메뉴 건너뛰기




Volumn 65, Issue 5, 2013, Pages 207-218

Systematic review of 2008-2012 literature and update of recommendations for the use of methotrexate in rheumatic diseases, with a focus on rheumatoid arthritis

Author keywords

Evidence based medicine; Methotrexate; Recommendations; Rheumatic diseases; Rheumatoid arthritis

Indexed keywords

AZATHIOPRINE; DISEASE MODIFYING ANTIRHEUMATIC DRUG; FOLIC ACID; FOLINIC ACID; GLUCOCORTICOID; GOLD SALT; HYDROXYCHLOROQUINE; LEFLUNOMIDE; METHOTREXATE; SALAZOSULFAPYRIDINE; ANTIRHEUMATIC AGENT;

EID: 84890842060     PISSN: 00487449     EISSN: None     Source Type: Journal    
DOI: 10.4081/reumatismo.2013.207     Document Type: Review
Times cited : (14)

References (71)
  • 1
    • 77953729063 scopus 로고    scopus 로고
    • Italian consensus on the recommendations about the use of methotrexate for the treatment of rheumatic diseases with a focus on rheumatoid arthritis: Results from the 3E initiative
    • De Leonardis F, Alivernini S, Bonacci E, Buono AM, Bombardieri S, Ferraccioli GF, et al. Italian consensus on the recommendations about the use of methotrexate for the treatment of rheumatic diseases with a focus on rheumatoid arthritis: results from the "3E initiative". Reumatismo. 2010; 62: 34-45.
    • (2010) Reumatismo , vol.62 , pp. 34-45
    • de Leonardis, F.1    Alivernini, S.2    Bonacci, E.3    Buono, A.M.4    Bombardieri, S.5    Ferraccioli, G.F.6
  • 2
    • 0037938708 scopus 로고    scopus 로고
    • Updated method guidelines for systematic reviews in the cochrane collaboration back review group
    • Editorial Board of the Cochrane Collaboration Back Review Group
    • van Tulder M, Furlan A, Bombardier C, Bouter L; Editorial Board of the Cochrane Collaboration Back Review Group. Updated method guidelines for systematic reviews in the cochrane collaboration back review group. Spine (Phila Pa 1976). 2003; 28: 1290-9.
    • (2003) Spine (Phila Pa 1976) , vol.28 , pp. 1290-1299
    • van Tulder, M.1    Furlan, A.2    Bombardier, C.3    Bouter, L.4
  • 4
    • 4243430012 scopus 로고    scopus 로고
    • Oxford Centre for Evidence Based medicine, March, Available from, Accessed: November 2012
    • Oxford Centre for Evidence Based medicine. Levels of evidence (March 2009). Available from: http://www.cebm.net/index.aspx?o=1025/ Accessed: November 2012.
    • (2009) Levels of Evidence
  • 5
    • 84855721112 scopus 로고    scopus 로고
    • Liver stiffness correlates with methotrexate cumulative dose in patients with rheumatoid arthritis
    • Arena U, Stasi C, Mannoni A, Benucci M, Maddali-Bongi S, Cammelli D, et al. Liver stiffness correlates with methotrexate cumulative dose in patients with rheumatoid arthritis. Dig Liver Dis. 2012; 44: 149-53.
    • (2012) Dig Liver Dis , vol.44 , pp. 149-153
    • Arena, U.1    Stasi, C.2    Mannoni, A.3    Benucci, M.4    Maddali-Bongi, S.5    Cammelli, D.6
  • 6
    • 70350181571 scopus 로고    scopus 로고
    • Systematic review on the safety of methotrexate in rheumatoid arthritis regarding the reproductive system (fertility, pregnancy, and breastfeeding)
    • Martínez Lopez JA, Loza E, Carmona L. Systematic review on the safety of methotrexate in rheumatoid arthritis regarding the reproductive system (fertility, pregnancy, and breastfeeding). Clin Exp Rheumatol. 2009; 27: 678-84.
    • (2009) Clin Exp Rheumatol , vol.27 , pp. 678-684
    • Martínez, L.J.A.1    Loza, E.2    Carmona, L.3
  • 7
    • 84871657955 scopus 로고    scopus 로고
    • Association of hepatitis B with antirheumatic drugs: A case-control study
    • Oshima Y, Tsukamoto H, Tojo A. Association of hepatitis B with antirheumatic drugs: a case-control study. Mod Rheumatol. 2013; 23: 694-704.
    • (2013) Mod Rheumatol , vol.23 , pp. 694-704
    • Oshima, Y.1    Tsukamoto, H.2    Tojo, A.3
  • 8
    • 84865362085 scopus 로고    scopus 로고
    • Reactivation of hepatitis B virus in a hepatitis B surface antigen-negative patient with rheumatoid arthritis treated with methotrexate
    • Watanabe K, Takase K, Ohno S, Ideguchi H, Nozaki A, Ishigatsubo Y. Reactivation of hepatitis B virus in a hepatitis B surface antigen-negative patient with rheumatoid arthritis treated with methotrexate. Mod Rheumatol. 2012; 22: 470-3.
