메뉴 건너뛰기




Volumn 120, Issue 1, 2014, Pages 26-34

Molecular phenotype of the foci in multifocal invasive breast carcinomas: Intertumoral heterogeneity is related to shorter survival and may influence the choice of therapy

Author keywords

histologic grade; histologic type; intertumoral heterogeneity; molecular phenotypes; multifocal breast cancer

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR 2; ESTROGEN RECEPTOR; KI 67 ANTIGEN; PROGESTERONE RECEPTOR;

EID: 84890786511     PISSN: 0008543X     EISSN: 10970142     Source Type: Journal    
DOI: 10.1002/cncr.28375     Document Type: Article
Times cited : (37)

References (41)
  • 1
    • 0026072872 scopus 로고
    • Pathological prognostic factors in breast cancer. I the value of histological grade in breast cancer: Experience from a large study with long-term follow-up
    • Elston CW, Ellis IO,. Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long-term follow-up. Histopathology. 1991; 19: 403-410.
    • (1991) Histopathology. , vol.19 , pp. 403-410
    • Elston, C.W.1    Ellis, I.O.2
  • 2
    • 0036432767 scopus 로고    scopus 로고
    • Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: Experience from a large study with long-term follow-up. Author commentary
    • DOI 10.1046/j.1365-2559.2002.14691.x
    • Elston CW, Ellis IO,. Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long-term follow-up [C.W. Elston & I.O. Ellis. Histopathology 1991;19:403-410]. Histopathology. 2002; 41: 151-153 (Pubitemid 41713015)
    • (2002) Histopathology , vol.41 , Issue.SUPPL. 1 , pp. 151-153
    • Elston, C.W.1    Ellis, I.O.2
  • 3
    • 0026808390 scopus 로고
    • The Nottingham Prognostic Index in primary breast cancer
    • et al
    • Galea MH, Blamey RW, Elston CE, et al. The Nottingham Prognostic Index in primary breast cancer. Breast Cancer Res Treat. 1992; 22: 207-219.
    • (1992) Breast Cancer Res Treat. , vol.22 , pp. 207-219
    • Galea, M.H.1    Blamey, R.W.2    Elston, C.E.3
  • 4
    • 0034680102 scopus 로고    scopus 로고
    • Molecular portraits of human breast tumors
    • et al
    • Perou CM, Sorlie T, Eisen MB, et al. Molecular portraits of human breast tumors. Nature. 2000; 406: 747-752.
    • (2000) Nature. , vol.406 , pp. 747-752
    • Perou, C.M.1    Sorlie, T.2    Eisen, M.B.3
  • 6
    • 73949136029 scopus 로고    scopus 로고
    • The contribution of gene expression profiling to breast cancer classification, prognostication and prediction: A retrospective of the last decade
    • Weigelt B, Baehner FL, Reis-Filho JS,. The contribution of gene expression profiling to breast cancer classification, prognostication and prediction: a retrospective of the last decade. J Pathol. 2009; 220: 263-280.
    • (2009) J Pathol. , vol.220 , pp. 263-280
    • Weigelt, B.1    Baehner, F.L.2    Reis-Filho, J.S.3
  • 8
    • 79961009392 scopus 로고    scopus 로고
    • Differential efficacy of three cycles of CMF followed by tamoxifen in patients with ER-positive and ER-negative tumors: Long-term follow up on IBCSG Trial IX
    • et al
    • Aebi S, Sun Z, Braun D, et al. Differential efficacy of three cycles of CMF followed by tamoxifen in patients with ER-positive and ER-negative tumors: long-term follow up on IBCSG Trial IX. Ann Oncol. 2011; 22: 1981-1987.
    • (2011) Ann Oncol. , vol.22 , pp. 1981-1987
    • Aebi, S.1    Sun, Z.2    Braun, D.3
  • 9
    • 77950593219 scopus 로고    scopus 로고
    • The association between biological subtype and isolated regional nodal failure after breast-conserving therapy
    • et al
    • Wo JY, Taghian AG, Nguyen PL, et al. The association between biological subtype and isolated regional nodal failure after breast-conserving therapy. Int J Radiat Oncol Biol Phys. 2010; 77: 188-196.
    • (2010) Int J Radiat Oncol Biol Phys. , vol.77 , pp. 188-196
    • Wo, J.Y.1    Taghian, A.G.2    Nguyen, P.L.3
  • 10
    • 84864579906 scopus 로고    scopus 로고
    • How many molecular subtypes? Implications of the unique tumor principle in personalized medicine
