The role of zinc in acne and prevention of resistance: Have we missed the "base" effect?

International Journal of Dermatology

Volumn 53, Issue 1, 2014, Pages 125-127

  Sardana, Kabir ^a   Chugh, Shikha ^a   Garg, Vijay K ^a  

^a MAULANA AZAD MEDICAL COLLEGE   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPALENE; BENZOYL PEROXIDE; ERYTHROMYCIN; GLUCONATE ZINC; INTERLEUKIN 12; INTERLEUKIN 8; ISOTRETINOIN; METHIONINE BOUND ZINC; MINOCYCLINE; OXYTETRACYCLINE; PICOLINATE ZINC; RETINOID; TETRACYCLINE; TOLL LIKE RECEPTOR 2; UNCLASSIFIED DRUG; ZINC; ZINC ACETATE; ZINC ASCORBATE; ZINC CITRATE; ZINC OCTOATE; ZINC SULFATE; ZINC SULFATE ZINC CITRATE COMPLEX;

ACNE; ACNE VULGARIS; ANTIBIOTIC RESISTANCE; ANTIINFLAMMATORY ACTIVITY; ANTIMICROBIAL ACTIVITY; CYTOKINE PRODUCTION; DIETARY INTAKE; DISEASE SEVERITY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG EFFICACY; DRUG FORMULATION; DRUG MECHANISM; EFFERVESCENT TABLET; ETHNIC AND RACIAL GROUPS; HUMAN; IMMUNOSTIMULATION; INNATE IMMUNITY; MINIMUM INHIBITORY CONCENTRATION; NOTE; PROPIONIBACTERIUM ACNES; ROSACEA; TREATMENT RESPONSE;

ACNE VULGARIS; ADMINISTRATION, ORAL; ANTI-BACTERIAL AGENTS; DRUG RESISTANCE, BACTERIAL; DRUG THERAPY, COMBINATION; HUMANS; ROSACEA; ZINC COMPOUNDS;

EID: 84890778759     PISSN: 00119059     EISSN: 13654632     Source Type: Journal    
DOI: 10.1111/ijd.12264     Document Type: Note

References (12)

1. Tzellos T, Zampeli V, Makrantonaki E, et al. Treating acne with antibiotic-resistant bacterial colonization. Expert Opin Pharmacother 2011; 12: 1233-1247.
2. Iinuma K, Noguchi N, Nakaminami H, et al. Susceptibility of Propionibacterium acnes isolated from patients with acne vulgaris to zinc ascorbate and antibiotics. Clin Cosmet Investig Dermatol 2011; 4: 161-165.
3. Sardana K, Garg VK. An observational study of methionine-bound zinc with antioxidants for mild to moderate acne vulgaris. Dermatol Ther 2010; 23: 411-418.
4. Bamford JT, Gessert CE, Haller IV, et al. Randomized, double-blind trial of 220 mg zinc sulfate twice daily in the treatment of rosacea. Int J Dermatol 2012; 51: 459-462.
5. Wedekind KJ, Hortin AE, Baker DH. Methodology for assessing zinc bioavailability: efficacy estimates for zinc-methionine, zinc sulfate, and zinc oxide. J Anim Sci 1992; 70: 178-187.
6. Brocard A, Dréno B. Innate immunity: a crucial target for zinc in the treatment of inflammatory dermatosis. J Eur Acad Dermatol Venereol 2011; 25: 1146-1152.
7. Revuz J, Amblard P, Dreno B, et al. Efficacite′ du gluconate de zinc dans le traitement de l'acne′ inflammatoire. Abstr Dermatol 1990; 77: 2-4.
8. Dreno B, Moyse D, Alirezai M, et al. Multicenter randomized comparative double-blind controlled clinical trial of the safety and efficacy of zinc gluconate versus minocycline hydrochloride in the treatment of inflammatory acne vulgaris. Dermatology 2001; 203: 135-140.
9. Michaelsson G, Juhlin L, Ljunghall K. A double-blind study of the effect of zinc and oxytetracycline in acne vulgaris. Br J Dermatol 1977; 97: 561-566.
10. Cunliffe WJ, Burke B, Dodman B, et al. A double-blind trial of a zinc sulphate/citrate complex and tetracycline in the treatment of acne vulgaris. Br J Dermatol 1979; 101: 321-325.
11. Bojar RA, Eady EA, Jones CE, et al. Inhibition of erythromycin-resistant propionibacteria on the skin of acne patients by topical erythromycin with and without zinc. Br J Dermatol 1994; 130: 329-336.
12. Dreno B, Foulc P, Reynaud A, et al. Effect of zinc gluconate on Propionibacterium acnes resistance to erythromycin in patients with inflammatory acne: in vitro and in vivo study. Eur J Dermatol 2005; 15: 152-155.