Emerging concepts on the role of exosomes in lipid metabolic diseases

Biochimie

Volumn 96, Issue 1, 2014, Pages 67-74

  Record, Michel ^a,b,c   Poirot, Marc ^a,b,c   Silvente Poirot, Sandrine ^a,b,c  

^a CANCER RESEARCH CENTER OF TOULOUSE   (France)

^b INSTITUT CLAUDIUS REGAUD   (France)

^c UNIVERSITÉ PAUL SABATIER   (France)

Author keywords

Cancer; CD36; Cholesterol epoxyde hydrolase (CHEH); Docosahexaenoic acid (DHA); Eicosanoids; Phospholipases; Tamoxifen

Indexed keywords

CHOLESTEROL; ICOSANOID; LYSOPHOSPHATIDYLCHOLINE;

BIOLOGICAL ACTIVITY; CELL COMMUNICATION; CELL COMPARTMENTALIZATION; CELL FATE; CELL MIGRATION; CELL TRANSFER; CELL VIABILITY; DISORDERS OF CHOLESTEROL METABOLISM; DISORDERS OF LIPID METABOLISM; EXOSOME; HUMAN; ICOSANOID METABOLISM; INTERNALIZATION; LIPID TRANSPORT; NEOPLASM; REVIEW;

CANCER; CD36; CHOLESTEROL EPOXYDE HYDROLASE (CHEH); DOCOSAHEXAENOIC ACID (DHA); EICOSANOIDS; PHOSPHOLIPASES; TAMOXIFEN;

ANIMALS; BIOLOGICAL TRANSPORT; CELL COMMUNICATION; CHOLESTEROL; EXOSOMES; HUMANS; HYPERCHOLESTEROLEMIA; LIPID METABOLISM; LYSOPHOSPHATIDYLCHOLINES;

EID: 84890556960     PISSN: 03009084     EISSN: 61831638     Source Type: Journal    
DOI: 10.1016/j.biochi.2013.06.016     Document Type: Short Survey

References (84)

