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Volumn 34, Issue SUPPL1, 2014, Pages 120-126

HBeAg-negative chronic hepatitis B: Why do I treat my patients with nucleos(t)ide analogues?

Author keywords

Entecavir; HBeAg negative chronic hepatitis B; Nucleos(t)ide analogues; Tenofovir

Indexed keywords

ENTECAVIR; HEPATITIS B SURFACE ANTIGEN; HEPATITIS B(E) ANTIGEN; NUCLEOSIDE ANALOG; PEGINTERFERON; TENOFOVIR; TENOFOVIR DISOPROXIL;

EID: 84890867230     PISSN: 14783223     EISSN: 14783231     Source Type: Journal    
DOI: 10.1111/liv.12401     Document Type: Review
Times cited : (14)

References (46)
  • 1
    • 59749096640 scopus 로고    scopus 로고
    • Hepatitis B virus infection
    • Liaw YF, Chu CM. Hepatitis B virus infection. Lancet 2009; 373: 582-92.
    • (2009) Lancet , vol.373 , pp. 582-592
    • Liaw, Y.F.1    Chu, C.M.2
  • 2
    • 33646369150 scopus 로고    scopus 로고
    • Hepatitis B e antigen negative chronic hepatitis B - natural history and treatment
    • Hadziyannis SJ, Papatheodoridis GV. Hepatitis B e antigen negative chronic hepatitis B - natural history and treatment. Semin Liver Dis 2006; 26: 130-41.
    • (2006) Semin Liver Dis , vol.26 , pp. 130-141
    • Hadziyannis, S.J.1    Papatheodoridis, G.V.2
  • 3
    • 51049107683 scopus 로고    scopus 로고
    • Asian-Pacific consensus statement on the management of chronic hepatitis B: a 2008 update
    • Liaw YF, Leung N, Kao JH, et al. Asian-Pacific consensus statement on the management of chronic hepatitis B: a 2008 update. Hepatol Int 2008; 2: 263-83.
    • (2008) Hepatol Int , vol.2 , pp. 263-283
    • Liaw, Y.F.1    Leung, N.2    Kao, J.H.3
  • 4
    • 70349240414 scopus 로고    scopus 로고
    • Chronic hepatitis B: update 2009
    • Lok AS, McMahon BJ. Chronic hepatitis B: update 2009. Hepatology 2009; 50: 661-2.
    • (2009) Hepatology , vol.50 , pp. 661-662
    • Lok, A.S.1    McMahon, B.J.2
  • 5
    • 84862664371 scopus 로고    scopus 로고
    • EASL clinical practice guidelines: management of chronic hepatitis B
    • European Association for the Study of the Liver.
    • European Association for the Study of the Liver. EASL clinical practice guidelines: management of chronic hepatitis B. J Hepatol 2012; 57: 167-85.
    • (2012) J Hepatol , vol.57 , pp. 167-185
  • 6
  • 7
    • 79960727726 scopus 로고    scopus 로고
    • Entecavir treatment for chronic hepatitis B: adaptation is not needed for the majority of naïve patients with a partial virological response
    • Zoutendijk R, Reijnders JG, Brown A, et al. Entecavir treatment for chronic hepatitis B: adaptation is not needed for the majority of naïve patients with a partial virological response. Hepatology 2011; 54: 443-51.
    • (2011) Hepatology , vol.54 , pp. 443-451
    • Zoutendijk, R.1    Reijnders, J.G.2    Brown, A.3
  • 8
    • 84890864962 scopus 로고    scopus 로고
    • Profound virologic response in chronic hepatitis B (CHB) patients treated with entecavir
    • abstract 476].
    • Baqai SF, Hana Yi D, Gish RG, et al. Profound virologic response in chronic hepatitis B (CHB) patients treated with entecavir. Hepatology 2009; 50: 4 [abstract 476].
    • (2009) Hepatology , vol.50 , pp. 4
    • Baqai, S.F.1    Hana Yi, D.2    Gish, R.G.3
  • 9
    • 79960059346 scopus 로고    scopus 로고
    • Three years of continuous entecavir therapy in treatment-naïve chronic hepatitis B patients: VIRAL suppression, viral resistance, and clinical safety
    • Yuen MF, Seto WK, Fung J, et al. Three years of continuous entecavir therapy in treatment-naïve chronic hepatitis B patients: VIRAL suppression, viral resistance, and clinical safety. Am J Gastroenterol 2011; 106: 1264-71.