    • (2012) Mod Rheumatol , vol.22 , pp. 470-473
    • Watanabe, K.1    Takase, K.2    Ohno, S.3    Ideguchi, H.4    Nozaki, A.5    Ishigatsubo, Y.6
  • 9
    • 79953769108 scopus 로고    scopus 로고
    • Reactivation of hepatitis B in a patient with spondyloarthritis after the suspension of methotrexate and efficacy of treatment with antivirals in association to adalimumab
    • Cobeta García JC, Medrano M. Reactivation of hepatitis B in a patient with spondyloarthritis after the suspension of methotrexate and efficacy of treatment with antivirals in association to adalimumab. Reumatol Clin. 2011; 7: 200-2.
    • (2011) Reumatol Clin , vol.7 , pp. 200-202
    • Cobeta, G.J.C.1    Medrano, M.2
  • 10
    • 79953771671 scopus 로고    scopus 로고
    • How does one manage patients with rheumatoid arthritis and positive serology to hepatitis B, hepatitis C, human immunodeficiency virus?
    • Cabrera Villalba SR, Victoria Hernández Miguel M, Sanmartí Sala R. How does one manage patients with rheumatoid arthritis and positive serology to hepatitis B, hepatitis C, human immunodeficiency virus? Reumatol Clin. 2011; 7: 203-7.
    • (2011) Reumatol Clin , vol.7 , pp. 203-207
    • Cabrera, V.S.R.1    Victoria, H.M.M.2    Sanmartí, S.R.3
  • 11
    • 83555165073 scopus 로고    scopus 로고
    • Methotrexate for rheumatoid arthritis patients who are on hemodialysis
    • Al-Hasani H, Roussou E. Methotrexate for rheumatoid arthritis patients who are on hemodialysis. Rheumatol Int. 2011; 31: 1545-7.
    • (2011) Rheumatol Int , vol.31 , pp. 1545-1547
    • Al-Hasani, H.1    Roussou, E.2
  • 12
    • 67549101312 scopus 로고    scopus 로고
    • Optimal dosage and route of administration of methotrexate in rheumatoid arthritis: A systematic review of the literature
    • Visser K, van der Hejde D. Optimal dosage and route of administration of methotrexate in rheumatoid arthritis: a systematic review of the literature. Ann Rheum Dis. 2009; 68: 1094-9.
    • (2009) Ann Rheum Dis , vol.68 , pp. 1094-1099
    • Visser, K.1    van der Hejde, D.2
  • 13
    • 77957275016 scopus 로고    scopus 로고
    • Are switches from oral to subcutaneous methotrexate or addition of ciclosporin to methotrexate useful steps in a tight control treatment strategy for rheumatoid arthritis? A post hoc analysis of the CAMERA study
    • Bakker MF, Jacobs JW, Welsing PM, van der Werf JH, Linn-Rasker SP, van der Veen MJ, et al. Are switches from oral to subcutaneous methotrexate or addition of ciclosporin to methotrexate useful steps in a tight control treatment strategy for rheumatoid arthritis? A post hoc analysis of the CAMERA study. Ann Rheum Dis. 2010; 69: 1849-52.
    • (2010) Ann Rheum Dis , vol.69 , pp. 1849-1852
    • Bakker, M.F.1    Jacobs, J.W.2    Welsing, P.M.3    van der Werf, J.H.4    Linn-Rasker, S.P.5    van der Veen, M.J.6
  • 14
    • 38149057526 scopus 로고    scopus 로고
    • Comparison of the clinical efficacy and safety of subcutaneous versus oral administration of methotrexate in patients with active rheumatoid arthritis: Results of a six-month, multicenter, randomized, double-blind, controlled, phase IV trial
    • Braun J, Kästner P, Flaxenberg P, Währisch J, Hanke P, Demary W, et al. Comparison of the clinical efficacy and safety of subcutaneous versus oral administration of methotrexate in patients with active rheumatoid arthritis: results of a six-month, multicenter, randomized, double-blind, controlled, phase IV trial. Arthritis Rheum. 2008; 58: 73-81.
    • (2008) Arthritis Rheum , vol.58 , pp. 73-81
    • Braun, J.1    Kästner, P.2    Flaxenberg, P.3    Währisch, J.4    Hanke, P.5    Demary, W.6
  • 15
    • 80053545701 scopus 로고    scopus 로고
    • Implementation of a treat-to-target strategy in very early rheumatoid arthritis: Results of the Dutch Rheumatoid Arthritis Monitoring remission induction cohort study
    • Vermeer M, Kuper HH, Hoekstra M, Haagsma CJ, Posthumus MD, Brus HL, et al. Implementation of a treat-to-target strategy in very early rheumatoid arthritis: results of the Dutch Rheumatoid Arthritis Monitoring remission induction cohort study. Arthritis Rheum. 2011; 63: 2865-72.
    • (2011) Arthritis Rheum , vol.63 , pp. 2865-2872
    • Vermeer, M.1    Kuper, H.H.2    Hoekstra, M.3    Haagsma, C.J.4    Posthumus, M.D.5    Brus, H.L.6
  • 17
    • 60449119139 scopus 로고    scopus 로고
    • Effect of folic or folinic acid supplementation on methotrexate-associated safety and efficacy in inflammatory disease: A systematic review
    • Prey S, Paul C. Effect of folic or folinic acid supplementation on methotrexate-associated safety and efficacy in inflammatory disease: a systematic review. Br J Dermatol. 2009; 160: 622-8.