1. M. Mittelbrunn, and F. Sanchez-Madrid Intercellular communication: diverse structures for exchange of genetic information Nat. Rev. Mol. Cell. Biol. 13 2012 328 335
2. M. Record, C. Subra, S. Silvente-Poirot, and M. Poirot Exosomes as intercellular signalosomes and pharmacological effectors Biochem. Pharmacol. 81 2011 1171 1182
3. M. Record Exosomal lipids in cell-cell communication H.-G. Zhang, Emerging Concepts of Tumor Exosome-mediated Cell-cell Communication 2012 Springer USA 47 68
4. A. Bobrie, M. Colombo, G. Raposo, and C. Thery Exosome secretion: molecular mechanisms and roles in immune responses Traffic 12 2011 1659 1668
5. H. Peinado, M. Aleckovic, S. Lavotshkin, I. Matei, B. Costa-Silva, G. Moreno-Bueno, M. Hergueta-Redondo, C. Williams, G. Garcia-Santos, C. Ghajar, A. Nitadori-Hoshino, C. Hoffman, K. Badal, B.A. Garcia, M.K. Callahan, J. Yuan, V.R. Martins, J. Skog, R.N. Kaplan, M.S. Brady, J.D. Wolchok, P.B. Chapman, Y. Kang, J. Bromberg, and D. Lyden Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET Nat. Med. 18 2012 883 891
6. L. Alvarez-Erviti, Y. Seow, H. Yin, C. Betts, S. Lakhal, and M.J. Wood Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes Nat. Biotechnol. 29 2011 341 345
7. V. Luga, L. Zhang, A.M. Viloria-Petit, A.A. Ogunjimi, M.R. Inanlou, E. Chiu, M. Buchanan, A.N. Hosein, M. Basik, and J.L. Wrana Exosomes mediate stromal mobilization of autocrine Wnt-PCP signaling in breast cancer cell migration Cell 151 2012 1542 1556
8. T. Fujino, H. Asaba, M.J. Kang, Y. Ikeda, H. Sone, S. Takada, D.H. Kim, R.X. Ioka, M. Ono, H. Tomoyori, M. Okubo, T. Murase, A. Kamataki, J. Yamamoto, K. Magoori, S. Takahashi, Y. Miyamoto, H. Oishi, M. Nose, M. Okazaki, S. Usui, K. Imaizumi, M. Yanagisawa, J. Sakai, and T.T. Yamamoto Low-density lipoprotein receptor-related protein 5 (LRP5) is essential for normal cholesterol metabolism and glucose-induced insulin secretion Proc. Natl. Acad. Sci. U. S. A. 100 2003 229 234
9. J.C. Gross, V. Chaudhary, K. Bartscherer, and M. Boutros Active Wnt proteins are secreted on exosomes Nat. Cell Biol. 14 2012 1036 1045
10. C. Subra, D. Grand, K. Laulagnier, A. Stella, G. Lambeau, M. Paillasse, P. De Medina, B. Monsarrat, B. Perret, S. Silvente-Poirot, M. Poirot, and M. Record Exosomes account for vesicle-mediated transcellular transport of activatable phospholipases and prostaglandins J. Lipid Res. 51 2010 2105 2120
11. K. Laulagnier, C. Motta, S. Hamdi, S. Roy, F. Fauvelle, J.F. Pageaux, T. Kobayashi, J.P. Salles, B. Perret, C. Bonnerot, and M. Record Mast cell- and dendritic cell-derived exosomes display a specific lipid composition and an unusual membrane organization Biochem. J. 380 2004 161 171
12. D. Wang, and R.N. DuBois Eicosanoids and cancer Nat. Rev. Cancer 10 2010 181 193
13. S. Zarini, M.A. Gijon, A.E. Ransome, R.C. Murphy, and A. Sala Transcellular biosynthesis of cysteinyl leukotrienes in vivo during mouse peritoneal inflammation Proc. Natl. Acad. Sci. U. S. A. 106 2009 8296 8301
14. A. Sala, G. Folco, and R.C. Murphy Transcellular biosynthesis of eicosanoids Pharmacol. Rep. 62 2010 503 510
15. J. Esser, U. Gehrmann, F.L. D'Alexandri, A.M. Hidalgo-Estevez, C.E. Wheelock, A. Scheynius, S. Gabrielsson, and O. Radmark Exosomes from human macrophages and dendritic cells contain enzymes for leukotriene biosynthesis and promote granulocyte migration J. Allergy Clin. Immunol. 126 2010 1032 1040
16. M.P. Caby, D. Lankar, C. Vincendeau-Scherrer, G. Raposo, and C. Bonnerot Exosomal-like vesicles are present in human blood plasma Int. Immunol. 17 2005 879 887
17. H. Valadi, K. Ekstrom, A. Bossios, M. Sjostrand, J.J. Lee, and J.O. Lotvall Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells Nat. Cell Biol. 9 2007 654 659
