Effect of VEGF and CX43 on the promotion of neurological recovery by hyperbaric oxygen treatment in spinal cord-injured rats

Spine Journal

Volumn 14, Issue 1, 2014, Pages 119-127

  Liu, Xuehua ^a   Zhou, Yi ^b   Wang, Zhiwei ^a   Yang, Jing ^a   Gao, Chunjin ^a   Su, Qingjun ^a  

^a CAPITAL MEDICAL UNIVERSITY   (China)

^b SHENYANG MEDICAL COLLEGE   (China)

Author keywords

Connexin43; Hyperbaric oxygen treatment; Spinal cord injury; Vascular endothelial growth factor

Indexed keywords

CONNEXIN 43; MESSENGER RNA; VASCULOTROPIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CONVALESCENCE; HISTOPATHOLOGY; HYPERBARIC OXYGEN; MALE; MOTOR PERFORMANCE; NEUROLOGIC EXAMINATION; NONHUMAN; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; SPINAL CORD; SPINAL CORD INJURY; WESTERN BLOTTING;

CONNEXIN43; HYPERBARIC OXYGEN TREATMENT; SPINAL CORD INJURY; VASCULAR ENDOTHELIAL GROWTH FACTOR;

ANIMALS; CONNEXIN 43; HYPERBARIC OXYGENATION; MALE; MOTOR ACTIVITY; RATS; RATS, SPRAGUE-DAWLEY; RECOVERY OF FUNCTION; SPINAL CORD; SPINAL CORD INJURIES; TREATMENT OUTCOME; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84890559988     PISSN: 15299430     EISSN: 18781632     Source Type: Journal    
DOI: 10.1016/j.spinee.2013.06.084     Document Type: Article

References (33)

