Salt selection

Polymorphism: in the Pharmaceutical Industry

Volumn , Issue , 2006, Pages 309-332

  Stahl, Peter Heinrich ^a   Sutter, Bertrand ^b  

^a PHAD Analytical R and D ^*  (Germany)

^b NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Case reports; Pharmaceutical industry; Polymorphism; Salt formation; Salt polymorphism; Salt screening; Salt selection; Selection procedures; Selection strategies; Target properties of active substances for drug products

Indexed keywords

EID: 84890605478     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/3527607889.ch12     Document Type: Chapter

References (6)

1. S. K. Chandrasekaran, in Transdermal Delivery of Drugs. Vol. III, A. F. Kydonieus, B. Berner (Eds.), CRC Press, Boca Raton, FL, 1987, pp. 35-38.
2. A. Fini, G. Fazio, I. Rapaport, presented at DHEP Plasters: A new delivery system for a topical NSAID, Geneva, 1993. Abstract published in Drugs Exp. Clin. Res. 1993, 19, 81-88.
3. P.H. Stahl, Preparation of water-soluble compounds through salt formation, in The Practice of Medicinal Chemistry, C.G. Wermuth (Ed.), Academic Press/Elsevier Science, Amsterdam, Boston, 2003, p. 605.
4. S.H. Yalkowsky, Solubility and solubilization of nonelectrolytes, in Techniques of Solubilization of Drugs, S.H. Yalkowsky (Ed.), Marcel Dekker, New York, 1985, pp. 1-14.
5. N. Jain, S.H. Yalkowsky, Estimation of the aqueous solubility. I: Application to organic nonelectrolytes, J. Pharm. Sci. 2001, 90, 234-252.
6. Handbook of Pharmaceutical Salts. Properties, Selection, and Use, P.H. Stahl, C.G. Wermuth (Eds.), Verlag Helvetica Chimica Acta, Zürich/Wiley-VCH, Weinheim, 2002.