A non-genetic, epigenetic-like mechanism of telomere length inheritance

European Journal of Human Genetics

Volumn 22, Issue 1, 2014, Pages 10-11

  De Meyer, Tim ^a   Vandepitte, Katrien ^b   Denil, Simon ^a   De Buyzere, Marc L ^c   Rietzschel, Ernst R ^c   Bekaert, Sofie ^c  

^a GHENT UNIVERSITY   (Belgium)

^b UNIVERSITY OF LEUVEN   (Belgium)

^c GHENT UNIVERSITY HOSPITAL   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

AGING; CARDIOVASCULAR DISEASE; DNA SEQUENCE; EMBRYO DEVELOPMENT; ENVIRONMENTAL FACTOR; EPIGENETICS; GENE EXPRESSION; GENETIC VARIABILITY; HUMAN; INHERITANCE; LETTER; PRIORITY JOURNAL; PROGENY; SPERMATOGONIUM; SPERMATOZOON; TELOMERE; FEMALE; GENETICS; MALE; PATERNAL AGE; PEDIGREE; TELOMERE SHORTENING;

FEMALE; HUMANS; MALE; PATERNAL AGE; PEDIGREE; TELOMERE; TELOMERE SHORTENING;

EID: 84890796103     PISSN: 10184813     EISSN: 14765438     Source Type: Journal    
DOI: 10.1038/ejhg.2013.255     Document Type: Letter

References (16)

1. Broer L, Codd V, Nyholt DR et al: Meta-analysis of telomere length in 19713 subjects reveals high heritability, stronger maternal inheritance and a paternal age effect. Eur J Hum Genet 2013; 21: 1163-1168.
2. De Meyer T, Rietzschel ER, De Buyzere ML, Van Criekinge W, Bekaert S: Telomere length and cardiovascular aging: the means to the ends? Ageing Res Rev 2011; 10: 297-303.
3. Slagboom PE, Droog S, Boomsma DI: Genetic determination of telomere size in humans: a twin study of three age groups. Am J Hum Genet 1994; 55: 876-882.
4. Nawrot TS, Staessen JA, Gardner JP, Aviv A: Telomere length and possible link to X chromosome. Lancet 2004; 363: 507-510.
5. Nordfjall K, Svenson U, Norrback KF, Adolfsson R, Roos G: Large-scale parent-child comparison confirms a strong paternal influence on telomere length. Eur J Hum Genet 2010; 18: 385-389.
6. Schaetzlein S, Lucas-Hahn A, Lemme E et al: Telomere length is reset during early mammalian embryogenesis. Proc Natl Acad Sci USA 2004; 101: 8034-8038.
7. Codd V, Mangino M, van der Harst P et al: Common variants near TERC are associated with mean telomere length. Nat Genet 2010; 42: 197-199.
8. De Meyer T, Rietzschel ER, De Buyzere ML et al: Paternal age at birth is an important determinant of offspring telomere length. Hum Mol Genet 2007; 16: 3097-3102.
9. Chiang YJ, Calado RT, Hathcock KS, Lansdorp PM, Young NS, Hodes RJ: Telomere length is inherited with resetting of the telomere set-point. Proc Natl Acad Sci USA 2010; 107: 10148-10153.
10. Eisenberg DT: An evolutionary review of human telomere biology: the thrifty telomere hypothesis and notes on potential adaptive paternal effects. Am J Hum Biol 2011; 23: 149-167.
11. Berger SL, Kouzarides T, Shiekhattar R, Shilatifard A: An operational definition of epigenetics. Genes Dev 2009; 23: 781-783.
12. Zhang DD, Cheng LJ, Badner JA et al: Genetic Control of Individual Differences in Gene-Specific Methylation in Human Brain. Am J Hum Genet 2010; 86: 411-419.
13. Guilleret I, Yan P, Grange F, Braunschweig R, Bosman FT, Benhattar J: Hypermethylation of the human telomerase catalytic subunit (hTERT) gene correlates with telomerase activity. Int J Cancer 2002; 101: 335-341.
14. Ornish D, Lin J, Daubenmier J et al: Increased telomerase activity and comprehensive lifestyle changes: a pilot study. Lancet Oncol 2008; 9: 1048-1057.
15. Eisenberg DT: Inconsistent inheritance of telomere length (TL): is offspring TL more strongly correlated with maternal or paternal TL? Eur J Hum Genet 2014; 22: 8-9.
16. Eisenberg DT, Hayes MG, Kuzawa CW: Delayed paternal age of reproduction in humans is associated with longer telomeres across two generations of descendants. Proc Natl Acad Sci USA 2012; 109: 10251-10256.