    • (2009) Br J Dermatol , vol.160 , pp. 622-628
    • Prey, S.1    Paul, C.2
  • 18
    • 84921431104 scopus 로고    scopus 로고
    • Folic acid and folinic acid for reducing side effects in patients receiving methotrexate for rheumatoid arthritis
    • Ortiz Z, Shea B, Suarez Almazor M, Moher D, Wells G, Tugwell P. Folic acid and folinic acid for reducing side effects in patients receiving methotrexate for rheumatoid arthritis. Cochrane Database Syst Rev. 2000; (2): CD000951.
    • (2000) Cochrane Database Syst Rev , Issue.2
    • Ortiz, Z.1    Shea, B.2    Suarez, A.M.3    Moher, D.4    Wells, G.5    Tugwell, P.6
  • 19
    • 84862597742 scopus 로고    scopus 로고
    • Adverse effects of low dose methotrexate in rheumatoid arthritis patients
    • Gilani ST, Khan DA, Khan FA, Ahmed M. Adverse effects of low dose methotrexate in rheumatoid arthritis patients. J Coll Physicians Surg Pak. 2012; 22: 101-4.
    • (2012) J Coll Physicians Surg Pak , vol.22 , pp. 101-104
    • Gilani, S.T.1    Khan, D.A.2    Khan, F.A.3    Ahmed, M.4
  • 20
    • 77954429186 scopus 로고    scopus 로고
    • Methotrexate drug interactions in the treatment of rheumatoid arthritis: A systematic review
    • Bourrè-Tessier J, Haroui B. Methotrexate drug interactions in the treatment of rheumatoid arthritis: a systematic review. J Rheumatol. 2010; 37: 1416-21.
    • (2010) J Rheumatol , vol.37 , pp. 1416-1421
    • Bourrè-Tessier, J.1    Haroui, B.2
  • 21
    • 77953690218 scopus 로고    scopus 로고
    • Adverse events and factors associated with toxicity in patients with early rheumatoid arthritis treated with methotrexate tight control therapy: The CAMERA study
    • Verstappen SM, Bakker MF, Heurkens AH, van der Veen MJ, Kruize AA, Geurts MA, et al. Adverse events and factors associated with toxicity in patients with early rheumatoid arthritis treated with methotrexate tight control therapy: the CAMERA study. Ann Rheum Dis. 2010; 69: 1044-8.
    • (2010) Ann Rheum Dis , vol.69 , pp. 1044-1048
    • Verstappen, S.M.1    Bakker, M.F.2    Heurkens, A.H.3    van der Veen, M.J.4    Kruize, A.A.5    Geurts, M.A.6
  • 22
    • 76649094231 scopus 로고    scopus 로고
    • Risk and management of liver toxicity during methotrexate treatment in rheumatoid and psoriatic arthritis: A systematic review of the literature
    • Visser K, van der Heijde DM. Risk and management of liver toxicity during methotrexate treatment in rheumatoid and psoriatic arthritis: a systematic review of the literature. Clin Exp Rheumatol. 2009; 27: 1017-25.
    • (2009) Clin Exp Rheumatol , vol.27 , pp. 1017-1025
    • Visser, K.1    van der Heijde, D.M.2
  • 23
    • 67549107120 scopus 로고    scopus 로고
    • Long-term safety of methotrexate monotherapy in patients with rheumatoid arthritis: A systematic literature research
    • Salliot C, van der Heijde D. Long-term safety of methotrexate monotherapy in patients with rheumatoid arthritis: a systematic literature research. Ann Rheum Dis. 2009; 68: 1100-4.
    • (2009) Ann Rheum Dis , vol.68 , pp. 1100-1104
    • Salliot, C.1    van der Heijde, D.2
  • 24
    • 84855651987 scopus 로고    scopus 로고
    • Incidence of liver toxicity in inflammatory bowel disease patients treated with methotrexate: A meta-analysis of clinical trials
    • Khan N, Abbas AM, Whang N, Balart LA, Bazzano LA, Kelly TN. Incidence of liver toxicity in inflammatory bowel disease patients treated with methotrexate: a meta-analysis of clinical trials. Inflamm Bowel Dis. 2012; 18: 359-67.
    • (2012) Inflamm Bowel Dis , vol.18 , pp. 359-367
    • Khan, N.1    Abbas, A.M.2    Whang, N.3    Balart, L.A.4    Bazzano, L.A.5    Kelly, T.N.6
  • 25
    • 73449096104 scopus 로고    scopus 로고
    • Elevated liver enzyme tests among patients with rheumatoid arthritis or psoriatic arthritis treated with methotrexate and/or leflunomide
    • Curtis JR, Beukelman T, Onofrei A, Cassell S, Greenberg JD, Kavanaugh A, et al. Elevated liver enzyme tests among patients with rheumatoid arthritis or psoriatic arthritis treated with methotrexate and/or leflunomide. Ann Rheum Dis. 2010; 69: 43-7.
    • (2010) Ann Rheum Dis , vol.69 , pp. 43-47
    • Curtis, J.R.1    Beukelman, T.2    Onofrei, A.3    Cassell, S.4    Greenberg, J.D.5    Kavanaugh, A.6
  • 26
    • 83255164819 scopus 로고    scopus 로고
    • Leflunomide or methotrexate? Comparison of clinical efficacy and safety in low socio-economic rheumatoid arthritis patients
    • Ishaq M, Muhammad JS, Hameed K, Mirza AI. Leflunomide or methotrexate? Comparison of clinical efficacy and safety in low socio-economic rheumatoid arthritis patients. Mod Rheumatol. 2011; 21: 375-80.