18. S.T. Reddy, and H.R. Herschman Transcellular prostaglandin production following mast cell activation is mediated by proximal secretory phospholipase A2 and distal prostaglandin synthase 1 J. Biol. Chem. 271 1996 186 191
19. S.T. Reddy, and H.R. Herschman Prostaglandin synthase-1 and prostaglandin synthase-2 are coupled to distinct phospholipases for the generation of prostaglandin D2 in activated mast cells J. Biol. Chem. 272 1997 3231 3237
20. G.T. Wijewickrama, J.H. Kim, Y.J. Kim, A. Abraham, Y. Oh, B. Ananthanarayanan, M. Kwatia, S.J. Ackerman, and W. Cho Systematic evaluation of transcellular activities of secretory phospholipases A2. High activity of group V phospholipases A2 to induce eicosanoid biosynthesis in neighboring inflammatory cells J. Biol. Chem. 281 2006 10935 10944
21. X. Xiang, A. Poliakov, C. Liu, Y. Liu, Z.B. Deng, J. Wang, Z. Cheng, S.V. Shah, G.J. Wang, L. Zhang, W.E. Grizzle, J. Mobley, and H.G. Zhang Induction of myeloid-derived suppressor cells by tumor exosomes Int. J. Cancer 124 2009 2621 2633
22. K. Laulagnier, D. Grand, A. Dujardin, S. Hamdi, H. Vincent-Schneider, D. Lankar, J.P. Salles, C. Bonnerot, B. Perret, and M. Record PLD2 is enriched on exosomes and its activity is correlated to the release of exosomes FEBS Lett. 572 2004 11 14
23. R. Alonso, C. Mazzeo, I. Merida, and M. Izquierdo A new role of diacylglycerol kinase alpha on the secretion of lethal exosomes bearing Fas ligand during activation-induced cell death of T lymphocytes Biochimie 89 2007 213 221
24. K. Trajkovic, C. Hsu, S. Chiantia, L. Rajendran, D. Wenzel, F. Wieland, P. Schwille, B. Brugger, and M. Simons Ceramide triggers budding of exosome vesicles into multivesicular endosomes Science 319 2008 1244 1247
25. R. Sahu, S. Kaushik, C.C. Clement, E.S. Cannizzo, B. Scharf, A. Follenzi, I. Potolicchio, E. Nieves, A.M. Cuervo, and L. Santambrogio Microautophagy of cytosolic proteins by late endosomes Dev. Cell. 20 2011 131 139
26. R.A. Blackwood, J.E. Smolen, A. Transue, R.J. Hessler, D.M. Harsh, R.C. Brower, and S. French Phospholipase D activity facilitates Ca2+-induced aggregation and fusion of complex liposomes Am. J. Physiol. 272 1997 C1279 C1285
27. D. Padron, R.D. Tall, and M.G. Roth Phospholipase D2 is required for efficient endocytic recycling of transferrin receptors Mol. Biol. Cell 17 2006 598 606
28. J. Huotari, and A. Helenius Endosome maturation EMBO J. 30 2011 3481 3500
29. M. Costanzo, A. Baryshnikova, J. Bellay, Y. Kim, E.D. Spear, C.S. Sevier, H. Ding, J.L. Koh, K. Toufighi, S. Mostafavi, J. Prinz, R.P. St Onge, B. VanderSluis, T. Makhnevych, F.J. Vizeacoumar, S. Alizadeh, S. Bahr, R.L. Brost, Y. Chen, M. Cokol, R. Deshpande, Z. Li, Z.Y. Lin, W. Liang, M. Marback, J. Paw, B.J. San Luis, E. Shuteriqi, A.H. Tong, N. van Dyk, I.M. Wallace, J.A. Whitney, M.T. Weirauch, G. Zhong, H. Zhu, W.A. Houry, M. Brudno, S. Ragibizadeh, B. Papp, C. Pal, F.P. Roth, G. Giaever, C. Nislow, O.G. Troyanskaya, H. Bussey, G.D. Bader, A.C. Gingras, Q.D. Morris, P.M. Kim, C.A. Kaiser, C.L. Myers, B.J. Andrews, and C. Boone The genetic landscape of a cell Science 327 2010 425 431
30. B. Mesmin, and F.R. Maxfield Intracellular sterol dynamics Biochim. Biophys. Acta 1791 2009 636 645
31. M. Ostrowski, N.B. Carmo, S. Krumeich, I. Fanget, G. Raposo, A. Savina, C.F. Moita, K. Schauer, A.N. Hume, R.P. Freitas, B. Goud, P. Benaroch, N. Hacohen, M. Fukuda, C. Desnos, M.C. Seabra, F. Darchen, S. Amigorena, L.F. Moita, and C. Thery Rab27a and Rab27b control different steps of the exosome secretion pathway Nat. Cell Biol. 12 2010 19 30
32. N. Kosaka, H. Iguchi, Y. Yoshioka, F. Takeshita, Y. Matsuki, and T. Ochiya Secretory mechanisms and intercellular transfer of microRNAs in living cells J. Biol. Chem. 285 2010 17442 17452
