Prolonged QTc interval predicts all-cause mortality in patients with rheumatoid arthritis: An association driven by high inflammatory burden

Rheumatology (United Kingdom)

Volumn 53, Issue 1, 2014, Pages 131-137

  Panoulas, Vasileios F ^a,b   Toms, Tracey E ^b   Douglas, Karen M J ^b   Sandoo, Aamer ^b   Metsios, George S ^b   Stavropoulos Kalinoglou, Antonios ^b   Kitas, George D ^b,c  

^a IMPERIAL COLLEGE HEALTHCARE NHS TRUST   (United Kingdom)

^b RUSSELLS HALL HOSPITAL   (United Kingdom)

^c UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Death; Mortality; Prolongation; QTc; Rheumatoid arthritis; Sudden cardiac

Indexed keywords

C REACTIVE PROTEIN; RHEUMATOID FACTOR;

ADULT; AGING; ARTICLE; BODY MASS; CARDIOVASCULAR MORTALITY; CAUSE OF DEATH; CLINICAL FEATURE; DISEASE ASSOCIATION; ELECTROCARDIOGRAPHY; ERYTHROCYTE SEDIMENTATION RATE; FEMALE; FOLLOW UP; HEART LEFT VENTRICLE HYPERTROPHY; HUMAN; HYPERTENSION; INSULIN RESISTANCE; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; PREDICTOR VARIABLE; PRIORITY JOURNAL; QT INTERVAL; QT PROLONGATION; RHEUMATOID ARTHRITIS; SEX DIFFERENCE; SUDDEN CARDIAC DEATH;

DEATH; MORTALITY; PROLONGATION; QTC; RHEUMATOID ARTHRITIS; SUDDEN CARDIAC;

ARTHRITIS, RHEUMATOID; CAUSE OF DEATH; DEATH, SUDDEN, CARDIAC; ELECTROCARDIOGRAPHY; FEMALE; FOLLOW-UP STUDIES; GREAT BRITAIN; HUMANS; INCIDENCE; INFLAMMATION; LONG QT SYNDROME; MALE; MIDDLE AGED; PROGNOSIS; RETROSPECTIVE STUDIES; RISK FACTORS; SURVIVAL RATE;

EID: 84890921654     PISSN: 14620324     EISSN: 14620332     Source Type: Journal    
DOI: 10.1093/rheumatology/ket338     Document Type: Article

References (22)

1. Symmons D, Turner G, Webb R et al. The prevalence of rheumatoid arthritis in the United Kingdom: new estimates for a new century. Rheumatology 2002;41:793-800.
2. Solomon D, Karlson E, Rimm E et al. Cardiovascular morbidity and mortality in women diagnosed with rheumatoid arthritis. Circulation 2003;107:1303-7.
3. Stamatelopoulos KS, Kitas GD, Papamichael CM et al. Atherosclerosis in rheumatoid arthritis versus diabetes: a comparative study. Arterioscler Thromb Vasc Biol 2009;29:1702-8.
4. Lindhardsen J, Ahlehoff O, Gislason GH et al. The risk of myocardial infarction in rheumatoid arthritis and diabetes mellitus: a Danish nationwide cohort study. Ann Rheum Dis 2011;70:929-34.
5. Maradit-Kremers H, Crowson CS, Nicola PJ et al. Increased unrecognized coronary heart disease and sudden deaths in rheumatoid arthritis: a population-based cohort study. Arthritis Rheum 2005;52:402-11.
6. Montanez A, Ruskin JN, Hebert PR et al. Prolonged QTc interval and risks of total and cardiovascular mortality and sudden death in the general population: a review and qualitative overview of the prospective cohort studies. Arch Intern Med 2004;164:943-8.
7. Rana BS, Lim PO, Naas AA et al. QT interval abnormalities are often present at diagnosis in diabetes and are better predictors of cardiac death than ankle brachial pressure index and autonomic function tests. Heart 2005;91:44-50.
8. Kazumi T, Kawaguchi A, Hirano T et al. C-reactive protein in young, apparently healthy men: associations with serum leptin, QTc interval, and high-density lipoproteincholesterol. Metabolism 2003;52:1113-6.
9. Albert CM, Ma J, Rifai N et al. Prospective study of C-reactive protein, homocysteine, and plasma lipid levels as predictors of sudden cardiac death. Circulation 2002;105:2595-9.
10. Arnett FC, Edworthy SM, Bloch DA et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988;31:315-24.
11. Panoulas VF, Douglas KM, Milionis HJ et al. Prevalence and associations of hypertension and its control in patients with rheumatoid arthritis. Rheumatology 2007;46:1477-82.
12. Panoulas VF, Milionis HJ, Douglas KM et al. Association of serum uric acid with cardiovascular disease in rheumatoid arthritis. Rheumatology 2007;46:1466-70.
13. Heyden S, Bartel AG, Tabesh E et al. Angina pectoris and the Rose questionnaire. Arch Intern Med 1971;128:961-4.
14. Blackburn H. Electrocardiographic classification for population comparisons: the Minnesota code. J Electrocardiol 1969;2:5-9.
15. Rautaharju PM, Surawicz B, Gettes LS et al. AHA/ACCF/ HRS recommendations for the standardization and interpretation of the electrocardiogram. Part IV: the ST segment, T and U waves, and the QT interval: a scientific statement from the American Heart Association Electrocardiography and Arrhythmias Committee, Council on Clinical Cardiology; the American College of Cardiology Foundation; and the Heart Rhythm Society. Endorsed by the International Society for Computerized Electrocardiology. J Am Coll Cardiol 2009;53:982-91.
16. Rossing P, Breum L, Major-Pedersen A et al. Prolonged QTc interval predicts mortality in patients with type 1 diabetes mellitus. Diabet Med 2001;18:199-205.
17. Christensen PK, Gall MA, Major-Pedersen A et al. QTc interval length and QT dispersion as predictors of mortality in patients with non-insulin-dependent diabetes. Scand J Clin Lab Invest 2000;60:323-32.
18. Zhang Y, Post WS, Blasco-Colmenares E et al. Electrocardiographic QT interval and mortality: a meta-analysis. Epidemiology 2011;22:660-70.
19. Zabel M, Hohnloser SH, Behrens S et al. Electrophysiologic features of torsades de pointes: insights from a new isolated rabbit heart model. J Cardiovasc Electrophysiol 1997;8:1148-58.
20. Roden DM. Drug-induced prolongation of the QT interval. N Engl J Med 2004;350:1013-22.
21. Straus SM, Kors JA, De Bruin ML et al. Prolonged QTc interval and risk of sudden cardiac death in a population of older adults. J Am Coll Cardiol 2006;47:362-7.
22. Zhang R, Zhang YY, Huang XR et al. C-reactive protein promotes cardiac fibrosis and inflammation in angiotensin II-induced hypertensive cardiac disease. Hypertension 2010;55:953-60.