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Volumn , Issue , 2009, Pages 483-502

Antibodies and the Blood-Brain Barrier

Author keywords

Antibodies and blood brain barrier; Intrinsic antibody transport at BBB; Noninvasive modes for improving antibody delivery

Indexed keywords


EID: 84891003599     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9780470485408.ch21     Document Type: Chapter
Times cited : (4)

References (136)
  • 1
    • 0036319335 scopus 로고    scopus 로고
    • Astrocyte-endothelial interactions and blood-brain barrier permeability
    • Abbott, N.J. 2002. Astrocyte-endothelial interactions and blood-brain barrier permeability. J. Anat. 200(6):629-638.
    • (2002) J. Anat , vol.200 , Issue.6 , pp. 629-638
    • Abbott, N.J.1
  • 2
    • 29244463365 scopus 로고    scopus 로고
    • Astrocyte-endothelial interactions at the blood-brain barrier
    • Abbott, N.J., L. Ronnback, and E. Hansson. 2006. Astrocyte-endothelial interactions at the blood-brain barrier. Nature Rev. Neurosci. 7(1):41-53.
    • (2006) Nature Rev. Neurosci , vol.7 , Issue.1 , pp. 41-53
    • Abbott, N.J.1    Ronnback, L.2    Hansson, E.3
  • 3
    • 28244432240 scopus 로고    scopus 로고
    • The blood-brain barrier transmigrating single domain antibody: Mechanisms of transport and antigenic epitopes in human brain endothelial cells
    • Abulrob, A., H. Sprong, P. Henegouwen, and D. Stanimirovic. 2005. The blood-brain barrier transmigrating single domain antibody: Mechanisms of transport and antigenic epitopes in human brain endothelial cells. J. Neurochem. 95(4):1201-1214.
    • (2005) J. Neurochem , vol.95 , Issue.4 , pp. 1201-1214
    • Abulrob, A.1    Sprong, H.2    Henegouwen, P.3    Stanimirovic, D.4
  • 4
    • 0030993566 scopus 로고    scopus 로고
    • Delivery of loperamide across the blood-brain barrier with polysorbate 80-coated polybutylcyanoacrylate nanoparticles
    • Alyautdin, R.N., V.E. Petrov, K. Langer, A. Berthold, D.A. Kharkevich, and J. Kreuter. Delivery of loperamide across the blood-brain barrier with polysorbate 80-coated polybutylcyanoacrylate nanoparticles. Pharm. Res. 1997; 14(3):325-328.
    • (1997) Pharm. Res , vol.14 , Issue.3 , pp. 325-328
    • Alyautdin, R.N.1    Petrov, V.E.2    Langer, K.3    Berthold, A.4    Kharkevich, D.A.5    Kreuter, J.6
  • 5
    • 33645863163 scopus 로고    scopus 로고
    • Biodistribution of polysorbate 80-coated doxorubicin-loaded [C-14]-poly(butyl cyanoacrylate) nanoparticles after intravenous administration to glioblastoma-bearing rats
    • Ambruosi, A., A.S. Khalansky, H. Yamamoto, S.E. Gelperina, D.J. Begley, and J. Kreuter. 2006. Biodistribution of polysorbate 80-coated doxorubicin-loaded [C-14]-poly(butyl cyanoacrylate) nanoparticles after intravenous administration to glioblastoma-bearing rats. J. Drug Target. 14(2):97-105.
    • (2006) J. Drug Target , vol.14 , Issue.2 , pp. 97-105
    • Ambruosi, A.1    Khalansky, A.S.2    Yamamoto, H.3    Gelperina, S.E.4    Begley, D.J.5    Kreuter, J.6
  • 6
    • 30844462755 scopus 로고    scopus 로고
    • Body distribution of polysorbate-80 and doxorubicin-loaded [C-14]poly(butyl cyanoacrylate) nanoparticles after i.v. administration in rats. J
    • Ambruosi, A., H. Yamamoto, and J. Kreuter. 2005. Body distribution of polysorbate-80 and doxorubicin-loaded [C-14]poly(butyl cyanoacrylate) nanoparticles after i.v. administration in rats. J. Drug Target. 13(10):535-542.
    • (2005) Drug Target , vol.13 , Issue.10 , pp. 535-542
    • Ambruosi, A.1    Yamamoto, H.2    Kreuter, J.3
  • 7
    • 0023471290 scopus 로고
    • Astrocyte-mediated induction of tight junctions in brain capillary endothelium: An efficient in vitro model
    • Arthur, F.E., R.R. Shivers, and P.D. Bowman. 1987. Astrocyte-mediated induction of tight junctions in brain capillary endothelium: An efficient in vitro model. Dev. Brain Res. 36(1):155-159.
    • (1987) Dev. Brain Res , vol.36 , Issue.1 , pp. 155-159
    • Arthur, F.E.1    Shivers, R.R.2    Bowman, P.D.3
  • 8
    • 0033835996 scopus 로고    scopus 로고
    • Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease
    • Bard, F., C. Cannon, R. Barbour, et al. 2000. Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease. Nature Med. 6(8):916-919.
    • (2000) Nature Med , vol.6 , Issue.8 , pp. 916-919
    • Bard, F.1    Cannon, C.2    Barbour, R.3
  • 9
    • 0027594668 scopus 로고
    • Delivery of peptides and proteins through the blood-brain barrier
    • Bickel, U., T. Yoshikawa, and W.M. Pardridge. 1993. Delivery of peptides and proteins through the blood-brain barrier. Adv. Drug Deliv. Rev. 10(2-3):205-245.
    • (1993) Adv. Drug Deliv. Rev , vol.10 , Issue.2-3 , pp. 205-245
    • Bickel, U.1    Yoshikawa, T.2    Pardridge, W.M.3
  • 10
    • 0035292828 scopus 로고    scopus 로고
    • Delivery of peptides and proteins through the blood-brain barrier
    • Bickel, U., T. Yoshikawa, and W.M. Pardridge. 2001. Delivery of peptides and proteins through the blood-brain barrier. Adv. Drug Deliv. Rev. 46(1-3):247-279.
    • (2001) Adv. Drug Deliv. Rev , vol.46 , Issue.1-3 , pp. 247-279
    • Bickel, U.1    Yoshikawa, T.2    Pardridge, W.M.3
  • 11
    • 0030888267 scopus 로고    scopus 로고
    • Intracarotid infusion of RMP-7, a bradykinin analog, and transport of gallium-68 ethylenediamine tetraacetic acid into human gliomas
    • Black, K.L., T. Cloughesy, S.C. Huang, et al. 1997. Intracarotid infusion of RMP-7, a bradykinin analog, and transport of gallium-68 ethylenediamine tetraacetic acid into human gliomas. J. Neurosurg. 86(4):603-609.
    • (1997) J. Neurosurg , vol.86 , Issue.4 , pp. 603-609
    • Black, K.L.1    Cloughesy, T.2    Huang, S.C.3
  • 12
    • 0031763412 scopus 로고    scopus 로고
    • Drug delivery of antisense molecules to the brain for treatment of Alzheimer's disease and cerebral AIDS
    • Boado, R.J., H. Tsukamoto, and W.M. Pardridge. 1998. Drug delivery of antisense molecules to the brain for treatment of Alzheimer's disease and cerebral AIDS. J. Pharm. Sci. 87(11):1308-1315.
    • (1998) J. Pharm. Sci , vol.87 , Issue.11 , pp. 1308-1315
    • Boado, R.J.1    Tsukamoto, H.2    Pardridge, W.M.3
  • 13
    • 34547644135 scopus 로고    scopus 로고
    • Genetic engineering, expression, and activity of a fusion protein of a human neurotrophin and a molecular Trojan horse for delivery across the human blood-brain barrier
    • Boado, R.J., Y. Zhang, and W.M. Pardridge. 2007. Genetic engineering, expression, and activity of a fusion protein of a human neurotrophin and a molecular Trojan horse for delivery across the human blood-brain barrier. Biotechnol. Bioeng. 97(6):1376-1386.
    • (2007) Biotechnol. Bioeng , vol.97 , Issue.6 , pp. 1376-1386
    • Boado, R.J.1    Zhang, Y.2    Pardridge, W.M.3
  • 14
    • 33947686655 scopus 로고    scopus 로고
    • Fusion antibody for Alzheimer's disease with bidirectional transport across the blood-brain barrier and A-beta fibril disaggregation
    • a
    • Boado, R.J., Y. Zhang, C.F. Xia, and W.M. Pardridge. 2007a. Fusion antibody for Alzheimer's disease with bidirectional transport across the blood-brain barrier and A-beta fibril disaggregation. Bioconjug. Chem. 18(2):447-455.
    • (2007) Bioconjug. Chem , vol.18 , Issue.2 , pp. 447-455
    • Boado, R.J.1    Zhang, Y.2    Xia, C.F.3    Pardridge, W.M.4
  • 15
    • 33846897981 scopus 로고    scopus 로고
    • Humanization of anti-human insulin receptor antibody for drug targeting across the human blood-brain barrier
    • b
    • Boado, R.J., Y.F. Zhang, Y. Zhang, and W.M. Pardridge. 2007b. Humanization of anti-human insulin receptor antibody for drug targeting across the human blood-brain barrier. Biotechnol. Bioeng. 96(2):381-391.