    • (2011) Am J Gastroenterol , vol.106 , pp. 1264-1271
    • Yuen, M.F.1    Seto, W.K.2    Fung, J.3
  • 10
    • 84865139307 scopus 로고    scopus 로고
    • Long-term continuous entecavir therapy in nucleos(t)ide-naïve chronic hepatitis B patients
    • Ono A, Suzuki F, Kawamura Y, et al. Long-term continuous entecavir therapy in nucleos(t)ide-naïve chronic hepatitis B patients. J Hepatol 2012; 57: 508-14.
    • (2012) J Hepatol , vol.57 , pp. 508-514
    • Ono, A.1    Suzuki, F.2    Kawamura, Y.3
  • 11
    • 84890887185 scopus 로고    scopus 로고
    • 5-year entecavir treatment in NUC-naive, field-practice patients with chronic hepatitis B showed excellent viral suppression and safety profile but no prevention of HCC in cirrhosis
    • Lampertico P, Soffredini R, Viganò M, et al. 5-year entecavir treatment in NUC-naive, field-practice patients with chronic hepatitis B showed excellent viral suppression and safety profile but no prevention of HCC in cirrhosis. J Hepatol 2013; 58: S306.
    • (2013) J Hepatol , vol.58
    • Lampertico, P.1    Soffredini, R.2    Viganò, M.3
  • 12
    • 75349107764 scopus 로고    scopus 로고
    • Efficacy of entecavir in treatment-naïve patients with hepatitis B virus-related decompensated cirrhosis
    • Shim JH, Lee HC, Kim KM, et al. Efficacy of entecavir in treatment-naïve patients with hepatitis B virus-related decompensated cirrhosis. J Hepatol 2010; 52: 176-82.
    • (2010) J Hepatol , vol.52 , pp. 176-182
    • Shim, J.H.1    Lee, H.C.2    Kim, K.M.3
  • 13
    • 79959551969 scopus 로고    scopus 로고
    • Efficacy and safety of entecavir versus adefovir in chronic hepatitis B patients with hepatic decompensation: a randomized, open-label study
    • Liaw YF, Raptopoulou-Gigi M, Cheinquer H, et al. Efficacy and safety of entecavir versus adefovir in chronic hepatitis B patients with hepatic decompensation: a randomized, open-label study. Hepatology 2011; 54: 91-100.
    • (2011) Hepatology , vol.54 , pp. 91-100
    • Liaw, Y.F.1    Raptopoulou-Gigi, M.2    Cheinquer, H.3
  • 14
    • 84890886538 scopus 로고    scopus 로고
    • Effectiveness of tenofovir for chronic hepatitis B in field practice - 2 year interim results from the prospective German multicenter non-interventional study (GEMINIS)
    • Petersen J, Heyne R, Mauss S, et al. Effectiveness of tenofovir for chronic hepatitis B in field practice - 2 year interim results from the prospective German multicenter non-interventional study (GEMINIS). J Hepatol 2013; 58: S313.
    • (2013) J Hepatol , vol.58
    • Petersen, J.1    Heyne, R.2    Mauss, S.3
  • 15
    • 84890873442 scopus 로고    scopus 로고
    • Virological response and tolerance of tenofovir DF (TDF) in the elderly is similar to younger patients in real life practice
    • Hézode C, Causse X, Larrey D, et al. Virological response and tolerance of tenofovir DF (TDF) in the elderly is similar to younger patients in real life practice. J Hepatol 2013; 58: S303.
    • (2013) J Hepatol , vol.58
    • Hézode, C.1    Causse, X.2    Larrey, D.3
  • 16
    • 84901403605 scopus 로고    scopus 로고
    • Four years of tenofovir monotherapy for NUC naïve field practice European patients suppress HBV replication in most patients with a favourable renal safety profile but do not prevent HCC in patients with or without cirrhosis
    • Lampertico P, Soffredini R, Yurdaydin C, et al. Four years of tenofovir monotherapy for NUC naïve field practice European patients suppress HBV replication in most patients with a favourable renal safety profile but do not prevent HCC in patients with or without cirrhosis. Hepatology 2013; 58(Suppl. 1): A933.