33. D.J. Gibbings, C. Ciaudo, M. Erhardt, and O. Voinnet Multivesicular bodies associate with components of miRNA effector complexes and modulate miRNA activity Nat. Cell Biol. 11 2009 1143 1149
34. K. Laulagnier, H. Vincent-Schneider, S. Hamdi, C. Subra, D. Lankar, and M. Record Characterization of exosome subpopulations from RBL-2H3 cells using fluorescent lipids Blood Cells Mol. Dis. 35 2005 116 121
35. C. Thery, M. Ostrowski, and E. Segura Membrane vesicles as conveyors of immune responses Nat. Rev. Immunol. 9 2009 581 593
36. D. Feng, W.L. Zhao, Y.Y. Ye, X.C. Bai, R.Q. Liu, L.F. Chang, Q. Zhou, and S.F. Sui Cellular internalization of exosomes occurs through phagocytosis Traffic 11 2010 675 687
37. D. Skokos, H.G. Botros, C. Demeure, J. Morin, R. Peronet, G. Birkenmeier, S. Boudaly, and S. Mecheri Mast cell-derived exosomes induce phenotypic and functional maturation of dendritic cells and elicit specific immune responses in vivo J. Immunol. 170 2003 3037 3045
38. L. Zhou, H.Y. Choi, W.P. Li, F. Xu, and J. Herz LRP1 controls cPLA2 phosphorylation, ABCA1 expression and cellular cholesterol export PLoS One 4 2009 e6853
39. H. Vincent-Schneider, C. Thery, D. Mazzeo, D. Tenza, G. Raposo, and C. Bonnerot Secretory granules of mast cells accumulate mature and immature MHC class II molecules J. Cell. Sci. 114 2001 323 334
40. L. Zakharova, M. Svetlova, and A.F. Fomina T cell exosomes induce cholesterol accumulation in human monocytes via phosphatidylserine receptor J. Cell Physiol. 212 2007 174 181
41. S. Beck, G. Lambeau, K. Scholz-Pedretti, M.H. Gelb, M.J. Janssen, S.H. Edwards, D.C. Wilton, J. Pfeilschifter, and M. Kaszkin Potentiation of tumor necrosis factor alpha-induced secreted phospholipase A2 (sPLA2)-IIA expression in mesangial cells by an autocrine loop involving sPLA2 and peroxisome proliferator-activated receptor alpha activation J. Biol. Chem. 278 2003 29799 29812
42. M. Fabbri, A. Paone, F. Calore, R. Galli, E. Gaudio, R. Santhanam, F. Lovat, P. Fadda, C. Mao, G.J. Nuovo, N. Zanesi, M. Crawford, G.H. Ozer, D. Wernicke, H. Alder, M.A. Caligiuri, P. Nana-Sinkam, D. Perrotti, and C.M. Croce MicroRNAs bind to Toll-like receptors to induce prometastatic inflammatory response Proc. Natl. Acad. Sci. U. S. A. 109 2012 E2110 E2116
43. S. Amigorena, and A. Savina Intracellular mechanisms of antigen cross presentation in dendritic cells Curr. Opin. Immunol. 22 2010 109 117
44. F.G. van der Goot, and J. Gruenberg Intra-endosomal membrane traffic Trends Cell Biol. 16 2006 514 521
45. T. Falguieres, P.P. Luyet, C. Bissig, C.C. Scott, M.C. Velluz, and J. Gruenberg In vitro budding of intralumenal vesicles into late endosomes is regulated by Alix and Tsg101 Mol. Biol. Cell 19 2008 4942 4955
46. T. Kobayashi, M.H. Beuchat, J. Chevallier, A. Makino, N. Mayran, J.M. Escola, C. Lebrand, P. Cosson, and J. Gruenberg Separation and characterization of late endosomal membrane domains J. Biol. Chem. 277 2002 32157 32164
47. M. Mahankali, H.J. Peng, K.M. Henkels, M.C. Dinauer, and J. Gomez-Cambronero Phospholipase D2 (PLD2) is a guanine nucleotide exchange factor (GEF) for the GTPase Rac2 Proc. Natl. Acad. Sci. U. S. A. 108 2011 19617 19622
48. W.J. van Blitterswijk, and H. Hilkmann Rapid attenuation of receptor-induced diacylglycerol and phosphatidic acid by phospholipase D-mediated transphosphatidylation: formation of bisphosphatidic acid EMBO J. 12 1993 2655 2662
49. W. Mobius, E. van Donselaar, Y. Ohno-Iwashita, Y. Shimada, H.F. Heijnen, J.W. Slot, and H.J. Geuze Recycling compartments and the internal vesicles of multivesicular bodies harbor most of the cholesterol found in the endocytic pathway Traffic 4 2003 222 231
50. N.S. Tan, N.S. Shaw, N. Vinckenbosch, P. Liu, R. Yasmin, B. Desvergne, W. Wahli, and N. Noy Selective cooperation between fatty acid binding proteins and peroxisome proliferator-activated receptors in regulating transcription Mol. Cell. Biol. 22 2002 5114 5127
