (2011). Patterns of progression in malignant glioma following anti-VEGF therapy: perceptions and evidence. Curr. Neurol. Neurosci. Rep. 11, 305-312.
-
(2011)
Curr. Neurol. Neurosci. Rep.
, vol.11
, pp. 305-312
-
-
Wick, W.1
Wick, A.2
Weiler, M.3
Weller, M.4
|