Immunopathogenic characterization of cutaneous inflammation in Behçet's disease

Journal of the European Academy of Dermatology and Venereology

Volumn 28, Issue 1, 2014, Pages 51-57

  Cho, S ^a   Kim, J ^b   Cho, S B ^a   Zheng, Z ^a   Choi, M J ^a   Kim, D Y ^a   Bang, D ^a  

^a Yonsei University College of Medicine   (South Korea)

^b I Dermatology Clinic   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CD11B ANTIGEN; CD4 ANTIGEN; CD68 ANTIGEN; CD8 ANTIGEN; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 4; TRANSCRIPTION FACTOR FOXP3;

ACUTE FEBRILE NEUTROPHILIC DERMATOSIS; ADULT; ARTICLE; BEHCET DISEASE; CD4 CD8 RATIO; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CLINICAL ARTICLE; CONTROLLED STUDY; DERMATITIS; ERYTHEMA MULTIFORME; ERYTHEMA NODOSUM; FEMALE; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IMMUNOPATHOLOGY; IMMUNOPHENOTYPING; INFLAMMATORY INFILTRATE; MACROPHAGE; MALE; MIDDLE AGED; NEUTROPHIL; NONHUMAN; PAPULE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PUSTULE; YOUNG ADULT;

ADULT; BEHCET SYNDROME; CYTOKINES; DERMATITIS; FEMALE; HUMANS; MALE; MIDDLE AGED; PHENOTYPE; YOUNG ADULT;

EID: 84890553712     PISSN: 09269959     EISSN: 14683083     Source Type: Journal    
DOI: 10.1111/jdv.12054     Document Type: Article

References (44)