    • (2011) Mod Rheumatol , vol.21 , pp. 375-380
    • Ishaq, M.1    Muhammad, J.S.2    Hameed, K.3    Mirza, A.I.4
  • 27
    • 84865780053 scopus 로고    scopus 로고
    • Efficacy of leflunomide 100mg weekly compared to low dose methotrexate in patients with active rheumatoid arthritis. Double blind, randomized clinical trial
    • Jaimes-Hernández J, Meléndez-Mercado CI, Mendoza-Fuentes A, Aranda-Pereira P, Castañeda-Hernández G. Efficacy of leflunomide 100mg weekly compared to low dose methotrexate in patients with active rheumatoid arthritis. Double blind, randomized clinical trial. Reumatol Clin. 2012; 8: 243-9.
    • (2012) Reumatol Clin , vol.8 , pp. 243-249
    • Jaimes-Hernández, J.1    Meléndez-Mercado, C.I.2    Mendoza-Fuentes, A.3    Aranda-Pereira, P.4    Castañeda-Hernández, G.5
  • 28
    • 62549155817 scopus 로고    scopus 로고
    • Rheumatoid arthritis, its treatments and the risk of tuberculosis in Quebec, Canada
    • Brassard P, Lowe AM, Bernatsky S, Kezouh A, Suissa S. Rheumatoid arthritis, its treatments and the risk of tuberculosis in Quebec, Canada. Arthritis Rheum. 2009; 61: 300-4.
    • (2009) Arthritis Rheum , vol.61 , pp. 300-304
    • Brassard, P.1    Lowe, A.M.2    Bernatsky, S.3    Kezouh, A.4    Suissa, S.5
  • 29
    • 84872744288 scopus 로고    scopus 로고
    • Does methotrexate increase the risk of varicella or herpes zoster infection in patients with rheumatoid arthritis? A systematic literature review
    • Zhang N, Wilkinson S, Riaz M, Östör AJ, Nisar MK. Does methotrexate increase the risk of varicella or herpes zoster infection in patients with rheumatoid arthritis? A systematic literature review. Clin Exp Rheumatol. 2012; 30: 962-71.
    • (2012) Clin Exp Rheumatol , vol.30 , pp. 962-971
    • Zhang, N.1    Wilkinson, S.2    Riaz, M.3    Östör, A.J.4    Nisar, M.K.5
  • 30
    • 77950441072 scopus 로고    scopus 로고
    • The effect of methotrexate on cardiovascular disease in patients with rheumatoid arthritis: A systematic literature review
    • Westlake SL, Colebatch AN, Baird J, Kiely P, Quinn M, Choy E, et al. The effect of methotrexate on cardiovascular disease in patients with rheumatoid arthritis: a systematic literature review. Rheumatology (Oxford). 2010; 49: 295-307.
    • (2010) Rheumatology (Oxford) , vol.49 , pp. 295-307
    • Westlake, S.L.1    Colebatch, A.N.2    Baird, J.3    Kiely, P.4    Quinn, M.5    Choy, E.6
  • 31
    • 80054698399 scopus 로고    scopus 로고
    • Systematic review and meta-analysis of methotrexate use and risk of cardiovascular disease
    • Micha R, Imamura F, Wyler von Ballmoos M, Solomon DH, Hernán MA, et al. Systematic review and meta-analysis of methotrexate use and risk of cardiovascular disease. Am J Cardiol. 2011; 108: 1362-70.
    • (2011) Am J Cardiol , vol.108 , pp. 1362-1370
    • Micha, R.1    Imamura, F.2    Wyler von Ballmoos, M.3    Solomon, D.H.4    Hernán, M.A.5
  • 33
    • 84868649842 scopus 로고    scopus 로고
    • Protective effect of methotrexate in patients with rheumatoid arthritis and cardiovascular comorbidity
    • Marks JL, Edwards CJ. Protective effect of methotrexate in patients with rheumatoid arthritis and cardiovascular comorbidity. Ther Adv Muscoloskelet Dis. 2012; 4: 149-57.
    • (2012) Ther Adv Muscoloskelet Dis , vol.4 , pp. 149-157
    • Marks, J.L.1    Edwards, C.J.2
  • 34
    • 84857161352 scopus 로고    scopus 로고
    • Methotrexate and post operative complications in patients with rheumatoid arthritis undergoing elective orthopaedic surgery--a ten year follow-up
    • Sreekumar R, Gray J, Kay P, Grennan DM. Methotrexate and post operative complications in patients with rheumatoid arthritis undergoing elective orthopaedic surgery--a ten year follow-up. Acta Orthop Belg. 2011; 77: 823-6.
    • (2011) Acta Orthop Belg , vol.77 , pp. 823-826
    • Sreekumar, R.1    Gray, J.2    Kay, P.3    Grennan, D.M.4
  • 35
    • 84860547595 scopus 로고    scopus 로고
    • Outcomes after anti-rheumatic drug use before and during pregnancy: A cohort study among 150,000 pregnant women and expectant fathers
    • Viktil KK, Engeland A, Furu K. Outcomes after anti-rheumatic drug use before and during pregnancy: a cohort study among 150,000 pregnant women and expectant fathers. Scand J Rheumatol. 2012; 41: 196-201.
