Role of sirtuins in kidney disease

Current Opinion in Nephrology and Hypertension

Volumn 23, Issue 1, 2014, Pages 75-79

  Kitada, Munehiro ^a   Kume, Shinji ^b   Koya, Daisuke ^a  

^a KANAZAWA MEDICAL UNIVERSITY   (Japan)

^b SHIGA UNIVERSITY OF MEDICAL SCIENCE   (Japan)

Author keywords

anti inflammation; antiapoptosis; antifibrosis; autophagy; SIRT1; SIRT3

Indexed keywords

SIRTUIN 1; SIRTUIN 3; SODIUM ION;

ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; APOPTOSIS; AUTOPHAGY; BLOOD PRESSURE REGULATION; CYST; EPITHELIUM CELL; FIBROSIS; HUMAN; INFLAMMATION; KIDNEY CELL; KIDNEY DISEASE; KIDNEY POLYCYSTIC DISEASE; KIDNEY TUBULE CELL; LIPOTOXICITY; PRIORITY JOURNAL; REVIEW;

ANIMALS; AUTOPHAGY; BLOOD PRESSURE; FIBROSIS; HUMANS; INFLAMMATION MEDIATORS; KIDNEY; KIDNEY DISEASES; SIGNAL TRANSDUCTION; SIRTUINS;

EID: 84890553396     PISSN: 10624821     EISSN: 14736543     Source Type: Journal    
DOI: 10.1097/01.mnh.0000437330.85675.ac     Document Type: Review

References (36)