    • (2007) Biotechnol. Bioeng , vol.96 , Issue.2 , pp. 381-391
    • Boado, R.J.1    Zhang, Y.F.2    Zhang, Y.3    Pardridge, W.M.4
  • 16
    • 38449110954 scopus 로고    scopus 로고
    • Genetic engineering of a lysoso-mal enzyme fusion protein for targeted delivery across the human blood-brain barrier
    • Boado, R.J., Y. Zhang, Y.F. Zhang, C.F. Xia, Y.T. Wang, W.M. Pardridge. 2008. Genetic engineering of a lysoso-mal enzyme fusion protein for targeted delivery across the human blood-brain barrier. Biotechnol. Bioeng. 99(2):475-484.
    • (2008) Biotechnol. Bioeng , vol.99 , Issue.2 , pp. 475-484
    • Boado, R.J.1    Zhang, Y.2    Zhang, Y.F.3    Xia, C.F.4    Wang, Y.T.5    Pardridge, W.M.6
  • 17
    • 0002720024 scopus 로고
    • Assessment with the electron microscope of the permeability to peroxidase of cerebral endothelium and epithelium in mice and sharks
    • In, ed. C. Crone and N.A. Lassen. Copenhagen: Munksgaard.
    • Brightman, M.W., T.S. Reese, and N. Feder. 1970. Assessment with the electron microscope of the permeability to peroxidase of cerebral endothelium and epithelium in mice and sharks. In Capillary Permeability, ed. C. Crone and N.A. Lassen. Copenhagen: Munksgaard.
    • (1970) Capillary Permeability
    • Brightman, M.W.1    Reese, T.S.2    Feder, N.3
  • 18
    • 0025886797 scopus 로고
    • Molecular and cellular mechanisms of receptor-mediated endocytosis
    • Brown, V.I., and M.I. Greene. 1991. Molecular and cellular mechanisms of receptor-mediated endocytosis. DNA CellBiol. 10(6):399-409.
    • (1991) DNA CellBiol , vol.10 , Issue.6 , pp. 399-409
    • Brown, V.I.1    Greene, M.I.2
  • 19
    • 0036510066 scopus 로고    scopus 로고
    • Caveolin-1 expression is maintained in rat and human astroglioma cell lines
    • Cameron, P.L., C.D. Liu, D.K. Smart, S.T. Hantus, J.R. Fick, and R.S. Cameron. 2002. Caveolin-1 expression is maintained in rat and human astroglioma cell lines. Glia 37(3):275-290.
    • (2002) Glia , vol.37 , Issue.3 , pp. 275-290
    • Cameron, P.L.1    Liu, C.D.2    Smart, D.K.3    Hantus, S.T.4    Fick, J.R.5    Cameron, R.S.6
  • 20
    • 0034454980 scopus 로고    scopus 로고
    • Endocytosis and transcytosis of an immuno-liposome-based brain drug delivery system
    • Cerletti, A., J. Drewe, G. Fricker, A.N. Eberle, and J. Huwyler. 2000. Endocytosis and transcytosis of an immuno-liposome-based brain drug delivery system. J. Drug Target. 8(6):435-436.
    • (2000) J. Drug Target , vol.8 , Issue.6 , pp. 435-436
    • Cerletti, A.1    Drewe, J.2    Fricker, G.3    Eberle, A.N.4    Huwyler, J.5
  • 21
    • 0035845753 scopus 로고    scopus 로고
    • Functional feature of a novel model of blood brain barrier: Studies on permeation of test compounds
    • Cestelli, A., C. Catania, S. D'Agostino, et al. 2001. Functional feature of a novel model of blood brain barrier: Studies on permeation of test compounds. J. Control. Release 76(1-2):139-147.
    • (2001) J. Control. Release , vol.76 , Issue.1-2 , pp. 139-147
    • Cestelli, A.1    Catania, C.2    D'Agostino, S.3
  • 23
    • 0033996507 scopus 로고    scopus 로고
    • Transport across the primate blood-brain barrier of a genetically engineered chimeric monoclonal antibody to the human insulin receptor
    • Coloma, M.J., H.J. Lee, A. Kurihara, et al. 2000. Transport across the primate blood-brain barrier of a genetically engineered chimeric monoclonal antibody to the human insulin receptor. Pharm. Res. 17(3):266-274.
    • (2000) Pharm. Res , vol.17 , Issue.3 , pp. 266-274
    • Coloma, M.J.1    Lee, H.J.2    Kurihara, A.3
  • 24
    • 0000712439 scopus 로고
    • Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites
    • Cordon-Cardo, C., J.P. Obrien, D. Casals, et al. 1989. Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites. Proc. Natl. Acad. Sci. USA 86(2):695-698.
    • (1989) Proc. Natl. Acad. Sci. USA , vol.86 , Issue.2 , pp. 695-698
    • Cordon-Cardo, C.1    Obrien, J.P.2    Casals, D.3
  • 25
    • 10644228142 scopus 로고    scopus 로고
    • Efficient cancer therapy with a nanobody-based conjugate
    • Cortez-Retamozo, V., N. Backmann, P.D. Senter, et al. 2004. Efficient cancer therapy with a nanobody-based conjugate. Cancer Res. 64(8):2853-2857.
    • (2004) Cancer Res , vol.64 , Issue.8 , pp. 2853-2857
    • Cortez-Retamozo, V.1    Backmann, N.2    Senter, P.D.3
  • 27
    • 30844472909 scopus 로고    scopus 로고
    • IgG-assisted age-dependent clearance of Alzheimer's amyloid beta peptide by the blood-brain barrier neonatal Fc receptor
    • Deane, R., A. Sagare, K. Hamm, et al. 2005. IgG-assisted age-dependent clearance of Alzheimer's amyloid beta peptide by the blood-brain barrier neonatal Fc receptor. J. Neurosci. 25(50):11495-11503.
    • (2005) J. Neurosci , vol.25 , Issue.50 , pp. 11495-11503
    • Deane, R.1    Sagare, A.2    Hamm, K.3
  • 28
    • 0035902619 scopus 로고    scopus 로고
    • Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease
    • DeMattos, R.B., K.R. Bales, D.J. Cummins, J.C. Dodart, S.M. Paul, and D.M. Holtzman. 2001. Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease. Proc. Natl. Acad. Sci. U.S.A. 98(15):8850-8855.
    • (2001) Proc. Natl. Acad. Sci. U.S.A , vol.98 , Issue.15 , pp. 8850-8855
    • DeMattos, R.B.1    Bales, K.R.2    Cummins, D.J.3    Dodart, J.C.4    Paul, S.M.5    Holtzman, D.M.6
  • 29
    • 18744415035 scopus 로고    scopus 로고
    • High transcytosis of melanotransferrin (P97) across the blood brain barrier
    • Demeule, M., J. Poirier, J. Jodoin, et al. 2002. High transcytosis of melanotransferrin (P97) across the blood brain barrier. J. Neurochem. 83(4):924-933.
    • (2002) J. Neurochem , vol.83 , Issue.4 , pp. 924-933
    • Demeule, M.1    Poirier, J.2    Jodoin, J.3
  • 30
    • 0038044258 scopus 로고    scopus 로고
    • Immunotherapy for Alzheimer's disease
    • Dodel, R.C., H. Hampel, and Y.S. Du. 2003. Immunotherapy for Alzheimer's disease. Lancet Neurol. 2(4):215-220.
    • (2003) Lancet Neurol , vol.2 , Issue.4 , pp. 215-220
    • Dodel, R.C.1    Hampel, H.2    Du, Y.S.3
  • 31
    • 20044387390 scopus 로고    scopus 로고
    • Brain pericytes contribute to the induction and up-regulation of blood-brain barrier functions through transforming growth factor-beta production
    • Dohgu, S., F. Takata, A. Yamauchi, et al. 2005. Brain pericytes contribute to the induction and up-regulation of blood-brain barrier functions through transforming growth factor-beta production. Brain Res. 1038(2):208-215.
    • (2005) Brain Res , vol.1038 , Issue.2 , pp. 208-215
    • Dohgu, S.1    Takata, F.2    Yamauchi, A.3
  • 32
    • 0023636719 scopus 로고
    • Blood-brain barrier transcytosis of insulin in developing rabbits
    • Duffy, K.R., and W.M. Pardridge. 1987. Blood-brain barrier transcytosis of insulin in developing rabbits. Brain Res. 420(1):32-38.
    • (1987) Brain Res , vol.420 , Issue.1 , pp. 32-38
    • Duffy, K.R.1    Pardridge, W.M.2
  • 33
    • 84890985139 scopus 로고    scopus 로고
    • Elan Corporation. Accessed April 21, 2008.
    • Elan Corporation. N.D. Elan: Alzheimer's Research (http://www.elan.com/research_development/Alzheimers/Default.asp. Accessed April 21, 2008.)