    • Ogino S, Fuchs CS, Giovannucci E,. How many molecular subtypes? Implications of the unique tumor principle in personalized medicine. Expert Rev Mol Diagn. 2012; 12: 621-628.
    • (2012) Expert Rev Mol Diagn. , vol.12 , pp. 621-628
    • Ogino, S.1    Fuchs, C.S.2    Giovannucci, E.3
  • 13
    • 77953248475 scopus 로고    scopus 로고
    • Subtyping of breast cancer by immunohistochemistry to investigate a relationship between subtype and short and term survival: A collaborative analysis of data for 10,159 cases from 12 studies [serial online]
    • et al
    • Blows FM, Driver KE, Schimdt MK, et al. Subtyping of breast cancer by immunohistochemistry to investigate a relationship between subtype and short and term survival: a collaborative analysis of data for 10,159 cases from 12 studies [serial online]. PLoS Med. 2010; 7: e1000279.
    • (2010) PLoS Med. , vol.7
    • Blows, F.M.1    Driver, K.E.2    Schimdt, M.K.3
  • 15
    • 0020059001 scopus 로고
    • Multicentric breast carcinomas: Clinical-radiographic-pathologic whole organ studies and 10-year survival
    • Egan RL,. Multicentric breast carcinomas: clinical-radiographic- pathologic whole organ studies and 10-year survival. Cancer. 1982; 49: 1123-1130. (Pubitemid 12187811)
    • (1982) Cancer , vol.49 , Issue.6 , pp. 1123-1130
    • Egan, R.L.1
  • 16
    • 0021883671 scopus 로고
    • Histologic multifocality of Tis, T1-2 breast carcinomas: Implications for clinical trials of breast-conserving surgery
    • DOI 10.1002/1097-0142(19850901) 56:5<979::AID-CNCR2820560502>3.0. CO;2-N
    • Holland R, Veiling SH, Mravunac M, et al. Histologic multifocality of Tis, T1-2 breast carcinomas. Implications for clinical trials of breast conserving surgery. Cancer. 1985; 56: 979-990. (Pubitemid 15003474)
    • (1985) Cancer , vol.56 , Issue.5 , pp. 979-990
    • Holland, R.1    Veling, S.H.J.2    Mravunac, M.3    Hendriks, J.H.C.L.4
  • 17
    • 84868202364 scopus 로고    scopus 로고
    • Axillary lymph node status in unifocal, multifocal, and diffuse breast carcinomas: Differences are related to macrometastatic disease
    • Tot T,. Axillary lymph node status in unifocal, multifocal, and diffuse breast carcinomas: differences are related to macrometastatic disease. Ann Surg Oncol. 2012; 19: 3395-3401.
    • (2012) Ann Surg Oncol. , vol.19 , pp. 3395-3401
    • Tot, T.1
  • 18
    • 77953534410 scopus 로고    scopus 로고
    • Multicentric and multifocal versus unifocal breast cancer: Is the tumor-node-metastasis classification justified?
    • et al
    • Weissenbacher TM, Zschage M, Janni W, et al. Multicentric and multifocal versus unifocal breast cancer: is the tumor-node-metastasis classification justified? Breast Cancer Res Treat. 2010; 122: 27-34.
    • (2010) Breast Cancer Res Treat. , vol.122 , pp. 27-34
    • Weissenbacher, T.M.1    Zschage, M.2    Janni, W.3
  • 19
    • 77954216809 scopus 로고    scopus 로고
    • Multifocal breast cancer and survival: Each focus does matter particularly for larger tumours
    • Boyages J, Jayasinghe UW, Coombs N,. Multifocal breast cancer and survival: each focus does matter particularly for larger tumours. Eur J Cancer. 2010; 46: 1990-1996.
    • (2010) Eur J Cancer. , vol.46 , pp. 1990-1996
    • Boyages, J.1    Jayasinghe, U.W.2    Coombs, N.3
  • 20
    • 77957778470 scopus 로고    scopus 로고
    • Multiple synchronous (multifocal and multicentric) breast cancer: Clinical implications
    • et al
    • Bendifallah S, Werkoff G, Borie-Moutafoff C, et al. Multiple synchronous (multifocal and multicentric) breast cancer: clinical implications. Surg Oncol. 2010; 19: e115-e123.
    • (2010) Surg Oncol. , vol.19
    • Bendifallah, S.1    Werkoff, G.2    Borie-Moutafoff, C.3
  • 21
    • 80054710060 scopus 로고    scopus 로고
    • Breast cancer multifocality, disease extent, and survival
    • et al
    • Tot T, Gere M, Pekar Gy, et al. Breast cancer multifocality, disease extent, and survival. Hum Pathol. 2011; 42: 1761-1769.
    • (2011) Hum Pathol. , vol.42 , pp. 1761-1769
    • Tot, T.1    Gere, M.2    Pekar, G.3
  • 22
    • 33847041952 scopus 로고    scopus 로고
    • Oestrogen and progesterone status of individual foci in multifocal invasive ductal cancer