1. Coresh J, Astor BC, Greene T, et al. Prevalence of chronic kidney disease and decreased kidney function in the adult US population: Third National Health and Nutrition Examination Survey. Am J Kidney Dis 2003; 41:1-12.
2. Rule AD, Amer H, Cornell LD, et al. The association between age and nephrosclerosis on renal biopsy among healthy adults. Ann Intern Med 2010; 152:561-567.
3. Hsu CY, Iribarren C, McCulloch CE, et al. Risk factors for end-stage renal disease: 25-year follow-up. Arch Intern Med 2009; 169:342-350.
4. Fontana L, Partridge L, Longo VD. Extending healthy life span: From yeast to humans. Science 2010; 328:321-326.
5. Guarente L, Franklin H. Epstein lecture: Sirtuins, aging, and medicine. N Engl J Med 2011; 364:2235-2244.
6. Someya S, Yu W, Hallows WC, et al. Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction. Cell 2010; 143:802-812.
7. Nath KA. Tubulointerstitial changes as a major determinant in the progression of renal damage. Am J Kidney Dis 1992; 20:1-17.
8. Kalluri R, Weinberg RA. The basics of epithelial-mesenchymal transition. J Clin Invest 2009; 119:1420-1428.
9. Simic P, Williams EO, Bell EL, et al. SIRT1 suppresses the epithelial-tomesenchymal transition in cancer metastasis and organ fibrosis. Cell Rep 2013; 3:1175-1186. This article demonstrates that SIRT1 supresses TGF-b induced EMT in the kidney by deacetylating Smad4, and reduces renal fibrosis.
10. Yuan Y, Chen Y, Zhang P, et al. Mitochondrial dysfunction accounts for aldosterone-induced epithelial-to-mesenchymal transition of renal proximal tubular epithelial cells. Free Radic Biol Med 2012; 53:30-43.
11. Li J, Qu X, Ricardo SD, et al. Resveratrol inhibits renal fibrosis in the obstructed kidney: Potential role in deacetylation of Smad3. Am J Pathol 2010; 177:1065-1071.
12. He W, Wang Y, Zhang MZ, et al. Sirt1 activation protects the mouse renal medulla from oxidative injury. J Clin Invest 2010; 120:1056-1068.
13. Hasegawa K, Wakino S, Yoshioka K, et al. Sirt1 protects against oxidative stress-induced renal tubular cell apoptosis by the bidirectional regulation of catalase expression. Biochem Biophys Res Commun 2008; 372:51-56.
14. Hasegawa K, Wakino S, Yoshioka K, et al. Kidney-specific overexpression of Sirt1 protects against acute kidney injury by retaining peroxisome function. J Biol Chem 2010; 285:13045-13056.
15. Kim DH, Jung YJ, Lee JE, et al. SIRT1 activation by resveratrol ameliorates cisplatin-induced renal injury through deacetylation of p53. Am J Physiol Renal Physiol 2011; 301:F427-F435.
16. Navarro-Gonzalez JF, Mora-Fernandez C, Muros de Fuentes M, Garcia-Perez J. Inflammatory molecules and pathways in the pathogenesis of diabetic nephropathy. Nat Rev Nephrol 2011; 7:327-340.
17. Hayden MS, Ghosh S. Shared principles in NF-kappaB signaling. Cell 2008; 132:344-462.
18. Yeung F, Hoberg JE, Ramsey CS, et al. Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase. EMBO J 2004; 23:2369-2380.
19. Kitada M, Takeda A, Nagai T, et al. Dietary restriction ameliorates diabetic nephropathy through anti-inflammatory effects and regulation of the autophagy via restoration of Sirt1 in diabetic Wistar fatty (fa/fa) rats: A model of type 2 diabetes. Exp Diabetes Res 2011; 2011:908185.
20. Jung YJ, Lee JE, Lee AS, et al. SIRT1 overexpression decreases cisplatininduced acetylation of NF-kappaB p65 subunit and cytotoxicity in renal proximal tubule cells. Biochem Biophys Res Commun 2012; 419:206-210.
21. Thomas ME, Schreiner GF. Contribution of proteinuria to progressive renal injury: Consequences of tubular uptake of fatty acid bearing albumin. Am J Nephrol 1993; 13:385-398.
22. Koyama T, Kume S, Koya D, et al. SIRT3 attenuates palmitate-induced ROS production and inflammation in proximal tubular cells. Free Radic Biol Med 2011; 51:1258-1267.
23. Hattori T, Shindo S, Kawamura H. Apoptosis and expression of Bax protein and Fas antigen in glomeruli of a remnant-kidney model. Nephron 1998; 79:186-191.
24. Yuan Y, Huang S, Wang W, et al. Activation of peroxisome proliferatoractivated receptor-gamma coactivator 1alpha ameliorates mitochondrial dysfunction and protects podocytes from aldosterone-induced injury. Kidney Int 2012; 82:771-789. This article shows that SIRT1 activation protected against aldosterone-induced podocyte injuries with mitochondrial dysfunction through deacetylation and activation of PGC-1a.
25. Chuang PY, Dai Y, Liu R, et al. Alteration of forkhead box O (foxo4) acetylation mediates apoptosis of podocytes in diabetes mellitus. PLoS One 2011; 6:e23566.
26. Kume S, Haneda M, Kanasaki K, et al. Silent information regulator 2 (SIRT1) attenuates oxidative stress-induced mesangial cell apoptosis via p53 deacetylation. Free Radic Biol Med 2006; 40:2175-2182.
27. Kume S, Haneda M, Kanasaki K, et al. SIRT1 inhibits transforming growth factor beta-induced apoptosis in glomerular mesangial cells via Smad7 deacetylation. J Biol Chem 2007; 282:151-158.
28. Mizushima N, Levine B, Cuervo AM, Klionsky DJ. Autophagy fights disease through cellular self-digestion. Nature 2008; 451:1069-1075.
29. Kroemer G, Marino G, Levine B. Autophagy and the integrated stress response. Mol Cell 2010; 40:280-293.
30. Tanaka Y, Kume S, Kitada M, et al. Autophagy as a therapeutic target in diabetic nephropathy. Exp Diabetes Res 2012; 2012:628978.
31. Kitada M, Kume S, Takeda-Watanabe A, et al. Sirtuins and renal diseases: Relationship with aging and diabetic nephropathy. Clin Sci (Lond) 2013; 124:153-164.
32. Kume S, Uzu T, Horiike K, et al. Calorie restriction enhances cell adaptation to hypoxia through Sirt1-dependent mitochondrial autophagy in mouse aged kidney. J Clin Invest 2010; 120:1043-1055.
33. Miyazaki R, Ichiki T, Hashimoto T, et al. SIRT1, a longevity gene, downregulates angiotensin II type 1 receptor expression in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 2008; 28:1263-1269.
34. Benigni A, Corna D, Zoja C, et al. Disruption of the Ang II type 1 receptor promotes longevity in mice. J Clin Invest 2009; 119:524-530.
35. Zhang J. The direct involvement of SirT1 in insulin-induced insulin receptor substrate-2 tyrosine phosphorylation. J Biol Chem 2007; 282:34356-34364.
36. Zhou X, Fan LX, Sweeney WE Jr, et al. Sirtuin 1 inhibition delays cyst formation in autosomal-dominant polycystic kidney disease. J Clin Invest 2013; 123:3084-3098.