    • (2012) Scand J Rheumatol , vol.41 , pp. 196-201
    • Viktil, K.K.1    Engeland, A.2    Furu, K.3
  • 36
    • 80053954998 scopus 로고    scopus 로고
    • Rheumatoid arthritis and pregnancy: Safety considerations in pharmacological management
    • Makol A, Wright K, Amin S. Rheumatoid arthritis and pregnancy: safety considerations in pharmacological management. Drugs. 2011; 71: 1973-87.
    • (2011) Drugs , vol.71 , pp. 1973-1987
    • Makol, A.1    Wright, K.2    Amin, S.3
  • 37
    • 70349577501 scopus 로고    scopus 로고
    • Management of RA medications in pregnant patients
    • Østensen M, Förger F. Management of RA medications in pregnant patients. Nat Rev Rheumatol. 2009; 5: 382-90.
    • (2009) Nat Rev Rheumatol , vol.5 , pp. 382-390
    • Østensen, M.1    Förger, F.2
  • 38
    • 77953706155 scopus 로고    scopus 로고
    • Current evidence for the management of rheumatoid arthritis with synthetic disease-modifying antirheumatic drugs: A systematic literature review informing the EULAR recommendations for the management of rheumatoid arthritis
    • Gaujoux-Viala C, Smolen JS, Landewé R, Dougados M, Kvien TK, Mola EM, et al. Current evidence for the management of rheumatoid arthritis with synthetic disease-modifying antirheumatic drugs: a systematic literature review informing the EULAR recommendations for the management of rheumatoid arthritis. Ann Rheum Dis. 2010; 69: 1004-9.
    • (2010) Ann Rheum Dis , vol.69 , pp. 1004-1009
    • Gaujoux-Viala, C.1    Smolen, J.S.2    Landewé, R.3    Dougados, M.4    Kvien, T.K.5    Mola, E.M.6
  • 39
    • 84857697133 scopus 로고    scopus 로고
    • Low-dose prednisone inclusion in a methotrexate-based, tight control strategy for early rheumatoid arthritis: A randomized trial
    • Bakker MF, Jacobs JW, Welsing PM, Verstappen SM, Tekstra J, Ton E, et al. Low-dose prednisone inclusion in a methotrexate-based, tight control strategy for early rheumatoid arthritis: a randomized trial. Ann Intern Med. 2012; 156: 329-39.
    • (2012) Ann Intern Med , vol.156 , pp. 329-339
    • Bakker, M.F.1    Jacobs, J.W.2    Welsing, P.M.3    Verstappen, S.M.4    Tekstra, J.5    Ton, E.6
  • 40
    • 77957690264 scopus 로고    scopus 로고
    • Similar effects of disease-modifying antirheumatic drugs, glucocorticoids, and biologic agents on radiographic progression in rheumatoid arthritis: Meta-analysis of 70 randomized placebo-controlled or drug-controlled studies, including 112 comparisons
    • Graudal N, Jürgens G. Similar effects of disease-modifying antirheumatic drugs, glucocorticoids, and biologic agents on radiographic progression in rheumatoid arthritis: meta-analysis of 70 randomized placebo-controlled or drug-controlled studies, including 112 comparisons. Arthritis Rheum. 2010; 62: 2852-63.
    • (2010) Arthritis Rheum , vol.62 , pp. 2852-2863
    • Graudal, N.1    Jürgens, G.2
  • 41
    • 84860820505 scopus 로고    scopus 로고
    • Low-dose oral prednisone improves clinical and ultrasonographic remission rates in early rheumatoid arthritis: Results of a 12-month open-label randomised study
    • Montecucco C, Todoerti M, Sakellariou G, Scirè CA, Caporali R. Low-dose oral prednisone improves clinical and ultrasonographic remission rates in early rheumatoid arthritis: results of a 12-month open-label randomised study. Arthritis Res Ther. 2012; 14: R112.
    • (2012) Arthritis Res Ther , vol.14
    • Montecucco, C.1    Todoerti, M.2    Sakellariou, G.3    Scirè, C.A.4    Caporali, R.5
  • 42
    • 77951246294 scopus 로고    scopus 로고
    • Early disease control by low-dose prednisone comedication may affect the quality of remission in patients with early rheumatoid arthritis
    • Todoerti M, Scirè CA, Boffini N, Bugatti S, Montecucco C, Caporali R. Early disease control by low-dose prednisone comedication may affect the quality of remission in patients with early rheumatoid arthritis. Ann N Y Acad Sci. 2010; 1193: 139-45.
    • (2010) Ann N Y Acad Sci , vol.1193 , pp. 139-145
    • Todoerti, M.1    Scirè, C.A.2    Boffini, N.3    Bugatti, S.4    Montecucco, C.5    Caporali, R.6
  • 43
    • 77952467678 scopus 로고    scopus 로고
    • Methotrexate monotherapy versus methotrexate combination therapy with non-biologic disease modifying anti-rheumatic drugs for rheumatoid arthritis
    • Katchamart W, Trudeau J, Phumethum V, Bombardier C. Methotrexate monotherapy versus methotrexate combination therapy with non-biologic disease modifying anti-rheumatic drugs for rheumatoid arthritis. Cochrane Database Syst Rev. 2010; (4): CD008495.