    • (2013) Hepatology , vol.58 , Issue.SUPPL. 1
    • Lampertico, P.1    Soffredini, R.2    Yurdaydin, C.3
  • 17
    • 84878190783 scopus 로고    scopus 로고
    • Six years of treatment with Tenofovir DF for chronic hepatitis B virus infection is safe and well tolerated and associated with sustained virological, biochemical and serological responses with no detectable resistance
    • abstract 374].
    • Marcellin P, Buti M, Gane E, et al. Six years of treatment with Tenofovir DF for chronic hepatitis B virus infection is safe and well tolerated and associated with sustained virological, biochemical and serological responses with no detectable resistance. Hepatology 2012; 56: 4 [abstract 374].
    • (2012) Hepatology , vol.56 , pp. 4
    • Marcellin, P.1    Buti, M.2    Gane, E.3
  • 18
    • 78751491184 scopus 로고    scopus 로고
    • Tenofovir disoproxil fumarate (TDF), emtricitabine/TDF, and entecavir in patients with decompensated chronic hepatitis B liver disease
    • Liaw YF, Sheen IS, Lee CM, et al. Tenofovir disoproxil fumarate (TDF), emtricitabine/TDF, and entecavir in patients with decompensated chronic hepatitis B liver disease. Hepatology 2011; 53: 62-72.
    • (2011) Hepatology , vol.53 , pp. 62-72
    • Liaw, Y.F.1    Sheen, I.S.2    Lee, C.M.3
  • 19
    • 84865798344 scopus 로고    scopus 로고
    • Partial response to entecavir and tenofovir in naive patients with chronic epatiti B: clinical relevance and management
    • Lampertico P, Viganò M, Colombo M. Partial response to entecavir and tenofovir in naive patients with chronic epatiti B: clinical relevance and management. Curr Hepatitis Rep 2012; 11: 90-4.
    • (2012) Curr Hepatitis Rep , vol.11 , pp. 90-94
    • Lampertico, P.1    Viganò, M.2    Colombo, M.3
  • 20
    • 84881025752 scopus 로고    scopus 로고
    • Results of treatment of chronic hepatitis B with pegylated interferon
    • Viganò M, Mangia G, Lampertico P. Results of treatment of chronic hepatitis B with pegylated interferon. Clin Liver Dis 2013; 17: 425-43.
    • (2013) Clin Liver Dis , vol.17 , pp. 425-443
    • Viganò, M.1    Mangia, G.2    Lampertico, P.3
  • 21
    • 66149190942 scopus 로고    scopus 로고
    • Side effects of long-term oral antiviral therapy for hepatitis B
    • Fontana RJ. Side effects of long-term oral antiviral therapy for hepatitis B. Hepatology 2009; 49: S185-95.
    • (2009) Hepatology , vol.49
    • Fontana, R.J.1
  • 22
    • 84860209612 scopus 로고    scopus 로고
    • Long-term safety and tolerability of entecavir in patients with chronic hepatitis B in the rollover study ETV-901
    • Manns MP, Akarca US, Chang TT, et al. Long-term safety and tolerability of entecavir in patients with chronic hepatitis B in the rollover study ETV-901. Expert Opin Drug Saf 2012; 11: 361-8.
    • (2012) Expert Opin Drug Saf , vol.11 , pp. 361-368
    • Manns, M.P.1    Akarca, U.S.2    Chang, T.T.3
  • 23
    • 73149085984 scopus 로고    scopus 로고
    • Severe lactic acidosis during treatment of chronic hepatitis B with entecavir in patients with impaired liver function
    • Lange CM, Bojunga J, Hofmann WP, et al. Severe lactic acidosis during treatment of chronic hepatitis B with entecavir in patients with impaired liver function. Hepatology 2009; 50: 2001-6.
    • (2009) Hepatology , vol.50 , pp. 2001-2006
    • Lange, C.M.1    Bojunga, J.2    Hofmann, W.P.3
  • 24
    • 84890878608 scopus 로고    scopus 로고
    • Baraclude Package insert 2012. Available at Accessed November 2013.
    • Baraclude Package insert 2012. Available at packageinserts.bms.com/pi/pi_baraclude.pdf. Accessed November 2013.