    • Alzheimer's Research
    • Elan, N.D.1
  • 34
    • 0024329881 scopus 로고
    • The biochemistry of P-glycoprotein-mediated multidrug resistance
    • Endicott, J.A., and V. Ling. 1989. The biochemistry of P-glycoprotein-mediated multidrug resistance. Annu. Rev. Biochem. 58:137-171.
    • (1989) Annu. Rev. Biochem , vol.58 , pp. 137-171
    • Endicott, J.A.1    Ling, V.2
  • 35
    • 33845614387 scopus 로고    scopus 로고
    • Intraventricular or intrathecal use of polymyxins in patients with Gram-negative meningitis: A systematic review of the available evidence
    • Falagas, M.E., I.A. Bliziotis, and V.H. Tam. 2007. Intraventricular or intrathecal use of polymyxins in patients with Gram-negative meningitis: A systematic review of the available evidence. Int. J. Antimicrob. Agents 29(1):9-25.
    • (2007) Int. J. Antimicrob. Agents , vol.29 , Issue.1 , pp. 9-25
    • Falagas, M.E.1    Bliziotis, I.A.2    Tam, V.H.3
  • 36
    • 11844255631 scopus 로고    scopus 로고
    • Pharmacokinetics following intraventricular administration of chemotherapy in patients with neoplastic meningitis
    • Fleischhack, G., U. Jaehde, and U. Bode. 2005. Pharmacokinetics following intraventricular administration of chemotherapy in patients with neoplastic meningitis. Clin. Pharmacokinet. 44(1):1-31.
    • (2005) Clin. Pharmacokinet , vol.44 , Issue.1 , pp. 1-31
    • Fleischhack, G.1    Jaehde, U.2    Bode, U.3
  • 37
    • 0030438707 scopus 로고    scopus 로고
    • Characterization, receptor mapping and blood-brain barrier transcytosis of antibodies to the human transferrin receptor
    • Friden, P.M., T.S. Olson, R. Obar, L.R. Walus, and S.D. Putney. 1996. Characterization, receptor mapping and blood-brain barrier transcytosis of antibodies to the human transferrin receptor. J. Pharmacol. Exp. Ther. 278(3):1491-1498.
    • (1996) J. Pharmacol. Exp. Ther , vol.278 , Issue.3 , pp. 1491-1498
    • Friden, P.M.1    Olson, T.S.2    Obar, R.3    Walus, L.R.4    Putney, S.D.5
  • 39
    • 33646438600 scopus 로고    scopus 로고
    • Diphtheriatoxin receptor-targeted brain drug delivery
    • Gaillard, P., A. Brink, and A.G. de Boer. 2005. Diphtheriatoxin receptor-targeted brain drug delivery. Int. Congres. Series 1277:185-198.
    • (2005) Int. Congres. Series , vol.1277 , pp. 185-198
    • Gaillard, P.1    Brink, A.2    De Boer, A.G.3
  • 41
    • 33344460518 scopus 로고    scopus 로고
    • Influence of particle size on transport of methotrexate across blood brain barrier by polysorbate 80-coated polybutylcyanoacrylate nanoparticles
    • Gao, K., and X. Jiang. 2006. Influence of particle size on transport of methotrexate across blood brain barrier by polysorbate 80-coated polybutylcyanoacrylate nanoparticles. Int. J. Pharm. 310(1-2):213-219.
    • (2006) Int. J. Pharm , vol.310 , Issue.1-2 , pp. 213-219
    • Gao, K.1    Jiang, X.2
  • 42
    • 14144255054 scopus 로고    scopus 로고
    • Where is the blood-brain barrier. . really?
    • Ge, S.J., L. Song, and J.S. Pachter. 2005. Where is the blood-brain barrier. . really? J. Neurosci. Res. 79(4):421-427.
    • (2005) J. Neurosci. Res , vol.79 , Issue.4 , pp. 421-427
    • Ge, S.J.1    Song, L.2    Pachter, J.S.3
  • 43
    • 34147150749 scopus 로고    scopus 로고
    • Emerging monoclonal antibody therapies for malignant gliomas
    • Gerber, D.E., and J. Laterra. 2007. Emerging monoclonal antibody therapies for malignant gliomas. Expert Opin. Investig. Drugs 16(4):477-494.
    • (2007) Expert Opin. Investig. Drugs , vol.16 , Issue.4 , pp. 477-494
    • Gerber, D.E.1    Laterra, J.2
  • 44
    • 0025184360 scopus 로고
    • Transferrin receptors in rat central nervous system. An immuno-cytochemical study
    • Giometto, B., F. Bozza, V. Argentiero, et al. 1990. Transferrin receptors in rat central nervous system. An immuno-cytochemical study. J. Neurol. Sci. 98(1):81-90.
    • (1990) J. Neurol. Sci , vol.98 , Issue.1 , pp. 81-90
    • Giometto, B.1    Bozza, F.2    Argentiero, V.3
  • 45
    • 0031017561 scopus 로고    scopus 로고
    • Human blood-brain barrier leptin receptor. Binding and endocytosis in isolated human brain microvessels
    • Golden, P.L., T.J. Maccagnan, and W.M. Pardridge. 1997. Human blood-brain barrier leptin receptor. Binding and endocytosis in isolated human brain microvessels. J. Clin. Invest. 99(1):14-18.
    • (1997) J. Clin. Invest , vol.99 , Issue.1 , pp. 14-18
    • Golden, P.L.1    Maccagnan, T.J.2    Pardridge, W.M.3
  • 46
    • 0032712180 scopus 로고    scopus 로고
    • Significant transport of doxorubicin into the brain with polysorbate 80-coated nanoparticles
    • Gulyaev, A.E., S.E. Gelperina, I.N. Skidan, A.S. Antropov, G.Y. Kivman, and J. Kreuter. 1999. Significant transport of doxorubicin into the brain with polysorbate 80-coated nanoparticles. Pharm. Res. 16(10):1564-1569.
    • (1999) Pharm. Res , vol.16 , Issue.10 , pp. 1564-1569
    • Gulyaev, A.E.1    Gelperina, S.E.2    Skidan, I.N.3    Antropov, A.S.4    Kivman, G.Y.5    Kreuter, J.6
  • 47
    • 0031808220 scopus 로고    scopus 로고
    • Tyrosine hydroxylase and Parkinson's disease
    • Haavik, J., and K. Toska. 1998. Tyrosine hydroxylase and Parkinson's disease. Mol. Neurobiol. 16(3):285-309.
    • (1998) Mol. Neurobiol , vol.16 , Issue.3 , pp. 285-309
    • Haavik, J.1    Toska, K.2
  • 48
    • 0019458387 scopus 로고
    • Insulin and insulin receptors in rodent brain
    • Havrankova, J., M. Brownstein, and J. Roth. 1981. Insulin and insulin receptors in rodent brain. Diabetologia 20 (Suppl 1):268-273.
    • (1981) Diabetologia , vol.20 , Issue.SUPPL. 1 , pp. 268-273
    • Havrankova, J.1    Brownstein, M.2    Roth, J.3
  • 49
    • 0042023711 scopus 로고    scopus 로고
    • Alzheimer disease in the U.S. population: Prevalence estimates using the 2000 census
    • Hebert, L.E., P.A. Scherr, J.L. Bienias, D.A. Bennett, and D.A. Evans. 2003. Alzheimer disease in the U.S. population: Prevalence estimates using the 2000 census. Arch. Neurol. 60(8):1119-1122.
    • (2003) Arch. Neurol , vol.60 , Issue.8 , pp. 1119-1122
    • Hebert, L.E.1    Scherr, P.A.2    Bienias, J.L.3    Bennett, D.A.4    Evans, D.A.5
  • 50
    • 27144432842 scopus 로고    scopus 로고
    • Engineered antibody fragments and the rise of single domains
    • Holliger, P., and P.J. Hudson. 2005. Engineered antibody fragments and the rise of single domains. Nature Biotechnol. 23(9):1126-1136.
    • (2005) Nature Biotechnol , vol.23 , Issue.9 , pp. 1126-1136
    • Holliger, P.1    Hudson, P.J.2
  • 51
    • 0030447660 scopus 로고    scopus 로고
    • Brain drug delivery of small molecules using immunoliposomes
    • Huwyler, J., D.F. Wu, and W.M. Pardridge. 1996. Brain drug delivery of small molecules using immunoliposomes. Proc. Natl. Acad. Sci. U.S.A. 93(24):14164-14169.
    • (1996) Proc. Natl. Acad. Sci. U.S.A , vol.93 , Issue.24 , pp. 14164-14169
    • Huwyler, J.1    Wu, D.F.2    Pardridge, W.M.3
  • 52
    • 0030987679 scopus 로고    scopus 로고
    • Receptor mediated delivery of daunomycin using immuno-liposomes: Pharmacokinetics and tissue distribution in the rat
    • Huwyler, J., J. Yang, and W.M. Pardridge. 1997. Receptor mediated delivery of daunomycin using immuno-liposomes: Pharmacokinetics and tissue distribution in the rat. J. Pharmacol. Exp. Ther. 282(3):1541-1546.