    • (2010) Cochrane Database Syst Rev , Issue.4
    • Katchamart, W.1    Trudeau, J.2    Phumethum, V.3    Bombardier, C.4
  • 44
    • 68049124945 scopus 로고    scopus 로고
    • Addition of infliximab compared with addition of sulfasalazine and hydroxychloroquine to methotrexate in patients with early rheumatoid arthritis (Swefot trial): 1-year results of a randomised trial
    • van Vollenhoven RF, Ernestam S, Geborek P, Petersson IF, Cöster L, Waltbrand E, et al. Addition of infliximab compared with addition of sulfasalazine and hydroxychloroquine to methotrexate in patients with early rheumatoid arthritis (Swefot trial): 1-year results of a randomised trial. Lancet. 2009; 374: 459-66.
    • (2009) Lancet , vol.374 , pp. 459-466
    • van Vollenhoven, R.F.1    Ernestam, S.2    Geborek, P.3    Petersson, I.F.4    Cöster, L.5    Waltbrand, E.6
  • 45
    • 84860511740 scopus 로고    scopus 로고
    • Conventional combination treatment versus biological treatment in methotrexate-refractory early rheumatoid arthritis: 2 year follow-up of the randomised, non-blinded, parallel-group Swefot trial
    • van Vollenhoven RF, Geborek P, Forslind K, Albertsson K, Ernestam S, Petersson IF, et al. Conventional combination treatment versus biological treatment in methotrexate-refractory early rheumatoid arthritis: 2 year follow-up of the randomised, non-blinded, parallel-group Swefot trial. Lancet. 2012; 379: 1712-20.
    • (2012) Lancet , vol.379 , pp. 1712-1720
    • van Vollenhoven, R.F.1    Geborek, P.2    Forslind, K.3    Albertsson, K.4    Ernestam, S.5    Petersson, I.F.6
  • 46
    • 77955896561 scopus 로고    scopus 로고
    • Efficacy and safety of different doses and retreatment of rituximab: A randomised, placebo-controlled trial in patients who are biological naïve with active rheumatoid arthritis and an inadequate response to methotrexate (Study Evaluating Rituximab's Efficacy in MTX iNadequate rE-sponders (SERENE))
    • Emery P, Deodhar A, Rigby WF, Isaacs JD, Combe B, Racewicz AJ, et al. Efficacy and safety of different doses and retreatment of rituximab: a randomised, placebo-controlled trial in patients who are biological naïve with active rheumatoid arthritis and an inadequate response to methotrexate (Study Evaluating Rituximab's Efficacy in MTX iNadequate rE-sponders (SERENE)). Ann Rheum Dis. 2010; 69: 1629-35.
    • (2010) Ann Rheum Dis , vol.69 , pp. 1629-1635
    • Emery, P.1    Deodhar, A.2    Rigby, W.F.3    Isaacs, J.D.4    Combe, B.5    Racewicz, A.J.6
  • 47
    • 76949092129 scopus 로고    scopus 로고
    • The addition of tocilizumab to DMARD therapy for rheumatoid arthritis: A meta-analysis of randomized controlled trials
    • An MM, Zou Z, Shen H, Zhang JD, Cao YB, Jiang YY. The addition of tocilizumab to DMARD therapy for rheumatoid arthritis: a meta-analysis of randomized controlled trials. Eur J Clin Pharmacol. 2010; 66: 49-59.
    • (2010) Eur J Clin Pharmacol , vol.66 , pp. 49-59
    • An, M.M.1    Zou, Z.2    Shen, H.3    Zhang, J.D.4    Cao, Y.B.5    Jiang, Y.Y.6
  • 48
    • 84865655947 scopus 로고    scopus 로고
    • A randomized comparative effectiveness study of oral triple therapy versus etanercept plus methotrexate in early aggressive rheumatoid arthritis: The treatment of Early Aggressive Rheumatoid Arthritis Trial
    • Moreland LW, O'Dell JR, Paulus HE, Curtis JR, Bathon JM, St Clair EW, et al. A randomized comparative effectiveness study of oral triple therapy versus etanercept plus methotrexate in early aggressive rheumatoid arthritis: the treatment of Early Aggressive Rheumatoid Arthritis Trial. Arthritis Rheum. 2012; 64: 2824-35.
    • (2012) Arthritis Rheum , vol.64 , pp. 2824-2835
    • Moreland, L.W.1    O'Dell, J.R.2    Paulus, H.E.3    Curtis, J.R.4    Bathon, J.M.5    St Clair, E.W.6
  • 50
    • 84890808741 scopus 로고    scopus 로고
    • Leucopenia in rheumatoid arthritis patients prescribed methotrexate as combination or monotherapy
    • Poster 108
    • Reynolds ND, Edwards MH, Hull RG, Ledingham JM. Leucopenia in rheumatoid arthritis patients prescribed methotrexate as combination or monotherapy. BSR and BHPR Annual meetings 2009. Poster 108.