    • et al
    • Garimella V, Long ED, O'Kane SL, et al. Oestrogen and progesterone status of individual foci in multifocal invasive ductal cancer. Acta Oncol. 2007; 46: 204-207.
    • (2007) Acta Oncol. , vol.46 , pp. 204-207
    • Garimella, V.1    Long, E.D.2    O'Kane, S.L.3
  • 23
    • 84864942671 scopus 로고    scopus 로고
    • Multicentric/multifocal breast cancer with a single histotype: Is the biological characterization of all individual foci justified?
    • et al
    • Buggi F, Folli S, Curcio A, et al. Multicentric/multifocal breast cancer with a single histotype: is the biological characterization of all individual foci justified? Ann Oncol. 2012; 23: 2042-2046.
    • (2012) Ann Oncol. , vol.23 , pp. 2042-2046
    • Buggi, F.1    Folli, S.2    Curcio, A.3
  • 24
    • 83055194663 scopus 로고    scopus 로고
    • The hormone receptor, human epidermal growth factor receptor 2, and molecular subtype status of individual tumor foci in multifocal/multicentric invasive ductal carcinoma of breast
    • et al
    • Choi Y, Kim EJ, Seol H, et al. The hormone receptor, human epidermal growth factor receptor 2, and molecular subtype status of individual tumor foci in multifocal/multicentric invasive ductal carcinoma of breast. Hum Pathol. 2012; 43: 48-55.
    • (2012) Hum Pathol. , vol.43 , pp. 48-55
    • Choi, Y.1    Kim, E.J.2    Seol, H.3
  • 25
    • 84890792876 scopus 로고    scopus 로고
    • The clinical relevance of the distribution of the lesions in 500 consecutive breast cancer cases documented in large-format histological sections
    • Tot T,. The clinical relevance of the distribution of the lesions in 500 consecutive breast cancer cases documented in large-format histological sections. Cancer. 2007; 7: 581-587.
    • (2007) Cancer. , vol.7 , pp. 581-587
    • Tot, T.1
  • 27
    • 80052781512 scopus 로고    scopus 로고
    • Early and more advanced unifocal and multifocal breast carcinomas and their molecular phenotypes
    • Tot T,. Early and more advanced unifocal and multifocal breast carcinomas and their molecular phenotypes. Clin Breast Cancer. 2011; 11: 258-263.
    • (2011) Clin Breast Cancer. , vol.11 , pp. 258-263
    • Tot, T.1
  • 28
    • 79960980007 scopus 로고    scopus 로고
    • Strategies for subtypes-dealing with the diversity of breast cancer: Highlights of the St. Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2011
    • et al
    • Goldhirsch A, Wood WC, Coates AS, et al. Strategies for subtypes-dealing with the diversity of breast cancer: highlights of the St. Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2011. Ann Oncol. 2011; 22: 1736-1747.
    • (2011) Ann Oncol. , vol.22 , pp. 1736-1747
    • Goldhirsch, A.1    Wood, W.C.2    Coates, A.S.3
  • 30
    • 60849097255 scopus 로고    scopus 로고
    • Gene-expression signatures in breast cancer
    • Sotiriou C, Pusztai L,. Gene-expression signatures in breast cancer. N Engl J Med. 2009; 360: 790-800.
    • (2009) N Engl J Med. , vol.360 , pp. 790-800
    • Sotiriou, C.1    Pusztai, L.2
  • 31
    • 70349646887 scopus 로고    scopus 로고
    • Protocol for the examination of specimens from patients with invasive carcinoma of the breast
    • et al; Members of the Cancer Committee, College of American Pathologists
    • Lester SC, Bose S, Chen YY, et al. Members of the Cancer Committee, College of American Pathologists. Protocol for the examination of specimens from patients with invasive carcinoma of the breast. Arch Pathol Lab Med. 2009; 133: 1515-1538.
    • (2009) Arch Pathol Lab Med. , vol.133 , pp. 1515-1538
    • Lester, S.C.1    Bose, S.2    Chen, Y.Y.3
  • 33
    • 84867660329 scopus 로고    scopus 로고
    • Morphological heterogeneity of the simultaneous ipsilateral invasive tumor foci in breast carcinoma: A retrospective study of 418 cases of carcinomas
    • Boros M, Marian C, Moldovan C, Stolnicu S,. Morphological heterogeneity of the simultaneous ipsilateral invasive tumor foci in breast carcinoma: a retrospective study of 418 cases of carcinomas. Pathol Res Pract. 2012; 208: 604-609.