1. B.K. Kwon, W. Tetzlaff, and J.N. Grauer Pathophysiology and pharmacologic treatment of acute spinal cord injury Spine J 4 2004 451 464
2. M.D. Norenberg, J. Smith, and A. Marcillo The pathology of human spinal cord injury: defining the problems J Neurotrauma 21 2004 429 440
3. J.R. Bethea, and W.D. Dietrich Targeting the host inflammatory response in traumatic spinal cord injury Curr Opin Neurol 15 2002 355 360
4. K.S. Hung, S.H. Tsai, and T.C. Lee Gene transfer of insulin-like growth factor-I providing neuroprotection after spinal cord injury in rats J Neurosurg Spine 6 2007 35 46
5. R.J. Hurlbert Strategies of medical intervention in the management of acute spinal cord injury Spine 31 2006 S16 S21
6. D.C. Baptiste, and M.G. Fehlings Pharmacological approaches to repair the injured spinal cord J Neurotrauma 23 2006 318 334
7. Y. Liu, S. Figley, and S.K. Spratt An engineered transcription factor which activates VEGF-A enhances recovery after spinal cord injury Neurobiol Dis 37 2010 384 393
8. H. Nie, L. Xiong, and N. Lao Hyperbaric oxygen preconditioning induces tolerance against spinal cord ischemia by upregulation of antioxidant enzymes in rabbits J Cereb Blood Flow Metab 26 2006 666 674
9. K. Dayan, A. Keser, and S. Konyalioglu The effect of hyperbaric oxygen on neuroregeneration following acute thoracic spinal cord injury Life Sci 90 2012 360 364
10. E. Storkebaum, D. Lambrechts, and P. Carmeliet VEGF: once regarded as a specific angiogenic factor, now implicated in neuroprotection Bioessays 26 2004 943 954
11. S.S. Chew, C.S. Johnson, C.R. Green, and H.V. Danesh-Meyer Role of connexin43 in central nervous system injury Exp Neurol 225 2010 250 261
12. J.I. Nagy, and J.E. Rash Connexins and gap junctions of astrocytes and oligodendrocytes in the CNS Brain Res Brain Res Rev 32 2000 29 44
13. D.M. Basso, M.S. Beattie, and J.C. Bresnahan Graded histological and locomotor outcomes after spinal cord contusion using the NYU weight-drop device versus transaction Exp Neurol 139 1996 244 256
14. J.B. Gelderd, W.P. Fife, and D.E. Bowers Spinal cord transection in rats: the therapeutic effects of dimethyl sulfoxide and hyperbaric oxygen Ann N Y Acad Sci 411 1983 218 233
15. N.S. Al-Waili, G.J. Butler, and J. Beale Hyperbaric oxygen in the treatment of patients with cerebral stroke, brain trauma, and neurologic disease Adv Ther 22 2005 659 678
16. L. Wang, W. Li, and Z. Kang Hyperbaric oxygen preconditioning attenuates early apoptosis after spinal cord ischemia in rats J Neurotrauma 26 2009 55 66
17. K. Topuz, A. Colak, and B. Cemil Combined hyperbaric oxygen and hypothermia treatment on oxidative stress parameters after spinal cord injury: an experimental study Arch Med Res 41 2010 506 512
18. P.A. Tai, C.K. Chang, and K.C. Niu Attenuating experimental spinal cord injury by hyperbaric oxygen: stimulating production of vasculoendothelial and glial cell line-derived neurotrophic growth factors and interleukin-10 J Neurotrauma 27 2010 1121 1127
19. Y. Feng, P.G. Rhodes, and A.J. Bhatt Neuroprotective effects of vascular endothelial growth factor following hypoxic ischemic brain injury in neonatal rats Pediatr Res 64 2008 370 374
20. X.R. Zheng, S.S. Zhang, and Y.J. Yang Adenoviral vector-mediated transduction of VEGF improves neural functional recovery after hypoxia-ischemic brain damage in neonatal rats Brain Res Bull 81 2010 372 377
21. J.J. Herrera, O. Nesic, and P.A. Narayana Reduced vascular endothelial growth factor expression in contusive spinal cord injury J Neurotrauma 26 2009 995 1003
22. M. Sköld, S. Cullheim, and H. Hammarberg Induction of VEGF and VEGF receptors in the spinal cord after mechanical spinal injury and prostaglandin administration Eur J Neurosci 12 2000 3675 3686
23. F. Facchiano, E. Fernandez, and S. Mancarella Promotion of regeneration of corticospinal tract axons in rats with recombinant vascular endothelial growth factor alone and combined with adenovirus coding for this factor J Neurosurg 97 2002 161 168
24. J. Widenfalk, A. Lipson, and M. Jubran Vascular endothelial growth factor improves functional outcome and decreases secondary degeneration in experimental spinal cord contusion injury Neuroscience 120 2003 951 960
25. G.J. Gu, Y.P. Li, and Z.Y. Peng Mechanism of ischemic tolerance induced by hyperbaric oxygen preconditioning involves up-regulation of hypoxia-inducible factor-1a and erythropoietin in rats J Appl Physiol 104 2008 1185 1191
26. P. Ren, Z. Kang, and G. Gu Hyperbaric oxygen preconditioning promotes angiogenesis in rat liver after partial hepatectomy Life Sci 83 2008 236 241
27. C. Haupt, O.W. Witte, and C. Frahm Temporal profile of connexin 43 expression after photothrombotic lesion in rat brain Neuroscience 144 2007 562 570
28. A. Ohsumi, H. Nawashiro, and N. Otani Alteration of gap junction proteins (connexins) following lateral fluid percussion injury in rats Acta Neurochir Suppl 96 2006 148 150
29. I.H. Lee, E. Lindqvist, and O. Kiehn Glial and neuronal connexin expression patterns in the rat spinal cord during development and following injury J Comp Neurol 489 2005 1 10
30. E. Theriault, U.N. Frankenstein, E.L. Hertzberg, and J.I. Nagy Connexin43 and astrocytic gap junctions in the rat spinal cord after acute compression injury J Comp Neurol 382 1997 199 214
31. T. Asklund, I.B. Appelskog, and O. Ammerpohl Gap junction-mediated bystander effect in primary cultures of human malignant gliomas with recombinant expression of the HSVtk gene Exp Cell Res 284 2003 183 193
32. M. Cronin, P.N. Anderson, and J.E. Cook Blocking connexin43 expression reduces inflammation and improves functional recovery after spinal cord injury Mol Cell Neurosci 39 2008 152 160
33. S.J. O'Carroll, M. Alkadhi, L.F.B. Nicholson, and C.R. Green Connexin43 mimetic peptides reduce swelling, astrogliosis, and neuronal cell death after spinal cord injury Cell Commun Adhes 15 2008 27 42