    • (2009) BSR and BHPR Annual Meetings
    • Reynolds, N.D.1    Edwards, M.H.2    Hull, R.G.3    Ledingham, J.M.4
  • 51
    • 61449238213 scopus 로고    scopus 로고
    • EULAR recommendations for the management of primary small and medium vessel vasculitis
    • Mukhtyar C, Guillevin L, Cid MC, Dasgupta B, de Groot K, Gross W, et al. EULAR recommendations for the management of primary small and medium vessel vasculitis. Ann Rheum Dis. 2009; 68: 310-7.
    • (2009) Ann Rheum Dis , vol.68 , pp. 310-317
    • Mukhtyar, C.1    Guillevin, L.2    Cid, M.C.3    Dasgupta, B.4    de Groot, K.5    Gross, W.6
  • 54
    • 78650532904 scopus 로고    scopus 로고
    • Use of methotrexate in patients with systemic lupus erythematosus and primary Sjögren's syndrome
    • Winzer M, Aringer M. Use of methotrexate in patients with systemic lupus erythematosus and primary Sjögren's syndrome. Clin Exp Rheumatol. 2010; 28: 156S-9S.
    • (2010) Clin Exp Rheumatol , vol.28
    • Winzer, M.1    Aringer, M.2
  • 56
    • 84857238069 scopus 로고    scopus 로고
    • A systematic literature review of drug therapies for the treatment of psoriatic arthritis: Current evidence and meta-analysis informing the EULAR recommendations for the management of psoriatic arthritis
    • Ash Z, Gaujoux-Viala C, Gossec L, Hensor EM, FitzGerald O, Winthrop K, et al. A systematic literature review of drug therapies for the treatment of psoriatic arthritis: current evidence and meta-analysis informing the EULAR recommendations for the management of psoriatic arthritis. Ann Rheum Dis. 2012; 71: 319-26.
    • (2012) Ann Rheum Dis , vol.71 , pp. 319-326
    • Ash, Z.1    Gaujoux-Viala, C.2    Gossec, L.3    Hensor, E.M.4    Fitzgerald, O.5    Winthrop, K.6
  • 57
    • 45049085438 scopus 로고    scopus 로고
    • The effectiveness of a traditional therapeutical approach in early psoriatic arthritis: Results of a pilot randomised 6-month trial with methotrexate
    • Scarpa R, Peluso R, Atteno M, Manguso F, Spanò A, Iervolino S, et al. The effectiveness of a traditional therapeutical approach in early psoriatic arthritis: results of a pilot randomised 6-month trial with methotrexate. Clin Rheumatol. 2008; 27: 823-6.
    • (2008) Clin Rheumatol , vol.27 , pp. 823-826
    • Scarpa, R.1    Peluso, R.2    Atteno, M.3    Manguso, F.4    Spanò, A.5    Iervolino, S.6
  • 58
    • 40649111400 scopus 로고    scopus 로고
    • Reappraisal of the effectiveness of methotrexate in psoriatic arthritis: Results from a longitudinal observational cohort
    • Chandran V, Schentag CT, Gladman DD. Reappraisal of the effectiveness of methotrexate in psoriatic arthritis: results from a longitudinal observational cohort. J Rheumatol. 2008; 35: 469-71.
    • (2008) J Rheumatol , vol.35 , pp. 469-471
    • Chandran, V.1    Schentag, C.T.2    Gladman, D.D.3
  • 59
    • 77950302418 scopus 로고    scopus 로고
    • Effectiveness and retention rates of methotrexate in psoriatic arthritis in comparison with methotrexate-treated patients with rheumatoid arthritis
    • Lie E, van der Heijde D, Uhlig T, Heiberg MS, Koldingsnes W, Rødevand E, et al. Effectiveness and retention rates of methotrexate in psoriatic arthritis in comparison with methotrexate-treated patients with rheumatoid arthritis. Ann Rheum Dis. 2010; 69: 671-6.
    • (2010) Ann Rheum Dis , vol.69 , pp. 671-676
    • Lie, E.1    van der Heijde, D.2    Uhlig, T.3    Heiberg, M.S.4    Koldingsnes, W.5    Rødevand, E.6
  • 60
    • 78650529461 scopus 로고    scopus 로고
    • Use of methotrexate in patients with psoriatic arthritis
    • Ceponis A, Kavanaugh A. Use of methotrexate in patients with psoriatic arthritis. Clin Exp Rheumatol. 2010; 28: 132S-7S.
    • (2010) Clin Exp Rheumatol , vol.28
    • Ceponis, A.1    Kavanaugh, A.2
  • 62
    • 66149100618 scopus 로고    scopus 로고
    • EULAR recommendations for the treatment of systemic sclerosis: A report from the EULAR Scleroderma Trials and Research group (EUSTAR)
    • Kowal-Bielecka O, Landewé R, Avouac J, Chwiesko S, Miniati I, Czirjak L, et al. EULAR recommendations for the treatment of systemic sclerosis: a report from the EULAR Scleroderma Trials and Research group (EUSTAR). Ann Rheum Dis. 2009; 68: 620-8.
