Paroxysmal Nocturnal Haemoglobinuria

Postgraduate Haematology: Fifth Edition

Volumn , Issue , 2007, Pages 169-175

  Luzzatto, Lucio ^a   Notaro, Rosario ^a  

^a UNIVERSITY OF GENOA   (Italy)

Author keywords

Acquired aplastic anaemia (AAA); Haemolytic anaemia; Paroxysmal nocturnal haemoglobinuria (PNH); Supportive treatment; Thrombosis

Indexed keywords

EID: 84890746685     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9780470987056.ch11     Document Type: Chapter

References (23)

1. Araten D, Nafa K, Pakdeesuwan K et al. (1999) Clonal populations of hematopoietic cells with paroxysmal nocturnal hemoglobinuria genotype and phenotype are present in normal individuals. Proceedings of the National Academy of Sciences of the USA 96:5209-14.
2. Bessler M, Mason PJ, Hillmen P et al. (1994) Paroxysmal nocturnal haemoglobinuria (PNH) is caused by somatic mutations in the PIG-A gene. EMBO Journal 13: 110-17.
3. Bessler M, Schaefer A, Keller P (2001) Paroxysmal nocturnal hemoglobinuria:insights from recent advances in molecular biology. Transfusion Medicine Review 15: 255-67.
4. Ham TH (1937) Chronic hemolytic anemia with paroxysmal nocturnal hemoglobinuria. A study of the mechanism of hemolysis in relation to acid-base equilibrium. New England Journal of Medicine 217: 915-18.
5. Hillmen P, Lewis SM, Bessler M et al. (1995) Natural history of paryxysmal nocturnal hemoglobinuria. New England Journal of Medicine 333: 1253-8.
6. Hillmen P, Hall C, Marsh JC et al. (2004) Effect of eculizumab on hemolysis and transfusion requirements in patients with paroxysmal nocturnal hemoglobinuria. New England Journal of Medicine 350: 552-9.
7. Karadimitris A, Manavalan JS, Thaler HT et al. (2000) Abnormal Tcell repertoire is consistent with immune process underlying the pathogenesis of paroxysmal nocturnal hemoglobinuria. Blood 96:2613-20.
8. Karadimitris A, Luzzatto L (2001) The cellular pathogenesis of paroxysmal nocturnal haemoglobinuria. Leukemia 15: 1148-52.
9. Lewis SM, Dacie JV (1967) The aplastic anaemia-paroxysmal nocturnal haemoglobinuria syndrome. British Journal of Haematology 13: 236-51.
10. Luzzatto L, Bessler M (1996) The dual pathogenesis of paroxysmal nocturnal hemoglobinuria. Current Opinion in Hematology 3:101-10.
11. Luzzatto L, Notaro R (2003) Paroxysmal nocturnal hemoglobinuria. In: Blood: Principles and Practice of Hematology (RI Handlin, SE Lux, TP Stossel, eds), 2nd edn, pp. 319-34. Lippincott Williams & Wilkins, Philadelphia.
12. Miyata T, Takeda J, Iida J et al. (1993) The cloning of PIG-A, a component in the early step of GPI-anchor biosynthesis. Science 259: 1318-20.
13. Omine M, Kinoshita T (ed.) (2003) Paroxysmal Nocturnal Hemoglobinuria and Related Disorders - Molecular Aspects and Pathogenesis, p. 285. Springer-Verlag, Tokyo.
14. Oni SB, Osunkoya BO, Luzzatto L (1970) Paroxysmal nocturnal hemoglobinuria: evidence for monoclonal origin of abnormal red cells. Blood 36: 145-52.
15. Raiola AM, Van Lint MT, Lamparelli T et al. (2000) Bone marrow transplantation for paroxysmal nocturnal hemoglobinuria. Haematologica 85(1): 59-62.
16. Rosse WF (1986) The control of complement activation by the blood cells in paroxysmal nocturnal haemoglobinuria. Blood 67:268-9.
17. Rosse WF, Dacie JV (1966) Immune lysis of normal human and paroxysmal nocturnal hemoglobinuria (PNH) red blood cells. I The sensitivity of PNH red cells to lysis by complement and specific antibody. Journal of Clinical Investigation 45: 736-48.
18. Rotoli B, Luzzatto L (1989) Paroxysmal nocturnal hemoglobinuria. Seminars in Hematology 26: 201-7.
19. Shichishima T, Saitoh Y, Terasawa T et al. (1999) Complement sensitivity of erythrocytes in a patient with inherited complete deficiency of CD59 or with the Inab phenotype. British Journal of Haematology 104: 303-6.
20. Watanabe R, Inoue N, Westfall B et al. (1998) The first step of glycosylphosphatidylinositol biosynthesis is mediated by a complex of PIG-A, PIG-H, PIG-C and GPI1. EMBO Journal 17: 877-85.
21. Wiedmer T, Hall SE, Ortel TL et al. (1993) Complement-induced vesiculation and exposure of membrane prothrombinase sites in platelets of paroxysmal nocturnal hemoglobinuria. Blood 82:1192-6.
22. Young NS, Moss, J (ed.) (2000) Paroxysmal Nocturnal Hemoglobinuria and the GPI-linked Proteins, p. 279. Academic Press, New York.
23. Zoumbos NC, Gascon P, Djeu JY et al. (1985) Circulating activated suppressor T lymphocytes in aplastic anemia. New England Journal of Medicine 312: 257-65.