    • (1997) J. Pharmacol. Exp. Ther , vol.282 , Issue.3 , pp. 1541-1546
    • Huwyler, J.1    Yang, J.2    Pardridge, W.M.3
  • 53
    • 17644378667 scopus 로고    scopus 로고
    • Immunogenicity of engineered antibodies
    • Hwang, W.Y., and J. Foote. 2005. Immunogenicity of engineered antibodies. Methods 36(1):3-10.
    • (2005) Methods , vol.36 , Issue.1 , pp. 3-10
    • Hwang, W.Y.1    Foote, J.2
  • 55
    • 34547642139 scopus 로고    scopus 로고
    • Blood-brain barrier transport of therapeutics via receptor-mediation
    • Jones, A.R., and E.V. Shusta. 2007. Blood-brain barrier transport of therapeutics via receptor-mediation. Pharm. Res. 24(9):1759-1771.
    • (2007) Pharm. Res , vol.24 , Issue.9 , pp. 1759-1771
    • Jones, A.R.1    Shusta, E.V.2
  • 56
    • 0028147299 scopus 로고
    • Pharmacokinetics and saturable blood-brain barrier transport of biotin bound to a conjugate of avidin and a monoclonal antibody to the transferrin receptor
    • Kang, Y.S., U. Bickel, and W.M. Pardridge. 1994. Pharmacokinetics and saturable blood-brain barrier transport of biotin bound to a conjugate of avidin and a monoclonal antibody to the transferrin receptor. Drug Metab. Dispos. 22(1):99-105.
    • (1994) Drug Metab. Dispos , vol.22 , Issue.1 , pp. 99-105
    • Kang, Y.S.1    Bickel, U.2    Pardridge, W.M.3
  • 57
    • 3242777026 scopus 로고    scopus 로고
    • Modulation of the blood-brain barrier in oncology: Therapeutic opportunities for the treatment of brain tumours?
    • Kemper, E.M., W. Boogerd, I. Thuis, J.H. Beijnen, and O. van Tellingen. 2004. Modulation of the blood-brain barrier in oncology: Therapeutic opportunities for the treatment of brain tumours? Cancer Treat. Rev. 30(5):415-423.
    • (2004) Cancer Treat. Rev , vol.30 , Issue.5 , pp. 415-423
    • Kemper, E.M.1    Boogerd, W.2    Thuis, I.3    Beijnen, J.H.4    Van Tellingen, O.5
  • 58
    • 0028558577 scopus 로고
    • Intravenous administration of a transferrin receptor antibody nerve growth-factor conjugate prevents the degeneration of cholinergic striatal neurons in a model of Huntington disease
    • Kordower, J.H., V. Charles, R. Bayer, et al. 1994. Intravenous administration of a transferrin receptor antibody nerve growth-factor conjugate prevents the degeneration of cholinergic striatal neurons in a model of Huntington disease. Proc. Natl. Acad. Sci. U.S.A. 91(19):9077-9080.
    • (1994) Proc. Natl. Acad. Sci. U.S.A , vol.91 , Issue.19 , pp. 9077-9080
    • Kordower, J.H.1    Charles, V.2    Bayer, R.3
  • 59
    • 0032421248 scopus 로고    scopus 로고
    • Serum proteins as drug carriers of anticancer agents: A review
    • Kratz, F., and U. Beyer. 1998. Serum proteins as drug carriers of anticancer agents: A review. Drug Deliv. 5(4):281-299.
    • (1998) Drug Deliv , vol.5 , Issue.4 , pp. 281-299
    • Kratz, F.1    Beyer, U.2
  • 60
    • 0035984812 scopus 로고    scopus 로고
    • Apolipoprotein-mediated transport of nanoparticle-bound drugs across the blood-brain barrier
    • Kreuter, J., D. Shamenkov, V. Petrov, et al. 2002. Apolipoprotein-mediated transport of nanoparticle-bound drugs across the blood-brain barrier. J. Drug Target. 10(4):317-325.
    • (2002) J. Drug Target , vol.10 , Issue.4 , pp. 317-325
    • Kreuter, J.1    Shamenkov, D.2    Petrov, V.3
  • 61
    • 0031965788 scopus 로고    scopus 로고
    • Outwitting the blood-brain barrier for therapeutic purposes: Osmotic opening and other means
    • Kroll, R.A., and E.A. Neuwelt. 1998. Outwitting the blood-brain barrier for therapeutic purposes: Osmotic opening and other means. Neurosurgery. 42(5):1083-1099.
    • (1998) Neurosurgery , vol.42 , Issue.5 , pp. 1083-1099
    • Kroll, R.A.1    Neuwelt, E.A.2
  • 62
    • 0031720748 scopus 로고    scopus 로고
    • Improving drug delivery to intracerebral tumor and surrounding brain in a rodent model: A comparison of osmotic versus bradykinin modification of the blood-brain and/or blood-tumor barriers
    • Kroll, R.A., M.A. Pagel, L.L. Muldoon, S. Roman-Goldstein, S.A. Fiamengo, and E.A. Neuwelt. 1998. Improving drug delivery to intracerebral tumor and surrounding brain in a rodent model: A comparison of osmotic versus bradykinin modification of the blood-brain and/or blood-tumor barriers. Neurosurgery 43(4):879-886.
    • (1998) Neurosurgery , vol.43 , Issue.4 , pp. 879-886
    • Kroll, R.A.1    Pagel, M.A.2    Muldoon, L.L.3    Roman-Goldstein, S.4    Fiamengo, S.A.5    Neuwelt, E.A.6
  • 63
    • 0031451777 scopus 로고    scopus 로고
    • Tumor regression with regional distribution of the targeted toxin TF-CRM107 in patients with malignant brain tumors
    • Laske, D.W., R.J. Youle, and E.H. Oldfield. 1997. Tumor regression with regional distribution of the targeted toxin TF-CRM107 in patients with malignant brain tumors. Nature Med. 3(12):1362-1368.
    • (1997) Nature Med , vol.3 , Issue.12 , pp. 1362-1368
    • Laske, D.W.1    Youle, R.J.2    Oldfield, E.H.3
  • 64
    • 0002595302 scopus 로고    scopus 로고
    • Targeting rat anti-mouse transferrin receptor monoclonal antibodies through blood-brain barrier in mouse
    • Lee, H.J., B. Engelhardt, J. Lesley, U. Bickel, and W.M. Pardridge. 2000. Targeting rat anti-mouse transferrin receptor monoclonal antibodies through blood-brain barrier in mouse. J. Pharmacol. Exp. Ther. 292(3):1048-1052.
    • (2000) J. Pharmacol. Exp. Ther , vol.292 , Issue.3 , pp. 1048-1052
    • Lee, H.J.1    Engelhardt, B.2    Lesley, J.3    Bickel, U.4    Pardridge, W.M.5
  • 65
    • 0029582767 scopus 로고
    • Distribution of drugs following controlled delivery to the brain interstitium
    • Mak, M., L. Fung, J.F. Strasser, and W.M. Saltzman. 1995. Distribution of drugs following controlled delivery to the brain interstitium. J. Neurooncol. 26(2):91-102.
    • (1995) J. Neurooncol , vol.26 , Issue.2 , pp. 91-102
    • Mak, M.1    Fung, L.2    Strasser, J.F.3    Saltzman, W.M.4
  • 66
    • 34247151602 scopus 로고    scopus 로고
    • Seizure-promoting effect of blood-brain barrier disruption
    • Marchi, N., L. Angelov, T. Masaryk, et al. 2007. Seizure-promoting effect of blood-brain barrier disruption. Epilepsia 48(4):732-742.
    • (2007) Epilepsia , vol.48 , Issue.4 , pp. 732-742
    • Marchi, N.1    Angelov, L.2    Masaryk, T.3
  • 67
    • 0026001576 scopus 로고
    • Distribution and number of transferrin receptors in Parkinson's disease and in MPTP-treated mice
    • Mash, D.C., J. Pablo, B.E. Buck, J. Sanchezramos, and W.J. Weiner. 1991. Distribution and number of transferrin receptors in Parkinson's disease and in MPTP-treated mice. Exp. Neurol. 114(1):73-81.
    • (1991) Exp. Neurol , vol.114 , Issue.1 , pp. 73-81
    • Mash, D.C.1    Pablo, J.2    Buck, B.E.3    Sanchezramos, J.4    Weiner, W.J.5
  • 68
    • 0033986092 scopus 로고    scopus 로고
    • Cognitive outcomes and long-term follow-up results after enhanced chemotherapy delivery for primary central nervous system lymphoma
    • McAllister, L.D., N.D. Doolittle, P.E. Guastadisegni, et al. 2000. Cognitive outcomes and long-term follow-up results after enhanced chemotherapy delivery for primary central nervous system lymphoma. Neurosurgery 46(1):51-60.
    • (2000) Neurosurgery , vol.46 , Issue.1 , pp. 51-60
    • McAllister, L.D.1    Doolittle, N.D.2    Guastadisegni, P.E.3
  • 69
    • 0344921448 scopus 로고    scopus 로고
    • Successful treatment of Echovirus 27 meningoencepha-litis in agammaglobulinaemia with intraventricular injection of gammaglobulin. A case report
    • Mellouli, E., Z. Arrouji, M. Debre, and M. Bejaoui. 2003. Successful treatment of Echovirus 27 meningoencepha-litis in agammaglobulinaemia with intraventricular injection of gammaglobulin. A case report. Arch. Pediatr. 10(2):130-133.
