Case 40-2013: A 36-year-old man with agitation and paranoia

New England Journal of Medicine

Volumn 369, Issue 26, 2013, Pages 2536-2545

  Benzer, Theodore I ^a,b   Nejad, Shamim H ^a,b   Flood, James G ^a,b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARNITINE; DEXMEDETOMIDINE; HALOPERIDOL; METHCATHINONE; PHENOBARBITAL; CENTRAL STIMULANT AGENT; DESIGNER DRUG; HYPNOTIC SEDATIVE AGENT; MONOMETHYLPROPION; PROPIOPHENONE DERIVATIVE; PSYCHOTROPIC AGENT;

ADULT; AGITATION; ALCOHOLISM; ARTICLE; CASE REPORT; CLINICAL EXAMINATION; CLINICAL FEATURE; CONTINUOUS INFUSION; DELIRIUM; DIFFERENTIAL DIAGNOSIS; DRUG INTOXICATION; HUMAN; HYPERTENSION; LOW DRUG DOSE; MALE; MIDDLE AGED; PARANOIA; PATIENT SAFETY; PRIORITY JOURNAL; SUBSTANCE ABUSE; TACHYCARDIA; PARANOID DISORDERS; PSYCHOMOTOR AGITATION; PSYCHOSES, SUBSTANCE-INDUCED; CLINICAL OBSERVATION; CLINICAL STUDY; DIAGNOSIS; PARANOID PSYCHOSIS; PSYCHOSIS; RESTLESSNESS;

ADULT; CENTRAL NERVOUS SYSTEM STIMULANTS; DESIGNER DRUGS; DIAGNOSIS, DIFFERENTIAL; HUMANS; HYPNOTICS AND SEDATIVES; MALE; PARANOID DISORDERS; PROPIOPHENONES; PSYCHOMOTOR AGITATION; PSYCHOSES, SUBSTANCE-INDUCED; PSYCHOTROPIC DRUGS;

EID: 84890959449     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMcpc1304051     Document Type: Article

References (12)

1. Kao L, Moore GP, Jackimczyk K. The combative patient. In: Marx JA, Hockberger RS, Walls RM, et al., eds. Rosen's emergency medicine. 7th ed. Philadelphia: Mosby Elsevier, 2009:2440-7.
2. Nelson LS, Lewin NA, Howland MA, et al. Initial evaluation of the patient: vital signs and toxic syndromes. In: Nelson LS, Lewin NA, Howland MA, et al., eds. Goldfrank's toxicologic emergencies. 9th ed. New York: McGraw-Hill Medical, 2010:33-6.
3. Kelly JP. Cathinone derivatives: a review of their chemistry, pharmacology and toxicology. Drug Test Anal 2011;3:439-53.
4. Puopolo PR, Volpicelli SA, Johnson DM, Flood JG. Emergency toxicology testing (detection, confirmation, and quantification) of basic drugs in serum by liquid chromatography with photodiode array detection. Clin Chem 1991;37:2124-30.
5. Takahashi M, Nagashima M, Suzuki J, Seto T, Yasuda I, Yoshida T. Creation and application of psychoactive designer drugs data library using liquid chromatography with photodiode array spectrophotometry detector and gas chromatography-mass spectrometry. Talanta 2009;77:1245-72.
6. Dal Cason TL. Synthesis and identification of N,N-dimethylcathinone hydrochloride. Microgram J 2007;5(1-4):3-12 (http://www.justice.gov/dea/pr/ microgram-journals/2007/journal-v5-num14.pdf).
7. Bell L. On a form of disease resembling some advanced stages of mania and fever. Am J Insanity 1849;6:97-127.
8. Fink M. Delirious mania. Bipolar Disord 1999;1:54-60.
9. Menon DV, Wang Z, Fadel PJ, et al. Central sympatholysis as a novel countermeasure for cocaine-induced sympathetic activation and vasoconstriction in humans. J Am Coll Cardiol 2007;50:626-33.
10. Young R, Glennon RA. Discriminative stimulus effects of S(-)-methcathinone (CAT): a potent stimulant drug of abuse. Psychopharmacology (Berl) 1998;140:250-6.
11. Alves E, Binienda Z, Carvalho F, et al. Acetyl-L-carnitine provides effective in vivo neuroprotection over 3,4-methylene-dioximethamphetamine- induced mitochondrial neurotoxicity in the adolescent rat brain. Neuroscience 2009;158:514-23.
12. National Conference of State Legislatures. Substituted cathinones (a.k.a. "bath salts") enactments. November 28, 2012 (http://www.ncsl.org/ issues-research/justice/substituted-cathinones-enactments.aspx).