Perspectives and future directions of human pluripotent stem cell-based Therapies: Lessons from geron's clinical trial for spinal cord injury

Stem Cells and Development

Volumn 23, Issue 1, 2014, Pages 1-4

  Lukovic, Dunja ^a   Stojkovic, Miodrag ^b,c   Moreno Manzano, Victoria ^d   Bhattacharya, Shomi Shanker ^a   Erceg, Slaven ^a  

^a CABIMER Andalusian Center for Molecular Biology and Regenerative Medicine CSIC University of Seville UPO   (Spain)

^b Spebo Medical ^*  (Serbia)

^c University of Kragujevac Medical Faculty   (Serbia)

^d CENTRO DE INVESTIGACIÓN PRÍNCIPE FELIPE   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CELL DIFFERENTIATION; CLINICAL TRIAL (TOPIC); GOOD MANUFACTURING PRACTICE; HEALTH CARE COST; HUMAN; NONHUMAN; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; REVIEW; SPINAL CORD INJURY; STEM CELL TRANSPLANTATION; BIOLOGICAL THERAPY; CYTOLOGY; ECONOMICS; EMBRYONIC STEM CELL; OLIGODENDROGLIA; PROCEDURES; SPINAL CORD INJURIES; TRANSPLANTATION;

ANIMALIA;

CELL DIFFERENTIATION; CELL- AND TISSUE-BASED THERAPY; EMBRYONIC STEM CELLS; HUMANS; OLIGODENDROGLIA; PLURIPOTENT STEM CELLS; SPINAL CORD INJURIES; STEM CELL TRANSPLANTATION;

EID: 84890826651     PISSN: 15473287     EISSN: 15578534     Source Type: Journal    
DOI: 10.1089/scd.2013.0266     Document Type: Review

References (10)

1. Ichim T, NH Riordan and DF Stroncek. (2011). The king is dead, long live the king: entering a new era of stem cell research and clinical development. J Transl Med 9:218.
2. Thomson JA, J Itskovitz-Eldor, SS Shapiro, MA Waknitz, JJ Swiergiel, VS Marshall and JM Jones. (1998). Embryonic stem cell lines derived from human blastocysts. Science 282:1145-1147. (Pubitemid 28516247)
3. Keirstead HS, G Nistor, G Bernal, M Totoiu, F Cloutier, K Sharp and O Steward. (2005). Human embryonic stem cellderived oligodendrocyte progenitor cell transplants remyelinate and restore locomotion after spinal cord injury. J Neurosci 25:4694-4705. (Pubitemid 40664118)
4. Erceg S, M Ronaghi, M Oria, MG Rosello, MA Arago, MG Lopez, I Radojevic, V Moreno-Manzano, FJ Rodriguez-Jimenez, et al. (2010). Transplanted oligodendrocytes and motoneuron progenitors generated from human embryonic stem cells promote locomotor recovery after spinal cord transection. Stem Cells 28:1541-1549.
5. Moreno-Manzano V, FJ Rodriguez-Jimenez, M Garcia-Rosello, S Lainez, S Erceg, MT Calvo, M Ronaghi, M Lloret, R Planells-Cases, JM Sanchez-Puelles and M Stojkovic. (2009). Activated spinal cord ependymal stem cells rescue neurological function. Stem Cells 27:733-743.
6. Swistowski A, J Peng, Y Han, AM Swistowska, MS Rao and X Zeng. (2009). Xeno-free defined conditions for culture of human embryonic stem cells, neural stem cells and dopaminergic neurons derived from them. PLoS One 4:e6233.
7. Swistowski A, J Peng, Q Liu, P Mali, MS Rao, L Cheng and X Zeng. (2010). Efficient generation of functional dopaminergic neurons from human induced pluripotent stem cells under defined conditions. Stem Cells 28:1893-1904.
8. Tannenbaum SE, TT Turetsky, O Singer, E Aizenman, S Kirshberg, N Ilouz, Y Gil, Y Berman-Zaken, TS Perlman, et al. (2012). Derivation of xeno-free and GMP-grade human embryonic stem cells-platforms for future clinical applications. PLoS One 7:e35325.
9. Fawcett JW, A Curt, JD Steeves, WP Coleman, MH Tuszynski, D Lammertse, PF Bartlett, AR Blight, V Dietz, et al. (2007). Guidelines for the conduct of clinical trials for spinal cord injury as developed by the ICCP panel: spontaneous recovery after spinal cord injury and statistical power needed for therapeutic clinical trials. Spinal Cord 45:190-205. (Pubitemid 46340848)
10. Schwartz SD, JP Hubschman, G Heilwell, V Franco-Cardenas, CK Pan, RM Ostrick, E Mickunas, R Gay, I Klimanskaya and R Lanza. (2012). Embryonic stem cell trials for macular degeneration: a preliminary report. Lancet 379:713-720.