    • (2009) Ann Rheum Dis , vol.68 , pp. 620-628
    • Kowal-Bielecka, O.1    Landewé, R.2    Avouac, J.3    Chwiesko, S.4    Miniati, I.5    Czirjak, L.6
  • 63
    • 76749109420 scopus 로고    scopus 로고
    • Can disease-modifying anti-rheumatic drugs be discontinued in long-standing rheumatoid arthritis? A 15 years follow-up
    • Tiippana-Kinnunen T, Paimela L, Kautiainen H, Laasonen L, Leirisalo-Repo M. Can disease-modifying anti-rheumatic drugs be discontinued in long-standing rheumatoid arthritis? A 15 years follow-up. Scand J Rheumatol. 2010; 39: 12-8.
    • (2010) Scand J Rheumatol , vol.39 , pp. 12-18
    • Tiippana-Kinnunen, T.1    Paimela, L.2    Kautiainen, H.3    Laasonen, L.4    Leirisalo-Repo, M.5
  • 64
    • 78751703180 scopus 로고    scopus 로고
    • Discontinuing treatment in patients with rheumatoid arthritis in sustained clinical remission: Exploratory analyses from the BeSt study
    • Klarenbeek NB, van der Kooij SM, Güler-Yüksel M, van Groenendael JH, Han KH, Kerstens PJ, et al. Discontinuing treatment in patients with rheumatoid arthritis in sustained clinical remission: exploratory analyses from the BeSt study. Ann Rheum Dis. 2011; 70: 315-9.
    • (2011) Ann Rheum Dis , vol.70 , pp. 315-319
    • Klarenbeek, N.B.1    van der Kooij, S.M.2    Güler-Yüksel, M.3    van Groenendael, J.H.4    Han, K.H.5    Kerstens, P.J.6
  • 65
    • 77957261808 scopus 로고    scopus 로고
    • Radiographic progression and remission rates in early rheumatoid arthritis-MRI bone oedema and anti-CCP predicted radiographic progression in the 5-year extension of the double-blind randomised CIMESTRA trial
    • Hetland ML, Stengaard-Pedersen K, Junker P, Østergaard M, Ejbjerg BJ, Jacobsen S, et al. Radiographic progression and remission rates in early rheumatoid arthritis-MRI bone oedema and anti-CCP predicted radiographic progression in the 5-year extension of the double-blind randomised CIMESTRA trial. Ann Rheum Dis. 2010; 69: 1789-95.
    • (2010) Ann Rheum Dis , vol.69 , pp. 1789-1795
    • Hetland, M.L.1    Stengaard-Pedersen, K.2    Junker, P.3    Østergaard, M.4    Ejbjerg, B.J.5    Jacobsen, S.6
  • 66
    • 79958158140 scopus 로고    scopus 로고
    • Rheumatoid arthritis: 2011 remission criteria are a new benchmark for RA therapy
    • Bykerk VP. Rheumatoid arthritis: 2011 remission criteria are a new benchmark for RA therapy. Nat Rev Rheumatol. 2011; 7: 317-8.
    • (2011) Nat Rev Rheumatol , vol.7 , pp. 317-318
    • Bykerk, V.P.1
  • 67
    • 76649119459 scopus 로고    scopus 로고
    • Rheumatoid arthritis: Can we achieve true drug-free remission in patients with RA?
    • Goekoop-Ruiterman YP, Huizinga TW. Rheumatoid arthritis: can we achieve true drug-free remission in patients with RA? Nat Rev Rheumatol. 2010; 6: 68-70.
    • (2010) Nat Rev Rheumatol , vol.6 , pp. 68-70
    • Goekoop-Ruiterman, Y.P.1    Huizinga, T.W.2
  • 68
    • 67649695241 scopus 로고    scopus 로고
    • Portuguese recommendations for the use of methotrexate in the treatment of rheumatoid arthritis
    • Canhão H, Santos MJ, Costa L, Bogas M, Mourão AF, Machado P, et al. Portuguese recommendations for the use of methotrexate in the treatment of rheumatoid arthritis. Acta Reumatol Port. 2009; 34: 78-95.
    • (2009) Acta Reumatol Port , vol.34 , pp. 78-95
    • Canhão, H.1    Santos, M.J.2    Costa, L.3    Bogas, M.4    Mourão, A.F.5    Machado, P.6
  • 69
    • 84856271157 scopus 로고    scopus 로고
    • Can the medication in patients with rheumatoidarthritis in remission be stopped?
    • Nóvoa Medina FJ, Francisco H.F. Can the medication in patients with rheumatoidarthritis in remission be stopped? Reumatol Clin. 2012; 8: 39-41.
    • (2012) Reumatol Clin , vol.8 , pp. 39-41
    • Nóvoa, M.F.J.1    Francisco, H.F.2
  • 71
    • 84859832981 scopus 로고    scopus 로고
    • 2012 update of the 2008 American College of Rheumatology recommendations for the use of disease-modifying antirheumatic drugs and biologic agents in the treatment of rheumatoid arthritis
    • Singh JA, Furst DE, Bharat A, Curtis JR, Kavanaugh AF, Kremer JM, et al. 2012 update of the 2008 American College of Rheumatology recommendations for the use of disease-modifying antirheumatic drugs and biologic agents in the treatment of rheumatoid arthritis. Arthritis Care Res (Hoboken). 2012; 64: 625-39.
    • (2012) Arthritis Care Res (Hoboken) , vol.64 , pp. 625-639
    • Singh, J.A.1    Furst, D.E.2    Bharat, A.3    Curtis, J.R.4    Kavanaugh, A.F.5    Kremer, J.M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.