    • (2003) Arch. Pediatr , vol.10 , Issue.2 , pp. 130-133
    • Mellouli, E.1    Arrouji, Z.2    Debre, M.3    Bejaoui, M.4
  • 71
    • 0033961913 scopus 로고    scopus 로고
    • Transferrin and transferrin receptor function in brain barrier systems
    • Moos, T., and E.H. Morgan. 2000. Transferrin and transferrin receptor function in brain barrier systems. Cell Mol. Neurobiol. 20(1):77-95.
    • (2000) Cell Mol. Neurobiol , vol.20 , Issue.1 , pp. 77-95
    • Moos, T.1    Morgan, E.H.2
  • 72
  • 73
    • 0021716682 scopus 로고
    • Chimeric human antibody molecules: Mouse antigen-binding domains with human constant region domains
    • Morrison, S.L., M.J. Johnson, L.A. Herzenberg, and V.T. Oi. 1984. Chimeric human antibody molecules: Mouse antigen-binding domains with human constant region domains. Proc. Natl. Acad. Sci. U.S.A. 81(21):6851-6855.
    • (1984) Proc. Natl. Acad. Sci. U.S.A , vol.81 , Issue.21 , pp. 6851-6855
    • Morrison, S.L.1    Johnson, M.J.2    Herzenberg, L.A.3    Oi, V.T.4
  • 74
    • 0036480118 scopus 로고    scopus 로고
    • Selection of phage-displayed llama singledomain antibodies that transmigrate across human blood-brain barrier endothelium
    • Muruganandam, A., J. Tanha, S. Narang, and D. Stanimirovic. 2002. Selection of phage-displayed llama singledomain antibodies that transmigrate across human blood-brain barrier endothelium. FASEB J. 16(2):240-242.
    • (2002) FASEB J , vol.16 , Issue.2 , pp. 240-242
    • Muruganandam, A.1    Tanha, J.2    Narang, S.3    Stanimirovic, D.4
  • 75
    • 84890973194 scopus 로고    scopus 로고
    • NINDS Overview
    • National Institute of Neurological Disorders and Stroke., April 15, 2005;, AccessedApril 10, 2008).
    • National Institute of Neurological Disorders and Stroke. 2005. NINDS Overview (April 15, 2005; http://www. ninds.nih.gov/about_ninds/ninds_overview.htm. AccessedApril 10, 2008).
    • (2005)
  • 76
    • 0020327951 scopus 로고
    • Effects of adrenal-cortical steroids and osmotic blood-brain barrier opening on methotrexate delivery to gliomas in the rodent: The factor of the blood-brain barrier
    • Neuwelt, E.A., P.A. Barnett, D.D. Bigner, and E.P. Frenkel. 1982. Effects of adrenal-cortical steroids and osmotic blood-brain barrier opening on methotrexate delivery to gliomas in the rodent: The factor of the blood-brain barrier. Proc. Natl. Acad. Sci. U.S.A. 79(14):4420-4423.
    • (1982) Proc. Natl. Acad. Sci. U.S.A , vol.79 , Issue.14 , pp. 4420-4423
    • Neuwelt, E.A.1    Barnett, P.A.2    Bigner, D.D.3    Frenkel, E.P.4
  • 77
    • 0037393454 scopus 로고    scopus 로고
    • Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: A case report
    • Nicoll, J.A.R., D. Wilkinson, C. Holmes, P. Steart, H. Markham, and R.O. Weller. 2003. Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: A case report. Nature Med. 9(4):448-452.
    • (2003) Nature Med , vol.9 , Issue.4 , pp. 448-452
    • Nicoll, J.A.R.1    Wilkinson, D.2    Holmes, C.3    Steart, P.4    Markham, H.5    Weller, R.O.6
  • 78
    • 10744230547 scopus 로고    scopus 로고
    • Subacute meningoencephalitis in a subset of patients with AD after A beta 42 immunization
    • Orgogozo, J.M., S. Gilman, J.F. Dartigues, et al. 2003. Subacute meningoencephalitis in a subset of patients with AD after A beta 42 immunization. Neurology 61(1):46-54.
    • (2003) Neurology , vol.61 , Issue.1 , pp. 46-54
    • Orgogozo, J.M.1    Gilman, S.2    Dartigues, J.F.3
  • 79
    • 8744266243 scopus 로고    scopus 로고
    • Efficient transfer of receptor-associated protein (RAP) across the blood-brain barrier
    • Pan, W.H., A.J. Kastin, T.C. Zankel, P. van Kerkhof, T. Terasaki, and G.J. Bu. 2004. Efficient transfer of receptor-associated protein (RAP) across the blood-brain barrier. J. Cell. Sci. 117(21):5071-5078.
    • (2004) J. Cell. Sci , vol.117 , Issue.21 , pp. 5071-5078
    • Pan, W.H.1    Kastin, A.J.2    Zankel, T.C.3    Van Kerkhof, P.4    Terasaki, T.5    Bu, G.J.6
  • 80
    • 0004119930 scopus 로고
    • Peptide Drug Delivery to the Brain
    • New York: Raven Press.
    • Pardridge, W.M. 1991. Peptide Drug Delivery to the Brain. New York: Raven Press.
    • (1991)
    • Pardridge, W.M.1
  • 81
    • 0003819402 scopus 로고    scopus 로고
    • Brain Drug Targeting: The Future of Brain Drug Development
    • Cambridge, UK: Cambridge University Press.
    • Pardridge, W.M. 2001. Brain Drug Targeting: The Future of Brain Drug Development. Cambridge, UK: Cambridge University Press.
    • (2001)
    • Pardridge, W.M.1
  • 82
    • 0036463371 scopus 로고    scopus 로고
    • Drug and gene targeting to the brain with molecular Trojan horses
    • Pardridge, W.M. 2002. Drug and gene targeting to the brain with molecular Trojan horses. Nature Rev. DrugDiscov. 1(2):131-139.
    • (2002) Nature Rev. DrugDiscov , vol.1 , Issue.2 , pp. 131-139
    • Pardridge, W.M.1
  • 83
    • 0023227218 scopus 로고
    • Human blood-brain barrier transferrin receptor
    • Pardridge, W.M., J. Eisenberg, and J. Yang. 1987. Human blood-brain barrier transferrin receptor. Metabolism 36(9):892-895.
    • (1987) Metabolism , vol.36 , Issue.9 , pp. 892-895
    • Pardridge, W.M.1    Eisenberg, J.2    Yang, J.3
  • 84
    • 0029009048 scopus 로고
    • Human insulin receptor monoclonal antibody undergoes high affinity binding to human brain capillaries in vitro and rapid transcytosis through the blood-brain barrier
    • a
    • Pardridge, W.M., Y.S. Kang, J.L. Buciak, and J. Yang. 1995a. Human insulin receptor monoclonal antibody undergoes high affinity binding to human brain capillaries in vitro and rapid transcytosis through the blood-brain barrier. Pharm. Res. 12(6):807-816.
    • (1995) Pharm. Res , vol.12 , Issue.6 , pp. 807-816
    • Pardridge, W.M.1    Kang, Y.S.2    Buciak, J.L.3    Yang, J.4
  • 85
    • 0029115713 scopus 로고
    • Enhanced cellular uptake and in vivo biodistribution of a monoclonal antibody following cationization
    • b
    • Pardridge, W.M., Y.S. Kang, J. Yang, and J.L. Buciak. 1995b. Enhanced cellular uptake and in vivo biodistribution of a monoclonal antibody following cationization. J. Pharm. Sci. 84(8):943-948.
    • (1995) J. Pharm. Sci , vol.84 , Issue.8 , pp. 943-948
    • Pardridge, W.M.1    Kang, Y.S.2    Yang, J.3    Buciak, J.L.4
  • 87
    • 20044374196 scopus 로고    scopus 로고
    • Safety and feasibility of convection-enhanced delivery of cotara for the treatment of malignant glioma: Initial experience in 51 patients
    • Patel, S.J., W.R. Shapiro, D.W. Laske, et al. 2005. Safety and feasibility of convection-enhanced delivery of cotara for the treatment of malignant glioma: Initial experience in 51 patients. Neurosurgery 56(6):1243-1252.
    • (2005) Neurosurgery , vol.56 , Issue.6 , pp. 1243-1252
    • Patel, S.J.1    Shapiro, W.R.2    Laske, D.W.3
  • 88
    • 0032825682 scopus 로고    scopus 로고
    • An antibody-avidin fusion protein specific for the transferrin receptor serves as a delivery vehicle for effective brain targeting: Initial applications in anti-HIV antisense drug delivery to the brain
    • Penichet, M.L., Y.S. Kang, W.M. Pardridge, S.L. Morrison, and S.U. Shin. 1999. An antibody-avidin fusion protein specific for the transferrin receptor serves as a delivery vehicle for effective brain targeting: Initial applications in anti-HIV antisense drug delivery to the brain. J. Immunol. 163(8):4421-4426.