  • 25
    • 79954611097 scopus 로고    scopus 로고
    • Tenofovir-associated kidney toxicity in HIV-infected patients: a review of the evidence
    • Hall AM, Hendry BM, Nitsch D, Connolly JO. Tenofovir-associated kidney toxicity in HIV-infected patients: a review of the evidence. Am J Kidney Dis 2011; 57: 773-80.
    • (2011) Am J Kidney Dis , vol.57 , pp. 773-780
    • Hall, A.M.1    Hendry, B.M.2    Nitsch, D.3    Connolly, J.O.4
  • 26
    • 84890869059 scopus 로고    scopus 로고
    • Tefnofovir DF (TDF) is safe and well tolerated in chronic hepatitis B (CHB) patients with pre-existing mild renal impairment
    • Fung S, Kwan P, Horban A, et al. Tefnofovir DF (TDF) is safe and well tolerated in chronic hepatitis B (CHB) patients with pre-existing mild renal impairment. J Hepatolo 2013; 58: S301.
    • (2013) J Hepatolo , vol.58
    • Fung, S.1    Kwan, P.2    Horban, A.3
  • 27
    • 84977778970 scopus 로고    scopus 로고
    • Incidence and clinical consequences of reduced tubular phosphate re-absorption in naïve chronic hepatitis B patients either untreated or treated with tenofovir for 2 years in a field practice
    • Viganò M, Lampertico P, Mangia G, et al. Incidence and clinical consequences of reduced tubular phosphate re-absorption in naïve chronic hepatitis B patients either untreated or treated with tenofovir for 2 years in a field practice. Hepatology 2013; 58(Suppl. 1): 978A.
    • (2013) Hepatology , vol.58 , Issue.SUPPL. 1
    • Viganò, M.1    Lampertico, P.2    Mangia, G.3
  • 28
    • 84890865046 scopus 로고    scopus 로고
    • Tenofovir-associated Fanconi Syndrome in patients with chronic hepatitis B monoinfection
    • doi: 10.3851/IMP2649. [Epub ahead of print].
    • Gracey DM, Snelling P, McKenzie P, Strasser SI. Tenofovir-associated Fanconi Syndrome in patients with chronic hepatitis B monoinfection. Antivir Ther 2013; doi: 10.3851/IMP2649. [Epub ahead of print].
    • (2013) Antivir Ther
    • Gracey, D.M.1    Snelling, P.2    McKenzie, P.3    Strasser, S.I.4
  • 29
    • 84890883790 scopus 로고    scopus 로고
    • A tenofovir-associated Fanconi syndrome in a chronic hepatitis B patient previously exposed to adefovir dipivoxil
    • Submitted.
    • Viganò M, Brocchieri A, Mangia G, et al. A tenofovir-associated Fanconi syndrome in a chronic hepatitis B patient previously exposed to adefovir dipivoxil. J Hepatol 2013; Submitted.
    • (2013) J Hepatol
    • Viganò, M.1    Brocchieri, A.2    Mangia, G.3
  • 30
    • 84890864058 scopus 로고    scopus 로고
    • Tenofovir monotherapy is effective for Adefovir experienced patients but requires careful monitoring of glomerular and tubular function and proactive dose reductions: a 4-year study in 320 patients
    • Lampertico P, Mangia G, Viganò M, et al. Tenofovir monotherapy is effective for Adefovir experienced patients but requires careful monitoring of glomerular and tubular function and proactive dose reductions: a 4-year study in 320 patients. Hepatology 2013; 58(Suppl. 1): 649A.
    • (2013) Hepatology , vol.58 , Issue.SUPPL. 1
    • Lampertico, P.1    Mangia, G.2    Viganò, M.3
  • 31
    • 84878204383 scopus 로고    scopus 로고
    • Long-term therapy for chronic hepatitis B: hepatitis B virus DNA suppression leading to cirrhosis reversal
    • Marcellin P, Asselah T. Long-term therapy for chronic hepatitis B: hepatitis B virus DNA suppression leading to cirrhosis reversal. J Gastroenterol Hepatol 2013; 28: 912-23.