1. James DG,. Behçet's syndrome. N Engl J Med 1979; 301: 431-432.
2. Chun SI, Su WP, Lee S, Rogers RS Jr,. Erythema nodosum-like lesions in Behçet's syndrome: a histopathologic study of 30 cases. J Cutan Pathol 1989; 16: 259-265.
3. International Study Group for Behçet's Disease. Criteria for diagnosis of Behçet's disease. Lancet 1990; 335: 1078-1080.
4. Kurokawa MS, Yoshikawa H, Suzuki N,. Behçet's disease. Semin Respir Crit Care Med 2004; 25: 557-568.
5. Pay S, Simsek I, Erdem H, Dinc A,. Immunopathogenesis of Behçet's disease with special emphasize on the possible role of antigen presenting cells. Rheumatol Int 2007; 27: 417-424.
6. Hirohata S, Kikuchi H,. Behçet's disease. Arthritis Res Ther 2003; 5: 139-146.
7. Lew W, Chang JY, Jung JY, Bang D,. Increased expression of interleukin-23 p19 mRNA in erythema nodosum-like lesions of Behçet's disease. Br J Dermatol 2008; 158: 505-511.
8. Hamzaoui K, Hamzaoui A, Guemira F, et al. Cytokine profile in Behçet's disease patients. Relationship with disease activity. Scand J Rheumatol 2002; 31: 205-210.
9. Evereklioglu C, Er H, Turkoz Y, Cekmen M,. Serum levels of TNF-alpha, sIL-2R, IL-6, and IL-8 are increased and associated with elevated lipid peroxidation in patients with Behçet's disease. Mediators Inflamm 2002; 11: 87-93.
10. Aridogan BC, Yildirim M, Baysal V, et al. Serum levels of IL-4, IL-10, IL-12, IL-13 and IFN-gamma in Behçet's disease. J Dermatol 2003; 30: 602-607.
11. Turan B, Gallati H, Erdi H, et al. Systemic levels of the T cell regulatory cytokines IL-10 and IL-12 in Behçet's disease; soluble TNFR-75 as a biological marker of disease activity. J Rheumatol 1997; 24: 128-132.
12. Melikoglu M, Uysal S, Krueger JG, et al. Characterization of the divergent wound-healing responses occurring in the pathergy reaction and normal healthy volunteers. J Immunol 2006; 177: 6415-6421.
13. Senturk T, Aydintug O, Kuzu I, et al. Adhesion molecule expression in erythema nodosum-like lesions in Behçet's disease. A histopathological and immunohistochemical study. Rheumatol Int 1998; 18: 51-57.
14. Dalghous AM, Freysdottir J, Fortune F,. Expression of cytokines, chemokines, and chemokine receptors in oral ulcers of patients with Behçet's disease (BD) and recurrent aphthous stomatitis is Th1-associated, although Th2-association is also observed in patients with BD. Scand J Rheumatol 2006; 35: 472-475.
15. Jorizzo JL, Abernethy JL, White WL, et al. Mucocutaneous criteria for the diagnosis of Behçet's disease: an analysis of clinicopathologic data from multiple international centers. J Am Acad Dermatol 1995; 32: 968-976.
16. Chun SI, Su WP, Lee S,. Histopathologic study of cutaneous lesions in Behçet's syndrome. J Dermatol 1990; 17: 333-341.
17. Honma T, Bang D, Saito T, et al. Ultrastructure of lymphocyte-mediated fat-cell lysis in erythema nodosum-like lesions of Behçet's syndrome. Arch Dermatol 1987; 123: 1650-1654.
18. Kaneko F, Takahashi Y, Muramatsu Y, Miura Y,. Immunological studies on aphthous ulcer and erythema nodosum-like eruptions in Behçet's disease. Br J Dermatol 1985; 113: 303-312.
19. Honma T, Bang D, Saito T, et al. Assessment of apoptosis of infiltrating lymphocytes in erythema nodosum-like lesions of corticosteroid-treated patients with Behçet's syndrome. J Submicrosc Cytol Pathol 1989; 21: 691-701.
20. Bang D, Honma T, Saito T, et al. The pathogenesis of vascular changes in erythema nodosum-like lesions of Behçet's syndrome: an electron microscopic study. Hum Pathol 1987; 18: 1172-1179.
21. Pipitone N, Boiardi L, Olivieri I, et al. Clinical manifestations of Behçet's disease in 137 Italian patients: results of a multicenter study. Clin Exp Rheumatol 2004; 22: S46-S51.
22. Jaber L, Milo G, Halpern GJ, et al. Prevalence of Behçet's disease in an Arab community in Israel. Ann Rheum Dis 2002; 61: 365-366.
23. Vaiopoulos G, Konstantopoulou P, Evangelatos N, Kaklamanis PH,. The spectrum of mucocutaneous manifestations in Adamantiades-Behçet's disease in Greece. J Eur Acad Dermatol Venereol 2010; 24: 434-438.
24. Lee ES, Bang D, Lee S,. Dermatologic manifestation of Behçet's disease. Yonsei Med J 1997; 38: 380-389.
25. Mangelsdorf HC, White WL, Jorizzo JL,. Behçet's disease. Report of twenty-five patients from the United States with prominent mucocutaneous involvement. J Am Acad Dermatol 1996; 34: 745-750.
26. Galli SJ, Borregaard N, Wynn TA,. Phenotypic and functional plasticity of cells of innate immunity: macrophages, mast cells and neutrophils. Nat Immunol 2011; 12: 1035-1044.
27. Hamzaoui K, Hamzaoui A, Houman H,. CD4+CD25+ regulatory T cells in patients with Behçet's disease. Clin Exp Rheumatol 2006; 24: S71-S78.
28. Sugita S, Yamada Y, Kaneko S, et al. Induction of regulatory T cells by infliximab in Behcet's disease. Invest Ophthalmol Vis Sci 2011; 52: 476-484.
29. Sabat R, Philipp S, Höflich C, et al. Immunopathogenesis of psoriasis. Exp Dermatol 2007; 16: 779-798.
30. Nagafuchi H, Takeno M, Yoshikawa H, et al. Excessive expression of Txk, a member of the Tec family of tyrosine kinases, contributes to excessive Th1 cytokine production by T lymphocytes in patients with Behçet's disease. Clin Exp Immunol 2005; 139: 363-370.
31. Ben Ahmed M, Houman H, Miled M, et al. Involvement of chemokines and Th1 cytokines in the pathogenesis of mucocutaneous lesions of Behçet's disease. Arthritis Rheum 2004; 50: 2291-2295.
32. al-Dalaan A, al-Sedairy S, al-Balaa S, et al. Enhanced interleukin 8 secretion in circulation of patients with Behçet's disease. J Rheumatol 1995; 22: 904-907.
33. Frassanito MA, Dammacco R, Cafforio P, Dammacco F,. Th1 polarization of the immune response in Behçet's disease: a putative pathogenetic role of interleukin-12. Arthritis Rheum 1999; 42: 1967-1974.
34. Raziuddin S, al-Dalaan A, Bahabri S, et al. Divergent cytokine production profile in Behçet's disease. Altered Th1/Th2 cell cytokine pattern. J Rheumatol 1998; 25: 329-333.
35. Remmers EF, Cosan F, Kirino Y, et al. Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with Behçet's disease. Nat Genet 2010; 42: 698-702.
36. Mizuki N, Meguro A, Ota M, et al. Genome-wide association studies identify IL23R-IL12RB2 and IL10 as Behçet's disease susceptibility loci. Nat Genet 2010; 42: 703-706.
37. Hamzaoui K,. Th17 cells in Behçet's disease: a new immunoregulatory axis. Clin Exp Rheumatol 2011; 29: S71-S76.
38. Hamzaoui K, Bouali E, Ghorbel I, et al. Expression of Th-17 and RORγt mRNA in Behçet's Disease. Med Sci Monit 2011; 17: CR227-CR234.
39. Hamzaoui K, Hamzaoui A,. Immunological responses in patients with Behçet's disease: advances in understanding. Expert Rev Ophthalmol 2012; 7: 261-270.
40. Zhou ZY, Chen SL, Shen N, Lu Y,. Cytokines and Behcet's disease. Autoimmun Rev 2012; 11: 699-704.
41. Kim J, Park JA, Lee EY, et al. Imbalance of Th17 to Th1 cells in Behçet's disease. Clin Exp Rheumatol 2010; 28: S16-S19.
42. Jenkins SJ, Ruckerl D, Cook PC, et al. Local macrophage proliferation, rather than recruitment from the blood, is a signature of TH2 inflammation. Science 2011; 332: 1284-1288.
43. Helming L,. Inflammation: cell recruitment versus local proliferation. Curr Biol 2011; 21: R548-R550.
44. Hamzaoui K, Bouali E, Houman H,. Th17 trafficking cells in behcet's disease skin lesions. In, Amit N, ed. Inflammatory Diseases-A Modern Perspective. In Tech, Rijeka, Croatia, 2011: 27-42.