    • (1999) J. Immunol , vol.163 , Issue.8 , pp. 4421-4426
    • Penichet, M.L.1    Kang, Y.S.2    Pardridge, W.M.3    Morrison, S.L.4    Shin, S.U.5
  • 89
    • 8344225300 scopus 로고    scopus 로고
    • Changes in the business of culture
    • Pissarra, N. 2004. Changes in the business of culture. Nature Biotechnol. 22:1355-1356.
    • (2004) Nature Biotechnol , vol.22 , pp. 1355-1356
    • Pissarra, N.1
  • 90
    • 0028273935 scopus 로고
    • Glycation increases the permeability of proteins across the blood-nerve and blood-brain barriers
    • Poduslo, J.F., and G.L. Curran. 1994. Glycation increases the permeability of proteins across the blood-nerve and blood-brain barriers. Mol. Brain Res. 23(1-2):157-162.
    • (1994) Mol. Brain Res , vol.23 , Issue.1-2 , pp. 157-162
    • Poduslo, J.F.1    Curran, G.L.2
  • 91
    • 0029976387 scopus 로고    scopus 로고
    • Polyamine modification increases the permeability of proteins at the blood-nerve and blood-brain barriers
    • Poduslo, J.F., and G.L. Curran. 1996. Polyamine modification increases the permeability of proteins at the blood-nerve and blood-brain barriers. J. Neurochem. 66(4):1599-1609.
    • (1996) J. Neurochem , vol.66 , Issue.4 , pp. 1599-1609
    • Poduslo, J.F.1    Curran, G.L.2
  • 92
    • 0035968932 scopus 로고    scopus 로고
    • Amyloidbetapeptide as a vaccine for Alzheimer's disease involves receptor-mediated transport at the blood-brain barrier
    • Poduslo, J.F., and G.L. Curran. 2001. Amyloidbetapeptide as a vaccine for Alzheimer's disease involves receptor-mediated transport at the blood-brain barrier. Neuroreport 12(15):3197-3200.
    • (2001) Neuroreport , vol.12 , Issue.15 , pp. 3197-3200
    • Poduslo, J.F.1    Curran, G.L.2
  • 93
    • 0028301348 scopus 로고
    • Macromolecular permeability across the blood-nerve and blood-brain barriers
    • Poduslo, J.F., G.L. Curran, and C.T. Berg. 1994. Macromolecular permeability across the blood-nerve and blood-brain barriers. Proc. Natl. Acad. Sci. U.S.A. 91(12):5705-5709.
    • (1994) Proc. Natl. Acad. Sci. U.S.A , vol.91 , Issue.12 , pp. 5705-5709
    • Poduslo, J.F.1    Curran, G.L.2    Berg, C.T.3
  • 94
    • 0032995727 scopus 로고    scopus 로고
    • Receptor-mediated transport of human amyloid beta-protein 1-40 and 1-42 at the blood-brain barrier
    • Poduslo, J.F., G.L. Curran, B. Sanyal, and D.J. Selkoe. 1999. Receptor-mediated transport of human amyloid beta-protein 1-40 and 1-42 at the blood-brain barrier. Neurobiol. Dis. 6(3):190-199.
    • (1999) Neurobiol. Dis , vol.6 , Issue.3 , pp. 190-199
    • Poduslo, J.F.1    Curran, G.L.2    Sanyal, B.3    Selkoe, D.J.4
  • 95
    • 0036889760 scopus 로고    scopus 로고
    • Targeted drug delivery via the transferrin receptor-mediated endocytosis pathway
    • Qian, Z.M., H.Y. Li, H.Z. Sun, and K. Ho. 2002. Targeted drug delivery via the transferrin receptor-mediated endocytosis pathway. Pharmacol. Rev. 54(4):561-587.
    • (2002) Pharmacol. Rev , vol.54 , Issue.4 , pp. 561-587
    • Qian, Z.M.1    Li, H.Y.2    Sun, H.Z.3    Ho, K.4
  • 96
    • 0036675599 scopus 로고    scopus 로고
    • Angiogenesis of the blood-brain barrier in vitro and the function of cerebral pericytes
    • Ramsauer, M., D. Krause, and R. Dermietzel. 2002. Angiogenesis of the blood-brain barrier in vitro and the function of cerebral pericytes. FASEB J. 16(8):1274-1276.
    • (2002) FASEB J , vol.16 , Issue.8 , pp. 1274-1276
    • Ramsauer, M.1    Krause, D.2    Dermietzel, R.3
  • 97
    • 0026638367 scopus 로고
    • Permeability of bovine brain microvessel endothelial cells in vitro: Barrier tightening by a factor released from astroglioma cells
    • Raub, T.J., S.L. Kuentzel, and G.A. Sawada. 1992. Permeability of bovine brain microvessel endothelial cells in vitro: Barrier tightening by a factor released from astroglioma cells. Exp. Cell. Res. 199(2):330-340.
    • (1992) Exp. Cell. Res , vol.199 , Issue.2 , pp. 330-340
    • Raub, T.J.1    Kuentzel, S.L.2    Sawada, G.A.3
  • 98
    • 34548229364 scopus 로고    scopus 로고
    • FcRn: The neonatal Fc receptor comes of age
    • Roopenian, D.C., and S. Akilesh. 2007. FcRn: The neonatal Fc receptor comes of age. Nature Rev. Immunol. 7(9):715-725.
    • (2007) Nature Rev. Immunol , vol.7 , Issue.9 , pp. 715-725
    • Roopenian, D.C.1    Akilesh, S.2
  • 100
    • 0026322983 scopus 로고
    • A cell culture model of the blood-brain barrier
    • Rubin, L.L., D.E. Hall, S. Porter, et al. 1991. A cell culture model of the blood-brain barrier. J. Cell Biol. 115(6):1725-1735.
    • (1991) J. Cell Biol , vol.115 , Issue.6 , pp. 1725-1735
    • Rubin, L.L.1    Hall, D.E.2    Porter, S.3
  • 101
    • 24044472050 scopus 로고    scopus 로고
    • Identification of a universal VHH framework to graft non-canonical antigen-binding loops of camel single-domain antibodies
    • Saerens, D., M. Pellis, R. Loris, et al. 2005. Identification of a universal VHH framework to graft non-canonical antigen-binding loops of camel single-domain antibodies. J. Mol. Biol. 352(3):597-607.
    • (2005) J. Mol. Biol , vol.352 , Issue.3 , pp. 597-607
    • Saerens, D.1    Pellis, M.2    Loris, R.3
  • 102
    • 12944309909 scopus 로고    scopus 로고
    • Unarmed, tumor-specific monoclonal antibody effectively treats brain tumors
    • Sampson, J.H., L.E. Crotty, S. Lee, et al. 2000. Unarmed, tumor-specific monoclonal antibody effectively treats brain tumors. Proc. Natl. Acad. Sci. U.S.A. 97(13):7503-7508.
    • (2000) Proc. Natl. Acad. Sci. U.S.A , vol.97 , Issue.13 , pp. 7503-7508
    • Sampson, J.H.1    Crotty, L.E.2    Lee, S.3
  • 103
    • 0033536163 scopus 로고    scopus 로고
    • Immunization with amyloid-beta attenuates Alzheimer disease-like pathology in the PDAPP mouse
    • Schenk, D., R. Barbour, W. Dunn, et al. 1999. Immunization with amyloid-beta attenuates Alzheimer disease-like pathology in the PDAPP mouse. Nature 400(6740):173-177.
    • (1999) Nature , vol.400 , Issue.6740 , pp. 173-177
    • Schenk, D.1    Barbour, R.2    Dunn, W.3
  • 104
    • 0036079202 scopus 로고    scopus 로고
    • Expression of the neonatal Fc receptor (FcRn) at the blood-brain barrier
    • Schlachetzki, F., C.N. Zhu, and W.M. Pardridge. 2002. Expression of the neonatal Fc receptor (FcRn) at the blood-brain barrier. J. Neurochem. 81(1):203-206.
    • (2002) J. Neurochem , vol.81 , Issue.1 , pp. 203-206
    • Schlachetzki, F.1    Zhu, C.N.2    Pardridge, W.M.3
  • 105
    • 0343267787 scopus 로고    scopus 로고
    • Nanoparticles, a drug carrier system to pass the blood-brain barrier, permit central analgesic effects of i.v. dalargin injections
    • Schroder, U., and B.A. Sabel. 1996. Nanoparticles, a drug carrier system to pass the blood-brain barrier, permit central analgesic effects of i.v. dalargin injections. Brain Res. 710(1-2):121-124.
    • (1996) Brain Res , vol.710 , Issue.1-2 , pp. 121-124
    • Schroder, U.1    Sabel, B.A.2
  • 106
    • 0034687846 scopus 로고    scopus 로고
    • Antisense imaging of gene expression in the brain in vivo
    • Shi, N., R.J. Boado, and W.M. Pardridge. 2000. Antisense imaging of gene expression in the brain in vivo. Proc. Natl. Acad. Sci. U.S.A. 97(26):14709-14714.