51. J.U. Scher, and M.H. Pillinger The anti-inflammatory effects of prostaglandins J. Investig. Med. 57 2009 703 708
52. L. Lalier, P.F. Cartron, F. Pedelaborde, C. Olivier, D. Loussouarn, S.A. Martin, K. Meflah, J. Menanteau, and F.M. Vallette Increase in PGE2 biosynthesis induces a Bax dependent apoptosis correlated to patients' survival in glioblastoma multiforme Oncogene 26 2007 4999 5009
53. B.H. Majed, and R.A. Khalil Molecular mechanisms regulating the vascular prostacyclin pathways and their adaptation during pregnancy and in the newborn Pharmacol. Rev. 64 2012 540 582
54. V.L. Schuster Prostaglandin transport Prostaglandins Other Lipid. Mediat. 68-69 2002 633 647
55. B. Kedjouar, P. de Medina, M. Oulad-Abdelghani, B. Payre, S. Silvente-Poirot, G. Favre, J.C. Faye, and M. Poirot Molecular characterization of the microsomal tamoxifen binding site J. Biol. Chem. 279 2004 34048 34061
56. P. de Medina, M.R. Paillasse, G. Segala, M. Poirot, and S. Silvente-Poirot Identification and pharmacological characterization of cholesterol-5,6-epoxide hydrolase as a target for tamoxifen and AEBS ligands Proc. Natl. Acad. Sci. U. S. A. 107 2010 13520 13525
57. P. de Medina, M.R. Paillasse, G. Segala, F. Khallouki, S. Brillouet, F. Dalenc, F. Courbon, M. Record, M. Poirot, and S. Silvente-Poirot Importance of cholesterol and oxysterols metabolism in the pharmacology of tamoxifen and other AEBS ligands Chem. Phys. Lipids 164 2011 432 437
58. S. Silvente-Poirot, and M. Poirot Cholesterol epoxide hydrolase and cancer Curr. Opin. Pharmacol. 12 2012 696 703
59. N. Hajjaji, C. Couet, P. Besson, and P. Bougnoux DHA effect on chemotherapy-induced body weight loss: an exploratory study in a rodent model of mammary tumors Nutr. Cancer 64 2012 1000 1007
60. P. Bougnoux, N. Hajjaji, M.N. Ferrasson, B. Giraudeau, C. Couet, and O. Le Floch Improving outcome of chemotherapy of metastatic breast cancer by docosahexaenoic acid: a phase II trial Br. J. Cancer 101 2009 1978 1985
61. K. Carayon, K. Chaoui, E. Ronzier, I. Lazar, J. Bertrand-Michel, V. Roques, S. Balor, F. Terce, A. Lopez, L. Salome, and E. Joly Proteolipidic composition of exosomes changes during reticulocyte maturation J. Biol. Chem. 286 2011 34426 34439
62. M.R. Paillasse, P. de Medina, G. Amouroux, L. Mhamdi, M. Poirot, and S. Silvente-Poirot Signaling through cholesterol esterification: a new pathway for the cholecystokinin 2 receptor involved in cell growth and invasion J. Lipid Res. 50 2009 2203 2211
63. K.L. Bowden, N.J. Bilbey, L.M. Bilawchuk, E. Boadu, R. Sidhu, D.S. Ory, H. Du, T. Chan, and G.A. Francis Lysosomal acid lipase deficiency impairs regulation of ABCA1 gene and formation of high density lipoproteins in cholesteryl ester storage disease J. Biol. Chem. 286 2011 30624 30635
64. K. Strauss, C. Goebel, H. Runz, W. Mobius, S. Weiss, I. Feussner, M. Simons, and A. Schneider Exosome secretion ameliorates lysosomal storage of cholesterol in Niemann-Pick type C disease J. Biol. Chem. 285 2010 26279 26288
65. J. Chevallier, Z. Chamoun, G. Jiang, G. Prestwich, N. Sakai, S. Matile, R.G. Parton, and J. Gruenberg Lysobisphosphatidic acid controls endosomal cholesterol levels J. Biol. Chem. 283 2008 27871 27880
66. H. Matsuo, J. Chevallier, N. Mayran, I. Le Blanc, C. Ferguson, J. Faure, N.S. Blanc, S. Matile, J. Dubochet, R. Sadoul, R.G. Parton, F. Vilbois, and J. Gruenberg Role of LBPA and Alix in multivesicular liposome formation and endosome organization Science 303 2004 531 534
67. T. Aung, B. Chapuy, D. Vogel, D. Wenzel, M. Oppermann, M. Lahmann, T. Weinhage, K. Menck, T. Hupfeld, R. Koch, L. Trumper, and G.G. Wulf Exosomal evasion of humoral immunotherapy in aggressive B-cell lymphoma modulated by ATP-binding cassette transporter A3 Proc. Natl. Acad. Sci. U. S. A. 108 2011 15336 15341
