Graphene oxide can induce in vitro and in vivo mutagenesis

Scientific Reports

Volumn 3, Issue , 2013, Pages

  Liu, Yuanyuan ^a   Luo, Yi ^a   Wu, Jing ^b   Wang, Yinsong ^a   Yang, Xiaoying ^a   Yang, Rui ^a   Wang, Baiqi ^a   Yang, Jinrong ^a   Zhang, Ning ^a  

^a TIANJIN MEDICAL UNIVERSITY   (China)

^b TIANJIN THIRD CENTRAL HOSPITAL   (China)

Author keywords

[No Author keywords available]

Indexed keywords

GRAPHITE; OXIDE; PROTEIN KINASE C EPSILON;

ANIMAL; APOPTOSIS; BONE MARROW CELL; CELL CYCLE CHECKPOINT; CELL PROLIFERATION; CELL SURVIVAL; CHEMICALLY INDUCED; CHEMISTRY; CLUSTER ANALYSIS; DNA DAMAGE; DNA REPLICATION; DRUG EFFECTS; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETICS; HUMAN; MALE; METABOLISM; MICRONUCLEUS; MOUSE; MUTAGENESIS; PATHOLOGY; TUMOR CELL LINE;

ANIMALS; APOPTOSIS; BONE MARROW CELLS; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; CLUSTER ANALYSIS; DNA DAMAGE; DNA REPLICATION; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GRAPHITE; HUMANS; MALE; MICE; MICRONUCLEI, CHROMOSOME-DEFECTIVE; MUTAGENESIS; OXIDES; PROTEIN KINASE C-EPSILON;

EID: 84890619638     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep03469     Document Type: Article

References (42)