    • (2000) Proc. Natl. Acad. Sci. U.S.A , vol.97 , Issue.26 , pp. 14709-14714
    • Shi, N.1    Boado, R.J.2    Pardridge, W.M.3
  • 107
    • 0034815482 scopus 로고    scopus 로고
    • Receptor-mediated gene targeting to tissues in vivo following intravenous administration of pegylated immunoliposomes
    • Shi, N.Y., R.J. Boado, and W.M. Pardridge. 2001. Receptor-mediated gene targeting to tissues in vivo following intravenous administration of pegylated immunoliposomes. Pharm. Res. 18(8):1091-1095.
    • (2001) Pharm. Res , vol.18 , Issue.8 , pp. 1091-1095
    • Shi, N.Y.1    Boado, R.J.2    Pardridge, W.M.3
  • 108
    • 0035940380 scopus 로고    scopus 로고
    • Brain-specific expression of an exogenous gene after i.v. administration
    • Shi, N.Y., Y. Zhang, C.N. Zhu, R.J. Boado, and W.M. Pardridge. 2001. Brain-specific expression of an exogenous gene after i.v. administration. Proc. Natl. Acad. Sci. U.S.A. 98(22):12754-12759.
    • (2001) Proc. Natl. Acad. Sci. U.S.A , vol.98 , Issue.22 , pp. 12754-12759
    • Shi, N.Y.1    Zhang, Y.2    Zhu, C.N.3    Boado, R.J.4    Pardridge, W.M.5
  • 109
    • 33745263735 scopus 로고    scopus 로고
    • Endocytosis at the blood-brain barrier: From basic understanding to drug delivery strategies
    • Smith, M.W., and M. Gumbleton. 2006. Endocytosis at the blood-brain barrier: From basic understanding to drug delivery strategies. J. Drug Target. 14(4):191-214.
    • (2006) J. Drug Target , vol.14 , Issue.4 , pp. 191-214
    • Smith, M.W.1    Gumbleton, M.2
  • 111
    • 0036228917 scopus 로고    scopus 로고
    • Enhanced neuroprotective effects ofbasic fibroblast growth factor in regional brain ischemia after conjugation to a blood-brain barrier delivery vector
    • Song, B.W., H.V. Vinters, D.F. Wu, and W.M. Pardridge. 2002. Enhanced neuroprotective effects ofbasic fibroblast growth factor in regional brain ischemia after conjugation to a blood-brain barrier delivery vector. J. Pharmacol. Exp. Ther. 301(2):605-610.
    • (2002) J. Pharmacol. Exp. Ther , vol.301 , Issue.2 , pp. 605-610
    • Song, B.W.1    Vinters, H.V.2    Wu, D.F.3    Pardridge, W.M.4
  • 112
    • 12144288634 scopus 로고    scopus 로고
    • Chemotherapy of glioblastoma in rats using doxorubicin-loaded nanoparticles
    • Steiniger, S.C.J., J. Kreuter, A.S. Khalansky, et al. 2004. Chemotherapy of glioblastoma in rats using doxorubicin-loaded nanoparticles. Int. J. Cancer 109(5):759-767.
    • (2004) Int. J. Cancer , vol.109 , Issue.5 , pp. 759-767
    • Steiniger, S.C.J.1    Kreuter, J.2    Khalansky, A.S.3
  • 113
    • 0025074116 scopus 로고
    • Specialized localization of P-glycoprotein recognized by Mrk 16 monoclonal antibody in endothelial cells of the brain and the spinal cord
    • Sugawara, I., H. Hamada, T. Tsuruo, and S. Mori. 1990. Specialized localization of P-glycoprotein recognized by Mrk 16 monoclonal antibody in endothelial cells of the brain and the spinal cord. Jpn. J. Cancer Res. 81(8):727-730.
    • (1990) Jpn. J. Cancer Res , vol.81 , Issue.8 , pp. 727-730
    • Sugawara, I.1    Hamada, H.2    Tsuruo, T.3    Mori, S.4
  • 114
    • 10044244293 scopus 로고    scopus 로고
    • Imaging endogenous gene expression in brain cancer in vivo with In-111-peptide nucleic acid antisense radiopharmaceuticals and brain drug-targeting technology
    • Suzuki, T., D.F. Wu, F. Schlachetzki, J.Y. Li, R.J. Boado, and W.M. Pardridge. 2004. Imaging endogenous gene expression in brain cancer in vivo with In-111-peptide nucleic acid antisense radiopharmaceuticals and brain drug-targeting technology. J. Nuclear Med. 45(10):1766-1775.
    • (2004) J. Nuclear Med , vol.45 , Issue.10 , pp. 1766-1775
    • Suzuki, T.1    Wu, D.F.2    Schlachetzki, F.3    Li, J.Y.4    Boado, R.J.5    Pardridge, W.M.6
  • 115
    • 0023425237 scopus 로고
    • Tightjunctions of brain endothelium in vitro are enhanced by astroglia
    • Tao-Cheng, J.H., Z. Nagy, and M.W. Brightman. 1987. Tightjunctions of brain endothelium in vitro are enhanced by astroglia. J. Neurosci. 7(10):3293-3299.
    • (1987) J. Neurosci , vol.7 , Issue.10 , pp. 3293-3299
    • Tao-Cheng, J.H.1    Nagy, Z.2    Brightman, M.W.3
  • 116
    • 0025740904 scopus 로고
    • Cationization of immunoglobulin G results in enhanced organ uptake of the protein after intravenous administration in rats and primate
    • Triguero, D., J.L. Buciak, and W.M. Pardridge. 1991. Cationization of immunoglobulin G results in enhanced organ uptake of the protein after intravenous administration in rats and primate. J. Pharmacol. Exp. Ther. 258(1):186-192.
    • (1991) J. Pharmacol. Exp. Ther , vol.258 , Issue.1 , pp. 186-192
    • Triguero, D.1    Buciak, J.L.2    Pardridge, W.M.3
  • 117
    • 0001120209 scopus 로고
    • Blood-brain barrier transport of cationized immunoglobulin G enhanced delivery compared to native protein
    • Triguero, D., J.B. Buciak, J. Yang, and W.M. Pardridge. 1989. Blood-brain barrier transport of cationized immunoglobulin G enhanced delivery compared to native protein. Proc. Natl. Acad. Sci. U.S.A. 86(12): 4761-4765.
    • (1989) Proc. Natl. Acad. Sci. U.S.A , vol.86 , Issue.12 , pp. 4761-4765
    • Triguero, D.1    Buciak, J.B.2    Yang, J.3    Pardridge, W.M.4
  • 118
    • 0026760889 scopus 로고
    • P-glycoprotein as the drug efflux pump in primary cultured bovine brain capillary endothelial-cells
    • Tsuji, A., T. Terasaki, Y. Takabatake, et al. 1992. P-glycoprotein as the drug efflux pump in primary cultured bovine brain capillary endothelial-cells. Life Sci. 51(18):1427-1437.
    • (1992) Life Sci , vol.51 , Issue.18 , pp. 1427-1437
    • Tsuji, A.1    Terasaki, T.2    Takabatake, Y.3
  • 119
    • 7644238625 scopus 로고    scopus 로고
    • Practice guidelines for the management of bacterial meningitis
    • Tunkel, A.R., B.J. Hartman, S.L. Kaplan, et al. 2004. Practice guidelines for the management of bacterial meningitis. Clin. Infect. Dis. 39(9):1267-1284.
    • (2004) Clin. Infect. Dis , vol.39 , Issue.9 , pp. 1267-1284
    • Tunkel, A.R.1    Hartman, B.J.2    Kaplan, S.L.3
  • 120
    • 0021985413 scopus 로고
    • Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes
    • Ullrich, A., J.R. Bell, E.Y. Chen, et al. 1985. Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes. Nature 313(6005):756-761.
    • (1985) Nature , vol.313 , Issue.6005 , pp. 756-761
    • Ullrich, A.1    Bell, J.R.2    Chen, E.Y.3
  • 121
    • 0021714013 scopus 로고
    • Effects of bradykinin on permeability and diameter of pial vessels in vivo
    • Unterberg, A., Wahl, M., and A. Baethmann. 1984. Effects of bradykinin on permeability and diameter of pial vessels in vivo. J. Cereb. Blood Flow Metab. 4(4):574-585.
    • (1984) J. Cereb. Blood Flow Metab , vol.4 , Issue.4 , pp. 574-585
    • Unterberg, A.1    Wahl, M.2    Baethmann, A.3
  • 122
    • 4344630950 scopus 로고    scopus 로고
    • Developmentally regulated mannose 6-phosphate receptor-mediated transport of a lysosomal enzyme across the blood-brain barrier
    • Urayama, A., J.H. Grubb, W.S. Sly, and W.A. Banks. 2004. Developmentally regulated mannose 6-phosphate receptor-mediated transport of a lysosomal enzyme across the blood-brain barrier. Proc. Natl. Acad. Sci. U.S.A. 101(34):12658-12663.