    • (2012) Pathol Res Pract. , vol.208 , pp. 604-609
    • Boros, M.1    Marian, C.2    Moldovan, C.3    Stolnicu, S.4
  • 34
    • 0014492997 scopus 로고
    • The study of mammary carcinoma by mammography and whole organ sectioning. Early observations
    • Gallager HS, Martin JE,. The study of mammary carcinoma by mammography and whole organ sectioning. Early observations. Cancer. 1969; 23: 855-873.
    • (1969) Cancer. , vol.23 , pp. 855-873
    • Gallager, H.S.1    Martin, J.E.2
  • 35
    • 84871721294 scopus 로고    scopus 로고
    • Subgross morphology, the sick lobe hypothesis, and the success of breast conservation [serial online]
    • Tot T,. Subgross morphology, the sick lobe hypothesis, and the success of breast conservation [serial online]. Int J Breast Cancer. 2011; 2011: 634021.
    • (2011) Int J Breast Cancer. , vol.2011 , pp. 634021
    • Tot, T.1
  • 36
    • 84890787428 scopus 로고    scopus 로고
    • Imaging-assisted large-format breast pathology: Program rationale and development in a nonprofit health system in the United States [serial online]
    • Tucker FL,. Imaging-assisted large-format breast pathology: program rationale and development in a nonprofit health system in the United States [serial online]. Int J Breast Cancer. 2012; 2012: 171792.
    • (2012) Int J Breast Cancer. , vol.2012 , pp. 171792
    • Tucker, F.L.1
  • 37
    • 79956213741 scopus 로고    scopus 로고
    • Multifocality in "basal-like" breast carcinomas and its influence on lymph node status
    • Tot T, Pekar G,. Multifocality in "basal-like" breast carcinomas and its influence on lymph node status. Ann Surg Oncol. 2011; 18: 1671-1677.
    • (2011) Ann Surg Oncol. , vol.18 , pp. 1671-1677
    • Tot, T.1    Pekar, G.2
  • 38
    • 84890788128 scopus 로고    scopus 로고
    • The role of large-format histopathology in assessing subgross morphological prognostic parameters: A single institution report of 1000 consecutive breast cancer cases [serial online]
    • Tot T,. The role of large-format histopathology in assessing subgross morphological prognostic parameters: a single institution report of 1000 consecutive breast cancer cases [serial online]. Int J Breast Cancer. 2012; 2012: 395415.
    • (2012) Int J Breast Cancer. , vol.2012 , pp. 395415
    • Tot, T.1
  • 39
    • 56949100368 scopus 로고    scopus 로고
    • Multifocality as a prognostic factor in breast cancer patients registered in Danish Breast Cancer Cooperative Group (DBCG) 1996-2001
    • et al
    • Joergensen LE, Gunnarsdottir KA, Lanng C, et al. Multifocality as a prognostic factor in breast cancer patients registered in Danish Breast Cancer Cooperative Group (DBCG) 1996-2001. Breast. 2008; 17: 587-591.
    • (2008) Breast. , vol.17 , pp. 587-591
    • Joergensen, L.E.1    Gunnarsdottir, K.A.2    Lanng, C.3
  • 40
    • 84874742950 scopus 로고    scopus 로고
    • Multifocal breast cancer documented in large-format histology sections: Long-term follow-up results by molecular phenotypes
    • et al
    • Pekar G, Hofmeyer S, Tabar L, et al. Multifocal breast cancer documented in large-format histology sections: long-term follow-up results by molecular phenotypes. Cancer. 2013; 119: 1132-1139.
    • (2013) Cancer. , vol.119 , pp. 1132-1139
    • Pekar, G.1    Hofmeyer, S.2    Tabar, L.3
  • 41
    • 84890805919 scopus 로고    scopus 로고
    • Characterization of different foci of multifocal breast cancer using genomic, transcriptomic and epigenomic data [abstract]
    • December 4-8, San Antonio, TX. Cancer Res. 2012 Abstract nr S60-2
    • Desmedt C, Nik-Zainal S, Fumagalli D, et al. Characterization of different foci of multifocal breast cancer using genomic, transcriptomic and epigenomic data [abstract]. Abstracts: Thirty-Fifth Annual CTRC-AACR San Antonio Breast Cancer Symposium; December 4-8, 2012; San Antonio, TX. Cancer Res. 2012;72(24 suppl). Abstract nr S60-2.
    • (2012) Abstracts: Thirty-Fifth Annual CTRC-AACR San Antonio Breast Cancer Symposium , vol.72 , Issue.24 SUPPL.
    • Desmedt, C.1    Nik-Zainal, S.2    Fumagalli, D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.