1. Novoselov, K. S. et al. Electric field effect in atomically thin carbon films. Science 306, 666-669 (2004). (Pubitemid 39440910)
2. Geim, A. K. & Novoselov, K. S. The rise of graphene. Nat. Mater. 6, 183-191 (2007). (Pubitemid 46353764)
3. Geim, A. K. Graphene: status and prospects. Science 324, 1530-1534 (2009).
4. Huang, Y., Liang, J. J. & Chen, Y. S. An overview of the applications of graphenebased materials in supercapacitors. Small 8, 1805-1834 (2012).
5. Balandin,A.A. Superior thermal conductivity of single-layer graphene. Nano Lett. 9, 902-907 (2008).
6. Lee, C.,Wei, X. D., Kysar, J. W. & Hone, J. Measurement of the elastic properties and intrinsic strength of monolayer graphene. Science 321, 385-388 (2008). (Pubitemid 352029970)
7. Yang, X. Y. et al. High-efficiency loading and controlled release of doxorubicin hydrochloride on graphene oxide. J. Phys. Chem. C 112, 17554-17558 (2008).
8. Liu, Z., Robinson, J. T., Sun, X. & Dai, H. PEGylated nanographene oxide for delivery of water-insoluble cancer drugs. J. Am. Chem. Soc. 130, 10876-10877 (2008).
9. Yang, K. et al. Graphene in mice: ultrahigh in vivo tumor uptake and efficient photothermal therapy. Nano Lett. 10, 3318-3323 (2010).
10. Wu, J. et al. Graphene oxide used as a carrier for adriamycin can reverse drug resistance in breast cancer cells. Nanotechnology 23, 355101 (2012).
11. Yang, K. et al. Graphene in mice: ultrahigh in vivo tumor uptake and efficient photothermal therapy. Nano Lett. 10, 3318-3323 (2010).
12. Robinson, J. T. et al. Ultrasmall reduced graphene oxide with high near-infrared absorbance for photothermal therapy. J. Am. Chem. Soc. 133, 6825-6831 (2011).
13. Yang, K. et al. Multimodal imaging guided photothermal therapy using functionalized graphene nanosheets anchored with magnetic nanoparticles. Adv. Mater. 24, 1868-1872 (2012).
14. Tung, V. C., Allen, M. J., Yang, Y. & Kaner, R. B. High-throughput solution processing of large-scale graphene. Nat. Nanotechnol. 4, 25-29 (2009).
15. Lu, W. B. et al. High-yield, large-scale production of few-layer graphene flakes within seconds: using chlorosulfonic acid andH2O2 as exfoliating agents. J.Mater. Chem. 22, 8775-8777 (2012).
16. Lv, M. et al. Effect of graphene oxide on undifferentiated and retinoic aciddifferentiated SH-SY5Y cells line. Nanoscale 4, 3861-3866 (2012).
17. Wang, K. et al. Biocompatibility of graphene oxide. Nanoscale Res. Lett. 6, 8 (2011).
18. Chang, Y. L. et al. In vitro toxicity evaluation of graphene oxide on A549 cells. Toxicol. Lett. 200, 201-210 (2011).
19. Zhang, X. et al. Distribution and biocompatibility studies of grapheme oxide in mice after intravenous administration. Carbon 49, 986-995 (2011).
20. Liu, Z., Robinson, J. T., Sun, X. M. & Dai, H. J. PEGylated nanographene oxide for delivery of water-insoluble cancer drugs. J. Am. Chem. Soc. 130, 10876-10877 (2008).
21. Yang, K. et al. In vivo pharmacokinetics, long-term biodistribution and toxicology of PEGylated graphene in mice. ACS Nano 5, 516-522 (2011).
22. Xing, Y. et al. DNA damage in embryonic stem cells caused by nanodiamonds. ACS Nano 5, 2376-2384 (2011).
23. Zhu, L., Chang, D. W., Dai, L. & Hong, Y. DNA damage induced by multiwalled carbon nanotubes in mouse embryonic stem cells. Nano Lett. 7, 3592-3597 (2007).
24. Ren, H. et al.DNAcleavage system of nanosized graphene oxide sheets and copper ions. ACS Nano 4, 7169-7174 (2010).
25. Becerril, H. A. et al. Evaluation of solution-processed reduced graphene oxide films as transparent conductors. ACS Nano 2, 463-470 (2008).
26. Yang, X. Y. et al. High-efficiency loading and controlled release of doxorubicin hydrochloride on graphene oxide. J. Phys. Chem. C 112, 17554-17558 (2008).
27. Shan, C. et al.Water-soluble graphene covalently functionalized by biocompatible poly-L-lysine. Langmuir 25, 12030-12033 (2009).
28. Marcano, D. C. et al. Improved synthesis of graphene oxide. ACS Nano 4, 4806-4814 (2010).
29. Shang, J. et al. The Origin of fluorescence from graphene oxide. Sci. Rep. 2, 792 (2012).
30. Herreo, J. A., Valencia, A. & Dopazo, J. A hierarchical unsuperuised growing neural network for clustering gene expression patterns. Bioinformatics 17, 126-136 (2001). (Pubitemid 32208521)
31. Schmid, W. The Micronucleus Test. Mutat. Res. 31, 9-15 (1975).
32. Gollapudi, B. B. & McFadden, L. G. Sample size for the estimation of polychromatic to normochromatic erythrocyte ratio in the bone marrow micronucleus test. Mutat. Res. 347, 97-99 (1995).
33. Sun, X. et al. Nano-graphene oxide for cellular imaging and drug delivery. Nano Res. 1, 203-212 (2008).
34. Lerman, L. S. Structural considerations in the interaction of DNA and acridines. J. Mol. Biol. 3, 18-30 (1961).
35. Lerman, L. S. Acridine mutagens and DNA structure. J. Cell. Physiol. 64, S1-S18 (1964).
36. Graves, D. E. & Velea, L. M. Intercalative binding of small molecules to nucleic acid. Curr. Org. Chem. 4, 915-929 (2000).
37. Shiloh, Y. ATM and related protein kinases: safeguarding genome integrity. Nat. Rev. Cancer 3, 155-168 (2003). (Pubitemid 37328868)
38. Lavin, M. F. et al. ATM signaling and genomic stability in response to DNA damage. Mutat. Res. 569, 123-132 (2005). (Pubitemid 39643262)
39. Tarsounas, M., Davies, A. A. & West, S. C. RAD51 localization and activation following DNA damage. Phil. Trans. R. Soc. Lond. B. 359, 87-93 (2004). (Pubitemid 38106451)
40. Joseph, E. K. & Levine, J. D. Caspase signaling in neuropathic and inflammatory pain in the rat. Eur. J. Neurosci. 20, 2896-2902 (2004).
41. Berthet, C. & Kaldis, P. Cdk2 and Cdk4 cooperatively control the expression of Cdc2. Cell Division 1, 10 (2006).
42. Krishna, G. & Hayashi, M. In vivo rodent micronucleus assay: protocol, conduct and data interpretation. Mutat. Res. 455, 155-166 (2000).