    • (2004) Proc. Natl. Acad. Sci. U.S.A , vol.101 , Issue.34 , pp. 12658-12663
    • Urayama, A.1    Grubb, J.H.2    Sly, W.S.3    Banks, W.A.4
  • 123
    • 33947424302 scopus 로고    scopus 로고
    • Mining a yeast library for brain endothelial cell-binding antibodies
    • Wang, X.X., Y.K. Cho, and E.V. Shusta. 2007. Mining a yeast library for brain endothelial cell-binding antibodies. Nature Methods 4(2):143-145.
    • (2007) Nature Methods , vol.4 , Issue.2 , pp. 143-145
    • Wang, X.X.1    Cho, Y.K.2    Shusta, E.V.3
  • 124
    • 35848935409 scopus 로고    scopus 로고
    • Intravenous siRNA of brain cancer with receptor targeting and avidin-biotin technology
    • Xia, C.F., Y. Zhang, Y. Zhang, R.J. Boado, and W.M. Pardridge. 2007. Intravenous siRNA of brain cancer with receptor targeting and avidin-biotin technology. Pharm. Res. 24(12):2309-2316.
    • (2007) Pharm. Res , vol.24 , Issue.12 , pp. 2309-2316
    • Xia, C.F.1    Zhang, Y.2    Zhang, Y.3    Boado, R.J.4    Pardridge, W.M.5
  • 125
    • 0028289716 scopus 로고
    • Distribution of intracerebral ventricularly administered neurotrophins in rat brain and its correlation with trk receptor expression
    • Yan, Q., C. Matheson, J. Sun, M.J. Radeke, S.C. Feinstein, and J.A. Miller. 1994. Distribution of intracerebral ventricularly administered neurotrophins in rat brain and its correlation with trk receptor expression. Exp. Neurol. 127(1):23-36.
    • (1994) Exp. Neurol , vol.127 , Issue.1 , pp. 23-36
    • Yan, Q.1    Matheson, C.2    Sun, J.3    Radeke, M.J.4    Feinstein, S.C.5    Miller, J.A.6
  • 126
    • 11344294790 scopus 로고    scopus 로고
    • Development of a syngeneic rat brain tumor model expressing EGFRvIII and its use for molecular targeting studies with monoclonal antibody L8A4
    • Yang, W.L., R.F. Barth, G. Wu, et al. 2005. Development of a syngeneic rat brain tumor model expressing EGFRvIII and its use for molecular targeting studies with monoclonal antibody L8A4. Clin. Cancer Res. 11(1):341-350.
    • (2005) Clin. Cancer Res , vol.11 , Issue.1 , pp. 341-350
    • Yang, W.L.1    Barth, R.F.2    Wu, G.3
  • 127
    • 0037249449 scopus 로고    scopus 로고
    • Intravenous nonviral gene therapy causes normalization of striatal tyrosine hydroxylase and reversal of motor impairment in experimental parkinsonism
    • Zhang, Y., F. Calon, C.N. Zhu, R.J. Boado, and W.M. Pardridge. 2003. Intravenous nonviral gene therapy causes normalization of striatal tyrosine hydroxylase and reversal of motor impairment in experimental parkinsonism. Hum. Gene Ther. 14(1):1-12.
    • (2003) Hum. Gene Ther , vol.14 , Issue.1 , pp. 1-12
    • Zhang, Y.1    Calon, F.2    Zhu, C.N.3    Boado, R.J.4    Pardridge, W.M.5
  • 128
    • 0035283233 scopus 로고    scopus 로고
    • Mediated efflux of IgGmoleculesfrombraintoblood across the blood-brain barrier
    • a
    • Zhang, Y., and W.M. Pardridge. 2001a. Mediated efflux of IgGmoleculesfrombraintoblood across the blood-brain barrier. J. Neuroimmunol. 114(1-2):168-172.
    • (2001) J. Neuroimmunol , vol.114 , Issue.1-2 , pp. 168-172
    • Zhang, Y.1    Pardridge, W.M.2
  • 129
    • 0034988984 scopus 로고    scopus 로고
    • Neuroprotection in transient focal brain ischemia after delayed intravenous administration of brain-derived neurotrophic factor conjugated to a blood-brain barrier drug targeting system
    • b
    • Zhang, Y., and W.M. Pardridge. 2001b. Neuroprotection in transient focal brain ischemia after delayed intravenous administration of brain-derived neurotrophic factor conjugated to a blood-brain barrier drug targeting system. Stroke 32(6):1378-1383.
    • (2001) Stroke , vol.32 , Issue.6 , pp. 1378-1383
    • Zhang, Y.1    Pardridge, W.M.2
  • 130
    • 33748438120 scopus 로고    scopus 로고
    • Blood-brain barrier targeting of BDNF improves motor function in rats with middle cerebral artery occlusion
    • Zhang, Y., and W.M. Pardridge. 2006. Blood-brain barrier targeting of BDNF improves motor function in rats with middle cerebral artery occlusion. Brain Res. 1111(1):227-229.
    • (2006) Brain Res , vol.1111 , Issue.1 , pp. 227-229
    • Zhang, Y.1    Pardridge, W.M.2
  • 131
    • 0347555450 scopus 로고    scopus 로고
    • Organ-specific gene expression in the rhesus monkey eye following intravenous non-viral gene transfer
    • Zhang, Y., F. Schlachetzki, J.Y. Li, R.J. Boado, and W.M. Pardridge. 2003. Organ-specific gene expression in the rhesus monkey eye following intravenous non-viral gene transfer. Mol. Vis. 9:465-472.
    • (2003) Mol. Vis , vol.9 , pp. 465-472
    • Zhang, Y.1    Schlachetzki, F.2    Li, J.Y.3    Boado, R.J.4    Pardridge, W.M.5
  • 132
    • 0037222013 scopus 로고    scopus 로고
    • Global non-viral gene transfer to the primate brain following intravenous administration
    • Zhang, Y., F. Schlachetzki, and W.M. Pardridge. 2003. Global non-viral gene transfer to the primate brain following intravenous administration. Mol. Ther. 7(1):11-18.
    • (2003) Mol. Ther , vol.7 , Issue.1 , pp. 11-18
    • Zhang, Y.1    Schlachetzki, F.2    Pardridge, W.M.3
  • 133
    • 1842636306 scopus 로고    scopus 로고
    • Normalization of striatal tyrosine hydroxylase and reversal of motor impairment in experimental parkinsonism with intravenous nonviral gene therapy and a brain-specific promoter
    • a
    • Zhang, Y., F. Schlachetzki, Y.F. Zhang, R.J. Boado, and W.M. Pardridge. 2004a. Normalization of striatal tyrosine hydroxylase and reversal of motor impairment in experimental parkinsonism with intravenous nonviral gene therapy and a brain-specific promoter. Hum. Gene Ther. 15(4):339-350.
    • (2004) Hum. Gene Ther , vol.15 , Issue.4 , pp. 339-350
    • Zhang, Y.1    Schlachetzki, F.2    Zhang, Y.F.3    Boado, R.J.4    Pardridge, W.M.5
  • 134
    • 2542561420 scopus 로고    scopus 로고
    • Intravenous RNA interference gene therapy targeting the human epidermal growth factor receptor prolongs survival in intracranial brain cancer
    • b
    • Zhang, Y., Y.F. Zhang, J. Bryant, A. Charles, R.J. Boado, and W.M. Pardridge. 2004b. Intravenous RNA interference gene therapy targeting the human epidermal growth factor receptor prolongs survival in intracranial brain cancer. Clin. Cancer Res. 10(11):3667-3677.
    • (2004) Clin. Cancer Res , vol.10 , Issue.11 , pp. 3667-3677
    • Zhang, Y.1    Zhang, Y.F.2    Bryant, J.3    Charles, A.4    Boado, R.J.5    Pardridge, W.M.6
  • 135
    • 0036665418 scopus 로고    scopus 로고
    • Antisense gene therapy of brain cancer with an artificial virus gene delivery system
    • Zhang, Y., C.N. Zhu, and W.M. Pardridge. 2002. Antisense gene therapy of brain cancer with an artificial virus gene delivery system. Mol. Ther. 6(1):67-72.
    • (2002) Mol. Ther , vol.6 , Issue.1 , pp. 67-72
    • Zhang, Y.1    Zhu, C.N.2    Pardridge, W.M.3
  • 136
    • 0029920929 scopus 로고    scopus 로고
    • Glycoprotein 330/megalin: Probable role in receptor-mediated transport of apolipoprotein J alone and in a complex with Alzheimer disease amyloid beta at the blood-brain and blood-cerebrospinal fluid barriers
    • Zlokovic, B.V., C.L. Martel, E. Matsubara, et al. 1996. Glycoprotein 330/megalin: Probable role in receptor-mediated transport of apolipoprotein J alone and in a complex with Alzheimer disease amyloid beta at the blood-brain and blood-cerebrospinal fluid barriers. Proc. Natl. Acad. Sci. U.S.A. 93(9):4229-4234.
    • (1996) Proc. Natl. Acad. Sci. U.S.A , vol.93 , Issue.9 , pp. 4229-4234
    • Zlokovic, B.V.1    Martel, C.L.2    Matsubara, E.3


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