    • (2013) J Gastroenterol Hepatol , vol.28 , pp. 912-923
    • Marcellin, P.1    Asselah, T.2
  • 32
    • 77956639159 scopus 로고    scopus 로고
    • Long-term entecavir therapy results in reversal fibrosis/cirrhosis and continued histologic improvement in chronic hepatitis B patients
    • Chang TT, Liaw Y-F, Wu SS, et al. Long-term entecavir therapy results in reversal fibrosis/cirrhosis and continued histologic improvement in chronic hepatitis B patients. Hepatology 2010; 52: 886-937.
    • (2010) Hepatology , vol.52 , pp. 886-937
    • Chang, T.T.1    Liaw, Y.-F.2    Wu, S.S.3
  • 33
    • 79951684909 scopus 로고    scopus 로고
    • Long-term treatment with entecavir induces reversal of advanced fibrosis or cirrhosis in patients with chronic hepatitis B
    • Schiff ER, Lee SS, Chao YC, et al. Long-term treatment with entecavir induces reversal of advanced fibrosis or cirrhosis in patients with chronic hepatitis B. Clin Gastroenterol Hepatol 2011; 9: 274-6.
    • (2011) Clin Gastroenterol Hepatol , vol.9 , pp. 274-276
    • Schiff, E.R.1    Lee, S.S.2    Chao, Y.C.3
  • 34
    • 84873726484 scopus 로고    scopus 로고
    • Regression of cirrhosis during treatment with tenofovir disoproxil fumarate for chronic hepatitis B: a 5-year open-label follow-up study
    • Marcellin P, Gane E, Buti M, et al. Regression of cirrhosis during treatment with tenofovir disoproxil fumarate for chronic hepatitis B: a 5-year open-label follow-up study. Lancet 2013; 381: 468-75.
    • (2013) Lancet , vol.381 , pp. 468-475
    • Marcellin, P.1    Gane, E.2    Buti, M.3
  • 35
    • 84875850936 scopus 로고    scopus 로고
    • Virological response to entecavir is associated with a better clinical outcome in chronic hepatitis B patients with cirrhosis
    • Zoutendijk R, Reijnders JG, Zoulim F, et al. Virological response to entecavir is associated with a better clinical outcome in chronic hepatitis B patients with cirrhosis. Gut 2013; 62: 760-5.
    • (2013) Gut , vol.62 , pp. 760-765
    • Zoutendijk, R.1    Reijnders, J.G.2    Zoulim, F.3
  • 36
    • 84887025945 scopus 로고    scopus 로고
    • Entecavir treatment reduces hepatic events and deaths in chronic hepatitis B patients with liver cirrhosis
    • doi: 10.1002/hep.26301. [Epub ahead of print].
    • Wong GL, Chan HL, Mak CH, et al. Entecavir treatment reduces hepatic events and deaths in chronic hepatitis B patients with liver cirrhosis. Hepatology 2013; doi: 10.1002/hep.26301. [Epub ahead of print].
    • (2013) Hepatology
    • Wong, G.L.1    Chan, H.L.2    Mak, C.H.3
  • 37
    • 84886894897 scopus 로고    scopus 로고
    • Long term tenofovir disoproxil fumarate (TDF) therapy and the risk of hepatocellular carcinoma
    • Kim WR, Berg T, Loomba R, et al. Long term tenofovir disoproxil fumarate (TDF) therapy and the risk of hepatocellular carcinoma. J Hepatol 2013; 58: S19.
    • (2013) J Hepatol , vol.58
    • Kim, W.R.1    Berg, T.2    Loomba, R.3
  • 38
    • 84872045830 scopus 로고    scopus 로고
    • The role of HBsAg quantification for monitoring natural history and treatment outcome
    • Martinot-Peignoux M, Lapalus M, Asselah T, Marcellin P. The role of HBsAg quantification for monitoring natural history and treatment outcome. Liver Int 2013; 33(Suppl. 1): 125-32.
    • (2013) Liver Int , vol.33 , Issue.SUPPL. 1 , pp. 125-132
    • Martinot-Peignoux, M.1    Lapalus, M.2    Asselah, T.3    Marcellin, P.4
  • 39
    • 79951669706 scopus 로고    scopus 로고
    • Kinetics of hepatitis B surface antigen differ between treatment with peginterferon and entecavir
    • Reijnders JG, Rijckborst V, Sonneveld MJ, et al. Kinetics of hepatitis B surface antigen differ between treatment with peginterferon and entecavir. J Hepatol 2011; 54: 449-54.