68. S. Engelbrecht, E. Kaltenborn, M. Griese, and S. Kern The surfactant lipid transporter ABCA3 is N-terminally cleaved inside LAMP3-positive vesicles FEBS Lett. 584 2010 4306 4312
69. S. Silvente-Poirot, and M. Poirot Cholesterol metabolism and cancer: the good, the bad and the ugly Curr. Opin. Pharmacol. 12 2012 673 676
70. S.F. Nielsen, B.G. Nordestgaard, and S.E. Bojesen Statin use and reduced cancer-related mortality N. Engl. J. Med. 367 2012 1792 1802
71. P. de Medina, M.R. Paillasse, G. Segala, M. Voisin, L. Mhamdi, F. Dalenc, M. Lacroix-Triki, T. Filleron, F. Pont, T.A. Saati, C. Morisseau, B.D. Hammock, S. Silvente-Poirot, and M. Poirot Dendrogenin A arises from cholesterol and histamine metabolism and shows cell differentiation and anti-tumour properties Nat. Commun. 4 2013 1840 10.1038/ncomms2835
72. S. Silvente-Poirot, M. Record, P. de Medina, C. Subra, B. Payré, M.R. Paillasse, M. Poirot, Dendrogenin A modifies aggressive melanoma cells to secrete exosomes with antitumor activity, International Workshop on Exosomes (2011) January 19-22, Paris, France.
73. M. Poirot, S. Silvente-Poirot, and R.R. Weichselbaum Cholesterol metabolism and resistance to tamoxifen Curr. Opin. Pharmacol. 12 2012 683 689
74. S.P. Pitroda, N.N. Khodarev, M.A. Beckett, D.W. Kufe, and R.R. Weichselbaum MUC1-induced alterations in a lipid metabolic gene network predict response of human breast cancers to tamoxifen treatment Proc. Natl. Acad. Sci. U. S. A. 106 2009 5837 5841
75. Q. Huang, F. Li, X. Liu, W. Li, W. Shi, F.F. Liu, B. O'Sullivan, Z. He, Y. Peng, A.C. Tan, L. Zhou, J. Shen, G. Han, X.J. Wang, J. Thorburn, A. Thorburn, A. Jimeno, D. Raben, J.S. Bedford, and C.Y. Li Caspase 3-mediated stimulation of tumor cell repopulation during cancer radiotherapy Nat. Med. 17 2011 860 866
76. L. Blanc, C. Barres, P. Bette-Bobillo, and M. Vidal Reticulocyte-secreted exosomes bind natural IgM antibodies: involvement of a ROS-activatable endosomal phospholipase iPLA2 Blood 110 2007 3407 3416
77. L. Blanc, and M. Vidal Secreted exosomes from reticulocytes express an eat-me signal Med. Sci. (Paris) 24 2008 462 463
78. L. Luketic, J. Delanghe, P.T. Sobol, P. Yang, E. Frotten, K.L. Mossman, J. Gauldie, J. Bramson, and Y. Wan Antigen presentation by exosomes released from peptide-pulsed dendritic cells is not suppressed by the presence of active CTL J. Immunol. 179 2007 5024 5032
79. G. Raposo, H.W. Nijman, W. Stoorvogel, R. Liejendekker, C.V. Harding, C.J. Melief, and H.J. Geuze B lymphocytes secrete antigen-presenting vesicles J. Exp. Med. 183 1996 1161 1172
80. L. Zitvogel, A. Regnault, A. Lozier, J. Wolfers, C. Flament, D. Tenza, P. Ricciardi-Castagnoli, G. Raposo, and S. Amigorena Eradication of established murine tumors using a novel cell-free vaccine: dendritic cell-derived exosomes Nat. Med. 4 1998 594 600
81. J.H. Kabarowski G2A and LPC: regulatory functions in immunity Prostaglandins Other Lipid. Mediat. 89 2009 73 81
82. L. Perrin-Cocon, S. Agaugue, F. Coutant, P. Saint-Mezard, A. Guironnet-Paquet, J.F. Nicolas, P. Andre, and V. Lotteau Lysophosphatidylcholine is a natural adjuvant that initiates cellular immune responses Vaccine 24 2006 1254 1263
83. L. Perrin-Cocon, S. Agaugue, F. Coutant, A. Masurel, S. Bezzine, G. Lambeau, P. Andre, and V. Lotteau Secretory phospholipase A2 induces dendritic cell maturation Eur. J. Immunol. 34 2004 2293 2302
84. P. de Medina, M.R. Paillasse, B. Payre, S. Silvente-Poirot, and M. Poirot Synthesis of new alkylaminooxysterols with potent cell differentiating activities: identification of leads for the treatment of cancer and neurodegenerative diseases J. Med. Chem. 52 2009 7765 7777