    • (2011) J Hepatol , vol.54 , pp. 449-454
    • Reijnders, J.G.1    Rijckborst, V.2    Sonneveld, M.J.3
  • 40
    • 80053928899 scopus 로고    scopus 로고
    • HBsAg kinetics in patients with chronic hepatitis B (CHB) treated with tenofovir disoproxil fumarate (TDF) for up to 4 years
    • Marcellin P, Heathcote EJ, Buti M, et al. HBsAg kinetics in patients with chronic hepatitis B (CHB) treated with tenofovir disoproxil fumarate (TDF) for up to 4 years. J Hepatol 2011; 54: 740A.
    • (2011) J Hepatol , vol.54
    • Marcellin, P.1    Heathcote, E.J.2    Buti, M.3
  • 41
    • 84865772501 scopus 로고    scopus 로고
    • Hepatitis B surface antigen declines and clearance during long-term tenofovir therapy in patients coinfected with HBV and HIV
    • Zoutendijk R, Zaaijer HL, de Vries-Sluijs TE, et al. Hepatitis B surface antigen declines and clearance during long-term tenofovir therapy in patients coinfected with HBV and HIV. J Infect Dis 2012; 206: 974-80.
    • (2012) J Infect Dis , vol.206 , pp. 974-980
    • Zoutendijk, R.1    Zaaijer, H.L.2    de Vries-Sluijs, T.E.3
  • 42
    • 84888287261 scopus 로고    scopus 로고
    • Off therapy durability of response to Entecavir therapy in hepatitis B e antigen negative chronic hepatitis B patients
    • doi: 10.1002/hep.26549. [Epub ahead of print]
    • Jeng WJ, Sheen IS, Chen YC, et al. Off therapy durability of response to Entecavir therapy in hepatitis B e antigen negative chronic hepatitis B patients. Hepatology 2013; doi: 10.1002/hep.26549. [Epub ahead of print]
    • (2013) Hepatology
    • Jeng, W.J.1    Sheen, I.S.2    Chen, Y.C.3
  • 43
    • 84861865262 scopus 로고    scopus 로고
    • Adding pegylated interferon to a current nucleos(t)ide therapy leads to HBsAg seroconversion in a subgroup of patients with chronic hepatitis B
    • Kittner JM, Sprinzl MF, Grambihler A, et al. Adding pegylated interferon to a current nucleos(t)ide therapy leads to HBsAg seroconversion in a subgroup of patients with chronic hepatitis B. J Clin Virol 2012; 54: 93-5.
    • (2012) J Clin Virol , vol.54 , pp. 93-95
    • Kittner, J.M.1    Sprinzl, M.F.2    Grambihler, A.3
  • 44
    • 84555207424 scopus 로고    scopus 로고
    • Add-on of Peg interferon to a stable nucleoside regimen led to loos of HBsAg in chronic hepatitis HBeAg-negative patients
    • Ouzan D, Penaranda G, Joly H, et al. Add-on of Peg interferon to a stable nucleoside regimen led to loos of HBsAg in chronic hepatitis HBeAg-negative patients. Hepatology 2011; 54: 1015A.
    • (2011) Hepatology , vol.54
    • Ouzan, D.1    Penaranda, G.2    Joly, H.3
  • 45
    • 84881025712 scopus 로고    scopus 로고
    • Add-on Peg-IFN improves HBsAg kinetics in patients long-term fully suppressed by nucleos(t)ide analogs
    • Lampertico P, Invernizzi F, Soffredini R, et al. Add-on Peg-IFN improves HBsAg kinetics in patients long-term fully suppressed by nucleos(t)ide analogs. J Hepatol 2012; 56: S2-207.
    • (2012) J Hepatol , vol.56
    • Lampertico, P.1    Invernizzi, F.2    Soffredini, R.3
  • 46
    • 84890876014 scopus 로고    scopus 로고
    • Improvement of HBsAg loss by additional PegIFN in nucleoside analogs treated chronic hepatitis B patients
    • Wu Z, Sheng J, Li L, et al. Improvement of HBsAg loss by additional PegIFN in nucleoside analogs treated chronic hepatitis B patients. Hepatology 2012; 56: 404A.
    • (2012) Hepatology , vol.56
    • Wu, Z.1    Sheng, J.2    Li, L.3


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